| 1 | 1Nantahala Capital Management, LLC | 5,013,0525.0M | $22M | 8.80% | — |
| 2 | 2BlackRock, Inc. | 3,195,5303.2M | $14M | 5.61% | — |
| 3 | 3AIGH Capital Management LLC | 3,100,0003.1M | $14M | 5.44% | ADD 55% |
| 4 | 4Cable Car Capital, LP | 3,007,3293.0M | $13M | 5.28% | ADD 20% |
| 5 | 5SUVRETTA CAPITAL MANAGEMENT, LLC | 2,676,0002.7M | $12M | 4.70% | — |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 2,164,8512.2M | $10M | 3.80% | NEW† |
| 7 | 7Propel Bio Management, LLC | 1,329,8991.3M | $6M | 2.33% | ADD 60% |
| 8 | 8KENNEDY CAPITAL MANAGEMENT LLC | 1,263,5111.3M | $6M | 2.22% | ADD 20% |
| 9 | 9GEODE CAPITAL MANAGEMENT, LLC | 1,209,7971.2M | $5M | 2.12% | ADD 6% |
| 10 | 10GOLDMAN SACHS GROUP INC | 1,130,6191.1M | $5M | 1.98% | ADD 125% |
| 11 | 11STATE STREET CORP | 957,328957,328 | $4M | 1.68% | ADD 7% |
| 12 | 12NAN FUNG TRINITY (HK) LTD | 956,770956,770 | $4M | 1.68% | — |
| 13 | 13AWM Investment Company, Inc. | 803,130803,130 | $4M | 1.41% | ADD 4% |
| 14 | 14683 Capital Management, LLC | 770,000770,000 | $3M | 1.35% | — |
| 15 | 15Stonepine Capital Management, LLC | 746,587746,587 | $3M | 1.31% | ADD 5% |
| 16 | 16SILVERARC CAPITAL MANAGEMENT, LLC | 648,942648,942 | $3M | 1.14% | ADD 3% |
| 17 | 17J. Goldman & Co LP | 640,530640,530 | $3M | 1.12% | ADD 61% |
| 18 | 18Diametric Capital, LP | 611,520611,520 | $3M | 1.07% | TRIM -12% |
| 19 | 19Balyasny Asset Management L.P. | 589,847589,847 | $3M | 1.03% | — |
| 20 | 20CITIGROUP INC | 522,445522,445 | $2M | 0.92% | — |
| 21 | 21Simplify Asset Management Inc. | 507,988507,988 | $2M | 0.89% | — |
| 22 | 22NATIONAL BANK OF CANADA /FI/ | 500,000500,000 | $2M | 0.88% | NEW |
| 23 | 23Knoll Capital Management, LLC | 485,515485,515 | $2M | 0.85% | ADD 106% |
| 24 | 24NORTHERN TRUST CORP | 435,973435,973 | $2M | 0.76% | ADD 4% |
| 25 | 25SUSQUEHANNA INTERNATIONAL GROUP, LLP | 432,370432,370 | $2M | 0.76% | TRIM -38% |
| 26 | 26MILLENNIUM MANAGEMENT LLC | 425,426425,426 | $2M | 0.75% | ADD 24% |
| 27 | 27TANG CAPITAL MANAGEMENT LLC | 400,000400,000 | $2M | 0.70% | TRIM -60% |
| 28 | 28BANK OF AMERICA CORP /DE/ | 394,274394,274 | $2M | 0.69% | TRIM -22% |
| 29 | 29VANGUARD FIDUCIARY TRUST CO | 339,515339,515 | $2M | 0.60% | NEW |
| 30 | 30MORGAN STANLEY | 337,562337,562 | $2M | 0.59% | TRIM -29% |
| 31 | 31VANGUARD PORTFOLIO MANAGEMENT LLC | 270,976270,976 | $1M | 0.48% | NEW |
| 32 | 32JPMORGAN CHASE & CO | 266,497266,497 | $1M | 0.47% | ADD 1148% |
| 33 | 33UBS Group AG | 233,924233,924 | $1M | 0.41% | ADD 46% |
| 34 | 34MARSHALL WACE, LLP | 216,305216,305 | $969,047 | 0.38% | NEW |
| 35 | 35GROUP ONE TRADING LLC | 209,607209,607 | $939,039 | 0.37% | TRIM -35% |
