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BCRX US Equity

Biocryst Pharmaceuticals IncHealth Care · Biological Products, (No Diagnostic Substances) · CIK 882796 · FY ends Dec 31
$9.70
-0.24 (-2.41%)
USD · as of 2026-08-18 · marketstack
54 registered studies · 3 active

Studies where BCRX is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.

53 interventional · 1 expanded access · 21 with posted results

Held by 17 tracked-famous managers (TWO SIGMA INVESTMENTS, LP, MILLENNIUM MANAGEMENT LLC, JANE STREET GROUP, LLC, RENAISSANCE TECHNOLOGIES LLC, AQR CAPITAL MANAGEMENT LLC, +12 more) · FINRA short interest 12.4 days to cover (settled 2026-07-31) · government filings 180d: none disclosed

StudyPhaseStatusInterventionsConditionsEnrollmentPrimary completionReadout inUpdated
Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat StudiesNCT04933721Number and proportion of subjects with a treatment-related TEAEOpen-label · PreventionPhase 3Enrolling by invitationDrug: berotralstatHereditary Angioedema, HAE139Aug 2031≤ 1,838 d2025-12-23
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BCX17725NCT06539507Incidence of treatment-emergent adverse events (TEAEs)Randomized · Double-masked · TreatmentPhase 1RecruitingDrug: BCX17725, PlaceboNetherton Syndrome78Oct 2026≤ 73 d2026-06-16
Berotralstat Treatment in Children With Hereditary AngioedemaNCT05453968results2026-02-25Area Under the Plasma Concentration-Time Curve From Time 0 to the Last Measurable Concentration (AUC0-last) of BerotralstatNon-randomized · Open-label · PreventionStudy Protocol · Statistical Analysis PlanPhase 3Active, not recruitingDrug: BerotralstatHereditary Angioedema, Pediatric292024-09-11actual2026-02-25
A Study of Avoralstat In Participants With Diabetic Macular EdemaNCT07228559The safety and tolerability of avoralstat in participants with DME. Incidence and severity of ocular (study eye) and systemic treatment emergent adverse events (TEAEs).Open-label · TreatmentPhase 1Terminatedsponsor's stated reason: Strategic decisionDrug: avoralstatDiabetic Macular Edema (DME)32026-04-17actual2026-05-11
Long-term Safety of BCX9930 in Participants With Paroxysmal Nocturnal HemoglobinuriaNCT05741346results2025-10-24Number of Participants With Treatment-emergent Events (TEAEs)Open-label · TreatmentStudy Protocol · Statistical Analysis PlanPhase 2Terminatedsponsor's stated reason: Sponsor decisionDrug: BCX9930Paroxysmal Nocturnal Hemoglobinuria282025-01-31actual2025-10-24
Dose Escalation of BCX10013 in Participants with Paroxysmal Nocturnal Hemoglobinuria (PNH)NCT06100900Number of Participants with Treatment-Emergent Adverse Events (TEAEs) and Graded Laboratory Abnormalities, and Changes From Baseline (CFB) in Laboratory Analytes, Vital signs, Electrocardiograms (ECGs), and Physical Examination Findings.Open-label · TreatmentPhase 1CompletedDrug: BCX10013Paroxysmal Nocturnal Hemoglobinuria82024-12-11actual2025-01-08
A Long-Term Safety Study of BCX9930 in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)NCT04702568results2024-12-13Number of Participants With Treatment Emergent Adverse Events (TEAEs)Non-randomized · Open-label · TreatmentStudy Protocol · Statistical Analysis PlanPhase 2Terminatedsponsor's stated reason: Sponsor decisionDrug: BCX9930, Eculizumab, RavulizumabParoxysmal Nocturnal Hemoglobinuria, PNH192023-10-04actual2025-04-13
BCX9930 for the Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) in Participants Not Receiving Other Complement Inhibitor TherapyNCT05116787results2025-01-03Part 1: Change From Baseline in Hemoglobin at Week 12Randomized · Double-masked · TreatmentStudy Protocol · Statistical Analysis PlanPhase 2Terminatedsponsor's stated reason: Sponsor decisionDrug: Placebo, BCX9930 monotherapyParoxysmal Nocturnal Hemoglobinuria (PNH)122023-09-18actual2025-01-03
