| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,590,3032.6M | $81M | 14.40% | — |
| 2 | MORGAN STANLEY | 1,702,1571.7M | $53M | 9.47% | — |
| 3 | FMR LLC | 1,302,9741.3M | $41M | 7.25% | ADD 12% |
| 4 | BlackRock, Inc. | 646,914646,914 | $20M | 3.60% | ADD 6% |
| 5 | Woodline Partners LP | 640,001640,001 | $20M | 3.56% | ADD 143% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 549,796549,796 | $17M | 3.06% | NEW† |
| 7 | Opaleye Management Inc. | 300,000300,000 | $9M | 1.67% | ADD 3% |
| 8 | GW&K Investment Management, LLC | 232,141232,141 | $7M | 1.29% | NEW |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | 229,766229,766 | $7M | 1.28% | ADD 4% |
| 10 | MILLENNIUM MANAGEMENT LLC | 204,920204,920 | $6M | 1.14% | NEW |
| 11 | STATE STREET CORP | 193,148193,148 | $6M | 1.07% | ADD 10% |
| 12 | DIMENSIONAL FUND ADVISORS LP | 133,360133,360 | $4M | 0.74% | ADD 208% |
| 13 | TLS Advisors LLC | 114,867114,867 | $4M | 0.64% | ADD 140% |
| 14 | CITADEL ADVISORS LLC | 98,63898,638 | $3M | 0.55% | NEW |
| 15 | NORTHERN TRUST CORP | 93,49093,490 | $3M | 0.52% | ADD 3% |
| 16 | VANGUARD PORTFOLIO MANAGEMENT LLC | 85,79785,797 | $3M | 0.48% | NEW |
| 17 | Bank of New York Mellon Corp | 74,98474,984 | $2M | 0.42% | ADD 10% |
| 18 | UBS Group AG | 72,53372,533 | $2M | 0.40% | ADD 178% |
| 19 | Stonepine Capital Management, LLC | 69,50069,500 | $2M | 0.39% | TRIM -40% |
| 20 | Simcoe Capital LLC | 68,05368,053 | $2M | 0.38% | NEW |
| 21 | VANGUARD FIDUCIARY TRUST CO | 66,66466,664 | $2M | 0.37% | NEW |
| 22 | PANAGORA ASSET MANAGEMENT INC | 58,66258,662 | $2M | 0.33% | ADD 176% |
| 23 | HighVista Strategies LLC | 46,81446,814 | $1M | 0.26% | TRIM -59% |
| 24 | CM Management, LLC | 40,00040,000 | $1M | 0.22% | — |
| 25 | RBF Capital, LLC | 30,00030,000 | $941,100 | 0.17% | TRIM -50% |
| 26 | STATE OF WISCONSIN INVESTMENT BOARD | 28,89428,894 | $906,405 | 0.16% | NEW |
| 27 | Quadrature Capital Ltd | 28,49528,495 | $893,888 | 0.16% | NEW |
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,15127,151 | $851,727 | 0.15% | TRIM -8% |
| 29 | TWO SIGMA INVESTMENTS, LP | 26,07526,075 | $817,973 | 0.15% | ADD 168% |
| 30 | GOLDMAN SACHS GROUP INC | 23,99823,998 | $752,818 | 0.13% | ADD 49% |
| 31 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,58017,580 | $551,485 | 0.10% | — |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,39017,390 | $545,524 | 0.10% | ADD 81% |
| 33 | NANO CAP NEW MILLENNIUM GROWTH FUND L P | 17,00017,000 | $533,290 | 0.09% | ADD 13% |
| 34 | ExodusPoint Capital Management, LP | 14,66314,663 | $459,978 | 0.08% | NEW |
| 35 | JANE STREET GROUP, LLC | 14,51914,519 | $455,461 | 0.08% | NEW |
| 36 | Nuveen, LLC | 12,70612,706 | $398,587 | 0.07% | — |
| 37 | RHUMBLINE ADVISERS | 11,70511,705 | $367,175 | 0.07% | — |
| 38 | BANK OF AMERICA CORP /DE/ | 11,01811,018 | $345,634 | 0.06% | TRIM -8% |
| 39 | DIVERSIFIED MANAGEMENT INC | 10,00010,000 | $313,700 | 0.06% | — |
| 40 | REGIONS FINANCIAL CORP | 9,2509,250 | $290,173 | 0.05% | NEW |
| 41 | DEUTSCHE BANK AG\ | 8,4478,447 | $264,983 | 0.05% | ADD 6712% |
| 42 | Caption Management, LLC | 7,4337,433 | $233,173 | 0.04% | NEW |
| 43 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,8036,803 | $214,000 | 0.04% | NEW |
| 44 | Invesco Ltd. | 6,7826,782 | $212,751 | 0.04% | NEW |
| 45 | MetLife Investment Management, LLC | 5,6775,677 | $178,087 | 0.03% | — |
