| 1 | 1FMR LLC | 17,740,97217.7M | $377M | 14.22% | ADD 49% |
| 2 | 2ARK Investment Management LLC | 11,717,31711.7M | $249M | 9.39% | TRIM -7% |
| 3 | 3BlackRock, Inc. | 10,079,91310.1M | $214M | 8.08% | — |
| 4 | 4VANGUARD PORTFOLIO MANAGEMENT LLC | 6,912,9366.9M | $147M | 5.54% | NEW† |
| 5 | 5Quantinno Capital Management LP | 5,411,7615.4M | $115M | 4.34% | ADD 16% |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 5,269,5865.3M | $112M | 4.22% | NEW† |
| 7 | 7Sumitomo Mitsui Trust Group, Inc. | 5,110,2145.1M | $108M | 4.10% | TRIM -7% |
| 8 | 8Amova Asset Management Americas, Inc. | 5,104,1785.1M | $108M | 4.09% | TRIM -7% |
| 9 | 9GOLDMAN SACHS GROUP INC | 3,971,8004.0M | $84M | 3.18% | ADD 29% |
| 10 | 10GEODE CAPITAL MANAGEMENT, LLC | 2,904,2282.9M | $62M | 2.33% | ADD 4% |
| 11 | 11MORGAN STANLEY | 2,656,3532.7M | $56M | 2.13% | TRIM -17% |
| 12 | 12STATE STREET CORP | 2,588,7952.6M | $55M | 2.08% | ADD 3% |
| 13 | 13AQR CAPITAL MANAGEMENT LLC | 2,538,2562.5M | $54M | 2.03% | — |
| 14 | 14JACOBS LEVY EQUITY MANAGEMENT, INC | 2,283,4242.3M | $48M | 1.83% | TRIM -14% |
| 15 | 15Casdin Capital, LLC | 2,275,0002.3M | $48M | 1.82% | ADD 63% |
| 16 | 16MILLENNIUM MANAGEMENT LLC | 2,068,4142.1M | $44M | 1.66% | ADD 66% |
| 17 | 17DIMENSIONAL FUND ADVISORS LP | 2,042,9502.0M | $43M | 1.64% | ADD 35% |
| 18 | 18Capital World Investors | 1,452,3001.5M | $31M | 1.16% | — |
| 19 | 19T. Rowe Price Investment Management, Inc. | 1,279,3821.3M | $27M | 1.03% | TRIM -29% |
| 20 | 20CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,127,0561.1M | $24M | 0.90% | — |
| 21 | 21Blue Water Life Science Advisors, LP | 1,090,0001.1M | $23M | 0.87% | NEW |
| 22 | 22NORTHERN TRUST CORP | 1,048,0051.0M | $22M | 0.84% | ADD 5% |
| 23 | 23RENAISSANCE TECHNOLOGIES LLC | 1,008,7391.0M | $21M | 0.81% | TRIM -35% |
| 24 | 24Balyasny Asset Management L.P. | 989,522989,522 | $21M | 0.79% | NEW |
| 25 | 25BANK OF AMERICA CORP /DE/ | 964,579964,579 | $20M | 0.77% | TRIM -48% |
| 26 | 26Connor, Clark & Lunn Investment Management Ltd. | 938,408938,408 | $20M | 0.75% | ADD 32% |
| 27 | 27VANGUARD FIDUCIARY TRUST CO | 778,906778,906 | $17M | 0.62% | NEW |
| 28 | 28CITADEL ADVISORS LLC | 743,734743,734 | $16M | 0.60% | ADD 469% |
| 29 | 29JPMORGAN CHASE & CO | 785,505785,505 | $16M | 0.63% | TRIM -15% |
| 30 | 30IEQ CAPITAL, LLC | 700,684700,684 | $15M | 0.56% | TRIM -8% |
| 31 | 31Freshford Capital Management, LLC | 672,956672,956 | $14M | 0.54% | TRIM -19% |
| 32 | 32Nuveen, LLC | 625,796625,796 | $13M | 0.50% | ADD 165% |
| 33 | 33FEDERATED HERMES, INC. | 611,614611,614 | $13M | 0.49% | TRIM -5% |
