| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Cormorant Asset Management, LP | 17,878,59417.9M | $160M | 22.32% | — |
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,885,4464.9M | $44M | 6.10% | — |
| 3 | Omega Fund Management, LLC | 3,289,6613.3M | $29M | 4.11% | — |
| 4 | EcoR1 Capital, LLC | 2,823,1262.8M | $25M | 3.52% | — |
| 5 | Alphabet Inc. | 2,823,1262.8M | $25M | 3.52% | — |
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 2,818,3482.8M | $25M | 3.52% | TRIM -3% |
| 7 | ENAVATE SCIENCES GP, LLC | 2,626,9462.6M | $24M | 3.28% | — |
| 8 | CITADEL ADVISORS LLC | 2,528,7622.5M | $23M | 3.16% | — |
| 9 | NOVO HOLDINGS A/S | 2,185,9232.2M | $20M | 2.73% | ADD 11% |
| 10 | BlackRock, Inc. | 2,088,2972.1M | $19M | 2.61% | — |
| 11 | Laurion Capital Management LP | 1,922,6561.9M | $17M | 2.40% | ADD 31% |
| 12 | ARMISTICE CAPITAL, LLC | 1,328,0001.3M | $12M | 1.66% | ADD 33% |
| 13 | Aisling Capital Management LP | 1,018,0181.0M | $9M | 1.27% | ADD 80% |
| 14 | Paradigm Biocapital Advisors LP | 868,213868,213 | $8M | 1.08% | TRIM -62% |
| 15 | Octagon Capital Advisors LP | 719,000719,000 | $6M | 0.90% | TRIM -31% |
| 16 | ROYCE & ASSOCIATES LP | 636,522636,522 | $6M | 0.79% | NEW |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 579,234579,234 | $5M | 0.72% | ADD 3% |
| 18 | VANGUARD CAPITAL MANAGEMENT LLC | 538,441538,441 | $5M | 0.67% | NEW |
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 541,181541,181 | $5M | 0.68% | TRIM -50% |
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 437,889437,889 | $4M | 0.55% | TRIM -45% |
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000400,000 | $4M | 0.50% | TRIM -71% |
| 22 | Ensign Peak Advisors, Inc | 320,874320,874 | $3M | 0.40% | NEW |
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 290,806290,806 | $3M | 0.36% | ADD 4% |
| 24 | Casdin Capital, LLC | 282,312282,312 | $3M | 0.35% | — |
| 25 | Ikarian Capital, LLC | 270,231270,231 | $2M | 0.34% | ADD 23% |
| 26 | MILLENNIUM MANAGEMENT LLC | 265,954265,954 | $2M | 0.33% | ADD 10% |
| 27 | VANGUARD FIDUCIARY TRUST CO | 254,329254,329 | $2M | 0.32% | NEW |
| 28 | SCHRODER INVESTMENT MANAGEMENT GROUP | 249,161249,161 | $2M | 0.31% | NEW |
| 29 | FMR LLC | 240,300240,300 | $2M | 0.30% | — |
| 30 | Granahan Investment Management, LLC | 231,040231,040 | $2M | 0.29% | NEW |
| 31 | STATE STREET CORP | 226,278226,278 | $2M | 0.28% | ADD 4% |
| 32 | GOLDMAN SACHS GROUP INC | 167,573167,573 | $1M | 0.21% | ADD 77% |
| 33 | Sio Capital Management, LLC | 130,628130,628 | $1M | 0.16% | — |
| 34 | Hudson Bay Capital Management LP | 110,000110,000 | $984,500 | 0.14% | NEW |
| 35 | Woodline Partners LP | 103,707103,707 | $928,178 | 0.13% | — |
| 36 | NORTHERN TRUST CORP | 102,258102,258 | $915,209 | 0.13% | ADD 76% |
| 37 | RENAISSANCE TECHNOLOGIES LLC | 101,900101,900 | $912,005 | 0.13% | ADD 37% |
| 38 | MOORE CAPITAL MANAGEMENT, LP | 100,000100,000 | $895,000 | 0.12% | — |
| 39 | BNP PARIBAS FINANCIAL MARKETS | 90,81990,819 | $812,830 | 0.11% | ADD 243% |
| 40 | Avidity Partners Management LP | 87,70687,706 | $761,288 | 0.11% | NEW |
| 41 | Tidal Investments LLC | 82,17282,172 | $735,439 | 0.10% | NEW |
| 42 | Tema ETFs LLC | 82,17282,172 | $735,439 | 0.10% | NEW |
| 43 | BOOTHBAY FUND MANAGEMENT, LLC | 80,88480,884 | $723,912 | 0.10% | ADD 21% |
| 44 | HighVista Strategies LLC | 78,18778,187 | $699,774 | 0.10% | TRIM -66% |
| 45 | Qube Research & Technologies Ltd | 71,92571,925 | $643,729 | 0.09% | ADD 100% |
| 46 | XTX Topco Ltd | 59,74359,743 | $534,700 | 0.07% | ADD 109% |
| 47 | TD Asset Management Inc | 57,57257,572 | $515,269 | 0.07% | TRIM -51% |
