| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Pfizer Inc | 22,032,04022.0M | $50M | 9.04% | — |
| 2 | BlackRock, Inc. | 19,091,09519.1M | $47M | 7.83% | ADD 8% |
| 3 | TPG GP A, LLC | 18,716,30618.7M | $46M | 7.68% | — |
| 4 | STATE STREET CORP | 8,660,3068.7M | $21M | 3.55% | ADD 214% |
| 5 | PRIMECAP MANAGEMENT CO/CA/ | 8,379,8408.4M | $20M | 3.44% | ADD 3% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 6,921,3506.9M | $17M | 2.84% | NEW† |
| 7 | CITADEL ADVISORS LLC | 6,793,6206.8M | $17M | 2.79% | TRIM -44% |
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,380,9025.4M | $13M | 2.21% | ADD 68% |
| 9 | TWO SIGMA INVESTMENTS, LP | 5,375,4565.4M | $13M | 2.21% | ADD 57% |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 4,124,1784.1M | $10M | 1.69% | ADD 5% |
| 11 | Frazier Life Sciences Management, L.P. | 3,796,6683.8M | $9M | 1.56% | — |
| 12 | Woodline Partners LP | 3,501,0783.5M | $9M | 1.44% | — |
| 13 | Patient Square Capital LP | 3,450,0003.5M | $8M | 1.42% | TRIM -30% |
| 14 | MARSHALL WACE, LLP | 3,447,9843.4M | $8M | 1.41% | ADD 1107% |
| 15 | MILLENNIUM MANAGEMENT LLC | 3,322,0533.3M | $8M | 1.36% | ADD 80% |
| 16 | Candriam S.C.A. | 2,997,3183.0M | $7M | 1.23% | ADD 30% |
| 17 | Wildcat Capital Management, LLC | 2,920,7872.9M | $7M | 1.20% | — |
| 18 | GOLDMAN SACHS GROUP INC | 2,766,2442.8M | $7M | 1.13% | ADD 21% |
| 19 | D. E. Shaw & Co., Inc. | 2,763,7762.8M | $7M | 1.13% | ADD 115% |
| 20 | Boxer Capital Management, LLC | 2,725,0002.7M | $7M | 1.12% | NEW |
| 21 | AQR CAPITAL MANAGEMENT LLC | 2,484,7802.5M | $6M | 1.02% | ADD 74% |
| 22 | Nuveen, LLC | 2,315,0922.3M | $6M | 0.95% | ADD 751% |
| 23 | MPM BIOIMPACT LLC | 2,242,9332.2M | $5M | 0.92% | NEW |
| 24 | RENAISSANCE TECHNOLOGIES LLC | 2,139,3282.1M | $5M | 0.88% | TRIM -2% |
| 25 | BANK OF AMERICA CORP /DE/ | 2,134,4732.1M | $5M | 0.88% | ADD 112% |
| 26 | JACOBS LEVY EQUITY MANAGEMENT, INC | 2,013,5082.0M | $5M | 0.83% | NEW |
| 27 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1,694,1121.7M | $4M | 0.69% | NEW |
| 28 | UBS Group AG | 1,604,0901.6M | $4M | 0.66% | ADD 15% |
| 29 | FMR LLC | 1,589,8301.6M | $4M | 0.65% | ADD 10% |
| 30 | Aberdeen Group plc | 1,462,2191.5M | $4M | 0.60% | TRIM -30% |
| 31 | GordonMD Global Investments LP | 1,430,0001.4M | $3M | 0.59% | NEW |
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,396,5331.4M | $3M | 0.57% | ADD 3% |
| 33 | DAFNA Capital Management LLC | 1,370,1181.4M | $3M | 0.56% | — |
| 34 | JPMORGAN CHASE & CO | 1,434,6471.4M | $3M | 0.59% | ADD 47% |
| 35 | NORTHERN TRUST CORP | 1,285,7021.3M | $3M | 0.53% | ADD 7% |
| 36 | DIMENSIONAL FUND ADVISORS LP | 1,201,6551.2M | $3M | 0.49% | ADD 25% |
| 37 | Balyasny Asset Management L.P. | 1,182,8161.2M | $3M | 0.49% | NEW |
| 38 | VANGUARD FIDUCIARY TRUST CO | 1,091,8091.1M | $3M | 0.45% | NEW |
