ANNX US Equity

Annexon, Inc.

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Health Care · Pharmaceutical Preparations · CIK 1528115 · FYE 1231

$4.97

-0.16 (-3.12%)

USD · as of 2026-07-28 · marketstack

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Institutional ownership· 13F filers holding ANNX · 2026-Q1 methodology → sources →

217 holders

% of shares outstanding held

100.5%

Shares held (13F)

155,947,902

Reporting holders

217

Institutional 13F holdings sum to 100.5% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 23,443,455 shares (settlement 2026-04-30) accounts for the excess.

Top holders

largest 100 of 217 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	Redmile Group, LLC	14,549,76814.5M	$81M	9.38%	ADD 45%
2	BlackRock, Inc.	10,938,50910.9M	$61M	7.05%	ADD 22%
3	FMR LLC	10,635,64810.6M	$59M	6.86%	ADD 4%
4	BVF INC/IL	8,698,1738.7M	$48M	5.61%	TRIM -5%
5	STATE STREET CORP	6,919,2556.9M	$38M	4.46%	ADD 49%
6	VANGUARD CAPITAL MANAGEMENT LLC	5,956,5896.0M	$33M	3.84%	NEW†
7	Bain Capital Life Sciences Investors, LLC	5,212,6745.2M	$29M	3.36%	—
8	Bellevue Group AG	5,157,2905.2M	$29M	3.33%	—
9	MAK CAPITAL ONE LLC	4,724,0434.7M	$26M	3.05%	ADD 60%
10	ADAGE CAPITAL PARTNERS GP, L.L.C.	4,300,0004.3M	$24M	2.77%	TRIM -22%
11	BANK OF AMERICA CORP /DE/	4,259,9954.3M	$24M	2.75%	ADD 165%
12	Nuveen, LLC	4,246,3304.2M	$24M	2.74%	ADD 46%
13	Siren, L.L.C.	3,958,6464.0M	$22M	2.55%	NEW†
14	Balyasny Asset Management L.P.	3,886,9093.9M	$22M	2.51%	ADD 18%
15	AMERIPRISE FINANCIAL INC	3,449,1213.4M	$19M	2.22%	TRIM -21%
16	GEODE CAPITAL MANAGEMENT, LLC	3,377,8233.4M	$19M	2.18%	ADD 16%
17	Qube Research & Technologies Ltd	3,114,3143.1M	$17M	2.01%	ADD 31%
18	Palo Alto Investors LP	2,948,0902.9M	$16M	1.90%	ADD 24%
19	MORGAN STANLEY	2,735,9702.7M	$15M	1.76%	TRIM -4%
20	GREAT POINT PARTNERS LLC	2,500,0002.5M	$14M	1.61%	NEW
21	Woodline Partners LP	2,337,1372.3M	$13M	1.51%	TRIM -42%
22	Opaleye Management Inc.	2,331,7612.3M	$13M	1.50%	TRIM -10%
23	GOLDMAN SACHS GROUP INC	2,152,8802.2M	$12M	1.39%	ADD 22%
24	Point72 Asset Management, L.P.	1,871,7951.9M	$10M	1.21%	ADD 404%
25	VANGUARD PORTFOLIO MANAGEMENT LLC	1,483,0901.5M	$8M	0.96%	NEW
26	Y-Intercept (Hong Kong) Ltd	1,319,9131.3M	$7M	0.85%	NEW
27	Tetragon Partners GP Ltd	1,292,4551.3M	$7M	0.83%	TRIM -36%
28	UBS Group AG	1,245,9411.2M	$7M	0.80%	ADD 230%
29	MILLENNIUM MANAGEMENT LLC	1,238,6781.2M	$7M	0.80%	TRIM -56%
30	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1,102,4451.1M	$6M	0.71%	ADD 4%
31	NORTHERN TRUST CORP	1,086,9021.1M	$6M	0.70%	ADD 37%
32	DIMENSIONAL FUND ADVISORS LP	924,078924,078	$5M	0.60%	ADD 29%
33	KENNEDY CAPITAL MANAGEMENT LLC	912,323912,323	$5M	0.59%	ADD 43%
34	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	903,368903,368	$5M	0.58%	—
35	VANGUARD FIDUCIARY TRUST CO	888,552888,552	$5M	0.57%	NEW
36	MARSHALL WACE, LLP	861,475861,475	$5M	0.56%	ADD 65%
37	AQR CAPITAL MANAGEMENT LLC	777,253777,253	$4M	0.50%	—
38	Invesco Ltd.	763,005763,005	$4M	0.49%	TRIM -22%
39	ACADIAN ASSET MANAGEMENT LLC	758,232758,232	$4M	0.49%	TRIM -12%
40	Russell Investments Group, Ltd.	711,380711,380	$4M	0.46%	ADD 4%
41	D. E. Shaw & Co., Inc.	702,799702,799	$4M	0.45%	TRIM -33%
42	WELLS FARGO & COMPANY/MN	698,739698,739	$4M	0.45%	ADD 22%
43	Parkman Healthcare Partners LLC	674,013674,013	$4M	0.43%	ADD 12%
44	Ensign Peak Advisors, Inc	625,097625,097	$3M	0.40%	NEW
45	Longaeva Partners L.P.	620,401620,401	$3M	0.40%	TRIM -80%
46	CITADEL ADVISORS LLC	600,135600,135	$3M	0.39%	ADD 118%
47	DEERFIELD MANAGEMENT COMPANY, L.P.	583,913583,913	$3M	0.38%	—
48	Ikarian Capital, LLC	580,244580,244	$3M	0.37%	ADD 152%
