Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-21 | Kosacz Barbara | Director | +Grant | 3,586 | — | — |
| 2026-05-21 | Franklin Heather L | Director | +Grant | 3,586 | — | — |
| 2026-05-21 | PERRY MATTHEW D | Director | +Grant | 3,586 | — | — |
| 2026-05-21 | Hernday Natasha | Director | +Grant | 3,586 | — | — |
| 2026-05-21 | LIMBER JOSEPH M | Director | +Grant | 3,586 | — | — |
| 2026-05-21 | WYSZOMIERSKI JACK L | Director | +Grant | 3,586 | — | — |
| 2026-05-14 | BVF PARTNERS L P/IL | TenPercentOwner | +Conversion | 772,000 | $4.03 | $3M |
| 2026-05-14 | BVF PARTNERS L P/IL | TenPercentOwner | +Conversion | 412,000 | $4.03 | $2M |
| 2026-05-14 | BVF PARTNERS L P/IL | TenPercentOwner | +Conversion | 1,506,000 | $4.03 | $6M |
| 2026-05-14 | BVF PARTNERS L P/IL | TenPercentOwner | +Conversion | 2,313,000 | $4.03 | $9M |
| 2026-04-20 | Sitko Bradley | Officer | +Exercise | 3,737 | — | — |
| 2026-04-20 | Hughes Owen | Director,Officer | +Exercise | 10,568 | — | — |
| 2026-04-20 | Montano Maricel Perea | Officer | +Exercise | 3,370 | — | — |
| 2026-04-20 | Trigilio Jeffrey | Officer | +Exercise | 11,538 | — | — |
| 2026-04-13 | Trigilio Jeffrey | Officer | +Exercise | 4,000 | — | — |
| 2026-04-13 | Trigilio Jeffrey | Officer | −Tax w/h | 1,632 | $36.76 | $59,992 |
| 2026-03-27 | LIMBER JOSEPH M | Director | +Exercise | 3,026 | $11.20 | $33,891 |
| 2026-03-24 | WYSZOMIERSKI JACK L | Director | +Exercise | 3,026 | $11.20 | $33,891 |
| 2026-03-16 | Hughes Owen | Director,Officer | +Grant | 82,428 | — | — |
| 2026-03-11 | Montano Maricel Perea | Officer | +Grant | 26,289 | — | — |
| 2026-03-11 | Trigilio Jeffrey | Officer | +Grant | 90,000 | — | — |
| 2026-03-11 | Sitko Bradley | Officer | +Grant | 29,402 | — | — |
| 2026-03-11 | Sitko Bradley | Officer | +Grant | 30,000 | — | — |
| 2025-12-04 | Hughes Owen | Director,Officer | +Buy | 100,000 | $25.05 | $3M |
| 2025-09-22 | BURNS THOMAS M. | Officer | −Sell | 15 | $36.93 | $554 |
| 2025-09-22 | BURNS THOMAS M. | Officer | −Sell | 4,300 | $35.98 | $154,714 |
| 2025-09-22 | BURNS THOMAS M. | Officer | −Sell | 15 | $36.81 | $552 |
| 2025-09-19 | Montano Maricel Perea | Officer | +Exercise | 3,033 | — | — |
| 2025-09-19 | BURNS THOMAS M. | Officer | +Exercise | 11,846 | — | — |
| 2025-09-19 | Hughes Owen | Director,Officer | +Exercise | 35,567 | — | — |
| 2025-09-19 | Sitko Bradley | Officer | +Exercise | 6,712 | — | — |
| 2025-09-10 | Montano Maricel Perea | Officer | +Exercise | 9,101 | — | — |
| 2025-06-30 | Sitko Bradley | Officer | +Buy | 2,000 | $25.39 | $50,780 |
| 2025-05-21 | Kosacz Barbara | Director | +Grant | 5,971 | — | — |
| 2025-05-21 | Franklin Heather L | Director | +Grant | 5,971 | — | — |
| 2025-05-21 | Hernday Natasha | Director | +Grant | 5,971 | — | — |
| 2025-05-21 | PERRY MATTHEW D | Director | +Grant | 5,971 | — | — |
| 2025-05-21 | WYSZOMIERSKI JACK L | Director | +Grant | 5,971 | — | — |
| 2025-05-21 | Kosacz Barbara | Director | +Grant | 5,971 | — | — |
| 2025-05-20 | BURNS THOMAS M. | Officer | −Sell | 10,482 | $25.38 | $266,033 |
| 2025-05-20 | Hughes Owen | Director,Officer | −Sell | 25,637 | $25.38 | $650,667 |
| 2025-05-19 | BURNS THOMAS M. | Officer | +Exercise | 17,773 | — | — |