| 34 | 34IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 542,757542,757 | $12M | 0.44% | TRIM -14% |
| 35 | 35Trexquant Investment LP | 533,288533,288 | $11M | 0.43% | TRIM -29% |
| 36 | 36Meridiem Capital Partners LP | 523,998523,998 | $11M | 0.42% | NEW |
| 37 | 37VOLORIDGE INVESTMENT MANAGEMENT, LLC | 497,157497,157 | $11M | 0.40% | TRIM -60% |
| 38 | 38UBS Group AG | 494,762494,762 | $11M | 0.40% | TRIM -43% |
| 39 | 39Sands Capital Alternatives, LLC | 481,770481,770 | $10M | 0.39% | — |
| 40 | 40Russell Investments Group, Ltd. | 480,619480,619 | $10M | 0.39% | TRIM -10% |
| 41 | 41Quantedge Capital Pte Ltd | 416,553416,553 | $9M | 0.33% | ADD 104% |
| 42 | 42TWO SIGMA INVESTMENTS, LP | 402,427402,427 | $9M | 0.32% | TRIM -65% |
| 43 | 43Simplify Asset Management Inc. | 354,703354,703 | $8M | 0.28% | TRIM -27% |
| 44 | 44Bank of New York Mellon Corp | 347,562347,562 | $7M | 0.28% | — |
| 45 | 45AMERIPRISE FINANCIAL INC | 332,524332,524 | $7M | 0.27% | TRIM -13% |
| 46 | 46Bellevue Group AG | 329,492329,492 | $7M | 0.26% | ADD 2% |
| 47 | 47LORD, ABBETT & CO. LLC | 329,318329,318 | $7M | 0.26% | NEW |
| 48 | 48Allianz Asset Management GmbH | 320,009320,009 | $7M | 0.26% | NEW |
| 49 | 49Invesco Ltd. | 317,643317,643 | $7M | 0.25% | TRIM -5% |
| 50 | 50JANUS HENDERSON GROUP PLC | 305,268305,268 | $6M | 0.24% | TRIM -44% |
| 51 | 51Susquehanna Portfolio Strategies, LLC | 298,230298,230 | $6M | 0.24% | — |
| 52 | 52AMERICAN CENTURY COMPANIES INC | 292,201292,201 | $6M | 0.23% | ADD 8% |
| 53 | 53FRANKLIN RESOURCES INC | 286,398286,398 | $6M | 0.23% | ADD 15% |
| 54 | 54HSBC HOLDINGS PLC | 285,389285,389 | $6M | 0.23% | NEW |
| 55 | 55Summit Trail Advisors, LLC | 269,768269,768 | $6M | 0.22% | ADD 22% |
| 56 | 56Man Group plc | 269,264269,264 | $6M | 0.22% | TRIM -31% |
| 57 | 57Vestmark Advisory Solutions, Inc. | 251,030251,030 | $5M | 0.20% | TRIM -7% |
| 58 | 58OSSIAM | 229,300229,300 | $5M | 0.18% | — |
| 59 | 59Focus Partners Wealth | 224,496224,496 | $5M | 0.18% | ADD 19% |
| 60 | 60PRINCIPAL FINANCIAL GROUP INC | 226,830226,830 | $5M | 0.18% | TRIM -9% |
| 61 | 61ARCH Venture Management, LLC | 217,834217,834 | $5M | 0.17% | TRIM -70% |
| 62 | 62Tao Capital Management LP | 210,862210,862 | $4M | 0.17% | — |
| 63 | 63Swiss National Bank | 207,400207,400 | $4M | 0.17% | ADD 2% |
| 64 | 64Corient Private Wealth LLC | 211,270211,270 | $4M | 0.17% | TRIM -47% |
| 65 | 65UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 205,537205,537 | $4M | 0.16% | ADD 21% |
| 66 | 66Pictet Asset Management Holding SA | 219,049219,049 | $4M | 0.18% | TRIM -4% |
| 67 | 67LAZARD ASSET MANAGEMENT LLC | 182,984182,984 | $4M | 0.15% | TRIM -20% |
