Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-20 | Zeiher Bernhardt G | Director | +Buy | 5,000 | $5.86 | $29,300 |
| 2026-05-04 | Dowden Nathan J | Officer | −Sell | 15,000 | $15.33 | $229,950 |
| 2026-05-04 | Dowden Nathan J | Officer | +Exercise | 15,000 | $1.74 | $26,100 |
| 2026-05-04 | Sethuraman Natarajan | Officer | −Sell | 25,907 | $15.39 | $398,709 |
| 2026-04-01 | WENTWORTH KORY JAMES | Officer | −Sell | 2,500 | $12.95 | $32,375 |
| 2026-03-10 | WENTWORTH KORY JAMES | Officer | −Sell | 11,388 | $13.02 | $148,272 |
| 2026-03-10 | Dowden Nathan J | Officer | −Sell | 11,894 | $13.05 | $155,217 |
| 2026-03-09 | WENTWORTH KORY JAMES | Officer | −Sell | 5,089 | $13.00 | $66,157 |
| 2026-03-09 | Dowden Nathan J | Officer | −Sell | 3,116 | $13.02 | $40,570 |
| 2026-03-04 | WENTWORTH KORY JAMES | Officer | −Sell | 7,988 | $12.25 | $97,853 |
| 2026-03-03 | Sethuraman Natarajan | Officer | −Tax w/h | 7,577 | $11.76 | $89,106 |
| 2026-03-03 | Dowden Nathan J | Officer | −Tax w/h | 14,038 | $11.76 | $165,087 |
| 2026-03-03 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 5,712 | $11.76 | $67,173 |
| 2026-03-03 | Doshi Dipal | Director,Officer | −Tax w/h | 19,181 | $11.76 | $225,569 |
| 2026-03-02 | Sethuraman Natarajan | Officer | −Tax w/h | 3,898 | $11.66 | $45,451 |
| 2026-03-02 | Dowden Nathan J | Officer | −Tax w/h | 7,223 | $11.66 | $84,220 |
| 2026-03-02 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 2,939 | $11.66 | $34,269 |
| 2026-03-02 | Doshi Dipal | Director,Officer | −Tax w/h | 9,869 | $11.66 | $115,073 |
| 2026-03-01 | Sethuraman Natarajan | Officer | +Grant | 55,800 | — | — |
| 2026-03-01 | Dowden Nathan J | Officer | +Grant | 55,800 | — | — |
| 2026-03-01 | WENTWORTH KORY JAMES | Officer | +Grant | 44,600 | — | — |
| 2026-03-01 | Doshi Dipal | Director,Officer | +Grant | 139,400 | — | — |
| 2025-11-21 | WENTWORTH KORY JAMES | Officer | −Sell | 8,910 | $9.98 | $88,922 |
| 2025-11-20 | BAKER FELIX | TenPercentOwner | +Buy | 1,213 | $9.07 | $11,002 |
| 2025-11-20 | BAKER FELIX | TenPercentOwner | +Buy | 13,386 | $9.07 | $121,411 |
| 2025-11-20 | BAKER FELIX | TenPercentOwner | +Buy | 1,186 | $9.07 | $10,757 |
| 2025-11-20 | BAKER FELIX | TenPercentOwner | +Buy | 13,082 | $9.07 | $118,654 |
| 2025-11-14 | 5AM Ventures V, L.P. | TenPercentOwner | −Sell | 200,000 | $8.80 | $2M |
| 2025-11-14 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 200,000 | $8.80 | $2M |
| 2025-11-12 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 1,040 | $7.95 | $8,268 |
| 2025-11-12 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 80,881 | $7.73 | $625,210 |
| 2025-11-12 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 7,321 | $7.73 | $56,591 |
| 2025-11-12 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 11,494 | $7.95 | $91,377 |
| 2025-11-11 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 1,059 | $7.39 | $7,826 |
| 2025-11-11 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 30,879 | $7.54 | $232,828 |
| 2025-11-11 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 2,795 | $7.54 | $21,074 |
| 2025-11-11 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 11,701 | $7.39 | $86,470 |
| 2025-11-10 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 2,296 | $7.21 | $16,554 |
| 2025-11-10 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 25,364 | $7.21 | $182,874 |
| 2025-11-10 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 267 | $7.22 | $1,928 |
