Institutional 13F holdings sum to 106.1% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 4,817,273 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Deep Track Capital, LP | 3,600,0003.6M | $253M | 8.46% | ADD 20% |
| 2 | BlackRock, Inc. | 3,552,6123.6M | $249M | 8.35% | TRIM -6% |
| 3 | RTW INVESTMENTS, LP | 3,346,0253.3M | $235M | 7.86% | — |
| 4 | Paradigm Biocapital Advisors LP | 2,562,1542.6M | $180M | 6.02% | — |
| 5 | JANUS HENDERSON GROUP PLC | 2,240,9632.2M | $157M | 5.27% | ADD 16% |
| 6 | MORGAN STANLEY | 1,944,2721.9M | $136M | 4.57% | TRIM -5% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 1,760,5411.8M | $124M | 4.14% | NEW† |
| 8 | JENNISON ASSOCIATES LLC | 1,712,1241.7M | $120M | 4.02% | TRIM -23% |
| 9 | Assenagon Asset Management S.A. | 1,280,1941.3M | $90M | 3.01% | ADD 14% |
| 10 | BANK OF AMERICA CORP /DE/ | 1,194,3771.2M | $84M | 2.81% | ADD 58% |
| 11 | TANG CAPITAL MANAGEMENT LLC | 1,188,6241.2M | $83M | 2.79% | — |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 1,121,0911.1M | $79M | 2.63% | ADD 18% |
| 13 | STATE STREET CORP | 978,212978,212 | $69M | 2.30% | ADD 5% |
| 14 | Driehaus Capital Management LLC | 926,125926,125 | $65M | 2.18% | TRIM -21% |
| 15 | LORD, ABBETT & CO. LLC | 842,313842,313 | $59M | 1.98% | — |
| 16 | D. E. Shaw & Co., Inc. | 791,146791,146 | $55M | 1.86% | ADD 29% |
| 17 | Invesco Ltd. | 742,497742,497 | $52M | 1.74% | TRIM -27% |
| 18 | FMR LLC | 733,334733,334 | $51M | 1.72% | ADD 13% |
| 19 | Frazier Life Sciences Management, L.P. | 728,644728,644 | $51M | 1.71% | — |
| 20 | MILLENNIUM MANAGEMENT LLC | 564,579564,579 | $40M | 1.33% | ADD 383% |
| 21 | Clearbridge Investments, LLC | 545,351545,351 | $38M | 1.28% | ADD 8% |
| 22 | TORONTO DOMINION BANK | 510,253510,253 | $36M | 1.20% | — |
| 23 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 499,853499,853 | $35M | 1.17% | TRIM -15% |
| 24 | GOLDMAN SACHS GROUP INC | 439,626439,626 | $31M | 1.03% | ADD 16% |
| 25 | LOOMIS SAYLES & CO L P | 407,836407,836 | $29M | 0.96% | TRIM -8% |
| 26 | TimesSquare Capital Management, LLC | 388,590388,590 | $27M | 0.91% | ADD 17% |
| 27 | NORTHERN TRUST CORP | 352,957352,957 | $25M | 0.83% | ADD 3% |
| 28 | VANGUARD PORTFOLIO MANAGEMENT LLC | 335,889335,889 | $24M | 0.79% | NEW |
| 29 | FRANKLIN RESOURCES INC | 333,676333,676 | $23M | 0.78% | — |
| 30 | Ensign Peak Advisors, Inc | 332,982332,982 | $23M | 0.78% | TRIM -30% |
| 31 | MPM BIOIMPACT LLC | 329,750329,750 | $23M | 0.77% | — |
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 328,162328,162 | $23M | 0.77% | — |
| 33 | Qube Research & Technologies Ltd | 324,014324,014 | $23M | 0.76% | TRIM -19% |
