| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 7,880,0947.9M | $437M | 27.41% | — |
| 2 | BlackRock, Inc. | 1,681,3801.7M | $93M | 5.85% | TRIM -3% |
| 3 | TANG CAPITAL MANAGEMENT LLC | 1,330,8791.3M | $74M | 4.63% | — |
| 4 | MORGAN STANLEY | 993,905993,905 | $55M | 3.46% | TRIM -4% |
| 5 | STATE STREET CORP | 992,445992,445 | $55M | 3.45% | TRIM -6% |
| 6 | Affinity Asset Advisors, LLC | 940,000940,000 | $52M | 3.27% | ADD 111% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 853,151853,151 | $47M | 2.97% | NEW† |
| 8 | Palo Alto Investors LP | 638,161638,161 | $35M | 2.22% | TRIM -8% |
| 9 | 683 Capital Management, LLC | 625,000625,000 | $35M | 2.17% | TRIM -4% |
| 10 | D. E. Shaw & Co., Inc. | 579,296579,296 | $32M | 2.02% | TRIM -14% |
| 11 | First Light Asset Management, LLC | 565,431565,431 | $31M | 1.97% | TRIM -13% |
| 12 | Sanofi | 821,917821,917 | $30M | 2.86% | — |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 520,241520,241 | $29M | 1.81% | ADD 11% |
| 14 | VANGUARD PORTFOLIO MANAGEMENT LLC | 519,870519,870 | $29M | 1.81% | NEW |
| 15 | BANK OF AMERICA CORP /DE/ | 501,086501,086 | $28M | 1.74% | ADD 283% |
| 16 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 492,120492,120 | $27M | 1.71% | TRIM -12% |
| 17 | MILLENNIUM MANAGEMENT LLC | 475,572475,572 | $26M | 1.65% | TRIM -42% |
| 18 | FMR LLC | 472,704472,704 | $26M | 1.64% | ADD 1644% |
| 19 | TWO SIGMA INVESTMENTS, LP | 465,083465,083 | $26M | 1.62% | ADD 81% |
| 20 | FEDERATED HERMES, INC. | 364,121364,121 | $20M | 1.27% | ADD 22% |
| 21 | Woodline Partners LP | 344,256344,256 | $19M | 1.20% | TRIM -31% |
| 22 | GOLDMAN SACHS GROUP INC | 332,743332,743 | $18M | 1.16% | TRIM -17% |
| 23 | Synergy Asset Management, LLC | 317,106317,106 | $18M | 1.10% | NEW |
| 24 | Nuveen, LLC | 316,065316,065 | $18M | 1.10% | — |
| 25 | Squarepoint Ops LLC | 267,703267,703 | $15M | 0.93% | ADD 67% |
| 26 | Qube Research & Technologies Ltd | 254,736254,736 | $14M | 0.89% | ADD 134% |
| 27 | Sofinnova Investments, Inc. | 248,253248,253 | $14M | 0.86% | TRIM -14% |
| 28 | Apis Capital Advisors, LLC | 238,000238,000 | $13M | 0.83% | NEW |
| 29 | CITADEL ADVISORS LLC | 233,450233,450 | $13M | 0.81% | ADD 113% |
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 192,687192,687 | $11M | 0.67% | TRIM -3% |
| 31 | NORTHERN TRUST CORP | 183,519183,519 | $10M | 0.64% | — |
| 32 | Connor, Clark & Lunn Investment Management Ltd. | 158,562158,562 | $9M | 0.55% | ADD 29% |
| 33 | VANGUARD FIDUCIARY TRUST CO | 135,082135,082 | $7M | 0.47% | NEW |
| 34 | HSBC HOLDINGS PLC | 125,717125,717 | $7M | 0.44% | NEW |
| 35 | Ensign Peak Advisors, Inc | 125,633125,633 | $7M | 0.44% | TRIM -42% |
| 36 | Invesco Ltd. | 121,103121,103 | $7M | 0.42% | TRIM -2% |