| 2025-11-10 | Baker Bros. Advisors (GP) LLC | TenPercentOwner | +Buy | 2,947 | $7.22 | $21,277 |
| 2025-09-02 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 1,734 | $5.43 | $9,416 |
| 2025-09-02 | Sethuraman Natarajan | Officer | −Tax w/h | 1,760 | $5.43 | $9,557 |
| 2025-09-02 | Dowden Nathan J | Officer | −Tax w/h | 1,746 | $5.43 | $9,481 |
| 2025-09-02 | Doshi Dipal | Director,Officer | −Tax w/h | 8,723 | $5.43 | $47,366 |
| 2025-07-09 | 5AM Opportunities I, L.P. | TenPercentOwner | −Sell | 6,935 | $7.50 | $52,013 |
| 2025-07-09 | 5AM Opportunities I, L.P. | TenPercentOwner | −Sell | 20,065 | $7.50 | $150,488 |
| 2025-07-09 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 6,935 | $7.50 | $52,013 |
| 2025-07-09 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 20,065 | $7.50 | $150,488 |
| 2025-07-01 | Schwab Andrew J. | TenPercentOwner | −Sell | 18,578 | $7.12 | $132,275 |
| 2025-07-01 | Schwab Andrew J. | TenPercentOwner | −Sell | 6,422 | $7.12 | $45,725 |
| 2025-07-01 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 18,578 | $7.12 | $132,275 |
| 2025-07-01 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 6,422 | $7.12 | $45,725 |
| 2025-06-30 | Schwab Andrew J. | TenPercentOwner | −Sell | 6,422 | $6.81 | $43,734 |
| 2025-06-30 | Schwab Andrew J. | TenPercentOwner | −Sell | 18,578 | $6.81 | $126,516 |
| 2025-06-30 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 18,578 | $6.81 | $126,516 |
| 2025-06-30 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 6,422 | $6.81 | $43,734 |
| 2025-06-27 | Schwab Andrew J. | TenPercentOwner | −Sell | 19,265 | $6.91 | $133,121 |
| 2025-06-27 | Schwab Andrew J. | TenPercentOwner | −Sell | 55,735 | $6.91 | $385,129 |
| 2025-06-27 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 55,735 | $6.91 | $385,129 |
| 2025-06-27 | PARMAR KUSH | Director,TenPercentOwner | −Sell | 19,265 | $6.91 | $133,121 |
| 2025-04-03 | WENTWORTH KORY JAMES | Officer | +Exercise | 11,134 | $2.10 | $23,381 |
| 2025-03-17 | WENTWORTH KORY JAMES | Officer | −Sell | 1,784 | $10.67 | $19,035 |
| 2025-03-03 | Sethuraman Natarajan | Officer | −Tax w/h | 6,138 | $11.68 | $71,692 |
| 2025-03-03 | Dowden Nathan J | Officer | −Tax w/h | 5,144 | $11.68 | $60,082 |
| 2025-03-03 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 4,929 | $11.68 | $57,571 |
| 2025-03-03 | Doshi Dipal | Director,Officer | −Tax w/h | 17,566 | $11.68 | $205,171 |
| 2025-03-01 | Sethuraman Natarajan | Officer | +Grant | 60,800 | — | — |
| 2025-03-01 | Dowden Nathan J | Officer | +Grant | 60,800 | — | — |
| 2025-03-01 | WENTWORTH KORY JAMES | Officer | +Grant | 42,400 | — | — |
| 2025-03-01 | Doshi Dipal | Director,Officer | +Grant | 116,200 | — | — |
| 2024-12-11 | MPM ASSET MANAGEMENT INVESTORS BV2018 LLC | TenPercentOwner | −Sell | 21,787 | $20.23 | $440,751 |
| 2024-12-11 | MPM BioVentures 2018 GP LLC | TenPercentOwner | −Sell | 21,787 | $20.23 | $440,751 |
| 2024-12-10 | MPM ASSET MANAGEMENT INVESTORS BV2018 LLC | TenPercentOwner | −Sell | 22,935 | $20.77 | $476,360 |
| 2024-12-10 | MPM BioVentures 2018 GP LLC | TenPercentOwner | −Sell | 22,935 | $20.77 | $476,360 |
| 2024-12-03 | Sethuraman Natarajan | Officer | −Sell | 11,703 | $20.15 | $235,815 |
| 2024-12-02 | Sethuraman Natarajan | Officer | −Sell | 4,088 | $20.26 | $82,823 |
| 2024-12-02 | WENTWORTH KORY JAMES | Officer | −Sell | 5,000 | $20.00 | $100,000 |
| 2024-12-02 | WENTWORTH KORY JAMES | Officer | +Exercise | 5,000 | $2.10 | $10,500 |