BCX9930 for the Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) in Participants With Inadequate Response to C5 Inhibitor TherapyNCT05116774results2025-03-07Part 1: Change From Baseline in Hemoglobin at Week 24Randomized · Open-label · TreatmentStudy Protocol · Statistical Analysis PlanPhase 2Terminatedsponsor's stated reason: Sponsor decisionDrug: Eculizumab, Ravulizumab, BCX9930Paroxysmal Nocturnal Hemoglobinuria (PNH)122023-09-14actual2025-03-07
Study to Evaluate the Safety, Tolerability of BCX9930 in Participants With Either Complement 3 Glomerulopathy (C3G), Immunoglobulin A Nephropathy (IgAN), or Primary Membranous Nephropathy (PMN)NCT05162066results2024-05-02Percent Change From Baseline in 24-hour uPCR at Week 12Non-randomized · Open-label · TreatmentStudy Protocol · Statistical Analysis PlanPhase 2Terminatedsponsor's stated reason: Sponsor DecisionDrug: BCX9930Complement 3 Glomerulopathy, Immunoglobulin A Nephropathy, Membranous Nephropathy22022-09-23actual2024-05-02
A Long Term Safety Study of BCX7353 in Hereditary AngioedemaNCT03472040results2023-06-18Safety & TolerabilityOpen-label · PreventionStudy Protocol · Statistical Analysis PlanPhase 2/3CompletedDrug: BCX7353Hereditary Angioedema, HAE, Prophylaxis3872022-04-27actual2023-06-18
Study to Evaluate the Efficacy and Safety of BCX7353 as an Oral Treatment for the Prevention of HAE Attacks in JapanNCT03873116results2021-03-04Part 1: The Rate of Expert-confirmed HAE Attacks During Dosing in the Entire 24-week Treatment Period (Day 1 to Day 168)Randomized · Triple-masked · PreventionStudy Protocol · Statistical Analysis PlanPhase 3CompletedDrug: BCX7353 capsules, BCX7353 capsules, Placebo oral capsuleHereditary Angioedema, HAE192021-07-08actual2024-07-19
A Study to Evaluate the Safety, Pharmacokinetics and Antiviral Effects of Galidesivir in Yellow Fever or COVID-19NCT03891420number of subjects with treatment emergent adverse events and serious adverse eventsRandomized · Double-masked · TreatmentPhase 1Terminatedsponsor's stated reason: Sponsor decision to no longer pursue indications studied in this trialDrug: Galidesivir, PlaceboCOVID-19, Yellow Fever242021-01-31actual2021-05-27
First-in-Human Study of BCX9930 in Healthy Volunteers and Patients With PNHNCT04330534Incidence of graded treatment-emergent adverse eventsNon-randomized · Open-label · TreatmentPhase 1/2CompletedDrug: BCX9930, PlaceboParoxysmal Nocturnal Hemoglobinuria1682020-11-11actual2022-02-17
Safety, PK and Effectiveness of IV Peramivir Versus Oseltamivir in Pediatric Subjects With Uncomplicated InfluenzaNCT02369159results2021-03-23Safety and Tolerability, as Measured by the Number of Participants Experiencing Adverse Events.Randomized · Open-label · TreatmentStudy Protocol · Statistical Analysis PlanPhase 3CompletedDrug: Peramivir, OseltamivirInfluenza1372019-10-28actual2021-03-23
A Study to Evaluate the Single Dose Safety, Tolerability and Pharmacokinetics of IV BCX4430NCT03800173results2021-07-23Galidesivir Safety and Tolerability, as Measured by the Number of Participants Experiencing Adverse Events.Randomized · Double-masked · TreatmentStudy Protocol · Statistical Analysis PlanPhase 1CompletedDrug: galidesivir, placeboMarburg Virus Disease322019-04-30actual2021-07-23
Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAENCT03485911results2021-03-02Part 1: The Rate of Investigator-confirmed HAE Attacks During Dosing in the Entire 24-week Treatment Period (Day 1 to Day 168)Randomized · Triple-masked · PreventionStudy Protocol · Statistical Analysis PlanPhase 3CompletedDrug: BCX7353 capsules, Placebo oral capsuleHereditary Angioedema, HAE1212019-04-10actual2023-06-26
Study of BCX7353 as a Treatment for Attacks of Hereditary AngioedemaNCT03240133results2021-04-01Proportion of Subjects With Improved or Stable Composite Visual Analog Scale (VAS) ScoreRandomized · Double-masked · TreatmentStatistical Analysis Plan · Study ProtocolPhase 2CompletedDrug: BCX7353, PlaceboHereditary Angioedema (HAE)582019-01-29actual2021-04-01