49	SIRIOS CAPITAL MANAGEMENT L P	575,063575,063	$3M	0.37%	TRIM -19%
50	DEUTSCHE BANK AG\	562,181562,181	$3M	0.36%	—
51	RENAISSANCE TECHNOLOGIES LLC	544,300544,300	$3M	0.35%	TRIM -32%
52	WELLINGTON MANAGEMENT GROUP LLP	521,379521,379	$3M	0.34%	ADD 31%
53	Hennion & Walsh Asset Management, Inc.	509,689509,689	$3M	0.33%	TRIM -5%
54	SILVERARC CAPITAL MANAGEMENT, LLC	496,461496,461	$3M	0.32%	NEW
55	Board of Trustees of The Leland Stanford Junior University	482,550482,550	$3M	0.31%	—
56	TWO SIGMA INVESTMENTS, LP	471,391471,391	$3M	0.30%	ADD 42%
57	VOLORIDGE INVESTMENT MANAGEMENT, LLC	462,068462,068	$3M	0.30%	NEW
58	PRICE T ROWE ASSOCIATES INC /MD/	428,720428,720	$2M	0.28%	TRIM -4%
59	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	416,698416,698	$2M	0.27%	TRIM -35%
60	Trexquant Investment LP	403,657403,657	$2M	0.26%	NEW
61	Bank of New York Mellon Corp	395,019395,019	$2M	0.25%	ADD 9%
62	Susquehanna Portfolio Strategies, LLC	360,319360,319	$2M	0.23%	—
63	JPMORGAN CHASE & CO	323,894323,894	$2M	0.21%	ADD 503%
64	Cinctive Capital Management LP	268,640268,640	$1M	0.17%	TRIM -25%
65	BNP PARIBAS FINANCIAL MARKETS	255,371255,371	$1M	0.16%	ADD 315%
66	Swiss National Bank	236,000236,000	$1M	0.15%	NEW
67	Rafferty Asset Management, LLC	203,269203,269	$1M	0.13%	ADD 44%
68	SEI INVESTMENTS CO	203,236203,236	$1M	0.13%	ADD 249%
69	Rosalind Advisors, Inc.	200,000200,000	$1M	0.13%	NEW
70	IEQ CAPITAL, LLC	195,764195,764	$1M	0.13%	ADD 7%
71	Ishara Investments LP	174,250174,250	$965,345	0.11%	TRIM -77%
72	Engineers Gate Manager LP	174,141174,141	$964,741	0.11%	NEW
73	J. Goldman & Co LP	170,817170,817	$946,326	0.11%	TRIM -83%
74	BOOTHBAY FUND MANAGEMENT, LLC	166,164166,164	$920,549	0.11%	ADD 159%
75	RHUMBLINE ADVISERS	159,670159,670	$884,563	0.10%	ADD 26%
76	SUSQUEHANNA INTERNATIONAL GROUP, LLP	158,640158,640	$878,866	0.10%	TRIM -14%
77	ALGERT GLOBAL LLC	154,840154,840	$858,000	0.10%	NEW
78	JACOBS LEVY EQUITY MANAGEMENT, INC	148,941148,941	$825,133	0.10%	TRIM -78%
79	MANUFACTURERS LIFE INSURANCE COMPANY, THE	134,786134,786	$746,714	0.09%	ADD 4%
80	DIADEMA PARTNERS LP	132,916132,916	$736,355	0.09%	TRIM -62%
81	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	130,647130,647	$723,784	0.08%	NEW
82	Schonfeld Strategic Advisors LLC	123,282123,282	$682,981	0.08%	TRIM -76%
83	DAFNA Capital Management LLC	117,812117,812	$652,678	0.08%	TRIM -57%
84	VICTORY CAPITAL MANAGEMENT INC	115,527115,527	$640,019	0.07%	ADD 683%
85	Man Group plc	109,222109,222	$605,090	0.07%	NEW
86	ALLIANCEBERNSTEIN L.P.	119,050119,050	$597,631	0.08%	TRIM -15%
87	SCS Capital Management LLC	99,00099,000	$548,460	0.06%	NEW
88	BRIDGEWAY CAPITAL MANAGEMENT, LLC	97,80097,800	$541,812	0.06%	TRIM -29%
89	Connor, Clark & Lunn Investment Management Ltd.	92,70792,707	$513,597	0.06%	NEW
90	PROFUND ADVISORS LLC	90,95990,959	$503,913	0.06%	ADD 72%
91	J. Safra Sarasin Holding AG	90,48790,487	$501,298	0.06%	TRIM -23%
92	DNB Asset Management AS	88,61788,617	$490,938	0.06%	TRIM -25%
93	XTX Topco Ltd	80,49580,495	$445,942	0.05%	TRIM -67%
94	Legal & General Group Plc	80,04680,046	$443,454	0.05%	ADD 760%
95	VANGUARD ASSET MANAGEMENT, Ltd	79,48679,486	$440,352	0.05%	NEW
96	CAPTRUST FINANCIAL ADVISORS	79,17379,173	$438,613	0.05%	ADD 151%
97	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	76,25776,257	$414,110	0.05%	ADD 39%
98	MetLife Investment Management, LLC	72,44472,444	$401,340	0.05%	ADD 85%
99	POLEN CAPITAL MANAGEMENT LLCtracked	70,15270,152	$388,642	0.05%	NEW
100	Squarepoint Ops LLC	67,95667,956	$376,476	0.04%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

