| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | GILEAD SCIENCES, INC. | 4,505,3914.5M | $125M | 28.40% | — |
| 2 | FARALLON CAPITAL MANAGEMENT LLC | 1,227,5901.2M | $34M | 7.74% | — |
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,020,4101.0M | $28M | 6.43% | — |
| 4 | Commodore Capital LP | 1,000,0001.0M | $28M | 6.30% | — |
| 5 | JANUS HENDERSON GROUP PLC | 849,309849,309 | $23M | 5.35% | — |
| 6 | Paradigm Biocapital Advisors LP | 665,251665,251 | $18M | 4.19% | — |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 490,447490,447 | $14M | 3.09% | NEW† |
| 8 | Parkman Healthcare Partners LLC | 411,227411,227 | $11M | 2.59% | ADD 65% |
| 9 | STEMPOINT CAPITAL LP | 370,870370,870 | $10M | 2.34% | ADD 137% |
| 10 | Point72 Asset Management, L.P. | 344,105344,105 | $10M | 2.17% | TRIM -43% |
| 11 | Blackstone Inc. | 296,855296,855 | $8M | 1.87% | TRIM -7% |
| 12 | MILLENNIUM MANAGEMENT LLC | 233,650233,650 | $6M | 1.47% | ADD 138% |
| 13 | BlackRock, Inc. | 202,743202,743 | $6M | 1.28% | ADD 5% |
| 14 | B Group, Inc. | 175,706175,706 | $5M | 1.11% | — |
| 15 | MARSHALL WACE, LLP | 163,400163,400 | $5M | 1.03% | ADD 27% |
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 161,000161,000 | $4M | 1.01% | — |
| 17 | Patient Square Capital LP | 136,315136,315 | $4M | 0.86% | ADD 7% |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 132,971132,971 | $4M | 0.84% | — |
| 19 | Schonfeld Strategic Advisors LLC | 120,500120,500 | $3M | 0.76% | ADD 122% |
| 20 | Caption Management, LLC | 81,84181,841 | $2M | 0.52% | TRIM -23% |
| 21 | HighVista Strategies LLC | 74,73574,735 | $2M | 0.47% | NEW |
| 22 | VANGUARD FIDUCIARY TRUST CO | 71,60671,606 | $2M | 0.45% | NEW |
| 23 | Qube Research & Technologies Ltd | 69,25669,256 | $2M | 0.44% | ADD 64% |
| 24 | STATE STREET CORP | 56,68956,689 | $2M | 0.36% | ADD 7% |
| 25 | Seven Fleet Capital Management LP | 56,14756,147 | $2M | 0.35% | TRIM -24% |
| 26 | JPMORGAN CHASE & CO | 53,96253,962 | $1M | 0.34% | ADD 12% |
| 27 | MONIMUS CAPITAL MANAGEMENT, LP | 48,39048,390 | $1M | 0.31% | ADD 26% |
| 28 | GSA CAPITAL PARTNERS LLP | 45,04945,049 | $1M | 0.28% | ADD 255% |
| 29 | NORTHERN TRUST CORP | 41,01441,014 | $1M | 0.26% | — |
| 30 | Eversept Partners, LP | 40,88940,889 | $1M | 0.26% | TRIM -74% |
| 31 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 39,44639,446 | $1M | 0.25% | ADD 4% |
| 32 | GOLDMAN SACHS GROUP INC | 36,20536,205 | $1M | 0.23% | ADD 4% |
| 33 | JANE STREET GROUP, LLC | 34,49934,499 | $957,347 | 0.22% | TRIM -36% |
| 34 | MORGAN STANLEY | 33,05533,055 | $917,277 | 0.21% | ADD 47% |
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,94932,949 | $914,335 | 0.21% | TRIM -59% |
| 36 | 683 Capital Management, LLC | 27,86327,863 | $773,198 | 0.18% | — |
| 37 | BARCLAYS PLC | 27,05027,050 | $750,637 | 0.17% | ADD 9% |
| 38 | WELLINGTON MANAGEMENT GROUP LLP | 26,49626,496 | $735,265 | 0.17% | NEW |
| 39 | CITADEL ADVISORS LLC | 25,43725,437 | $705,877 | 0.16% | TRIM -23% |
| 40 | Squarepoint Ops LLC | 23,80423,804 | $660,561 | 0.15% | NEW |
| 41 | Trexquant Investment LP | 22,74122,741 | $631,063 | 0.14% | TRIM -20% |