| 34 | Nuveen, LLC | 315,290315,290 | $22M | 0.74% | TRIM -2% |
| 35 | Artisan Partners Limited Partnership | 307,307307,307 | $22M | 0.72% | TRIM -30% |
| 36 | BNP PARIBAS FINANCIAL MARKETS | 303,509303,509 | $21M | 0.71% | TRIM -15% |
| 37 | PRICE T ROWE ASSOCIATES INC /MD/ | 274,804274,804 | $19M | 0.65% | TRIM -47% |
| 38 | VANGUARD FIDUCIARY TRUST CO | 272,743272,743 | $19M | 0.64% | NEW |
| 39 | BRAIDWELL LP | 265,715265,715 | $19M | 0.62% | NEW |
| 40 | Tri Locum Partners LP | 252,588252,588 | $18M | 0.59% | NEW |
| 41 | Squarepoint Ops LLC | 241,033241,033 | $17M | 0.57% | ADD 1004% |
| 42 | Point72 Asset Management, L.P. | 226,251226,251 | $16M | 0.53% | ADD 501% |
| 43 | Rock Springs Capital Management LP | 225,179225,179 | $16M | 0.53% | TRIM -14% |
| 44 | Cormorant Asset Management, LP | 225,000225,000 | $16M | 0.53% | TRIM -10% |
| 45 | Integral Health Asset Management, LLC | 200,000200,000 | $14M | 0.47% | — |
| 46 | Vestal Point Capital, LP | 200,000200,000 | $14M | 0.47% | NEW |
| 47 | M&G PLC | 166,364166,364 | $12M | 0.39% | NEW |
| 48 | CITADEL ADVISORS LLC | 163,997163,997 | $12M | 0.39% | NEW |
| 49 | CANADA PENSION PLAN INVESTMENT BOARD | 152,200152,200 | $11M | 0.36% | — |
| 50 | Russell Investments Group, Ltd. | 145,926145,926 | $10M | 0.34% | TRIM -5% |
| 51 | Allspring Global Investments Holdings, LLC | 131,612131,612 | $9M | 0.31% | — |
| 52 | FIRST TRUST ADVISORS LP | 122,911122,911 | $9M | 0.29% | ADD 10% |
| 53 | DEUTSCHE BANK AG\ | 121,862121,862 | $9M | 0.29% | ADD 3% |
| 54 | Jefferies Financial Group Inc. | 118,810118,810 | $8M | 0.28% | — |
| 55 | Connor, Clark & Lunn Investment Management Ltd. | 111,437111,437 | $8M | 0.26% | TRIM -36% |
| 56 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 108,800108,800 | $8M | 0.26% | TRIM -33% |
| 57 | Bank of New York Mellon Corp | 106,782106,782 | $7M | 0.25% | — |
| 58 | Woodline Partners LP | 100,443100,443 | $7M | 0.24% | — |
| 59 | Universal- Beteiligungs- und Servicegesellschaft mbH | 90,66390,663 | $6M | 0.21% | TRIM -17% |
| 60 | WELLS FARGO & COMPANY/MN | 89,29389,293 | $6M | 0.21% | TRIM -25% |
| 61 | Sands Capital Alternatives, LLC | 85,00085,000 | $6M | 0.20% | — |
| 62 | UBS Group AG | 82,12482,124 | $6M | 0.19% | ADD 23% |
| 63 | COMMONWEALTH EQUITY SERVICES, LLC | 80,89280,892 | $6M | 0.19% | ADD 18% |
| 64 | Ally Bridge Group (NY) LLC | 80,85980,859 | $6M | 0.19% | NEW |
| 65 | PFM Health Sciences, LP | 80,22680,226 | $6M | 0.19% | ADD 193% |
| 66 | RENAISSANCE TECHNOLOGIES LLC | 73,40073,400 | $5M | 0.17% | ADD 15% |
| 67 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 71,13571,135 | $5M | 0.17% | TRIM -38% |
| 68 | Voleon Capital Management LP | 68,93568,935 | $5M | 0.16% | TRIM -11% |