| 46 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,6004,600 | $144,302 | 0.03% | ADD 2% |
| 47 | Vanguard Global Advisers, LLC | 4,0464,046 | $126,923 | 0.02% | NEW |
| 48 | WELLS FARGO & COMPANY/MN | 3,8653,865 | $121,230 | 0.02% | TRIM -64% |
| 49 | JPMORGAN CHASE & CO | 3,9923,992 | $120,758 | 0.02% | ADD 4% |
| 50 | OSAIC HOLDINGS, INC. | 3,4443,444 | $108,035 | 0.02% | TRIM -3% |
| 51 | Police & Firemen's Retirement System of New Jersey | 2,8562,856 | $89,593 | 0.02% | — |
| 52 | NEW YORK STATE COMMON RETIREMENT FUND | 2,3622,362 | $74,096 | 0.01% | — |
| 53 | BNP PARIBAS FINANCIAL MARKETS | 2,1932,193 | $68,794 | 0.01% | — |
| 54 | BARCLAYS PLC | 1,9651,965 | $61,642 | 0.01% | TRIM -87% |
| 55 | State of Alaska, Department of Revenue | 1,0501,050 | $32,000 | 0.01% | — |
| 56 | ROYAL BANK OF CANADA | 1,0021,002 | $31,000 | 0.01% | TRIM -19% |
| 57 | Ameritas Investment Partners, Inc. | 959959 | $30,084 | 0.01% | — |
| 58 | Legal & General Group Plc | 854854 | $26,790 | 0.00% | TRIM -13% |
| 59 | Russell Investments Group, Ltd. | 819819 | $25,691 | 0.00% | ADD 5% |
| 60 | CITIGROUP INC | 753753 | $23,621 | 0.00% | ADD 36% |
| 61 | Costello Asset Management, INC | 600600 | $18,822 | 0.00% | — |
| 62 | Tower Research Capital LLC (TRC) | 572572 | $17,944 | 0.00% | ADD 22% |
| 63 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 514514 | $16,124 | 0.00% | TRIM -12% |
| 64 | NATIXIS | 372372 | $11,670 | 0.00% | — |
| 65 | Truvestments Capital LLC | 290290 | $9,097 | 0.00% | — |
| 66 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 283283 | $8,878 | 0.00% | NEW |
| 67 | LOS ANGELES CAPITAL MANAGEMENT LLC | 190190 | $5,960 | 0.00% | TRIM -99% |
| 68 | GAMMA Investing LLC | 152152 | $4,768 | 0.00% | ADD 35% |
| 69 | Sterling Capital Management LLC | 145145 | $4,549 | 0.00% | TRIM -38% |
| 70 | CWM, LLC | 113113 | $3,545 | 0.00% | TRIM -16% |
| 71 | Optiver Holding B.V. | 9090 | $2,823 | 0.00% | ADD 36% |
| 72 | US BANCORP \DE\ | 6767 | $2,102 | 0.00% | NEW |
| 73 | EverSource Wealth Advisors, LLC | 5959 | $1,850 | 0.00% | TRIM -14% |
| 74 | Ancora Advisors LLC | 3131 | $972 | 0.00% | — |
| 75 | PNC FINANCIAL SERVICES GROUP, INC. | 2525 | $784 | 0.00% | — |
| 76 | MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV | 2020 | $628 | 0.00% | — |
| 77 | NISA INVESTMENT ADVISORS, LLC | 1919 | $596 | 0.00% | — |
| 78 | SBI Securities Co., Ltd. | 1414 | $439 | 0.00% | ADD 17% |
| 79 | Root Financial Partners, LLC | 1313 | $408 | 0.00% | NEW |
| 80 | Larson Financial Group LLC | 1010 | $314 | 0.00% | NEW |
| 81 | True Wealth Design, LLC | 44 | $126 | 0.00% | ADD 33% |
| 82 | Allworth Financial LP | 33 | $95 | 0.00% | TRIM -70% |
| 83 | ROTHSCHILD INVESTMENT LLC | 33 | $94 | 0.00% | — |
| 84 | TD Waterhouse Canada Inc. | 11 | $33 | 0.00% | — |
| 85 | MAI Capital Management | 11 | $32 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 3.6M | 3.0M | 2.6M | 2.6M | 2.6M | 2.6M | $81M |
| MORGAN STANLEY | 317K | 1.1M | 1.5M | 1.6M | 1.7M | 1.7M | $53M |
| FMR LLC | 1.1M | 1.1M | 1.1M | 1.1M | 1.2M | 1.3M | $41M |
| BlackRock, Inc. | 539K | 533K | 592K | 593K | 612K | 647K | $20M |
| Woodline Partners LP | 156K | 169K | 180K | 210K | 263K | 640K | $20M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 550K | $17M |
| Opaleye Management Inc. | 250K | 253K | 255K | 255K | 293K | 300K | $9M |
| GW&K Investment Management, LLC | — | — | — | — | — | 232K | $7M |
| GEODE CAPITAL MANAGEMENT, LLC | 182K | 187K | 204K | 212K | 222K | 230K | $7M |