Safety, PK and Effectiveness of IV Peramivir in Elderly and Higher Risk Subjects With Uncomplicated InfluenzaNCT02635724results2021-03-23Safety and Tolerability, as Measured by the Number of Adverse Events.Open-label · TreatmentStudy Protocol · Statistical Analysis PlanPhase 3CompletedDrug: PeramivirInfluenza74Apr 2018actual2021-03-23
Efficacy and Safety of BCX7353 to Prevent Angioedema Attacks in Subjects With Hereditary AngioedemaNCT02870972results2021-03-04Number of Confirmed HAE AttacksRandomized · Double-masked · PreventionStudy Protocol · Statistical Analysis PlanPhase 2CompletedDrug: BCX7353, PlaceboHereditary Angioedema (HAE)75Aug 2017actual2021-03-23
A Drug-Drug Interaction Study to Evaluate Drug Transporter InteractionsNCT03136237Cmax of probe substrateNon-randomized · Open-label · TreatmentPhase 1CompletedDrug: BCX7353, Digoxin, BCX7353 + digoxin, Rosuvastatin, rosuvastatin + BCX7353, Cyclosporine + BCX7353Hereditary Angioedema542017-08-15actual2017-10-26
A Relative Bioavailability Study of Two Formulations of BCX7353NCT03202784Geometric least-squares mean ratio for Cmax for test (blend in capsule) versus reference formulation (API in capsule)Randomized · Open-label · TreatmentPhase 1CompletedDrug: BCX7353Hereditary Angioedema242017-08-01actual2020-01-27
An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe SubstratesNCT02819102Cmax of probe substratesOpen-label · TreatmentPhase 1CompletedDrug: BCX7353 and probesHereditary Angioedema20Jun 2016actual2017-01-31
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of BCX4430NCT02319772Safety, measured by the frequency and severity of adverse events, laboratory abnormalities and other safety parameters following single (Part 1) and multiple (Part 2) doses of BCX4430Randomized · Quadruple-masked · TreatmentPhase 1CompletedDrug: BCX4430, PlaceboFilovirus Infections, Ebola Virus Infection94Mar 2016actual2016-07-07
Open-label, Long-term Safety Study of Avoralstat in Subjects With Hereditary AngioedemaNCT02670720Proportion of subjects who discontinue due to a treatment-emergent adverse event, who experience a treatment-emergent serious AE, who experience a Grade 3 or 4 AE and who experience Grade 3 or 4 laboratory abnormalitiesOpen-label · PreventionPhase 3Terminatedsponsor's stated reason: preceding efficacy study of avoralstat in its current formulation was not significant and does not support continued developmentDrug: avoralstatHereditary Angioedema, HAE6Feb 2016actual2016-02-17
12-Week Safety and Efficacy Study of BCX4161 as an Oral Prophylaxis Against HAE AttacksNCT02303626results2025-11-17The Mean Acute Angioedema Attack RateRandomized · Quadruple-masked · PreventionPhase 2/3CompletedDrug: BCX4161, PlaceboHereditary Angioedema, HAE110Jan 2016actual2025-11-17
First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese VolunteersNCT02448264Adverse eventsRandomized · Double-masked · TreatmentPhase 1CompletedDrug: BCX7353, Placebo to match BCX7353Hereditary Angioedema122Nov 2015actual2016-01-13
Study to Determine How BCX4161 is Metabolized and Eliminated by the BodyNCT02218294Mass balance of BCX4161 after a single oral dose of [14C] BCX4161 based upon radioactivity excreted in urine, expired air and fecesOpen-label · TreatmentPhase 1CompletedDrug: BCX4161Hereditary Angioedema7Sep 2014actual2014-10-29
A Study of the Relative Bioavailability of a New Formulation of BCX4161 and the Effect of Food on BCX4161NCT02125162Plasma pharmacokinetics to assess the relative bioavailability of BCX4161 soft gelatin capsules to hard gelatin capsulesRandomized · Open-label · TreatmentPhase 1CompletedDrug: BCX4161Hereditary Angioedema28Jul 2014actual2014-08-15
Safety and Efficacy of Oral BCX4161 as a Prophylactic Treatment for HAENCT01984788Number of acute angioedema attacksRandomized · Double-masked · PreventionPhase 2CompletedDrug: BCX4161, PlaceboHereditary Angioedema24May 2014actual2014-08-18