| 39 | MORGAN STANLEY | 998,845998,845 | $2M | 0.41% | ADD 42% |
| 40 | Invesco Ltd. | 684,519684,519 | $2M | 0.28% | ADD 12% |
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 654,180654,180 | $2M | 0.27% | ADD 35% |
| 42 | TD Asset Management Inc | 652,484652,484 | $2M | 0.27% | ADD 58% |
| 43 | Voleon Capital Management LP | 640,598640,598 | $2M | 0.26% | NEW |
| 44 | Raiffeisen Bank International AG | 700,000700,000 | $2M | 0.29% | TRIM -22% |
| 45 | IEQ CAPITAL, LLC | 614,189614,189 | $1M | 0.25% | ADD 41% |
| 46 | JANE STREET GROUP, LLC | 505,273505,273 | $1M | 0.21% | TRIM -77% |
| 47 | ALGERT GLOBAL LLC | 463,980463,980 | $1M | 0.19% | ADD 136% |
| 48 | Mitsubishi UFJ Asset Management Co., Ltd. | 428,700428,700 | $1M | 0.18% | ADD 209% |
| 49 | Bank of New York Mellon Corp | 395,187395,187 | $964,255 | 0.16% | TRIM -3% |
| 50 | Creative Planning | 364,809364,809 | $890,134 | 0.15% | ADD 33% |
| 51 | CITIGROUP INC | 353,335353,335 | $862,137 | 0.14% | TRIM -40% |
| 52 | XTX Topco Ltd | 315,743315,743 | $770,413 | 0.13% | TRIM -34% |
| 53 | Harold Davidson & Associates Inc. | 289,222289,222 | $705,702 | 0.12% | ADD 49% |
| 54 | Rafferty Asset Management, LLC | 282,346282,346 | $688,924 | 0.12% | NEW |
| 55 | Headlands Technologies LLC | 265,922265,922 | $648,850 | 0.11% | ADD 468% |
| 56 | HSBC HOLDINGS PLC | 260,404260,404 | $637,990 | 0.11% | TRIM -12% |
| 57 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 250,000250,000 | $610,000 | 0.10% | — |
| 58 | AMERIPRISE FINANCIAL INC | 244,592244,592 | $596,804 | 0.10% | NEW |
| 59 | Point72 Asset Management, L.P. | 221,335221,335 | $540,057 | 0.09% | ADD 113% |
| 60 | Tidal Investments LLC | 219,072219,072 | $534,536 | 0.09% | NEW |
| 61 | Tema ETFs LLC | 219,072219,072 | $534,536 | 0.09% | NEW |
| 62 | RHUMBLINE ADVISERS | 201,027201,027 | $490,496 | 0.08% | — |
| 63 | Russell Investments Group, Ltd. | 182,344182,344 | $444,917 | 0.07% | ADD 355% |
| 64 | Virtus Investment Advisers, LLC | 180,588180,588 | $440,635 | 0.07% | ADD 3% |
| 65 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 177,875177,875 | $434,015 | 0.07% | NEW |
| 66 | OpenArc Corporate Advisory, LLC | 172,258172,258 | $420,310 | 0.07% | ADD 6% |
| 67 | LPL Financial LLC | 172,250172,250 | $420,290 | 0.07% | — |
| 68 | PARTNERS CAPITAL INVESTMENT GROUP, LLP | 161,597161,597 | $394,297 | 0.07% | — |
| 69 | BARCLAYS PLC | 160,846160,846 | $392,463 | 0.07% | TRIM -75% |
| 70 | Cerity Partners LLC | 157,235157,235 | $383,653 | 0.06% | ADD 61% |
| 71 | Man Group plc | 154,683154,683 | $377,427 | 0.06% | TRIM -71% |
| 72 | GSA CAPITAL PARTNERS LLP | 151,722151,722 | $370,000 | 0.06% | TRIM -75% |
| 73 | CWM, LLC | 147,157147,157 | $359,063 | 0.06% | ADD 135% |
| 74 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 146,779146,779 | $358,000 | 0.06% | — |