| MILLENNIUM MANAGEMENT LLC | — | 14K | — | — | — | 205K | $6M |
| STATE STREET CORP | 145K | 145K | 153K | 167K | 175K | 193K | $6M |
| DIMENSIONAL FUND ADVISORS LP | 22K | 22K | 28K | 29K | 43K | 133K | $4M |
| TLS Advisors LLC | 119K | 119K | 119K | 115K | 48K | 115K | $4M |
| CITADEL ADVISORS LLC | 12K | 10K | — | 8K | — | 99K | $3M |
| NORTHERN TRUST CORP | 91K | 89K | 94K | 95K | 90K | 93K | $3M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Holder count only — too few computable %-of-shares-outstanding quarters for a % pane. Line breaks are quarters with no 13F record, never interpolated.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Item 4 is hereby amended to add the following: On July 14, 2026, the Issuer consummated the Merger with Ligand Pharmaceuticals Incorporated ("Parent") in accordance with the terms of that certain Agreement and Plan of Merger, dated April 27, 2026, as amended by Amendment No. 1 to the Agreement and Plan of Merger on May 16, 2026 (as amended, the "Merger Agreement"). Pursuant to the Merger Agreement, Flex Merger Sub, Inc., a wholly owned subsidiary of Parent merged with and into XOMA Royalty Holdi”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +549,796 | $17M | OPEN |
| Woodline Partners LP | +377,068 | $12M | ADD |
| GW&K Investment Management, LLC | +232,141 | $7M | OPEN |
| MILLENNIUM MANAGEMENT LLC | +204,920 | $6M | OPEN |
| FMR LLC | +141,085 | $4M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −701,657 | $22M | CLOSE |
| HighVista Strategies LLC | −66,103 | $2M | TRIM |
| Stonepine Capital Management, LLC | −45,500 | $1M | TRIM |
| RENAISSANCE TECHNOLOGIES LLC | −39,017 | $1M | CLOSE |
| RBF Capital, LLC | −30,000 | $941,100 | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 85 | 9,989,419 | 55.6% | $313M |
| 2025-Q4 | 74 | 8,664,107 | — | $231M |
| 2025-Q3 | 74 | 8,334,927 | — | $321M |
| 2025-Q2 | 66 | 8,180,996 | — | $206M |
| 2025-Q1 | 64 | 7,851,247 | — | $156M |
| 2024-Q4 | 65 | 7,817,076 | — | $205M |
| 2024-Q3 | 67 | 7,696,463 | — | $203M |
| 2024-Q2 | 60 | 7,678,571 | — | $181M |
| 2024-Q1 | 57 | 7,933,240 | — | $191M |
| 2023-Q4 | 59 | 7,532,673 | — | $139M |
| 2023-Q3 | 52 | 7,640,034 | — | $108M |
| 2023-Q2 | 58 | 7,616,837 | — | $139M |
| 2023-Q1 | 50 | 8,287,510 | — | $175M |
| 2022-Q4 | 49 | 6,606,659 | — | $121M |
| 2022-Q3 | 45 | 6,284,464 | — | $113M |
| 2022-Q2 | 46 | 6,225,457 | — | $139M |
| 2022-Q1 | 54 | 6,374,871 | — | $178M |
| 2021-Q4 | 53 | 6,398,420 | — | $133M |
| 2021-Q3 | 50 | 6,331,141 | — | $157M |
| 2021-Q2 | 52 | 6,289,543 | — | $214M |
| 2021-Q1 | 60 | 6,372,873 | — | $260M |
| 2020-Q4 | 60 | 6,437,818 | — | $284M |
| 2020-Q3 | 55 | 6,318,404 | — | $119M |
| 2020-Q2 | 57 | 6,298,645 | — | $124M |
| 2020-Q1 | 48 | 4,814,850 | — | $98M |
| 2019-Q4 | 53 | 4,624,889 | — | $126M |
| 2019-Q3 | 45 | 3,274,863 | — | $64M |
| 2019-Q2 | 48 | 3,918,916 | — | $58M |
| 2019-Q1 | 50 | 4,173,273 | — | $52M |
| 2018-Q4 | 51 | 4,268,484 | — | $54M |
| 2018-Q3 | 60 | 3,608,434 | — | $63M |
| 2018-Q2 | 63 | 3,660,477 | — | $76M |
| 2018-Q1 | 57 | 3,403,142 | — | $69M |
| 2017-Q4 | 57 | 3,238,262 | — | $115M |
| 2017-Q3 | 34 | 2,727,674 | — | $54M |
| 2017-Q2 | 31 | 2,498,508 | — | $17M |
| 2017-Q1 | 34 | 2,366,794 | — | $17M |
| 2016-Q4 | 39 | 1,098,602 | — | $5M |
| 2016-Q3 | 2 | 30,726 | — | $14,000 |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