Redmile Group, LLC

6.3M

10.1M

14.5M

$81M

BlackRock, Inc.

8.5M

8.0M

7.9M

9.0M

10.9M

$61M

FMR LLC

14.2M

13.3M

15.7M

11.1M

10.2M

10.6M

$59M

BVF INC/IL

7.0M

9.1M

8.7M

$48M

STATE STREET CORP

4.5M

2.0M

2.1M

4.7M

6.9M

$38M

VANGUARD CAPITAL MANAGEMENT LLC

—

6.0M

$33M

Bain Capital Life Sciences Investors, LLC

5.2M

$29M

Bellevue Group AG

5.2M

$29M

MAK CAPITAL ONE LLC

—

3.0M

4.7M

$26M

ADAGE CAPITAL PARTNERS GP, L.L.C.

—

1.5M

5.5M

4.3M

$24M

BANK OF AMERICA CORP /DE/

30K

1.0M

1.5M

1.3M

1.6M

4.3M

$24M

Nuveen, LLC

—

347K

256K

683K

2.9M

4.2M

$24M

Siren, L.L.C.

—

4.0M

$22M

Balyasny Asset Management L.P.

—

97K

—

1.3M

3.3M

3.9M

$22M

AMERIPRISE FINANCIAL INC

927K

4.0M

2.2M

4.3M

3.4M

$19M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	217	155,947,902	100.5%	$864M
2025-Q4	168	136,949,928	88.3%	$687M
2025-Q3	144	101,427,912	65.4%	$309M
2025-Q2	129	99,952,828	64.4%	$239M
2025-Q1	148	99,777,679	64.3%	$192M
2024-Q4	153	112,165,886	72.3%	$575M
2024-Q3	142	111,954,616	72.2%	$662M
2024-Q2	140	112,626,463	72.6%	$551M
2024-Q1	127	97,779,366	63.0%	$699M
2023-Q4	99	80,994,555

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · ANNX

Activists — 13D, active intent

Satter Muneer A7.2%NEWSCHEDULE 13D/A · Amd 2 · event 2025-11-19SEC →

10,444,134 shares

Large holders — 13G, passive (top 5 of 8 by % of class)

Holder

% of class

Type

As of

FMR LLC

11.9%

QII

2026-06-30

SEC →

Redmile Group, LLC

9.9%

Passive

2026-07-01

SEC →

BlackRock, Inc.