| 75 | CHOREO, LLC | 142,649142,649 | $348,064 | 0.06% | ADD 267% |
| 76 | DEUTSCHE BANK AG\ | 128,319128,319 | $313,098 | 0.05% | TRIM -2% |
| 77 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,760126,760 | $309,294 | 0.05% | ADD 39% |
| 78 | PROFUND ADVISORS LLC | 125,856125,856 | $307,089 | 0.05% | NEW |
| 79 | Smartleaf Asset Management LLC | 137,874137,874 | $306,080 | 0.06% | ADD 377% |
| 80 | WINTON GROUP Ltd | 121,200121,200 | $295,728 | 0.05% | NEW |
| 81 | ALLIANCEBERNSTEIN L.P. | 207,518207,518 | $284,300 | 0.09% | TRIM -30% |
| 82 | Squarepoint Ops LLC | 116,379116,379 | $283,965 | 0.05% | ADD 11% |
| 83 | Connor, Clark & Lunn Investment Management Ltd. | 113,964113,964 | $278,072 | 0.05% | ADD 186% |
| 84 | Mariner, LLC | 108,722108,722 | $265,154 | 0.04% | ADD 198% |
| 85 | Engineers Gate Manager LP | 105,915105,915 | $258,433 | 0.04% | NEW |
| 86 | Vanguard Global Advisers, LLC | 103,247103,247 | $251,923 | 0.04% | NEW |
| 87 | Polymer Capital Management (US) LLC | 100,676100,676 | $245,649 | 0.04% | NEW |
| 88 | NWI MANAGEMENT LP | 100,000100,000 | $244,000 | 0.04% | — |
| 89 | Virtu Financial LLC | 98,68598,685 | $241,000 | 0.04% | ADD 133% |
| 90 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 96,11496,114 | $238,363 | 0.04% | ADD 73% |
| 91 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 92,88692,886 | $222,321 | 0.04% | ADD 30% |
| 92 | CAPTRUST FINANCIAL ADVISORS | 89,93889,938 | $219,434 | 0.04% | ADD 69% |
| 93 | WELLS FARGO & COMPANY/MN | 89,18089,180 | $217,599 | 0.04% | TRIM -55% |
| 94 | Vanguard Personalized Indexing Management, LLC | 88,52388,523 | $215,996 | 0.04% | ADD 31% |
| 95 | ACADIAN ASSET MANAGEMENT LLC | 88,61988,619 | $214,000 | 0.04% | TRIM -91% |
| 96 | Quadrature Capital Ltd | 81,44481,444 | $198,723 | 0.03% | TRIM -70% |
| 97 | AXQ CAPITAL, LP | 73,93073,930 | $180,389 | 0.03% | NEW |
| 98 | MetLife Investment Management, LLC | 73,71773,717 | $179,869 | 0.03% | ADD 112% |
| 99 | TUDOR INVESTMENT CORP ET AL | 72,10572,105 | $175,936 | 0.03% | — |
| 100 | BNP PARIBAS FINANCIAL MARKETS | 70,96570,965 | $173,155 | 0.03% | TRIM -92% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Pfizer Inc | 22.0M | 22.0M | 22.0M | 22.0M | 22.0M | 22.0M | $50M |
| BlackRock, Inc. | 18.1M | 17.9M | 17.9M | 17.5M | 17.7M | 19.1M | $47M |
| TPG GP A, LLC | 18.7M | 18.7M | 18.7M | 18.7M | 18.7M | 18.7M | $46M |
| STATE STREET CORP | 7.2M | 2.8M | 2.7M | 2.8M | 2.8M | 8.7M | $21M |
| PRIMECAP MANAGEMENT CO/CA/ | 4.9M | 4.9M | 5.7M | 7.1M | 8.1M | 8.4M | $20M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 6.9M | $17M |
| CITADEL ADVISORS LLC | 5.3M | 10.2M | 10.3M | 14.0M | 12.1M | 6.8M | $17M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.5M | 4.2M | 4.0M | 3.7M | 3.2M | 5.4M | $13M |