| 36 | 36PANAGORA ASSET MANAGEMENT INC | 199,145199,145 | $892,170 | 0.35% | ADD 19% |
| 37 | 37FMR LLC | 194,813194,813 | $872,762 | 0.34% | ADD 16% |
| 38 | 38Bank of New York Mellon Corp | 193,632193,632 | $867,470 | 0.34% | — |
| 39 | 39SEI INVESTMENTS CO | 172,460172,460 | $772,621 | 0.30% | ADD 142% |
| 40 | 40RENAISSANCE TECHNOLOGIES LLC | 161,082161,082 | $721,647 | 0.28% | ADD 39% |
| 41 | 41CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,109127,109 | $569,448 | 0.22% | TRIM -4% |
| 42 | 42ExodusPoint Capital Management, LP | 122,944122,944 | $550,789 | 0.22% | NEW |
| 43 | 43Palo Alto Investors LP | 108,865108,865 | $487,715 | 0.19% | — |
| 44 | 44AQR CAPITAL MANAGEMENT LLC | 102,645102,645 | $459,850 | 0.18% | TRIM -10% |
| 45 | 45D. E. Shaw & Co., Inc. | 101,065101,065 | $452,771 | 0.18% | TRIM -5% |
| 46 | 46PRELUDE CAPITAL MANAGEMENT, LLC | 93,07393,073 | $416,967 | 0.16% | TRIM -16% |
| 47 | 47Pale Fire Capital SE | 69,84569,845 | $312,906 | 0.12% | TRIM -60% |
| 48 | 48XTX Topco Ltd | 69,12069,120 | $309,658 | 0.12% | ADD 40% |
| 49 | 49LPL Financial LLC | 65,14865,148 | $291,863 | 0.11% | ADD 4% |
| 50 | 50Headlands Technologies LLC | 63,34563,345 | $283,786 | 0.11% | NEW |
| 51 | 51Rangeley Capital, LLC | 60,00060,000 | $268,800 | 0.11% | ADD 4% |
| 52 | 52Nuveen, LLC | 56,71956,719 | $254,101 | 0.10% | — |
| 53 | 53RHUMBLINE ADVISERS | 55,84755,847 | $250,183 | 0.10% | — |
| 54 | 54CITADEL ADVISORS LLC | 55,83755,837 | $250,150 | 0.10% | TRIM -56% |
| 55 | 55BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,00050,000 | $224,000 | 0.09% | NEW |
| 56 | 56DEUTSCHE BANK AG\ | 44,92744,927 | $201,273 | 0.08% | ADD 14% |
| 57 | 57HARBOR CAPITAL ADVISORS, INC. | 35,09435,094 | $157,000 | 0.06% | NEW |
| 58 | 58DIMENSIONAL FUND ADVISORS LP | 34,37134,371 | $153,982 | 0.06% | NEW |
| 59 | 59LOS ANGELES CAPITAL MANAGEMENT LLC | 33,56133,561 | $150,353 | 0.06% | TRIM -78% |
| 60 | 60SIMPLEX TRADING, LLC | 31,09631,096 | $139,310 | 0.05% | TRIM -68% |
| 61 | 61PRICE T ROWE ASSOCIATES INC /MD/ | 31,00531,005 | $139,000 | 0.05% | ADD 29% |
| 62 | 62Brevan Howard Capital Management LP | 29,26329,263 | $131,098 | 0.05% | ADD 35% |
| 63 | 63BARCLAYS PLC | 27,24827,248 | $122,072 | 0.05% | TRIM -73% |
| 64 | 64MetLife Investment Management, LLC | 23,77223,772 | $106,499 | 0.04% | — |
| 65 | 65Invesco Ltd. | 22,97922,979 | $102,946 | 0.04% | — |
| 66 | 66ALLIANCEBERNSTEIN L.P. | 17,92017,920 | $94,438 | 0.03% | — |
| 67 | 67MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,76020,760 | $93,005 | 0.04% | ADD 3% |