| 42 | Connor, Clark & Lunn Investment Management Ltd. | 21,76121,761 | $603,868 | 0.14% | ADD 5% |
| 43 | TWO SIGMA INVESTMENTS, LP | 20,55020,550 | $570,263 | 0.13% | NEW |
| 44 | ADAR1 Capital Management, LLC | 19,94719,947 | $553,529 | 0.13% | — |
| 45 | Palumbo Wealth Management LLC | 19,64319,643 | $545,094 | 0.12% | TRIM -47% |
| 46 | FEDERATED HERMES, INC. | 18,90418,904 | $524,586 | 0.12% | TRIM -26% |
| 47 | VANGUARD PORTFOLIO MANAGEMENT LLC | 17,72317,723 | $491,813 | 0.11% | NEW |
| 48 | Hudson Bay Capital Management LP | 16,79916,799 | $466,172 | 0.11% | ADD 12% |
| 49 | RENAISSANCE TECHNOLOGIES LLC | 15,65115,651 | $434,315 | 0.10% | ADD 69% |
| 50 | Susquehanna Portfolio Strategies, LLC | 14,10014,100 | $391,275 | 0.09% | — |
| 51 | EntryPoint Capital, LLC | 12,38412,384 | $343,656 | 0.08% | NEW |
| 52 | Brevan Howard Capital Management LP | 11,11211,112 | $308,358 | 0.07% | NEW |
| 53 | Jump Financial, LLC | 10,91710,917 | $302,947 | 0.07% | NEW |
| 54 | BANK OF AMERICA CORP /DE/ | 10,90210,902 | $302,530 | 0.07% | ADD 113% |
| 55 | XTX Topco Ltd | 10,78510,785 | $299,284 | 0.07% | NEW |
| 56 | Engineers Gate Manager LP | 9,4239,423 | $261,489 | 0.06% | TRIM -9% |
| 57 | AMERICAN CENTURY COMPANIES INC | 9,1549,154 | $254,024 | 0.06% | NEW |
| 58 | CANADA PENSION PLAN INVESTMENT BOARD | 8,5008,500 | $235,875 | 0.05% | ADD 143% |
| 59 | OMERS ADMINISTRATION Corp | 8,1008,100 | $224,775 | 0.05% | TRIM -48% |
| 60 | Virtus Investment Advisers, LLC | 7,5537,553 | $209,596 | 0.05% | ADD 2% |
| 61 | CITIGROUP INC | 6,4836,483 | $179,903 | 0.04% | ADD 195% |
| 62 | Vanguard Global Advisers, LLC | 4,6154,615 | $128,066 | 0.03% | NEW |
| 63 | Tower Research Capital LLC (TRC) | 544544 | $15,096 | 0.00% | TRIM -10% |
| 64 | UBS Group AG | 364364 | $10,101 | 0.00% | TRIM -96% |
| 65 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 260260 | $7,215 | 0.00% | — |
| 66 | Aquatic Capital Management LLC | 220220 | $6,105 | 0.00% | NEW |
| 67 | RHUMBLINE ADVISERS | 190190 | $5,272 | 0.00% | — |
| 68 | BNP PARIBAS FINANCIAL MARKETS | 149149 | $4,135 | 0.00% | ADD 7350% |
| 69 | Accent Capital Management, LLC | 142142 | $3,941 | 0.00% | NEW |
| 70 | OSAIC HOLDINGS, INC. | 100100 | $2,775 | 0.00% | — |
| 71 | US BANCORP \DE\ | 5959 | $1,637 | 0.00% | — |
| 72 | FIFTH THIRD BANCORP | 5757 | $1,582 | 0.00% | NEW |
| 73 | EverSource Wealth Advisors, LLC | 5555 | $1,526 | 0.00% | — |
| 74 | Allworth Financial LP | 2929 | $805 | 0.00% | TRIM -9% |
| 75 | ROYAL BANK OF CANADA | 1616 | $0 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 2.2M | 2.2M | 2.2M | 4.5M | 4.5M | 4.5M | $125M |
| FARALLON CAPITAL MANAGEMENT LLC | — | — | — | 1.2M | 1.2M | 1.2M | $34M |
| RA CAPITAL MANAGEMENT, L.P. | — | — | — | 1.0M | 1.0M | 1.0M | $28M |
| Commodore Capital LP | — | — | — | 1.0M | 1.0M | 1.0M | $28M |
| JANUS HENDERSON GROUP PLC | — | — | — | 753K | 838K | 849K | $23M |
| Paradigm Biocapital Advisors LP | — | — | — | — | 665K | 665K | $18M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 490K | $14M |
| Parkman Healthcare Partners LLC | — | — | — | 251K | 249K | 411K | $11M |
| STEMPOINT CAPITAL LP | — | — | — | 66K | 157K | 371K | $10M |
