| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | SUVRETTA CAPITAL MANAGEMENT, LLC | 4,401,0834.4M | $102M | 9.45% | ADD 7% |
| 2 | INFINITUM ASSET MANAGEMENT, LLC | 4,148,9234.1M | $96M | 8.91% | — |
| 3 | HHLR ADVISORS, LTD.tracked | 3,929,1173.9M | $91M | 8.44% | — |
| 4 | ORBIMED ADVISORS LLC | 3,027,3283.0M | $70M | 6.50% | — |
| 5 | FMR LLC | 3,016,1323.0M | $70M | 6.48% | TRIM -19% |
| 6 | BlackRock, Inc. | 2,530,3012.5M | $58M | 5.43% | ADD 7% |
| 7 | Octagon Capital Advisors LP | 1,971,0542.0M | $45M | 4.23% | — |
| 8 | NOVO HOLDINGS A/S | 1,942,1421.9M | $45M | 4.17% | — |
| 9 | Sofinnova Investments, Inc. | 1,696,7521.7M | $39M | 3.64% | — |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 1,528,8931.5M | $35M | 3.28% | NEW† |
| 11 | General Catalyst Group Management, LLC | 1,494,7861.5M | $34M | 3.21% | — |
| 12 | STATE STREET CORP | 1,421,4151.4M | $33M | 3.05% | ADD 30% |
| 13 | Vivo Capital, LLC | 885,916885,916 | $20M | 1.90% | NEW |
| 14 | GOLDMAN SACHS GROUP INC | 853,427853,427 | $20M | 1.83% | ADD 15% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 803,652803,652 | $19M | 1.73% | ADD 7% |
| 16 | Point72 Asset Management, L.P. | 748,195748,195 | $17M | 1.61% | ADD 245% |
| 17 | HSG Holding Ltd | 663,308663,308 | $14M | 1.42% | — |
| 18 | Fund 1 Investments, LLC | 499,990499,990 | $12M | 1.07% | TRIM -12% |
| 19 | UBS Group AG | 486,263486,263 | $11M | 1.04% | ADD 8% |
| 20 | Balyasny Asset Management L.P. | 426,281426,281 | $10M | 0.92% | ADD 891% |
| 21 | MILLENNIUM MANAGEMENT LLC | 425,923425,923 | $10M | 0.91% | ADD 51% |
| 22 | D. E. Shaw & Co., Inc. | 368,795368,795 | $9M | 0.79% | ADD 58% |
| 23 | Logos Global Management LP | 350,000350,000 | $8M | 0.75% | NEW |
| 24 | NORTHERN TRUST CORP | 268,812268,812 | $6M | 0.58% | ADD 9% |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 258,772258,772 | $6M | 0.56% | ADD 3% |
| 26 | VANGUARD PORTFOLIO MANAGEMENT LLC | 253,852253,852 | $6M | 0.55% | NEW |
| 27 | NOMURA HOLDINGS INC | 242,050242,050 | $6M | 0.52% | NEW |
| 28 | VANGUARD FIDUCIARY TRUST CO | 217,127217,127 | $5M | 0.47% | NEW |
| 29 | AMERIPRISE FINANCIAL INC | 180,028180,028 | $4M | 0.39% | ADD 52% |
| 30 | Affinity Asset Advisors, LLC | 175,000175,000 | $4M | 0.38% | ADD 17% |
| 31 | CITADEL ADVISORS LLC | 166,157166,157 | $4M | 0.36% | TRIM -64% |
| 32 | Woodline Partners LP | 147,639147,639 | $3M | 0.32% | — |
| 33 | ADAR1 Capital Management, LLC | 141,814141,814 | $3M | 0.30% | NEW |
| 34 | MORGAN STANLEY | 128,546128,546 | $3M | 0.28% | ADD 32% |
| 35 | DIMENSIONAL FUND ADVISORS LP | 126,525126,525 | $3M | 0.27% | ADD 758% |
| 36 | Polymer Capital Management (HK) LTD | 122,276122,276 | $3M | 0.26% | NEW |
| 37 | Burkehill Global Management, LP | 100,000100,000 | $2M | 0.21% | — |
| 38 | E Fund Management Co., Ltd. | 93,95393,953 | $2M | 0.20% | NEW |
| 39 | BANK OF AMERICA CORP /DE/ | 80,20880,208 | $2M | 0.17% | ADD 42% |
| 40 | WELLINGTON MANAGEMENT GROUP LLP | 78,21378,213 | $2M | 0.17% | TRIM -5% |
| 41 | Bank of New York Mellon Corp | 75,44875,448 | $2M | 0.16% | ADD 3% |
| 42 | Qube Research & Technologies Ltd | 70,31770,317 | $2M | 0.15% | NEW |
| 43 | BARCLAYS PLC | 65,40865,408 | $2M | 0.14% | TRIM -49% |
| 44 | XTX Topco Ltd | 63,00263,002 | $1M | 0.14% | ADD 140% |