| 48 | Opaleye Management Inc. | 53,28253,282 | $476,874 | 0.07% | NEW |
| 49 | UBS Group AG | 50,45050,450 | $451,528 | 0.06% | TRIM -46% |
| 50 | ExodusPoint Capital Management, LP | 48,12248,122 | $430,692 | 0.06% | NEW |
| 51 | MORGAN STANLEY | 43,37443,374 | $388,197 | 0.05% | ADD 202% |
| 52 | Squarepoint Ops LLC | 43,19043,190 | $386,551 | 0.05% | ADD 275% |
| 53 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,69235,692 | $319,443 | 0.04% | TRIM -34% |
| 54 | ACADIAN ASSET MANAGEMENT LLC | 29,14829,148 | $260,000 | 0.04% | NEW |
| 55 | Vanguard Global Advisers, LLC | 18,16318,163 | $162,559 | 0.02% | NEW |
| 56 | AXQ CAPITAL, LP | 17,34717,347 | $155,256 | 0.02% | NEW |
| 57 | Diametric Capital, LP | 16,28016,280 | $145,706 | 0.02% | NEW |
| 58 | Brevan Howard Capital Management LP | 14,24814,248 | $127,520 | 0.02% | NEW |
| 59 | Quadrature Capital Ltd | 13,35113,351 | $119,491 | 0.02% | ADD 3% |
| 60 | Aquatic Capital Management LLC | 11,79311,793 | $105,547 | 0.01% | NEW |
| 61 | Bellevue Group AG | 6,9826,982 | $62,489 | 0.01% | NEW |
| 62 | Rockefeller Capital Management L.P. | 700700 | $6,265 | 0.00% | — |
| 63 | Accent Capital Management, LLC | 335335 | $2,998 | 0.00% | NEW |
| 64 | WELLS FARGO & COMPANY/MN | 300300 | $2,685 | 0.00% | — |
| 65 | BARCLAYS PLC | 212212 | $1,897 | 0.00% | NEW |
| 66 | ROYAL BANK OF CANADA | 154154 | $1,000 | 0.00% | NEW |
| 67 | Caitong International Asset Management Co., Ltd | 44 | $36 | 0.00% | NEW |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 2.9M | 2.9M | 2.9M | 17.9M | 17.9M | 17.9M | $160M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | — | — | — | 4.9M | 4.9M | 4.9M | $44M |
| Omega Fund Management, LLC | — | — | — | 3.3M | 3.3M | 3.3M | $29M |
| Alphabet Inc. | — | — | — | 2.8M | 2.8M | 2.8M | $25M |
| EcoR1 Capital, LLC | — | — | — | 2.8M | 2.8M | 2.8M | $25M |
| WELLINGTON MANAGEMENT GROUP LLP | 185K | 185K | 185K | 3.0M | 2.9M | 2.8M | $25M |
| ENAVATE SCIENCES GP, LLC | — | — | — | 2.6M | 2.6M | 2.6M | $24M |
| CITADEL ADVISORS LLC | 1.3M | 1.4M | 1.4M | 2.5M | 2.5M | 2.5M | $23M |
| NOVO HOLDINGS A/S | — | — | — | 2.0M | 2.0M | 2.2M | $20M |
| BlackRock, Inc. | 1.5M | 1.5M | 1.5M | 2.0M | 2.1M | 2.1M | $19M |
| Laurion Capital Management LP | 300K | 300K | 300K | 1.0M | 1.5M | 1.9M | $17M |
| ARMISTICE CAPITAL, LLC | — | — | — | 412K | 1.0M | 1.3M | $12M |
| Aisling Capital Management LP | — | — | — | 565K | 565K | 1.0M | $9M |
| Paradigm Biocapital Advisors LP | — | — | — | 1.9M | 2.3M | 868K | $8M |
| Octagon Capital Advisors LP | 250K | 250K | 250K | 1.0M | 1.0M | 719K | $6M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 67 | 57,479,041 | 71.8% | $514M |
| 2025-Q4 | 53 | 58,307,760 | 72.8% | $756M |
| 2025-Q3 | 42 | 56,812,379 | 70.9% | $658M |
| 2025-Q2 | 34 | 16,716,535 | 20.9% | $178M |
| 2025-Q1 | 31 | 16,487,496 | 20.6% | $186M |
| 2024-Q4 | 32 | 16,445,284 | 20.5% | $173M |
| 2024-Q3 | 31 | 16,373,466 | 20.4% | $171M |
| 2024-Q2 | 31 | 16,380,021 | 20.4% | $167M |
| 2024-Q1 | 29 | 16,068,960 | 20.1% | $167M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Item 4 is hereby amended and supplemented as follows: On July 1, 2026, Sponsor distributed 4,528,186 shares of Common Stock, pro rata, to its members for no consideration. Following such transaction, Sponsor holds no shares of Common Stock. As a result of Sponsor's pro rata distribution of shares to its members, (i) Fund III, a member of Sponsor, acquired 2,692,459 shares of Common Stock; (ii) Fund V, a member of Sponsor, acquired 1,704,862 shares of Common Stock; and (iii) Master Fund, a member”
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