| Point72 Asset Management, L.P. | — | — | — | 296K | 601K | 344K | $10M |
| Blackstone Inc. | — | — | — | 448K | 319K | 297K | $8M |
| MILLENNIUM MANAGEMENT LLC | — | — | — | 22K | 98K | 234K | $6M |
| BlackRock, Inc. | 82K | 79K | 90K | 170K | 192K | 203K | $6M |
| B Group, Inc. | 51K | 200K | 189K | 176K | 176K | 176K | $5M |
| MARSHALL WACE, LLP | 15K | 18K | — | 85K | 129K | 163K | $5M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +490,447 | $14M | OPEN |
| STEMPOINT CAPITAL LP | +214,142 | $6M | ADD |
| Parkman Healthcare Partners LLC | +161,870 | $4M | ADD |
| MILLENNIUM MANAGEMENT LLC | +135,429 | $4M | ADD |
| HighVista Strategies LLC | +74,735 | $2M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −572,898 | $16M | CLOSE |
| Point72 Asset Management, L.P. | −256,504 | $7M | TRIM |
| FRANKLIN RESOURCES INC | −210,528 | $6M | CLOSE |
| Eversept Partners, LP | −118,787 | $3M | TRIM |
| SUPERSTRING CAPITAL MANAGEMENT LP | −65,273 | $2M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 75 | 13,754,054 | 86.7% | $382M |
| 2025-Q4 | 69 | 13,724,214 | 86.8% | $467M |
| 2025-Q3 | 57 | 12,482,615 | — | $325M |
| 2025-Q2 | 33 | 3,148,532 | 41.2% | $57M |
| 2025-Q1 | 37 | 3,175,672 | 42.3% | $30M |
| 2024-Q4 | 35 | 3,185,761 | 50.1% | $50M |
| 2024-Q3 | 30 | 1,030,496 | 16.2% | $16M |
| 2024-Q2 | 27 | 1,175,323 | 21.3% | $16M |
| 2024-Q1 | 24 | 652,234 | 11.9% | $9M |
| 2023-Q4 | 45 | 8,678,693 | 13.2% | $7M |
| 2023-Q3 | 32 | 9,738,224 | 18.5% | $9M |
| 2023-Q2 | 32 | 10,465,393 | 20.1% | $12M |
| 2023-Q1 | 38 | 13,166,282 | 25.3% | $11M |
| 2022-Q4 | 40 | 14,193,778 | 29.1% | $18M |
| 2022-Q3 | 50 | 16,596,042 | 34.3% | $27M |
| 2022-Q2 | 54 | 17,190,228 | 35.7% | $36M |
| 2022-Q1 | 54 | 19,079,417 | 39.6% | $39M |
| 2021-Q4 | 62 | 23,315,813 | 48.7% | $54M |
| 2021-Q3 | 65 | 22,707,129 | 50.5% | $79M |
| 2021-Q2 | 91 | 27,095,124 | 67.5% | $105M |
| 2021-Q1 | 107 | 28,747,520 | 75.2% | $134M |
| 2020-Q4 | 109 | 27,660,329 | 83.8% | $167M |
| 2020-Q3 | 119 | 30,544,047 | 93.0% | $502M |
| 2020-Q2 | 106 | 30,210,263 | 92.0% | $705M |
| 2020-Q1 | 98 | 30,472,135 | — | $452M |
| 2019-Q4 | 100 | 28,689,449 | — | $587M |
| 2019-Q3 | 98 | 20,978,354 | 81.6% | $206M |
| 2019-Q2 | 106 | 21,673,198 | 84.7% | $294M |
| 2019-Q1 | 104 | 22,311,188 | 87.4% | $439M |
| 2018-Q4 | 107 | 21,583,903 | 84.8% | $488M |
| 2018-Q3 | 113 | 22,224,829 | 87.3% | $823M |
| 2018-Q2 | 105 | 16,674,692 | 81.1% | $654M |
| 2018-Q1 | 107 | 16,057,473 | 79.3% | $789M |
| 2017-Q4 | 98 | 15,572,913 | 89.5% | $704M |
| 2017-Q3 | 72 | 12,367,192 | 71.2% | $432M |
| 2017-Q2 | 65 | 12,545,334 | 72.3% | $259M |
| 2017-Q1 | 49 | 11,937,830 | 69.1% | $302M |
| 2016-Q4 | 38 | 11,672,037 | 67.8% | $140M |
| 2016-Q3 | 36 | 11,111,705 | 64.5% | $79M |
| 2016-Q2 | 44 | 11,282,702 | 65.5% | $62M |
| 2016-Q1 | 47 | 12,398,978 | 72.0% | $62M |
| 2015-Q4 | 49 | 12,347,409 | 71.7% | $92M |
| 2015-Q3 | 53 | 13,177,046 | 76.7% | $126M |
| 2015-Q2 | 58 | 12,067,732 | 70.3% | $232M |
| 2015-Q1 | 34 | 10,771,334 | 100.7% | $143M |
| 2014-Q4 | 24 | 4,299,403 | 40.4% | $33M |
| 2014-Q3 | 22 | 1,661,232 | 19.1% | $14M |