| 37 | VICTORY CAPITAL MANAGEMENT INC | 108,203108,203 | $6M | 0.38% | TRIM -2% |
| 38 | BNP PARIBAS FINANCIAL MARKETS | 96,97196,971 | $5M | 0.34% | TRIM -41% |
| 39 | HighMark Wealth Management LLC | 94,05094,050 | $5M | 0.33% | — |
| 40 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 93,73293,732 | $5M | 0.33% | — |
| 41 | RENAISSANCE TECHNOLOGIES LLC | 90,90090,900 | $5M | 0.32% | ADD 19% |
| 42 | JANE STREET GROUP, LLC | 86,03886,038 | $5M | 0.30% | — |
| 43 | Trexquant Investment LP | 85,16785,167 | $5M | 0.30% | ADD 45% |
| 44 | UBS Group AG | 79,67079,670 | $4M | 0.28% | ADD 14% |
| 45 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 78,95278,952 | $4M | 0.27% | TRIM -66% |
| 46 | CITIGROUP INC | 73,40673,406 | $4M | 0.26% | — |
| 47 | MARSHALL WACE, LLP | 68,04768,047 | $4M | 0.24% | NEW |
| 48 | Granahan Investment Management, LLC | 66,18266,182 | $4M | 0.23% | TRIM -47% |
| 49 | FRANKLIN RESOURCES INC | 65,82065,820 | $4M | 0.23% | NEW |
| 50 | PRUDENTIAL FINANCIAL INC | 64,05064,050 | $4M | 0.22% | NEW |
| 51 | Fisher Asset Management, LLC | 56,59656,596 | $3M | 0.20% | — |
| 52 | Point72 Asset Management, L.P. | 55,30355,303 | $3M | 0.19% | TRIM -97% |
| 53 | DEUTSCHE BANK AG\ | 52,03852,038 | $3M | 0.18% | ADD 262% |
| 54 | Bank of New York Mellon Corp | 51,11551,115 | $3M | 0.18% | TRIM -8% |
| 55 | XTX Topco Ltd | 50,53750,537 | $3M | 0.18% | ADD 31% |
| 56 | WELLINGTON MANAGEMENT GROUP LLP | 46,88146,881 | $3M | 0.16% | TRIM -23% |
| 57 | Penserra Capital Management LLC | 43,43043,430 | $2M | 0.15% | TRIM -23% |
| 58 | Bleakley Financial Group, LLC | 43,12043,120 | $2M | 0.15% | — |
| 59 | HRT FINANCIAL LP | 40,50440,504 | $2M | 0.14% | TRIM -42% |
| 60 | Moody Aldrich Partners LLC | 39,45539,455 | $2M | 0.14% | TRIM -17% |
| 61 | Tidal Investments LLC | 36,35236,352 | $2M | 0.13% | NEW |
| 62 | Susquehanna Portfolio Strategies, LLC | 35,94835,948 | $2M | 0.13% | — |
| 63 | MACKENZIE FINANCIAL CORP | 33,72033,720 | $2M | 0.12% | ADD 39% |
| 64 | Virtu Financial LLC | 33,32333,323 | $2M | 0.12% | NEW |
| 65 | WELLS FARGO & COMPANY/MN | 33,18033,180 | $2M | 0.12% | ADD 49% |
| 66 | AQR CAPITAL MANAGEMENT LLC | 32,46732,467 | $2M | 0.11% | ADD 23% |
| 67 | Tema ETFs LLC | 31,06931,069 | $2M | 0.11% | ADD 38% |
| 68 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 30,72730,727 | $2M | 0.11% | — |
| 69 | PRICE T ROWE ASSOCIATES INC /MD/ | 29,69129,691 | $2M | 0.10% | ADD 14% |
| 70 | JACOBS LEVY EQUITY MANAGEMENT, INC | 28,62528,625 | $2M | 0.10% | TRIM -48% |
| 71 | MARTINGALE ASSET MANAGEMENT L P | 28,14228,142 | $2M | 0.10% | NEW |
| 72 | Engineers Gate Manager LP | 27,81527,815 | $2M | 0.10% | ADD 156% |
| 73 | STATE OF WISCONSIN INVESTMENT BOARD | 27,61927,619 | $2M | 0.10% | ADD 208% |
| 74 | Swiss National Bank | 27,60027,600 | $2M | 0.10% | — |