| 2025-05-19 | Hughes Owen | Director,Officer | +Exercise | 53,359 | — | — |
| 2025-05-16 | BVF GP HOLDINGS LLC | TenPercentOwner | −Sell | 265,316 | $27.10 | $7M |
| 2025-05-16 | BVF GP HOLDINGS LLC | TenPercentOwner | −Sell | 127,407 | $27.10 | $3M |
| 2025-04-07 | LIMBER JOSEPH M | Director | +Buy | 5,243 | $25.60 | $134,221 |
| 2025-04-07 | Sitko Bradley | Officer | +Buy | 2,000 | $24.70 | $49,400 |
| 2025-04-04 | LIMBER JOSEPH M | Director | +Buy | 3,346 | $25.56 | $85,524 |
| 2025-04-04 | LIMBER JOSEPH M | Director | +Buy | 3,476 | $25.25 | $87,769 |
| 2025-04-03 | LIMBER JOSEPH M | Director | +Buy | 16,524 | $25.22 | $416,735 |
| 2025-04-03 | LIMBER JOSEPH M | Director | +Buy | 1,411 | $25.44 | $35,896 |
| 2025-04-01 | BURNS THOMAS M. | Officer | +Buy | 1,000 | $25.46 | $25,460 |
| 2025-03-31 | Sitko Bradley | Officer | +Buy | 1,000 | $19.98 | $19,980 |
| 2025-03-31 | Sitko Bradley | Officer | +Buy | 245 | $25.39 | $6,221 |
| 2025-03-21 | Sitko Bradley | Officer | +Buy | 2,800 | $25.43 | $71,204 |
| 2025-03-21 | Sitko Bradley | Officer | +Buy | 1,334 | $20.65 | $27,547 |
| 2025-01-24 | BIOTECHNOLOGY VALUE FUND L P | TenPercentOwner | −Sell | 339,679 | $26.10 | $9M |
| 2025-01-24 | BIOTECHNOLOGY VALUE FUND L P | TenPercentOwner | −Sell | 149,975 | $26.10 | $4M |
| 2025-01-24 | BIOTECHNOLOGY VALUE FUND L P | TenPercentOwner | −Sell | 85,776 | $26.10 | $2M |
| 2025-01-24 | BIOTECHNOLOGY VALUE FUND L P | TenPercentOwner | −Sell | 75,287 | $26.10 | $2M |
| 2025-01-08 | Sitko Bradley | Officer | +Buy | 75 | $25.60 | $1,920 |
| 2025-01-08 | Sitko Bradley | Officer | +Buy | 82 | $25.60 | $2,099 |
| 2025-01-08 | Sitko Bradley | Officer | +Buy | 75 | $25.90 | $1,943 |
| 2025-01-08 | Sitko Bradley | Officer | +Buy | 313 | $25.60 | $8,013 |
| 2024-12-31 | Sitko Bradley | Officer | +Buy | 300 | $25.90 | $7,770 |
| 2024-11-13 | Hughes Owen | Director,Officer | −Sell | 21,881 | $29.95 | $655,336 |
| 2024-11-13 | BURNS THOMAS M. | Officer | −Sell | 9,775 | $29.94 | $292,664 |
| 2024-11-11 | Hughes Owen | Director,Officer | +Exercise | 53,360 | — | — |
| 2024-11-11 | BURNS THOMAS M. | Officer | +Exercise | 17,773 | — | — |
| 2024-05-15 | PERRY MATTHEW D | Director,Other | +Grant | 6,070 | — | — |
| 2024-05-15 | WYSZOMIERSKI JACK L | Director | +Grant | 6,070 | — | — |
| 2024-05-15 | Hernday Natasha | Director | +Grant | 3,035 | — | — |
| 2023-10-03 | Sitko Bradley | Officer | +Buy | 250 | $13.89 | $3,473 |
| 2023-10-02 | Sitko Bradley | Officer | +Buy | 1,500 | $14.25 | $21,375 |
| 2023-10-02 | Hughes Owen | Director,Officer | +Buy | 1,000 | $13.83 | $13,830 |
| 2023-09-26 | Hughes Owen | Director,Officer | +Buy | 2,499 | $14.43 | $36,061 |
| 2023-09-25 | Hughes Owen | Director,Officer | +Buy | 1 | $14.65 | $15 |
| 2023-05-31 | Sitko Bradley | Officer | +Buy | 500 | $17.00 | $8,500 |
| 2023-05-31 | Sitko Bradley | Officer | +Buy | 1,000 | $17.20 | $17,200 |
| 2023-05-24 | Hughes Owen | Director,Officer | +Buy | 1,032 | $23.79 | $24,551 |
| 2023-05-23 | Hughes Owen | Director,Officer | +Buy | 200 | $23.33 | $4,666 |
| 2023-05-23 | Hughes Owen | Director,Officer | +Buy | 768 | $23.49 | $18,040 |
| 2023-05-23 | Sitko Bradley | Officer | +Buy | 850 | $19.00 | $16,150 |