QII

2026-06-30

SEC →

BIOTECHNOLOGY VALUE FUND L P

Institutional ownership· 13F filers holding ANNX · 2026-Q1 methodology → sources →

217 holders

% of shares outstanding held

100.5%

Shares held (13F)

155,947,902

Reporting holders

217

Top holders

largest 100 of 217 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	Redmile Group, LLC	14,549,76814.5M	$81M	9.38%	ADD 45%
2	BlackRock, Inc.	10,938,50910.9M	$61M	7.05%	ADD 22%
3	FMR LLC	10,635,64810.6M	$59M	6.86%	ADD 4%
4	BVF INC/IL	8,698,1738.7M	$48M	5.61%	TRIM -5%
5	STATE STREET CORP	6,919,2556.9M	$38M	4.46%	ADD 49%
6	VANGUARD CAPITAL MANAGEMENT LLC	5,956,5896.0M	$33M	3.84%	NEW†
7	Bain Capital Life Sciences Investors, LLC	5,212,6745.2M	$29M	3.36%	—
8	Bellevue Group AG	5,157,2905.2M	$29M	3.33%	—
9	MAK CAPITAL ONE LLC	4,724,0434.7M	$26M	3.05%	ADD 60%
10	ADAGE CAPITAL PARTNERS GP, L.L.C.	4,300,0004.3M	$24M	2.77%	TRIM -22%
11	BANK OF AMERICA CORP /DE/	4,259,9954.3M	$24M	2.75%	ADD 165%
12	Nuveen, LLC	4,246,3304.2M	$24M	2.74%	ADD 46%
13	Siren, L.L.C.	3,958,6464.0M	$22M	2.55%	NEW†
14	Balyasny Asset Management L.P.	3,886,9093.9M	$22M	2.51%	ADD 18%
15	AMERIPRISE FINANCIAL INC	3,449,1213.4M	$19M	2.22%	TRIM -21%
16	GEODE CAPITAL MANAGEMENT, LLC	3,377,8233.4M	$19M	2.18%	ADD 16%
17	Qube Research & Technologies Ltd	3,114,3143.1M	$17M	2.01%	ADD 31%
18	Palo Alto Investors LP	2,948,0902.9M	$16M	1.90%	ADD 24%
19	MORGAN STANLEY	2,735,9702.7M	$15M	1.76%	TRIM -4%
20	GREAT POINT PARTNERS LLC	2,500,0002.5M	$14M	1.61%	NEW
21	Woodline Partners LP	2,337,1372.3M	$13M	1.51%	TRIM -42%
22	Opaleye Management Inc.	2,331,7612.3M	$13M	1.50%	TRIM -10%
23	GOLDMAN SACHS GROUP INC	2,152,8802.2M	$12M	1.39%	ADD 22%
24	Point72 Asset Management, L.P.	1,871,7951.9M	$10M	1.21%	ADD 404%
25	VANGUARD PORTFOLIO MANAGEMENT LLC	1,483,0901.5M	$8M	0.96%	NEW
26	Y-Intercept (Hong Kong) Ltd	1,319,9131.3M	$7M	0.85%	NEW
27	Tetragon Partners GP Ltd	1,292,4551.3M	$7M	0.83%	TRIM -36%
28	UBS Group AG	1,245,9411.2M	$7M	0.80%	ADD 230%
29	MILLENNIUM MANAGEMENT LLC	1,238,6781.2M	$7M	0.80%	TRIM -56%
30	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1,102,4451.1M	$6M	0.71%	ADD 4%
31	NORTHERN TRUST CORP	1,086,9021.1M	$6M	0.70%	ADD 37%
32	DIMENSIONAL FUND ADVISORS LP	924,078924,078	$5M	0.60%	ADD 29%
33	KENNEDY CAPITAL MANAGEMENT LLC	912,323912,323	$5M	0.59%	ADD 43%
34	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	903,368903,368	$5M	0.58%	—
35	VANGUARD FIDUCIARY TRUST CO	888,552888,552	$5M	0.57%	NEW
36	MARSHALL WACE, LLP	861,475861,475	$5M	0.56%	ADD 65%
37	AQR CAPITAL MANAGEMENT LLC	777,253777,253	$4M	0.50%	—
38	Invesco Ltd.	763,005763,005	$4M	0.49%	TRIM -22%
39	ACADIAN ASSET MANAGEMENT LLC	758,232758,232	$4M	0.49%	TRIM -12%
40	Russell Investments Group, Ltd.	711,380711,380	$4M	0.46%	ADD 4%
41	D. E. Shaw & Co., Inc.	702,799702,799	$4M	0.45%	TRIM -33%
42	WELLS FARGO & COMPANY/MN	698,739698,739	$4M	0.45%	ADD 22%
43	Parkman Healthcare Partners LLC	674,013674,013	$4M	0.43%	ADD 12%
44	Ensign Peak Advisors, Inc	625,097625,097	$3M	0.40%	NEW
45	Longaeva Partners L.P.	620,401620,401	$3M	0.40%	TRIM -80%
46	CITADEL ADVISORS LLC	600,135600,135	$3M	0.39%	ADD 118%
47	DEERFIELD MANAGEMENT COMPANY, L.P.	583,913583,913	$3M	0.38%	—
48	Ikarian Capital, LLC	580,244580,244	$3M	0.37%	ADD 152%
49	SIRIOS CAPITAL MANAGEMENT L P	575,063575,063	$3M	0.37%	TRIM -19%
50	DEUTSCHE BANK AG\	562,181562,181	$3M	0.36%	—
51	RENAISSANCE TECHNOLOGIES LLC	544,300544,300	$3M	0.35%	TRIM -32%