| 75 | ALLIANCEBERNSTEIN L.P. | 31,32031,320 | $2M | 0.11% | ADD 3% |
| 76 | Rafferty Asset Management, LLC | 27,24927,249 | $2M | 0.09% | TRIM -23% |
| 77 | Eversept Partners, LP | 27,08927,089 | $2M | 0.09% | TRIM -78% |
| 78 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,57726,577 | $1M | 0.09% | NEW |
| 79 | SG Americas Securities, LLC | 24,85124,851 | $1M | 0.09% | ADD 138% |
| 80 | Headlands Technologies LLC | 24,55824,558 | $1M | 0.09% | TRIM -3% |
| 81 | RHUMBLINE ADVISERS | 23,84823,848 | $1M | 0.08% | TRIM -5% |
| 82 | Y-Intercept (Hong Kong) Ltd | 22,70122,701 | $1M | 0.08% | TRIM -31% |
| 83 | J. Goldman & Co LP | 21,20521,205 | $1M | 0.07% | NEW |
| 84 | HUSSMAN STRATEGIC ADVISORS, INC. | 21,00021,000 | $1M | 0.07% | NEW |
| 85 | CREDIT AGRICOLE S A | 20,00020,000 | $1M | 0.07% | TRIM -50% |
| 86 | DCF Advisers, LLC | 18,77518,775 | $1M | 0.07% | TRIM -47% |
| 87 | Walleye Capital LLC | 18,42518,425 | $1M | 0.06% | NEW |
| 88 | PDT Partners, LLC | 17,59517,595 | $975,819 | 0.06% | TRIM -59% |
| 89 | Creative Planning | 16,83616,836 | $933,725 | 0.06% | ADD 10% |
| 90 | LOS ANGELES CAPITAL MANAGEMENT LLC | 15,66415,664 | $868,725 | 0.05% | ADD 4% |
| 91 | CANADA PENSION PLAN INVESTMENT BOARD | 14,90014,900 | $826,354 | 0.05% | NEW |
| 92 | TWINBEECH CAPITAL LP | 14,51814,518 | $805,168 | 0.05% | NEW |
| 93 | VOYA INVESTMENT MANAGEMENT LLC | 14,34614,346 | $795,629 | 0.05% | ADD 12% |
| 94 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,00014,000 | $776,440 | 0.05% | — |
| 95 | Gotham Asset Management, LLC | 13,97213,972 | $774,887 | 0.05% | NEW |
| 96 | Cresset Asset Management, LLC | 13,86813,868 | $769,119 | 0.05% | TRIM -8% |
| 97 | Legal & General Group Plc | 13,83113,831 | $767,066 | 0.05% | TRIM -24% |
| 98 | Brookwood Investment Group LLC | 13,36213,362 | $741,057 | 0.05% | NEW |
| 99 | Russell Investments Group, Ltd. | 13,28813,288 | $736,952 | 0.05% | TRIM -33% |
| 100 | ACADIAN ASSET MANAGEMENT LLC | 13,21913,219 | $730,000 | 0.05% | ADD 128% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 7.9M | 7.9M | 7.9M | 7.9M | 7.9M | 7.9M | $437M |
| BlackRock, Inc. | 2.5M | 2.2M | 1.8M | 1.7M | 1.7M | 1.7M | $93M |
| TANG CAPITAL MANAGEMENT LLC | 1.3M | 1.5M | 1.3M | 1.3M | 1.3M | 1.3M | $74M |
| MORGAN STANLEY | 216K | 505K | 1.9M | 1.6M | 1.0M | 994K | $55M |
| STATE STREET CORP | 1.3M | 861K | 821K | 873K | 1.1M | 992K | $55M |
| Affinity Asset Advisors, LLC | — | — | — | — | 445K | 940K | $52M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 853K | $47M |
| Palo Alto Investors LP | 844K | 1.0M | 813K | 674K | 690K | 638K | $35M |
| 683 Capital Management, LLC | — | 196K | 500K | 547K | 648K | 625K | $35M |
| D. E. Shaw & Co., Inc. | 197K | 130K | 112K | 349K | 670K | 579K | $32M |