| 45 | JPMORGAN CHASE & CO | 65,87965,879 | $1M | 0.14% | TRIM -5% |
| 46 | Nuveen, LLC | 56,83956,839 | $1M | 0.12% | ADD 6% |
| 47 | Moody Aldrich Partners LLC | 56,08856,088 | $1M | 0.12% | — |
| 48 | Squarepoint Ops LLC | 55,43255,432 | $1M | 0.12% | TRIM -70% |
| 49 | Seven Fleet Capital Management LP | 50,25250,252 | $1M | 0.11% | NEW |
| 50 | SG Americas Securities, LLC | 48,71648,716 | $1M | 0.10% | TRIM -5% |
| 51 | TWO SIGMA INVESTMENTS, LP | 48,68248,682 | $1M | 0.10% | TRIM -37% |
| 52 | HRT FINANCIAL LP | 47,05347,053 | $1M | 0.10% | TRIM -12% |
| 53 | Jones Hill Capital LP | 45,80945,809 | $1M | 0.10% | NEW |
| 54 | Swiss National Bank | 40,00040,000 | $922,800 | 0.09% | — |
| 55 | Rafferty Asset Management, LLC | 37,25337,253 | $859,427 | 0.08% | ADD 29% |
| 56 | ALPS ADVISORS INC | 35,98635,986 | $830,197 | 0.08% | ADD 6% |
| 57 | MARSHALL WACE, LLP | 35,16535,165 | $811,257 | 0.08% | TRIM -64% |
| 58 | RHUMBLINE ADVISERS | 35,14835,148 | $810,853 | 0.08% | ADD 12% |
| 59 | SECTORAL ASSET MANAGEMENT INC | 30,01330,013 | $720,430 | 0.06% | TRIM -22% |
| 60 | Quantinno Capital Management LP | 30,99630,996 | $715,078 | 0.07% | NEW |
| 61 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,89830,898 | $712,817 | 0.07% | TRIM -87% |
| 62 | DEUTSCHE BANK AG\ | 27,97927,979 | $645,476 | 0.06% | ADD 30% |
| 63 | Corient Private Wealth LLC | 27,23927,239 | $607,754 | 0.06% | NEW |
| 64 | ALLIANCEBERNSTEIN L.P. | 28,20028,200 | $567,384 | 0.06% | — |
| 65 | Invesco Ltd. | 23,94123,941 | $552,319 | 0.05% | ADD 42% |
| 66 | PRICE T ROWE ASSOCIATES INC /MD/ | 22,59322,593 | $522,000 | 0.05% | ADD 40% |
| 67 | TUDOR INVESTMENT CORP ET AL | 22,10122,101 | $509,870 | 0.05% | NEW |
| 68 | Jump Financial, LLC | 21,90021,900 | $505,233 | 0.05% | TRIM -10% |
| 69 | Man Group plc | 20,72720,727 | $478,172 | 0.04% | NEW |
| 70 | AMERICAN CENTURY COMPANIES INC | 19,51519,515 | $450,211 | 0.04% | NEW |
| 71 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,36719,367 | $446,797 | 0.04% | TRIM -11% |
| 72 | ExodusPoint Capital Management, LP | 19,02519,025 | $438,907 | 0.04% | TRIM -68% |
| 73 | Optimize Financial Inc | 18,91618,916 | $436,392 | 0.04% | NEW |
| 74 | JANE STREET GROUP, LLC | 17,65817,658 | $407,370 | 0.04% | TRIM -83% |
| 75 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,72617,726 | $403,601 | 0.04% | ADD 15% |
| 76 | MetLife Investment Management, LLC | 17,32417,324 | $399,665 | 0.04% | ADD 4% |
| 77 | LOS ANGELES CAPITAL MANAGEMENT LLC | 17,30817,308 | $399,297 | 0.04% | TRIM -57% |
| 78 | PROFUND ADVISORS LLC | 16,81316,813 | $387,876 | 0.04% | ADD 53% |
| 79 | IvyRock Asset Management (HK) Ltd | 16,00016,000 | $369,120 | 0.03% | NEW |
| 80 | Caption Management, LLC | 15,96715,967 | $368,359 | 0.03% | NEW |
| 81 | AQR CAPITAL MANAGEMENT LLC | 15,92315,923 | $367,344 | 0.03% | ADD 39% |
| 82 | VOYA INVESTMENT MANAGEMENT LLC | 15,33115,331 | $353,687 | 0.03% | NEW |
| 83 | VANGUARD ASSET MANAGEMENT, Ltd | 14,89314,893 | $343,582 | 0.03% | NEW |
| 84 | Legal & General Group Plc | 14,67614,676 | $338,575 | 0.03% | TRIM -4% |
| 85 | Brooklyn Investment Group | 14,12514,125 | $325,864 | 0.03% | NEW |
| 86 | Quadrature Capital Ltd | 13,30713,307 | $306,992 | 0.03% | ADD 4% |
| 87 | Zurcher Kantonalbank (Zurich Cantonalbank) | 13,10613,106 | $302,355 | 0.03% | ADD 176% |