52	WELLINGTON MANAGEMENT GROUP LLP	521,379521,379	$3M	0.34%	ADD 31%
53	Hennion & Walsh Asset Management, Inc.	509,689509,689	$3M	0.33%	TRIM -5%
54	SILVERARC CAPITAL MANAGEMENT, LLC	496,461496,461	$3M	0.32%	NEW
55	Board of Trustees of The Leland Stanford Junior University	482,550482,550	$3M	0.31%	—
56	TWO SIGMA INVESTMENTS, LP	471,391471,391	$3M	0.30%	ADD 42%
57	VOLORIDGE INVESTMENT MANAGEMENT, LLC	462,068462,068	$3M	0.30%	NEW
58	PRICE T ROWE ASSOCIATES INC /MD/	428,720428,720	$2M	0.28%	TRIM -4%
59	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	416,698416,698	$2M	0.27%	TRIM -35%
60	Trexquant Investment LP	403,657403,657	$2M	0.26%	NEW
61	Bank of New York Mellon Corp	395,019395,019	$2M	0.25%	ADD 9%
62	Susquehanna Portfolio Strategies, LLC	360,319360,319	$2M	0.23%	—
63	JPMORGAN CHASE & CO	323,894323,894	$2M	0.21%	ADD 503%
64	Cinctive Capital Management LP	268,640268,640	$1M	0.17%	TRIM -25%
65	BNP PARIBAS FINANCIAL MARKETS	255,371255,371	$1M	0.16%	ADD 315%
66	Swiss National Bank	236,000236,000	$1M	0.15%	NEW
67	Rafferty Asset Management, LLC	203,269203,269	$1M	0.13%	ADD 44%
68	SEI INVESTMENTS CO	203,236203,236	$1M	0.13%	ADD 249%
69	Rosalind Advisors, Inc.	200,000200,000	$1M	0.13%	NEW
70	IEQ CAPITAL, LLC	195,764195,764	$1M	0.13%	ADD 7%
71	Ishara Investments LP	174,250174,250	$965,345	0.11%	TRIM -77%
72	Engineers Gate Manager LP	174,141174,141	$964,741	0.11%	NEW
73	J. Goldman & Co LP	170,817170,817	$946,326	0.11%	TRIM -83%
74	BOOTHBAY FUND MANAGEMENT, LLC	166,164166,164	$920,549	0.11%	ADD 159%
75	RHUMBLINE ADVISERS	159,670159,670	$884,563	0.10%	ADD 26%
76	SUSQUEHANNA INTERNATIONAL GROUP, LLP	158,640158,640	$878,866	0.10%	TRIM -14%
77	ALGERT GLOBAL LLC	154,840154,840	$858,000	0.10%	NEW
78	JACOBS LEVY EQUITY MANAGEMENT, INC	148,941148,941	$825,133	0.10%	TRIM -78%
79	MANUFACTURERS LIFE INSURANCE COMPANY, THE	134,786134,786	$746,714	0.09%	ADD 4%
80	DIADEMA PARTNERS LP	132,916132,916	$736,355	0.09%	TRIM -62%
81	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	130,647130,647	$723,784	0.08%	NEW
82	Schonfeld Strategic Advisors LLC	123,282123,282	$682,981	0.08%	TRIM -76%
83	DAFNA Capital Management LLC	117,812117,812	$652,678	0.08%	TRIM -57%
84	VICTORY CAPITAL MANAGEMENT INC	115,527115,527	$640,019	0.07%	ADD 683%
85	Man Group plc	109,222109,222	$605,090	0.07%	NEW
86	ALLIANCEBERNSTEIN L.P.	119,050119,050	$597,631	0.08%	TRIM -15%
87	SCS Capital Management LLC	99,00099,000	$548,460	0.06%	NEW
88	BRIDGEWAY CAPITAL MANAGEMENT, LLC	97,80097,800	$541,812	0.06%	TRIM -29%
89	Connor, Clark & Lunn Investment Management Ltd.	92,70792,707	$513,597	0.06%	NEW
90	PROFUND ADVISORS LLC	90,95990,959	$503,913	0.06%	ADD 72%
91	J. Safra Sarasin Holding AG	90,48790,487	$501,298	0.06%	TRIM -23%
92	DNB Asset Management AS	88,61788,617	$490,938	0.06%	TRIM -25%
93	XTX Topco Ltd	80,49580,495	$445,942	0.05%	TRIM -67%
94	Legal & General Group Plc	80,04680,046	$443,454	0.05%	ADD 760%
95	VANGUARD ASSET MANAGEMENT, Ltd	79,48679,486	$440,352	0.05%	NEW
96	CAPTRUST FINANCIAL ADVISORS	79,17379,173	$438,613	0.05%	ADD 151%
97	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	76,25776,257	$414,110	0.05%	ADD 39%
98	MetLife Investment Management, LLC	72,44472,444	$401,340	0.05%	ADD 85%
99	POLEN CAPITAL MANAGEMENT LLCtracked	70,15270,152	$388,642	0.05%	NEW
100	Squarepoint Ops LLC	67,95667,956	$376,476	0.04%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