A Study to Evaluate the Efficacy and Safety of IV Peramivir in Addition to Standard of Care Compared to Standard of Care Alone in Adults and Adolescents Who Are Hospitalized Due to InfluenzaNCT00958776results2015-02-12Time to Clinical Resolution (Kaplan-Meier Estimate)Randomized · Double-masked · TreatmentPhase 3Terminatedsponsor's stated reason: This study was terminated for futilityDrug: Peramivir+SOC, Placebo+SOCCough, Sore Throat, Nasal Congestion, Headache, Fever, Seasonal Influenza405Nov 2012actual2015-02-12
Study to Evaluate sUA Lowering Activity, Safety and Efficacy of Oral Ulodesine Added to AllopurinolNCT01265264To evaluate the dose response of ulodesine when combined with Allopurinol on sUA.Randomized · Quadruple-masked · TreatmentPhase 2CompletedDrug: ulodesine, PlaceboGout, Hyperuricemia, Arthritis, Joint Disease279Jul 2012actual2013-11-20
A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal InsufficiencyNCT01407874To evaluate the overall safety and tolerability of ulodesine when combined with allopurinol in subjects with moderate renal insufficiency by assessment of percent change from baseline in CD4+ lymphocytes at Day 85.Randomized · Triple-masked · TreatmentPhase 2CompletedDrug: Placebo, Ulodesine (BCX4208) 5 mg, Ulodesine (BCX4208) 10 mgGout, Hyperuricemia, Arthritis, Joint Disease, Renal Insufficiency20Jul 2012actual2013-11-20
Forodesine (BCX-1777) in Treating Patients With Refractory Stage IIA, Stage IIB, Stage III, Stage IVA, or Stage IVB Cutaneous T-Cell LymphomaNCT00098332Open-label · TreatmentPhase 1CompletedDrug: forodesine hydrochlorideLymphomaDec 2010actual2013-07-10
Phase II Study of Forodesine in Subjects With Chronic Lymphocytic Leukemia (CLL)NCT00640523Overall response rateNon-randomized · Open-label · TreatmentPhase 2CompletedDrug: forodesine HClChronic Lymphocytic Leukemia (CLL)23Nov 2010actual2012-01-23
Study to Evaluate sUA-Lowering Activity, Safety & PK Interaction of Oral BCX4208 & Allopurinol Admin. in Subjects w/GoutNCT01129648To estimate the dose response relationship of BCX4208 when administered as a monotherapy and in combination with allopurinol on sUA.Randomized · Quadruple-masked · TreatmentPhase 2CompletedDrug: Placebo, Allopurinol, Allopurinol, Allopurinol, BCX4208, Allopurinol, Allopurinol, Allopurinol, BCX4208, Allopurinol, Allopurinol, Allopurinol, BCX4208, Allopurinol, Allopurinol, Allopurinol, BCX4208Gout87Nov 2010actual2012-01-23
A Study to Evaluate the Efficacy and Safety of Intravenous Peramivir in Subjects With Uncomplicated Influenza.NCT01224795To evaluate the efficacy of peramivir administered intravenously compared to placebo on the time to alleviation of clinical symptoms with acute uncomplicated influenza.Randomized · Quadruple-masked · TreatmentPhase 3WithdrawnDrug: Peramivir, Placebo ComparatorInfluenza0Nov 2010actual2026-06-10
Safety Study of IV Peramivir in Hospitalized Subjects With Confirmed or Suspected InfluenzaNCT00957996results2015-02-12Change From Baseline in Influenza Virus Titer (48 Hours)Randomized · Open-label · TreatmentPhase 3CompletedDrug: Peramivir, PeramivirSeasonal Influenza, Cough, Sore Throat, Nasal Congestion, Myalgia, Headache, Fatigue234Oct 2010actual2015-02-12
Study to Evaluate the Urate-Lowering Activity and Safety of Oral BCX4208 Administered in Subjects With GoutNCT00985127To determine the effect of different doses of orally administered BCX4208 on serum uric acid (sUA)levels in subjects with gout.Randomized · Quadruple-masked · TreatmentPhase 2CompletedDrug: placebo, BCX4208Gout99Sep 2010actual2012-01-23
Forodesine in the Treatment of Cutaneous T-Cell LymphomaNCT00501735The primary objective of this study is to determine the objective response rate to treatment with oral forodesine in subjects with cutaneous manifestations of CTCL subjects, stages IIB, III, and IVA.Non-randomized · Open-label · TreatmentPhase 2CompletedDrug: Forodesine 200 mgCutaneous T-cell Lymphoma (CTCL),144Jul 2010actual2012-01-23
A Phase II, Multicenter, Randomized, Placebo -Controlled, Study To Evaluate The Efficacy and Safety Of Intramuscular Peramivir 600 mg In Subjects With Uncomplicated Acute InfluenzaNCT00705406results2015-02-16Time to Alleviation of Symptoms (Kaplan-Meier Estimate)Randomized · Double-masked · TreatmentPhase 2CompletedDrug: Peramivir, PlaceboAcute, Uncomplicated Human Influenza405Apr 2009actual2015-02-16
