SRRK US Equity

Scholar Rock Holding Corp

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Health Care · Biological Products, (No Diagnostic Substances) · CIK 1727196 · FYE 1231

$49.06

-0.31 (-0.63%)

USD · as of 2026-07-29 · marketstack

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Institutional ownership· 13F filers holding SRRK · 2026-Q1 methodology → sources →

274 holders

% of shares outstanding held

111.7%

Shares held (13F)

133,837,895

Reporting holders

274

Institutional 13F holdings sum to 111.7% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 14,906,364 shares (settlement 2026-04-30) accounts for the excess.

Top holders

largest 100 of 274 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	FMR LLC	17,243,15217.2M	$848M	14.39%	ADD 12%
2	Siren, L.L.C.	10,825,01310.8M	$532M	9.03%	—
3	Redmile Group, LLC	9,066,6219.1M	$446M	7.57%	ADD 74%
4	BlackRock, Inc.	7,469,2937.5M	$367M	6.23%	ADD 3%
5	SAMSARA BIOCAPITAL, LLC	6,897,6526.9M	$339M	5.76%	—
6	WELLINGTON MANAGEMENT GROUP LLP	6,717,6556.7M	$330M	5.61%	ADD 17%
7	PRICE T ROWE ASSOCIATES INC /MD/	6,206,6186.2M	$305M	5.18%	TRIM -3%
8	Orbis Allan Gray Ltd	4,179,9834.2M	$205M	3.49%	ADD 22%
9	STATE STREET CORP	4,031,3174.0M	$198M	3.36%	—
10	VANGUARD CAPITAL MANAGEMENT LLC	3,891,3473.9M	$191M	3.25%	NEW†
11	Bellevue Group AG	3,584,5733.6M	$176M	2.99%	TRIM -12%
12	JENNISON ASSOCIATES LLC	3,340,4923.3M	$164M	2.79%	ADD 20%
13	JANUS HENDERSON GROUP PLC	2,236,8372.2M	$110M	1.87%	ADD 26%
14	EVENTIDE ASSET MANAGEMENT, LLC	2,197,3852.2M	$108M	1.83%	TRIM -10%
15	GEODE CAPITAL MANAGEMENT, LLC	2,149,0362.1M	$106M	1.79%	ADD 6%
16	STEMPOINT CAPITAL LP	2,070,9922.1M	$102M	1.73%	ADD 134%
17	Hood River Capital Management LLC	2,049,6792.0M	$101M	1.71%	—
18	Polar Capital Holdings Plc	1,983,6282.0M	$98M	1.66%	ADD 50%
19	Driehaus Capital Management LLC	1,920,2331.9M	$94M	1.60%	—
20	Holocene Advisors, LP	1,890,9271.9M	$93M	1.58%	ADD 36%
21	Woodline Partners LP	1,500,4701.5M	$74M	1.25%	ADD 24%
22	GOLDMAN SACHS GROUP INC	1,398,9831.4M	$69M	1.17%	ADD 6%
23	BANK OF AMERICA CORP /DE/	1,336,6321.3M	$66M	1.12%	ADD 27%
24	Vestal Point Capital, LP	1,324,4221.3M	$65M	1.11%	ADD 89%
25	Paradigm Biocapital Advisors LP	1,226,0801.2M	$60M	1.02%	TRIM -60%
26	Capital World Investors	1,128,7521.1M	$55M	0.94%	—
27	MARSHALL WACE, LLP	1,060,2751.1M	$52M	0.88%	ADD 188%
28	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	981,915981,915	$48M	0.82%	ADD 18%
29	CITADEL ADVISORS LLC	900,799900,799	$44M	0.75%	ADD 82%
30	Pictet Asset Management Holding SA	875,084875,084	$43M	0.73%	TRIM -27%
31	FEDERATED HERMES, INC.	797,913797,913	$39M	0.67%	—
32	NORTHERN TRUST CORP	763,803763,803	$38M	0.64%	ADD 6%
33	Rock Springs Capital Management LP	739,816739,816	$36M	0.62%	—
34	VOYA INVESTMENT MANAGEMENT LLC	725,409725,409	$36M	0.61%	ADD 41%
35	BNP PARIBAS FINANCIAL MARKETS	723,875723,875	$36M	0.60%	ADD 31%
36	VANGUARD PORTFOLIO MANAGEMENT LLC	721,744721,744	$35M	0.60%	NEW
37	Ensign Peak Advisors, Inc	717,253717,253	$35M	0.60%	TRIM -14%
38	AMERICAN CENTURY COMPANIES INC	707,101707,101	$35M	0.59%	—
39	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	701,011701,011	$34M	0.59%	—
40	ADAGE CAPITAL PARTNERS GP, L.L.C.	700,000700,000	$34M	0.58%	NEW
41	Clearbridge Investments, LLC	691,418691,418	$34M	0.58%	ADD 134%
42	UBS Group AG	679,784679,784	$33M	0.57%	TRIM -25%
43	LOOMIS SAYLES & CO L P	638,629638,629	$31M	0.53%	TRIM -8%
