Clinical trials
catalyst calendar across sponsors →Studies where ALGN is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
5 interventional · 1 observational · 3 with posted results
Held by 15 tracked-famous managers (Ruane, Cunniff & Goldfarb L.P., AQR CAPITAL MANAGEMENT LLC, CITADEL ADVISORS LLC, D. E. Shaw & Co., Inc., Artisan Partners Limited Partnership, +10 more) · FINRA short interest 4.0 days to cover (settled 2026-07-31) · government filings 180d: none disclosed
| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| Invisalign® System with Mandibular AdvancementNCT06651944Comfort and fitOpen-label · Treatment | Not applicable | Recruiting | Device: Invisalign® System with mandibular advancement featuring occlusal blocks | Class II Malocclusion, Mandibular Advancement, Mandibular Retrognathism, Excessive Overjet | 36 | 2026-12-31 | in 133 d | 2024-10-23 |
| Hyrax Vs. Invisalign Palatal Expander Clinical StudyNCT06662279width of palate after expansionRandomized · Open-label · Treatment | Not applicable | Recruiting | Device: Removable Rapid Palatal Expander, Banded Palatal Expander | Malocclusions, Narrow Maxilla, Narrow Maxillary Arch, Crowding | 36 | Nov 2025 | — | 2024-12-04 |
| Class II Correction Study Using the Invisalign SystemNCT02376829results2023-05-06Rate of Tooth Movement at the End of Class II Correction.Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Invisalign System | Malocclusion | 164 | 2021-11-23actual | — | 2023-05-06 |
| Primer Aligner StudyNCT02550938results2021-02-03Total Treatment TimeRandomized · Open-label · TreatmentStudy Protocol ↗ | Not applicable | Completed | Device: Invisalign | Malocclusion | 253 | Sep 2020actual | — | 2021-02-03 |
| The Use of Clear Aligners With Movement Enhancement TechniquesNCT02087163results2019-04-24Tooth Movement ChangeOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Movement Enhancement Technique, Clear Aligner | Malocclusion | 90 | Dec 2018actual | — | 2020-01-31 |
| One Week Aligner EvaluationNCT02603289observationalPlanned to Final Tooth Position | — | Completed | Device: Invisalign | Malocclusion | 287 | Nov 2018actual | — | 2020-10-20 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19