Study of Forodesine Hydrochloride in Patients With Advanced, Fludarabine-refractory Chronic Lymphocytic Leukemia (CLL)NCT00289549Response rate after 2 cyclesof forodesine therapy.Non-randomized · Open-label · TreatmentPhase 2CompletedDrug: forodesine hydrochloride (BCX-1777)Leukemia, Lymphocytic, Chronic8Jan 2009actual2012-02-08
Evaluation of Efficacy and Safety of Peramivir in Adults With Acute Serious or Potentially Life-threatening InfluenzaNCT00453999results2015-02-12Time to Clinical Stability (Kaplan-Meier Estimate)Randomized · Quadruple-masked · TreatmentPhase 2CompletedDrug: Peramivir 200 mg, Peramivir 400 mg, OseltamivirInfluenza137Sep 2008actual2015-02-12
Intramuscular Peramivir in Subjects With Uncomplicated Acute InfluenzaNCT00610935results2021-03-17The Time to Alleviation of Clinical Signs and Symptoms of InfluenzaRandomized · Double-masked · TreatmentStudy Protocol and Statistical Analysis PlanPhase 3Terminatedsponsor's stated reason: This study was terminated for administrative reasons.Drug: Peramivir, PlaceboInfluenza82Feb 2008actual2021-03-17
Forodesine Hydrochloride (BCX-1777) for B-Cell Acute Lymphoblastic LeukemiaNCT00289562Open-label · TreatmentPhase 1/2CompletedDrug: forodesine hydrochloride (BCX-1777)B-cell Acute Lymphoblastic Leukemia20Dec 2007actual2012-01-20
Evaluation of the Efficacy and Safety of Peramivir in Subjects With Uncomplicated Acute Influenza.NCT00419263results2015-02-12Time to Alleviation of Symptoms (Kaplan-Meier Estimate)Randomized · Quadruple-masked · TreatmentPhase 2CompletedDrug: Peramivir 150 mg, Peramivir 300 mg, PlaceboInfluenza344Sep 2007actual2015-02-12
Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell LeukemiaNCT00095381Determine the sustained effectiveness of IV forodesine hydrochloride infusions in patients with advanced T-cell leukemia (T-ALL or T-PLL)Non-randomized · Open-label · TreatmentPhase 2CompletedDrug: forodesine hydrochloride (BCX-1777)Leukemia, T-Cell20Mar 2007actual2012-01-19
Study of Forodesine Hydrochloride in Patients With Relapsed/Refractory Precursor T-Lymphoblastic Leukemia/Lymphoma Who Have Failed Two or More Prior Treatment RegimensNCT00419081To determine the rate of complete remission for T lymphoblastic leukemia/lymphoma relapsed or refractory patients. The complete remission rate will be evaluated over the three-month Initial Treatment Period.Non-randomized · Open-label · TreatmentPhase 2Terminatedsponsor's stated reason: Issues with ManufacturingDrug: Forodesine Hydrochloride Sterile Solution, 5 mg/mL, Forodesine Hydrochloride Capsules (100 mg)Leukemia, Lymphoma100Mar 2007actual2012-01-23
BCX-1777 in Treating Patients With Refractory Cutaneous T-Cell LymphomaNCT00061880Open-label · TreatmentPhase 1/2CompletedDrug: forodesine hydrochlorideLymphomaJan 2005actual2013-05-30
BCX-1777 in Treating Patients With Refractory CancerNCT00073944Open-label · TreatmentPhase 1CompletedDrug: forodesine hydrochlorideCancerJan 2005actual2013-05-30
A Study of Peldesine (BCX-34) in HIV-Infected PatientsNCT00002237TreatmentPhase 1CompletedDrug: PeldesineHIV Infections2005-06-24
Study of Intravenous BCX-1777 in Relapsed or Refractory Aggressive T-Cell Leukemias or LymphomasNCT00035022Non-randomized · Open-label · TreatmentPhase 1/2CompletedDrug: BCX-1777Leukemia, Lymphocytic, Lymphoma712006-01-13
Intramuscular Peramivir for the Treatment of Uncomplicated InfluenzaNCT00486980Randomized · Double-maskedPhase 3Withdrawnsponsor's stated reason: This study was withdrawn for administrative reasons. The dose ranging plan for the program was revised".Drug: Peramivir 150mg, Peramivir 300mgInfluenza02026-06-01
Oral Berotralstat Expanded Access ProgramNCT04428632expanded accessApproved for marketingDrug: BerotralstatHereditary Angioedema, HAE, Prophylaxis2020-12-11

Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.

Source: ClinicalTrials.gov, retrieved 2026-08-19