| 1 | 1Vivo Capital, LLC | 3,153,6403.2M | $11M | 8.76% | NEW† |
| 2 | 2Commodore Capital LP | 2,333,7132.3M | $8M | 6.48% | NEW† |
| 3 | 3MILLENNIUM MANAGEMENT LLC | 2,222,5022.2M | $8M | 6.17% | ADD 2223% |
| 4 | 4Spruce Street Capital LP | 1,661,0731.7M | $6M | 4.61% | NEW† |
| 5 | 5Almitas Capital LLC | 1,479,1291.5M | $5M | 4.11% | — |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 1,011,0781.0M | $3M | 2.81% | NEW† |
| 7 | 7ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,0001.0M | $3M | 2.78% | NEW† |
| 8 | 8Woodline Partners LP | 993,671993,671 | $3M | 2.76% | ADD 581% |
| 9 | 9Boxer Capital Management, LLC | 749,035749,035 | $3M | 2.08% | NEW† |
| 10 | 10Stonepine Capital Management, LLC | 713,845713,845 | $2M | 1.98% | ADD 14% |
| 11 | 11AMERIPRISE FINANCIAL INC | 696,181696,181 | $2M | 1.93% | NEW |
| 12 | 12Sio Capital Management, LLC | 657,200657,200 | $2M | 1.82% | NEW |
| 13 | 13Ally Bridge Group (NY) LLC | 526,315526,315 | $2M | 1.46% | NEW |
| 14 | 14Prosight Management, LP | 515,754515,754 | $2M | 1.43% | NEW |
| 15 | 15BANK OF NOVA SCOTIA | 459,194459,194 | $2M | 1.27% | — |
| 16 | 16BANK OF AMERICA CORP /DE/ | 393,702393,702 | $1M | 1.09% | ADD 2% |
| 17 | 17BlackRock, Inc. | 318,768318,768 | $1M | 0.89% | — |
| 18 | 18JANE STREET GROUP, LLC | 303,649303,649 | $1M | 0.84% | ADD 1593% |
| 19 | 19LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 298,166298,166 | $1M | 0.83% | TRIM -31% |
| 20 | 20GEODE CAPITAL MANAGEMENT, LLC | 286,547286,547 | $980,838 | 0.80% | ADD 14% |
| 21 | 21BANK OF MONTREAL /CAN/ | 260,127260,127 | $889,634 | 0.72% | TRIM -38% |
| 22 | 22MORGAN STANLEY | 234,187234,187 | $800,920 | 0.65% | — |
| 23 | 23CANTOR FITZGERALD, L. P. | 200,000200,000 | $684,000 | 0.56% | NEW |
| 24 | 24Seven Fleet Capital Management LP | 199,701199,701 | $682,977 | 0.55% | NEW |
| 25 | 25RENAISSANCE TECHNOLOGIES LLC | 198,800198,800 | $679,896 | 0.55% | TRIM -41% |
| 26 | 26CITADEL ADVISORS LLC | 155,239155,239 | $530,917 | 0.43% | ADD 34% |
| 27 | 27VANGUARD FIDUCIARY TRUST CO | 137,708137,708 | $470,961 | 0.38% | NEW |
| 28 | 28STATE STREET CORP | 115,202115,202 | $393,991 | 0.32% | ADD 32% |
| 29 | 29Centiva Capital, LP | 75,00075,000 | $256,500 | 0.21% | NEW |
| 30 | 30UBS Group AG | 61,39261,392 | $209,961 | 0.17% | ADD 8% |
| 31 | 31Peapod Lane Capital LLC | 59,85459,854 | $206,903 | 0.17% | TRIM -90% |
| 32 | 32BRIDGEWAY CAPITAL MANAGEMENT, LLC | 59,90059,900 | $204,858 | 0.17% | — |
| 33 | 33NORTHERN TRUST CORP | 43,19643,196 | $147,730 | 0.12% | — |
| 34 | 34CAPTRUST FINANCIAL ADVISORS | 40,00040,000 | $136,800 | 0.11% | — |
| 35 | 35Persistent Asset Partners Ltd | 38,15538,155 | $130,490 | 0.11% | NEW |
| 36 | 36Hudson Bay Capital Management LP | 34,60534,605 | $118,349 | 0.10% | NEW |
| 37 | 37HRT FINANCIAL LP | 32,92432,924 | $112,000 | 0.09% | NEW |
| 38 | 38BNP PARIBAS FINANCIAL MARKETS | 30,07830,078 | $102,867 | 0.08% | ADD 9827% |
| 39 | 39Qube Research & Technologies Ltd | 24,16824,168 | $82,655 | 0.07% | ADD 137% |
| 40 | 40XTX Topco Ltd | 22,40222,402 | $76,615 | 0.06% | NEW |
| 41 | 41CITIGROUP INC | 19,08819,088 | $65,281 | 0.05% | NEW |
| 42 | 42MARSHALL WACE, LLP | 17,70017,700 | $60,534 | 0.05% | NEW |
| 43 | 43OMERS ADMINISTRATION Corp | 15,80015,800 | $54,036 | 0.04% | NEW |
| 44 | 44ADAR1 Capital Management, LLC | 13,86113,861 | $47,405 | 0.04% | NEW |
| 45 | 45Private Advisor Group, LLC | 12,50012,500 | $42,750 | 0.03% | TRIM -44% |
| 46 | 46FEDERATED HERMES, INC. | 8,3228,322 | $28,461 | 0.02% | TRIM -28% |
| 47 | 47Vanguard Global Advisers, LLC | 7,3347,334 | $25,082 | 0.02% | NEW |
| 48 | 48Caitong International Asset Management Co., Ltd | 2,6002,600 | $8,892 | 0.01% | NEW |
| 49 | 49Tower Research Capital LLC (TRC) | 574574 | $1,963 | 0.00% | TRIM -72% |
| 50 | 50BARCLAYS PLC | 400400 | $1,368 | 0.00% | NEW |
| 51 | 51OSAIC HOLDINGS, INC. | 300300 | $1,026 | 0.00% | — |
| 52 | 52SBI Securities Co., Ltd. | 201201 | $687 | 0.00% | — |