| 68 | 68Riverwater Partners LLC | 19,06619,066 | $85,416 | 0.03% | — |
| 69 | 69Vanguard Global Advisers, LLC | 18,60818,608 | $83,364 | 0.03% | NEW |
| 70 | 70WELLS FARGO & COMPANY/MN | 16,70216,702 | $74,825 | 0.03% | TRIM -65% |
| 71 | 71Cetera Investment Advisers | 15,84515,845 | $70,986 | 0.03% | TRIM -13% |
| 72 | 72Russell Investments Group, Ltd. | 14,05414,054 | $62,961 | 0.02% | ADD 7% |
| 73 | 73STIFEL FINANCIAL CORP | 13,97513,975 | $62,608 | 0.02% | NEW |
| 74 | 74ENVESTNET ASSET MANAGEMENT INC | 13,29113,291 | $59,544 | 0.02% | — |
| 75 | 75Legato Capital Management LLC | 13,18013,180 | $59,046 | 0.02% | — |
| 76 | 76MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,90112,901 | $57,796 | 0.02% | TRIM -5% |
| 77 | 77AMERICAN CENTURY COMPANIES INC | 12,71812,718 | $56,977 | 0.02% | NEW |
| 78 | 78INTECH INVESTMENT MANAGEMENT LLC | 12,19312,193 | $54,625 | 0.02% | TRIM -43% |
| 79 | 79Police & Firemen's Retirement System of New Jersey | 11,00511,005 | $49,302 | 0.02% | — |
| 80 | 80Kovack Advisors, Inc. | 10,56010,560 | $48,365 | 0.02% | NEW |
| 81 | 81Truvestments Capital LLC | 10,30710,307 | $46,175 | 0.02% | — |
| 82 | 82BNP PARIBAS FINANCIAL MARKETS | 9,8889,888 | $44,298 | 0.02% | ADD 3% |
| 83 | 83MAI Capital Management | 9,4339,433 | $42,260 | 0.02% | ADD 68% |
| 84 | 84Tower Research Capital LLC (TRC) | 7,5167,516 | $33,672 | 0.01% | ADD 105% |
| 85 | 85ROYAL BANK OF CANADA | 6,5006,500 | $29,000 | 0.01% | ADD 50% |
| 86 | 86Caption Management, LLC | 4,8744,874 | $21,836 | 0.01% | TRIM -91% |
| 87 | 87Allworth Financial LP | 4,5004,500 | $20,160 | 0.01% | — |
| 88 | 88Ameritas Investment Partners, Inc. | 4,4594,459 | $19,976 | 0.01% | — |
| 89 | 89Legal & General Group Plc | 3,9753,975 | $17,808 | 0.01% | TRIM -14% |
| 90 | 90UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,4123,412 | $15,286 | 0.01% | ADD 2446% |
| 91 | 91Federation des caisses Desjardins du Quebec | 3,0003,000 | $13,440 | 0.01% | NEW |
| 92 | 92CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,3642,364 | $10,591 | 0.00% | TRIM -12% |
| 93 | 93NEW YORK STATE COMMON RETIREMENT FUND | 1,7001,700 | $7,531 | 0.00% | — |
| 94 | 94SHP Wealth Management | 1,6681,668 | $7,472 | 0.00% | — |
| 95 | 95OSAIC HOLDINGS, INC. | 1,4311,431 | $6,409 | 0.00% | TRIM -25% |
| 96 | 96Rockefeller Capital Management L.P. | 1,2501,250 | $5,600 | 0.00% | — |
| 97 | 97JONES FINANCIAL COMPANIES LLLP | 1,0001,000 | $4,290 | 0.00% | — |
| 98 | 98GAMMA Investing LLC | 909909 | $4,072 | 0.00% | ADD 910% |
| 99 | 99Farther Finance Advisors, LLC | 618618 | $2,830 | 0.00% | TRIM -71% |
| 100 | 100Parallel Advisors, LLC | 400400 | $1,792 | 0.00% | — |