| TWO SIGMA INVESTMENTS, LP | 2.7M | 2.1M | 1.6M | 3.4M | 3.4M | 5.4M | $13M |
| GEODE CAPITAL MANAGEMENT, LLC | 3.2M | 3.4M | 3.8M | 3.8M | 3.9M | 4.1M | $10M |
| Frazier Life Sciences Management, L.P. | 2.9M | 3.9M | 3.9M | 3.9M | 3.9M | 3.8M | $9M |
| Woodline Partners LP | 4.4M | 4.4M | 4.4M | 4.4M | 3.5M | 3.5M | $9M |
| Patient Square Capital LP | 1.5M | 2.4M | 2.6M | 3.0M | 5.0M | 3.5M | $8M |
| MARSHALL WACE, LLP | — | — | — | — | 286K | 3.4M | $8M |
| MILLENNIUM MANAGEMENT LLC | — | 257K | 1.5M | 3.4M | 1.8M | 3.3M | $8M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“No amendment to this Item is being made.”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +6,921,350 | $17M | OPEN |
| STATE STREET CORP | +5,898,906 | $14M | ADD |
| MARSHALL WACE, LLP | +3,162,423 | $8M | ADD |
| Boxer Capital Management, LLC | +2,725,000 | $7M | OPEN |
| MPM BIOIMPACT LLC | +2,242,933 | $5M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −9,251,609 | $23M | CLOSE |
| CITADEL ADVISORS LLC | −5,317,800 | $13M | TRIM |
| TWO SIGMA ADVISERS, LP | −2,890,200 | $7M | CLOSE |
| Kalehua Capital Management LLC | −2,546,129 | $6M | CLOSE |
| JANE STREET GROUP, LLC | −1,655,110 | $4M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 208 | 184,152,766 | 75.5% | $445M |
| 2025-Q4 | 172 | 162,799,941 | 72.4% | $223M |
| 2025-Q3 | 170 | 163,106,686 | 73.5% | $202M |
| 2025-Q2 | 158 | 184,705,855 | 84.4% | $209M |
| 2025-Q1 | 171 | 197,160,552 | 90.7% | $302M |
| 2024-Q4 | 174 | 188,658,440 | 90.0% | $402M |
| 2024-Q3 | 156 | 168,459,723 | 80.6% | $472M |
| 2024-Q2 | 174 | 169,331,507 | 99.1% | $395M |
| 2024-Q1 | 161 | 140,873,455 | 83.3% | $629M |
| 2023-Q4 | 170 | 130,823,582 | 77.7% | $420M |
| 2023-Q3 | 154 | 130,302,116 | 77.7% | $413M |
| 2023-Q2 | 171 | 133,404,635 | 91.5% | $663M |
| 2023-Q1 | 176 | 119,235,968 | 82.5% | $589M |
| 2022-Q4 | 168 | 111,491,061 | 77.3% | $686M |
| 2022-Q3 | 192 | 106,289,802 | 73.9% | $1.1B |
| 2022-Q2 | 161 | 100,818,929 | 70.2% | $1.1B |
| 2022-Q1 | 180 | 91,956,618 | 64.4% | $839M |
| 2021-Q4 | 177 | 86,158,537 | 60.5% | $1.3B |
| 2021-Q3 | 169 | 87,970,513 | 61.9% | $2.3B |
| 2021-Q2 | 182 | 86,341,023 | 61.0% | $2.3B |
| 2021-Q1 | 169 | 88,373,965 | 62.8% | $3.1B |
| 2020-Q4 | 165 | 89,678,608 | 63.9% | $2.3B |
| 2020-Q3 | 162 | 85,248,714 | 61.2% | $3.2B |
| 2020-Q2 | 174 | 88,747,651 | 70.8% | $3.8B |
| 2020-Q1 | 115 | 73,758,080 | 59.1% | $1.4B |
| 2019-Q4 | 116 | 72,300,453 | 59.3% | $1.9B |
| 2019-Q3 | 95 | 90,082,161 | 74.0% | $2.5B |
| 2019-Q2 | 95 | 69,399,577 | 57.1% | $1.9B |
| 2019-Q1 | 87 | 65,701,386 | 54.1% | $1.9B |
| 2018-Q4 | 79 | 62,998,522 | 51.9% | $1.7B |
| 2016-Q1 | 1 | 4,033 | — | $115,000 |
| FMR LLC | 4.9% | QII | 2025-02-28 | SEC → |
| Frazier Life Sciences Public Fund, L.P. | 4.7% | Passive | 2026-04-16 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
