ABBV vs VRTX
AbbVie Inc. (ABBV) and Vertex Pharmaceuticals Inc / Ma (VRTX) are both filed with the SEC under Pharmaceutical Preparations. ABBV is 3.3× VRTX's size by market cap ($456.2B against $138.8B); ABBV trades at the higher fiscal-year P/E (109.4× against 35.7×); VRTX reports the higher net margin (32.9% against 6.9%); VRTX grew sales faster over three years (+10.4% against +1.8%); and over the past year VRTX returned +38.2% against ABBV's +25.8%.
| ABBV | VRTX | |
|---|---|---|
| Last close | $255.48 | $541.69 |
| Market cap | $456.2B | $138.8B |
| P/E (FY) | 109.4× | 35.7× |
| P/S | 7.5× | 11.6× |
| Operating margin | 24.6% | 34.8% |
| Net margin | 6.9% | 32.9% |
| Return on equity | — | 22.5% |
| Sales growth (3y) | +1.8% | +10.4% |
| EPS growth (3y) | -29.1% | +6.1% |
| Dividend yield | 2.6% | — |
| 1-year return | +25.8% | +38.2% |
Screener snapshot — prices as of 2026-08-28. Each side's last close is the most recent session the snapshot holds for that company, which can be an earlier one, and its 1-year return is measured to that close. Market caps struck on 2026-08-27. Last close, market cap and the 1-year return are price figures; every other row is computed over the company's latest filed fiscal year — FY2025 (ended 2025-12-31) for both. — not published for this company. A ratio goes unpublished for more than one reason: a component the calculation needs is not on file, the filing does not tag the line it is read from, or the calculation is not defined on the filed basis — EV/EBITDA is not printed on non-positive EBITDA, and return on equity is not computed on a zero or negative equity base.
Who holds them, and who has traded them
| ABBV | VRTX | |
|---|---|---|
| Institutional holders (13F) | 4,044 | 1,679 |
| Insider buyers − sellers (180d) | -2 | -5 |
| Congressional trades disclosed (180d) | 2 | 1 |
| Executive-branch officials on file — trades disclosed (180d) | 17 | 14 |
Counts only. The congressional figures count transactions dated in the trailing 180 days and disclosed in STOCK Act periodic transaction reports; amounts are filed as ranges and are never summed. The executive-branch figures count the same window of transactions, and they are scoped to one roster. The officials OGE posts for direct download. Insider buyers − sellers counts distinct people filing open-market Form 4 purchases minus distinct people filing open-market sales over the trailing 180 days, capped at ±5.
ABBV vs VRTX: common questions
- Is ABBV bigger than VRTX?
- ABBV carries the larger market cap — $456.2B against $138.8B, both struck on 2026-08-27.
- Which trades at a higher P/E, ABBV or VRTX?
- ABBV, at a fiscal-year 109.4× against 35.7× for VRTX. Both are price ÷ latest full-year diluted earnings per share, not a trailing-twelve-month P/E.
- How have ABBV and VRTX performed over the past year?
- VRTX returned +38.2% and ABBV +25.8%, measured on the trailing calendar year to the last close.
- How many institutions hold ABBV and VRTX?
- 4,044 13F filers report a position in ABBV and 1,679 in VRTX, on the latest quarter in the panel.
- Are ABBV and VRTX in the same industry?
- Both are filed with the SEC under Pharmaceutical Preparations, which is the classification this pairing is built on.
ABBV overview → · VRTX overview → · ABBV institutional ownership → · VRTX institutional ownership → · Congress and ABBV → · Congress and VRTX → · Executive branch and ABBV → · Executive branch and VRTX →
More in Pharmaceutical Preparations: ABBV vs ABT · ABBV vs ONC · ABBV vs REGN · ABBV vs TEVA
Stock comparisons lists every pair this site publishes.
Source: SPZCO — https://spzco.com/vs/abbv-vs-vrtx