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Clinical trials
catalyst calendar across sponsors →Studies where ADM is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
18 interventional
Held by 18 tracked-famous managers (Dodge & Cox, AQR CAPITAL MANAGEMENT LLC, Markel Group Inc., CITADEL ADVISORS LLC, Squarepoint Ops LLC, +13 more) · FINRA short interest 4.2 days to cover (settled 2026-07-31) · government filings 180d: 1 congress / 3 executive
| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| Effect of a Probiotic or Postbiotic on Gut Microbiome During Antibiotic TreatmentNCT07594860Changes in gut microbiome composition between baseline and day 14 as compared to placebo.Randomized · Triple-masked · Prevention | Not applicable | Not yet recruiting | Dietary supplement: Probiotic, Postbiotic, Placebo | Microbiome | 126 | 2027-05-31 | in 285 d | 2026-05-19 |
| Study to Evaluate the Efficacy of a Probiotic in Infantile Colic Symptoms ReliefNCT05432479Change in cry and fuss timeRandomized · Quadruple-masked · Treatment | Not applicable | Recruiting | Dietary supplement: Probiotic, Placebo | Infantile Colic | 80 | May 2026 | — | 2025-04-09 |
| Changes in Amino Acid Absorption After Adding a Probiotic to an Acute Protein FeedingNCT06701604Rate of amino acid absorptionRandomized · Double-masked · Basic science | Not applicable | Not yet recruiting | Dietary supplement: Single Strain Probiotic + Milk Protein, Placebo + Milk Protein | Amino Acid Absorption, Probiotic | 30 | 2026-01-15 | — | 2024-11-22 |
| Effect of a Multi-strain Probiotic on Recurrent Vulvovaginal CandidiasisNCT06480604Incidence of culture-confirmed VVC recurrence between baseline and day 180 as compared to placebo.Randomized · Triple-masked · Prevention | Not applicable | Recruiting | Dietary supplement: Probiotic, Placebo | Vulvovaginal Candidiasis | 126 | Jul 2025 | — | 2024-11-07 |
| Determination of the Safety and Efficacy of Two Probiotic StrainsNCT06466174Change in GSRS-IBS scoreRandomized · Triple-masked · Basic science | Not applicable | Unknown status | Dietary supplement: Placebo 1 to Probiotic A, Probiotic A to Placebo 1, Placebo 2 to Probiotic B, Probiotic B to Placebo 2 | Gastrointestinal Dysfunction | 100 | May 2026 | — | 2024-06-20 |
| Efficacy of Two Enzyme Cocktails in Healthy AdultsNCT06710392Change in the Gastrointestinal Symptoms Rating Scale - Irritable Bowel Syndrome (GSRS-IBS)Randomized · Triple-masked · Other | Not applicable | Terminatedsponsor's stated reason: The study was terminated due to insufficient enrollment and recruitment struggles | Dietary supplement: Enzyme Cocktail A, Enzyme Cocktail B, Placebo A, Placebo B | Digestive, Gastrointestinal Health | 18 | 2026-02-28actual | — | 2026-05-12 |
| Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight IndividualsNCT05428137Change in visceral fat areaRandomized · Double-masked · Treatment | Not applicable | Unknown status | Dietary supplement: Probiotic, Postbiotic · Other: Placebo | Obesity, Abdominal Obesity | 180 | Dec 2024 | — | 2024-03-05 |
| Safety and Efficacy of a Probiotic Supplement in IBS-DNCT05754177Change in total irritable bowel syndrome symptom severity score (IBS-SSS)Randomized · Triple-masked · Supportive care | Not applicable | Completed | Dietary supplement: Probiotic · Other: Placebo | Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome | 46 | 2024-12-30actual | — | 2025-03-06 |
| The Efficacy of a Probiotic for Functional Constipation (FC)NCT06083311Difference in change in Cleveland Clinic Constipation score (total) from baseline (V2) to study end (V3)Randomized · Triple-masked · Treatment | Not applicable | Completed | Dietary supplement: Probiotic, Placebo | Functional Constipation | 55 | 2024-12-17actual | — | 2025-04-09 |
| The Efficacy of a Probiotic for Antibiotic Associated Gastrointestinal SymptomsNCT05845073Change in the Gastrointestinal Symptom Rating Score - Irritable Bowel Syndrome (GSRS-IBS)Randomized · Triple-masked · Treatment | Not applicable | Completed | Dietary supplement: Probiotic, Placebo | Antibiotic-associated Diarrhea | 69 | 2024-07-25actual | — | 2025-04-09 |
| A Study to Assess the Effect of a Probiotic on Upper Respiratory Tract Infections in Healthy ChildrenNCT05577065Effect of 26 week consumption of probiotic on the total number of days that, otherwise healthy, children suffer from upper respiratory tract infection (URTI)Randomized · Quadruple-masked · Prevention | Not applicable | Completed | Dietary supplement: Probiotic, Placebo | Upper Respiratory Tract Infections, Upper Resp Tract Infection | 200 | 2024-03-13actual | — | 2025-04-09 |
| Pilot Study to Assess the Effect of a Postbiotic Blend on Moderate Self-reported AnxietyNCT05562739Change in Anxiety ratingRandomized · Quadruple-masked · Treatment | Not applicable | Completed | Dietary supplement: Postbiotic, Placebo | Anxiety | 10 | 2024-02-28actual | — | 2025-01-22 |
| Evaluation of Soy Isoflavones on Skin Ageing ParametersNCT06047145Change in Crow's Feet wrinkles (Ra)Randomized · Triple-masked · Prevention | Not applicable | Completed | Dietary supplement: soy isoflavones, Placebo | Skin Ageing | 66 | 2024-02-26actual | — | 2025-04-10 |
| Study to Assess the Effect of Multistrain Probiotic on the Immune Response to the Influenza VaccinationNCT06103994Change in serum strain-specific geometric mean antibody titers (determined by hemagglutination inhibition [HAI] tests)Randomized · Triple-masked · Treatment | Not applicable | Completed | Dietary supplement: Multistrain probiotic · Other: Placebo | Influenza | 120 | 2024-01-12actual | — | 2025-04-10 |
| Study of Efficacy of a Probiotic and Postbiotic in Overweight and Obese IndividualsNCT05440630Change in abdominal/visceral fat areaRandomized · Double-masked · Treatment | Not applicable | Withdrawnsponsor's stated reason: Unable to ship investigational product to trial site. | Dietary supplement: Probiotics, Postbiotic, Placebo | Obesity | 0 | 2023-10-30 | — | 2025-03-06 |
| Pilot Study to Assess the Effect of a Probiotic Blend on Moderate Self-reported Anxiety.NCT05562752Change in Anxiety ratingRandomized · Quadruple-masked · Treatment | Not applicable | Completed | Dietary supplement: Probiotic, Placebo | Anxiety | 100 | 2023-08-15actual | — | 2025-01-22 |
| Probiotics and Influenza Vaccination ResponseNCT05690373Seroconversion rateRandomized · Quadruple-masked · Prevention | Not applicable | Completed | Dietary supplement: Probiotic effect on influenza vaccine response | Vaccine Response | 100 | 2023-06-30actual | — | 2023-08-24 |
| Digestion of Gluten in the Presence of EnzymesNCT04489810Undigested wheat proteinRandomized · Triple-masked · Basic science | Not applicable | Completed | Dietary supplement: Placebo, Elevase®, DE111® · Other: Meal A, Meal B | Main Focus: Gluten and Starch Digestibility | 11 | 2021-04-08actual | — | 2025-04-10 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19