| First Light Asset Management, LLC | 869K | 4.6M | 3.5M | 990K | 646K | 565K | $31M |
| Sanofi | 822K | 822K | 822K | 822K | 822K | 822K | $30M |
| GEODE CAPITAL MANAGEMENT, LLC | 487K | 491K | 463K | 474K | 469K | 520K | $29M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 520K | $29M |
| BANK OF AMERICA CORP /DE/ | 18K | 1.1M | 1.1M | 127K | 131K | 501K | $28M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +853,151 | $32M | OPEN |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +519,870 | $19M | OPEN |
| Affinity Asset Advisors, LLC | +495,308 | $18M | ADD |
| FMR LLC | +445,596 | $16M | ADD |
| BANK OF AMERICA CORP /DE/ | +370,319 | $14M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| Point72 Asset Management, L.P. | −1,877,587 | $69M | TRIM |
| VANGUARD GROUP INC | −1,544,037 | $57M | CLOSE |
| TWO SIGMA ADVISERS, LP | −356,700 | $13M | CLOSE |
| MILLENNIUM MANAGEMENT LLC | −337,999 | $12M | TRIM |
| Woodline Partners LP | −156,767 | $6M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 206 | 28,235,752 | 98.2% | $1.6B |
| 2025-Q4 | 178 | 29,354,349 | 106.0% | $1.4B |
| 2025-Q3 | 166 | 31,685,633 | — | $981M |
| 2025-Q2 | 148 | 36,765,751 | — | $816M |
| 2025-Q1 | 153 | 40,052,771 | — | $745M |
| 2024-Q4 | 136 | 35,417,710 | — | $469M |
| 2024-Q3 | 160 | 33,662,678 | — | $1.1B |
| 2024-Q2 | 135 | 29,807,628 | 109.1% | $747M |
| 2024-Q1 | 133 | 30,506,588 | — | $687M |
| 2023-Q4 | 119 | 30,798,511 | — | $660M |
| 2023-Q3 | 116 | 30,419,408 | — | $546M |
| 2023-Q2 | 116 | 30,230,772 | — | $615M |
| 2023-Q1 | 113 | 31,330,507 | — | $682M |
| 2022-Q4 | 118 | 32,875,182 | — | $990M |
| 2022-Q3 | 114 | 32,557,744 | — | $831M |
| 2022-Q2 | 124 | 31,164,531 | — | $633M |
| 2022-Q1 | 131 | 29,691,375 | 107.3% | $735M |
| 2021-Q4 | 136 | 27,800,199 | 101.1% | $966M |
| 2021-Q3 | 127 | 27,612,443 | 100.7% | $749M |
| 2021-Q2 | 122 | 27,831,942 | 101.7% | $722M |
| 2021-Q1 | 122 | 29,170,765 | 106.6% | $629M |
| 2020-Q4 | 136 | 28,001,434 | 102.4% | $602M |
| 2020-Q3 | 132 | 29,117,737 | 106.6% | $429M |
| 2020-Q2 | 122 | 30,112,092 | — | $673M |
| 2020-Q1 | 116 | 31,285,148 | — | $442M |
| 2019-Q4 | 121 | 28,629,491 | 105.5% | $465M |
| 2019-Q3 | 119 | 29,110,226 | 107.6% | $1.0B |
| 2019-Q2 | 127 | 30,290,355 | — | $1.7B |
| 2019-Q1 | 129 | 29,116,741 | 107.9% | $2.1B |
| 2018-Q4 | 121 | 29,225,028 | 109.2% | $1.9B |
| 2018-Q3 | 129 | 28,876,262 | — | $2.9B |
| 2018-Q2 | 124 | 25,038,440 | 106.6% | $1.8B |
| 2018-Q1 | 134 | 24,351,168 | 102.3% | $2.5B |
| 2017-Q4 | 116 | 23,775,523 | 101.2% | $2.4B |
| 2017-Q3 | 71 | 17,781,333 | 87.4% | $621M |
| 2017-Q2 | 53 | 14,108,115 | 69.6% | $338M |
| 2017-Q1 | 51 | 14,156,321 | 69.8% | $392M |
| 2025-09-30 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