| 69 | Cinctive Capital Management LP | 68,76968,769 | $5M | 0.16% | ADD 138% |
| 70 | STATE OF WISCONSIN INVESTMENT BOARD | 67,08767,087 | $5M | 0.16% | ADD 110% |
| 71 | PDT Partners, LLC | 63,02663,026 | $4M | 0.15% | — |
| 72 | Swiss National Bank | 62,93362,933 | $4M | 0.15% | — |
| 73 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 62,70662,706 | $4M | 0.15% | TRIM -5% |
| 74 | CITIGROUP INC | 54,33554,335 | $4M | 0.13% | ADD 5% |
| 75 | HighVista Strategies LLC | 52,46452,464 | $4M | 0.12% | TRIM -2% |
| 76 | XTX Topco Ltd | 51,63451,634 | $4M | 0.12% | ADD 180% |
| 77 | FEDERATED HERMES, INC. | 49,09449,094 | $3M | 0.12% | — |
| 78 | Jump Financial, LLC | 47,60047,600 | $3M | 0.11% | TRIM -63% |
| 79 | ALLIANCEBERNSTEIN L.P. | 40,61640,616 | $3M | 0.10% | — |
| 80 | RHUMBLINE ADVISERS | 46,95846,958 | $3M | 0.11% | — |
| 81 | Calamos Advisors LLC | 43,83243,832 | $3M | 0.10% | ADD 27% |
| 82 | GordonMD Global Investments LP | 42,68042,680 | $3M | 0.10% | TRIM -36% |
| 83 | E. Ohman J:or Asset Management AB | 42,08742,087 | $3M | 0.10% | ADD 26% |
| 84 | Baird Financial Group, Inc. | 41,97741,977 | $3M | 0.10% | TRIM -11% |
| 85 | Lisanti Capital Growth, LLC | 41,81541,815 | $3M | 0.10% | TRIM -35% |
| 86 | Emerald Investment Advisers, LLC | 39,89639,896 | $3M | 0.09% | NEW |
| 87 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,69537,695 | $3M | 0.09% | ADD 25% |
| 88 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,40437,404 | $3M | 0.09% | TRIM -32% |
| 89 | Pictet Asset Management Holding SA | 38,19838,198 | $3M | 0.09% | — |
| 90 | Caption Management, LLC | 36,44836,448 | $3M | 0.09% | NEW |
| 91 | NEW YORK STATE COMMON RETIREMENT FUND | 35,91835,918 | $3M | 0.08% | TRIM -17% |
| 92 | RAYMOND JAMES FINANCIAL INC | 34,78434,784 | $2M | 0.08% | TRIM -2% |
| 93 | NOMURA HOLDINGS INC | 34,68534,685 | $2M | 0.08% | NEW |
| 94 | ALPS ADVISORS INC | 34,64734,647 | $2M | 0.08% | — |
| 95 | EFG International AG | 34,13334,133 | $2M | 0.08% | NEW |
| 96 | Public Sector Pension Investment Board | 32,00032,000 | $2M | 0.08% | TRIM -36% |
| 97 | ALGERT GLOBAL LLC | 31,76031,760 | $2M | 0.07% | TRIM -31% |
| 98 | Ikarian Capital, LLC | 31,16631,166 | $2M | 0.07% | — |
| 99 | SEI INVESTMENTS CO | 31,07531,075 | $2M | 0.07% | TRIM -28% |
| 100 | AQR CAPITAL MANAGEMENT LLC | 30,45330,453 | $2M | 0.07% | ADD 17% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | — | 1.5M | 1.8M | 3.0M | 3.0M | 3.6M | $253M |
| BlackRock, Inc. | 3.5M | 3.2M | 3.8M | 3.8M | 3.8M | 3.6M | $249M |
| RTW INVESTMENTS, LP | 3.2M | 3.3M | 3.1M | 3.2M | 3.3M | 3.3M | $235M |
| Paradigm Biocapital Advisors LP | 2.5M | 2.6M | 3.0M | 2.7M | 2.6M | 2.6M | $180M |