| 2023-05-19 | Sitko Bradley | Officer | +Buy | 1,000 | $19.50 | $19,500 |
| 2023-05-16 | Sitko Bradley | Officer | +Buy | 100 | $23.20 | $2,320 |
| 2023-05-16 | Sitko Bradley | Officer | +Buy | 100 | $23.25 | $2,325 |
| 2023-05-16 | Sitko Bradley | Officer | +Buy | 300 | $23.19 | $6,957 |
| 2023-05-15 | Sitko Bradley | Officer | +Buy | 1,500 | $23.40 | $35,100 |
| 2023-05-12 | Sitko Bradley | Officer | +Buy | 1,957 | $19.00 | $37,183 |
| 2023-05-12 | Sitko Bradley | Officer | +Buy | 43 | $18.66 | $802 |
| 2023-01-06 | BIOTECHNOLOGY VALUE FUND II LP | Director,TenPercentOwner | +Buy | 1,676 | $21.98 | $36,838 |
| 2023-01-06 | BIOTECHNOLOGY VALUE FUND II LP | Director,TenPercentOwner | +Buy | 1,573 | $21.98 | $34,575 |
| 2023-01-05 | BIOTECHNOLOGY VALUE FUND II LP | Director,TenPercentOwner | +Buy | 3,330 | $18.39 | $61,239 |
| 2023-01-05 | BIOTECHNOLOGY VALUE FUND II LP | Director,TenPercentOwner | +Buy | 15,670 | $18.39 | $288,171 |
| 2022-09-27 | BVF GP HOLDINGS LLC | Director,TenPercentOwner | +Buy | 678 | $16.89 | $11,451 |
| 2022-09-27 | BVF GP HOLDINGS LLC | Director,TenPercentOwner | +Buy | 1,004 | $16.89 | $16,958 |
| 2022-09-26 | BVF GP HOLDINGS LLC | Director,TenPercentOwner | +Buy | 3,339 | $16.83 | $56,195 |
| 2022-09-26 | BVF GP HOLDINGS LLC | Director,TenPercentOwner | +Buy | 3,021 | $16.83 | $50,843 |
| 2022-09-23 | BVF GP HOLDINGS LLC | Director,TenPercentOwner | +Buy | 6,715 | $16.50 | $110,798 |
| 2022-09-23 | BVF GP HOLDINGS LLC | Director,TenPercentOwner | +Buy | 9,885 | $16.50 | $163,103 |
| 2022-09-16 | BVF I GP LLC | Director,TenPercentOwner | +Buy | 10,897 | $17.89 | $194,947 |
| 2022-09-16 | BVF I GP LLC | Director,TenPercentOwner | +Buy | 13,396 | $17.89 | $239,654 |
| 2022-09-15 | BVF I GP LLC | Director,TenPercentOwner | +Buy | 5,575 | $17.96 | $100,127 |
| 2022-09-14 | BVF I GP LLC | Director,TenPercentOwner | +Buy | 26,441 | $17.25 | $456,107 |
| 2022-07-15 | Neal James R | Director,Officer | −Sell | 905 | $31.86 | $28,833 |
| 2022-07-15 | Neal James R | Director,Officer | −Sell | 3,212 | $31.19 | $100,182 |
| 2022-07-15 | Neal James R | Director,Officer | +Exercise | 25,000 | $4.03 | $100,750 |
| 2022-07-15 | Neal James R | Director,Officer | −Sell | 20,883 | $29.55 | $617,093 |
| 2022-07-15 | BURNS THOMAS M. | Officer | −Sell | 2,000 | $31.66 | $63,320 |
| 2022-07-15 | BURNS THOMAS M. | Officer | +Exercise | 2,000 | $4.03 | $8,060 |
| 2022-03-23 | BURNS THOMAS M. | Officer | +Exercise | 161 | $4.03 | $649 |
| 2022-03-23 | BURNS THOMAS M. | Officer | −Sell | 161 | $30.00 | $4,830 |
| 2022-03-23 | Neal James R | Director,Officer | +Exercise | 1,111 | $4.03 | $4,477 |
| 2022-03-23 | Neal James R | Director,Officer | −Sell | 1,111 | $30.02 | $33,352 |
| 2022-03-22 | BURNS THOMAS M. | Officer | +Exercise | 2,339 | $4.03 | $9,426 |
| 2022-03-22 | BURNS THOMAS M. | Officer | −Sell | 2,339 | $30.02 | $70,217 |
| 2022-03-22 | Neal James R | Director,Officer | −Sell | 2,339 | $30.02 | $70,217 |
| 2022-03-22 | Neal James R | Director,Officer | +Exercise | 2,339 | $4.03 | $9,426 |
| 2022-03-21 | BURNS THOMAS M. | Officer | +Exercise | 12,000 | $4.03 | $48,360 |
| 2022-03-21 | BURNS THOMAS M. | Officer | −Sell | 12,000 | $29.01 | $348,120 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