Redmile Group, LLC

6.3M

10.1M

14.5M

$81M

BlackRock, Inc.

8.5M

8.0M

7.9M

9.0M

10.9M

$61M

FMR LLC

14.2M

13.3M

15.7M

11.1M

10.2M

10.6M

$59M

BVF INC/IL

7.0M

9.1M

8.7M

$48M

STATE STREET CORP

4.5M

2.0M

2.1M

4.7M

6.9M

$38M

VANGUARD CAPITAL MANAGEMENT LLC

—

6.0M

$33M

Bain Capital Life Sciences Investors, LLC

5.2M

$29M

Bellevue Group AG

5.2M

$29M

MAK CAPITAL ONE LLC

—

3.0M

4.7M

$26M

ADAGE CAPITAL PARTNERS GP, L.L.C.

—

1.5M

5.5M

4.3M

$24M

BANK OF AMERICA CORP /DE/

30K

1.0M

1.5M

1.3M

1.6M

4.3M

$24M

Nuveen, LLC

—

347K

256K

683K

2.9M

4.2M

$24M

Siren, L.L.C.

—

4.0M

$22M

Balyasny Asset Management L.P.

—

97K

—

1.3M

3.3M

3.9M

$22M

AMERIPRISE FINANCIAL INC

927K

4.0M

2.2M

4.3M

3.4M

$19M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	217	155,947,902	100.5%	$864M
2025-Q4	168	136,949,928	88.3%	$687M
2025-Q3	144	101,427,912	65.4%	$309M
2025-Q2	129	99,952,828	64.4%	$239M
2025-Q1	148	99,777,679	64.3%	$192M
2024-Q4	153	112,165,886	72.3%	$575M
2024-Q3	142	111,954,616	72.2%	$662M
2024-Q2	140	112,626,463	72.6%	$551M
2024-Q1	127	97,779,366	63.0%	$699M
2023-Q4	99	80,994,555

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · ANNX

Activists — 13D, active intent

Satter Muneer A7.2%NEWSCHEDULE 13D/A · Amd 2 · event 2025-11-19SEC →

10,444,134 shares

Large holders — 13G, passive (top 5 of 8 by % of class)

Holder

% of class

Type

As of

FMR LLC

11.9%

QII

2026-06-30

SEC →

Redmile Group, LLC

9.9%

Passive

2026-07-01

SEC →

BlackRock, Inc.

QII

2026-06-30

SEC →

BIOTECHNOLOGY VALUE FUND L P

ANNX US Equity☆

Institutional ownership· 13F filers holding ANNX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · ANNX

Institutional ownership· 13F filers holding ANNX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · ANNX

ANNX US Equity