| JANUS HENDERSON GROUP PLC | 12K | 513K | 1.8M | 1.4M | 1.9M | 2.2M | $157M |
| MORGAN STANLEY | 2.0M | 2.0M | 2.1M | 1.9M | 2.0M | 1.9M | $136M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.8M | $124M |
| JENNISON ASSOCIATES LLC | 2.5M | 2.5M | 2.5M | 2.6M | 2.2M | 1.7M | $120M |
| Assenagon Asset Management S.A. | 1.1M | 1.1M | 998K | 1.2M | 1.1M | 1.3M | $90M |
| BANK OF AMERICA CORP /DE/ | 338K | 429K | 466K | 536K | 758K | 1.2M | $84M |
| TANG CAPITAL MANAGEMENT LLC | 2.3M | 2.5M | 2.5M | 2.5M | 1.2M | 1.2M | $83M |
| GEODE CAPITAL MANAGEMENT, LLC | 839K | 865K | 934K | 944K | 948K | 1.1M | $79M |
| STATE STREET CORP | 917K | 911K | 981K | 936K | 929K | 978K | $69M |
| Driehaus Capital Management LLC | — | 718K | 877K | 1.0M | 1.2M | 926K | $65M |
| LORD, ABBETT & CO. LLC | 1.3M | 1.3M | 995K | 986K | 856K | 842K | $59M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held |
|---|
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +1,760,541 | $124M | OPEN |
| Deep Track Capital, LP | +595,966 | $42M | ADD |
| MILLENNIUM MANAGEMENT LLC | +447,575 | $31M | ADD |
| BANK OF AMERICA CORP /DE/ | +436,271 | $31M | ADD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +335,889 | $24M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −2,399,560 | $168M | CLOSE |
| JENNISON ASSOCIATES LLC | −517,945 | $36M | TRIM |
| Invesco Ltd. | −269,860 | $19M | TRIM |
| Driehaus Capital Management LLC | −246,302 | $17M | TRIM |
| PRICE T ROWE ASSOCIATES INC /MD/ | −243,976 | $17M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| % shares out |
|---|
| Value held |
|---|
| 2026-Q1 | 253 | 45,142,312 | 106.1% | $3.2B |
| 2025-Q4 | 246 | 44,051,155 | 103.8% | $3.6B |
| 2025-Q3 | 220 | 44,971,109 | 106.5% | $2.7B |
| 2025-Q2 | 205 | 46,320,913 | — | $1.9B |
| 2025-Q1 | 195 | 43,989,199 | — | $2.3B |
| 2024-Q4 | 195 | 40,261,704 | 105.3% | $2.2B |
| 2024-Q3 | 162 | 43,877,115 | — | $1.4B |
| 2024-Q2 | 148 | 40,564,906 | 107.4% | $1.1B |
| 2024-Q1 | 157 | 44,271,050 | — | $1.6B |
| 2023-Q4 | 116 | 34,539,025 | 104.3% | $700M |
| 2023-Q3 | 105 | 29,793,106 | 91.3% | $529M |
| 2023-Q2 | 92 | 21,435,682 | 80.0% | $387M |
| 2023-Q1 | 74 | 20,066,701 | 75.1% | $252M |
| 2022-Q4 | 69 | 20,531,282 | 77.0% | $298M |
| 2022-Q3 | 75 | 20,489,176 | 76.9% | $351M |
| 2022-Q2 | 73 | 19,981,099 | 96.4% | $292M |
| 2022-Q1 | 51 | 13,210,424 | 63.8% | $222M |
| 2021-Q4 | 43 | 14,369,486 | 69.5% | $323M |
| 2021-Q3 | 44 | 12,869,550 | 62.6% | $277M |
| 2021-Q2 | 44 | 14,358,152 | 70.0% | $416M |
| 2021-Q1 | 41 | 12,761,893 | 62.2% | $410M |
| 2020-Q4 | 40 | 12,759,603 | 62.8% | $524M |
| 2024-12-31 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