| 88 | Susquehanna Portfolio Strategies, LLC | 12,25212,252 | $282,654 | 0.03% | NEW |
| 89 | WELLS FARGO & COMPANY/MN | 12,12412,124 | $279,700 | 0.03% | TRIM -62% |
| 90 | INTECH INVESTMENT MANAGEMENT LLC | 11,81911,819 | $272,664 | 0.03% | ADD 7% |
| 91 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,35711,357 | $262,006 | 0.02% | ADD 3% |
| 92 | Virtus Investment Advisers, LLC | 11,16511,165 | $257,577 | 0.02% | ADD 2% |
| 93 | Vanguard Global Advisers, LLC | 10,76310,763 | $248,302 | 0.02% | NEW |
| 94 | BNP PARIBAS FINANCIAL MARKETS | 9,5769,576 | $220,918 | 0.02% | ADD 75% |
| 95 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,0689,068 | $209,199 | 0.02% | NEW |
| 96 | GLENMEDE TRUST CO NA | 9,0619,061 | $209,037 | 0.02% | NEW |
| 97 | AXQ CAPITAL, LP | 8,9358,935 | $206,130 | 0.02% | NEW |
| 98 | Persistent Asset Partners Ltd | 8,1088,108 | $187,052 | 0.02% | — |
| 99 | Police & Firemen's Retirement System of New Jersey | 7,8817,881 | $181,815 | 0.02% | — |
| 100 | NEW YORK STATE COMMON RETIREMENT FUND | 7,7837,783 | $179,554 | 0.02% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2.2M | 2.3M | 3.4M | 3.7M | 4.1M | 4.4M | $102M |
| INFINITUM ASSET MANAGEMENT, LLC | 1.6M | 2.1M | 3.4M | 3.9M | 4.1M | 4.1M | $96M |
| HHLR ADVISORS, LTD.tracked | 4.5M | 4.5M | 4.5M | 4.5M | 3.9M | 3.9M | $91M |
| ORBIMED ADVISORS LLC | 3.0M | 3.0M | 3.0M | 3.0M | 3.0M | 3.0M | $70M |
| FMR LLC | 2.1M | 2.1M | 2.1M | 3.4M | 3.7M | 3.0M | $70M |
| BlackRock, Inc. | 2.1M | 2.1M | 1.8M | 2.0M | 2.4M | 2.5M | $58M |
| Octagon Capital Advisors LP | 2.1M | 2.1M | 1.9M | 2.0M | 2.0M | 2.0M | $45M |
| NOVO HOLDINGS A/S | 1.5M | 1.9M | 1.9M | 1.9M | 1.9M | 1.9M | $45M |
| Sofinnova Investments, Inc. | 1.7M | 1.7M | 1.7M | 1.7M | 1.7M | 1.7M | $39M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.5M | $35M |
| General Catalyst Group Management, LLC | 1.5M | 1.5M | 1.5M | 1.5M | 1.5M | 1.5M | $34M |
| STATE STREET CORP | 814K | 768K | 741K | 1.0M | 1.1M | 1.4M | $33M |
| Vivo Capital, LLC | — | — | — | — | — | 886K | $20M |
| GOLDMAN SACHS GROUP INC | 207K | 77K | 339K | 432K | 743K | 853K | $20M |
| GEODE CAPITAL MANAGEMENT, LLC | 596K | 615K | 596K | 716K | 754K | 804K | $19M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 139 | 42,089,366 | 90.4% | $969M |
| 2025-Q4 | 122 | 40,107,464 | 86.1% | $810M |
| 2025-Q3 | 106 | 38,584,345 | 82.8% | $713M |
| 2025-Q2 | 99 | 33,625,907 | 72.2% | $732M |
| 2025-Q1 | 83 | 29,075,131 | 62.4% | $539M |
| 2024-Q4 | 80 | 28,465,888 | 61.1% | $757M |
| 2024-Q3 | 68 | 25,922,059 | 55.7% | $613M |
| 2024-Q2 | 54 | 21,658,375 | 46.5% | $404M |
| 2024-Q1 | 53 | 21,906,782 | 47.0% | $390M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The Shares acquired by the Reporting Persons were acquired for the purpose of making an investment in the Issuer and not with the intention of acquiring control of the Issuer's business on behalf of the Reporting Persons' respective advisory clients. The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditi”
| HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 9.5% | Exempt | 2025-12-31 | SEC → |
| FMR LLC | 6.8% | QII | 2026-03-31 | SEC → |
| BlackRock, Inc. | 6.8% | QII | 2026-06-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