| 68 | 68Caprock Group, LLC | 181,822181,822 | $4M | 0.15% | TRIM -5% |
| 69 | 69HARVARD MANAGEMENT CO INC | 170,000170,000 | $4M | 0.14% | — |
| 70 | 70Caisse de depot et placement du Quebec | 165,250165,250 | $4M | 0.13% | NEW |
| 71 | 71PRICE T ROWE ASSOCIATES INC /MD/ | 163,215163,215 | $3M | 0.13% | ADD 38% |
| 72 | 72WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 152,187152,187 | $3M | 0.12% | ADD 28% |
| 73 | 73FINANCIAL CONSULATE, INC | 156,457156,457 | $3M | 0.13% | — |
| 74 | 74Exome Asset Management LLC | 154,194154,194 | $3M | 0.12% | TRIM -6% |
| 75 | 75SUSQUEHANNA INTERNATIONAL GROUP, LLP | 150,980150,980 | $3M | 0.12% | ADD 182% |
| 76 | 76ALGERT GLOBAL LLC | 147,310147,310 | $3M | 0.12% | TRIM -62% |
| 77 | 77RHUMBLINE ADVISERS | 143,379143,379 | $3M | 0.11% | — |
| 78 | 78WELLS FARGO & COMPANY/MN | 140,116140,116 | $3M | 0.11% | TRIM -59% |
| 79 | 79Cerity Partners LLC | 133,827133,827 | $3M | 0.11% | ADD 4% |
| 80 | 80PRELUDE CAPITAL MANAGEMENT, LLC | 133,038133,038 | $3M | 0.11% | ADD 45% |
| 81 | 81PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 127,250127,250 | $3M | 0.10% | — |
| 82 | 82MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 126,332126,332 | $3M | 0.10% | ADD 4% |
| 83 | 83CWM, LLC | 124,804124,804 | $3M | 0.10% | — |
| 84 | 84CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 123,142123,142 | $3M | 0.10% | TRIM -2% |
| 85 | 85DEUTSCHE BANK AG\ | 115,867115,867 | $2M | 0.09% | ADD 14% |
| 86 | 86MERCER GLOBAL ADVISORS INC /ADV | 114,972114,972 | $2M | 0.09% | ADD 38% |
| 87 | 87Gotham Asset Management, LLC | 114,953114,953 | $2M | 0.09% | ADD 21% |
| 88 | 88Schonfeld Strategic Advisors LLC | 113,724113,724 | $2M | 0.09% | NEW |
| 89 | 89VOYA INVESTMENT MANAGEMENT LLC | 113,345113,345 | $2M | 0.09% | ADD 222% |
| 90 | 90FRED ALGER MANAGEMENT, LLC | 111,879111,879 | $2M | 0.09% | ADD 10% |
| 91 | 91ENVESTNET ASSET MANAGEMENT INC | 108,632108,632 | $2M | 0.09% | ADD 76% |
| 92 | 92ROYAL BANK OF CANADA | 108,192108,192 | $2M | 0.09% | — |
| 93 | 93LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 107,216107,216 | $2M | 0.09% | ADD 108% |
| 94 | 94MARSHALL WACE, LLP | 102,272102,272 | $2M | 0.08% | ADD 12% |
| 95 | 95Capricorn Fund Managers Ltd | 101,800101,800 | $2M | 0.08% | NEW |
| 96 | 96VANGUARD ASSET MANAGEMENT, Ltd | 99,66199,661 | $2M | 0.08% | NEW |
| 97 | 97Universal- Beteiligungs- und Servicegesellschaft mbH | 96,31996,319 | $2M | 0.08% | TRIM -11% |
| 98 | 98ALLIANCEBERNSTEIN L.P. | 125,131125,131 | $2M | 0.10% | — |
| 99 | 99Engineers Gate Manager LP | 92,51392,513 | $2M | 0.07% | — |
| 100 | 100Legal & General Group Plc | 91,93391,933 | $2M | 0.07% | TRIM -10% |