| 2024-11-29 | Sethuraman Natarajan | Officer | −Sell | 100 | $20.00 | $2,000 |
| 2024-11-29 | WENTWORTH KORY JAMES | Officer | +Exercise | 1,000 | $2.10 | $2,100 |
| 2024-11-29 | WENTWORTH KORY JAMES | Officer | −Sell | 1,000 | $19.97 | $19,970 |
| 2024-11-13 | Sethuraman Natarajan | Officer | −Sell | 2,700 | $20.04 | $54,108 |
| 2024-11-11 | WENTWORTH KORY JAMES | Officer | −Sell | 8,637 | $19.98 | $172,567 |
| 2024-11-11 | WENTWORTH KORY JAMES | Officer | +Exercise | 6,000 | $2.10 | $12,600 |
| 2024-11-11 | Sethuraman Natarajan | Officer | −Sell | 1,409 | $20.01 | $28,194 |
| 2024-11-06 | Sethuraman Natarajan | Officer | −Sell | 2,745 | $19.32 | $53,033 |
| 2024-11-06 | Sethuraman Natarajan | Officer | −Sell | 9,554 | $18.71 | $178,755 |
| 2024-11-05 | Sethuraman Natarajan | Officer | −Sell | 5,171 | $18.18 | $94,009 |
| 2024-11-04 | Sethuraman Natarajan | Officer | −Sell | 749 | $18.02 | $13,497 |
| 2024-10-16 | Sethuraman Natarajan | Officer | −Sell | 600 | $18.00 | $10,800 |
| 2024-09-26 | Dowden Nathan J | Officer | −Sell | 847 | $16.00 | $13,552 |
| 2024-09-09 | Sethuraman Natarajan | Officer | −Sell | 2,642 | $15.09 | $39,868 |
| 2024-09-09 | Dowden Nathan J | Officer | −Sell | 1,904 | $15.07 | $28,693 |
| 2024-09-09 | WENTWORTH KORY JAMES | Officer | −Sell | 3,195 | $14.97 | $47,829 |
| 2024-09-06 | Sethuraman Natarajan | Officer | −Sell | 600 | $15.24 | $9,144 |
| 2024-09-06 | Dowden Nathan J | Officer | −Sell | 399 | $15.19 | $6,061 |
| 2024-09-05 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 165 | $15.13 | $2,496 |
| 2024-09-05 | Sethuraman Natarajan | Officer | −Tax w/h | 167 | $15.13 | $2,527 |
| 2024-09-05 | Dowden Nathan J | Officer | −Tax w/h | 171 | $15.13 | $2,587 |
| 2024-09-05 | Doshi Dipal | Director,Officer | −Tax w/h | 826 | $15.13 | $12,497 |
| 2024-09-04 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 941 | $15.42 | $14,510 |
| 2024-09-04 | Sethuraman Natarajan | Officer | −Tax w/h | 955 | $15.42 | $14,726 |
| 2024-09-04 | Dowden Nathan J | Officer | −Tax w/h | 983 | $15.42 | $15,158 |
| 2024-09-04 | Doshi Dipal | Director,Officer | −Tax w/h | 4,744 | $15.42 | $73,152 |
| 2024-09-03 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 14 | $17.70 | $248 |
| 2024-09-03 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 149 | $16.93 | $2,523 |
| 2024-09-03 | WENTWORTH KORY JAMES | Officer | −Tax w/h | 462 | $15.76 | $7,281 |
| 2024-09-03 | Sethuraman Natarajan | Officer | −Tax w/h | 14 | $17.70 | $248 |
| 2024-09-03 | Sethuraman Natarajan | Officer | −Tax w/h | 469 | $15.76 | $7,391 |
| 2024-09-03 | Sethuraman Natarajan | Officer | −Tax w/h | 151 | $16.93 | $2,556 |
| 2024-09-03 | Dowden Nathan J | Officer | −Tax w/h | 483 | $15.76 | $7,612 |
| 2024-09-03 | Dowden Nathan J | Officer | −Tax w/h | 156 | $16.93 | $2,641 |
| 2024-09-03 | Dowden Nathan J | Officer | −Tax w/h | 15 | $17.70 | $266 |
| 2024-09-03 | Doshi Dipal | Director,Officer | −Tax w/h | 2,328 | $15.76 | $36,689 |
| 2024-09-03 | Doshi Dipal | Director,Officer | −Tax w/h | 752 | $16.93 | $12,731 |
| 2024-09-03 | Doshi Dipal | Director,Officer | −Tax w/h | 72 | $17.70 | $1,274 |
| 2024-08-16 | Dowden Nathan J | Officer | −Sell | 502 | $16.70 | $8,383 |
| 2024-08-16 | Dowden Nathan J | Officer | −Sell | 26,595 | $16.26 | $432,435 |
| 2024-08-16 | Dowden Nathan J | Officer | +Exercise | 20,000 | $1.74 | $34,800 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