44	VANGUARD FIDUCIARY TRUST CO	589,048589,048	$29M	0.49%	NEW
45	Nuveen, LLC	581,654581,654	$29M	0.49%	TRIM -4%
46	JANE STREET GROUP, LLC	560,084560,084	$28M	0.47%	ADD 533%
47	Integral Health Asset Management, LLC	500,000500,000	$25M	0.42%	ADD 67%
48	Eagle Health Investments LP	494,019494,019	$24M	0.41%	ADD 36%
49	Fisher Asset Management, LLC	458,017458,017	$23M	0.38%	TRIM -14%
50	First Turn Management, LLC	446,390446,390	$22M	0.37%	TRIM -3%
51	ADAR1 Capital Management, LLC	407,273407,273	$20M	0.34%	ADD 485%
52	Casdin Capital, LLC	350,000350,000	$17M	0.29%	ADD 35%
53	SILVERARC CAPITAL MANAGEMENT, LLC	339,613339,613	$17M	0.28%	NEW
54	ARMISTICE CAPITAL, LLC	336,959336,959	$17M	0.28%	ADD 68%
55	NAN FUNG TRINITY (HK) LTD	285,495285,495	$14M	0.24%	ADD 8%
56	RAYMOND JAMES FINANCIAL INC	253,599253,599	$12M	0.21%	ADD 3%
57	DEUTSCHE BANK AG\	241,794241,794	$12M	0.20%	ADD 7%
58	Bank of New York Mellon Corp	232,672232,672	$11M	0.19%	—
59	Candriam S.C.A.	225,998225,998	$11M	0.19%	ADD 55%
60	TD Asset Management Inc	223,064223,064	$11M	0.19%	TRIM -21%
61	MORGAN STANLEY	219,027219,027	$11M	0.18%	TRIM -41%
62	AQR CAPITAL MANAGEMENT LLC	211,960211,960	$10M	0.18%	TRIM -24%
63	TWO SIGMA INVESTMENTS, LP	178,672178,672	$9M	0.15%	TRIM -56%
64	Universal- Beteiligungs- und Servicegesellschaft mbH	177,377177,377	$9M	0.15%	ADD 5%
65	MANUFACTURERS LIFE INSURANCE COMPANY, THE	173,765173,765	$9M	0.15%	TRIM -7%
66	Cinctive Capital Management LP	172,535172,535	$8M	0.14%	NEW
67	Granahan Investment Management, LLC	156,314156,314	$8M	0.13%	—
68	JPMORGAN CHASE & CO	174,419174,419	$8M	0.15%	ADD 2%
69	Balyasny Asset Management L.P.	149,714149,714	$7M	0.12%	ADD 799%
70	PEREGRINE CAPITAL MANAGEMENT LLC	146,606146,606	$7M	0.12%	TRIM -4%
71	SEI INVESTMENTS CO	143,359143,359	$7M	0.12%	ADD 19%
72	GordonMD Global Investments LP	132,500132,500	$7M	0.11%	NEW
73	iA Global Asset Management Inc.	123,212123,212	$6M	0.10%	—
74	Swiss National Bank	123,200123,200	$6M	0.10%	—
75	Invesco Ltd.	119,597119,597	$6M	0.10%	ADD 45%
76	EFG International AG	112,730112,730	$6M	0.09%	TRIM -5%
77	RHUMBLINE ADVISERS	112,501112,501	$6M	0.09%	ADD 3%
78	Rafferty Asset Management, LLC	104,456104,456	$5M	0.09%	TRIM -19%
79	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	102,912102,912	$5M	0.09%	TRIM -4%
80	XTX Topco Ltd	100,425100,425	$5M	0.08%	ADD 750%
81	FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A.	98,70098,700	$5M	0.08%	TRIM -4%
82	Artia Global Partners LP	96,28596,285	$5M	0.08%	—
83	SPHERA FUNDS MANAGEMENT LTD.	94,26594,265	$5M	0.08%	TRIM -40%
84	ALLIANCEBERNSTEIN L.P.	100,690100,690	$4M	0.08%	ADD 23%
85	Hudson Bay Capital Management LP	83,45083,450	$4M	0.07%	TRIM -17%
86	Nicholas Investment Partners, LP	82,51182,511	$4M	0.07%	NEW
87	Aisling Capital Management LP	77,03177,031	$4M	0.06%	—
88	Trexquant Investment LP	76,74876,748	$4M	0.06%	ADD 57%
89	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	74,91674,916	$4M	0.06%	ADD 23%
90	StoneCrest Wealth Management, Inc.	70,91470,914	$3M	0.06%	ADD 20%
91	ExodusPoint Capital Management, LP	67,06867,068	$3M	0.06%	TRIM -37%
92	VANGUARD ASSET MANAGEMENT, Ltd	64,61764,617	$3M	0.05%	NEW
93	Man Group plc	62,11862,118	$3M	0.05%	TRIM -66%
94	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	61,90661,906	$3M	0.05%	ADD 35%
95	Moody Aldrich Partners LLC	60,20160,201	$3M	0.05%	TRIM -29%
96	Ishara Investments LP	57,40057,400	$3M	0.05%	NEW
97	POLEN CAPITAL MANAGEMENT LLCtracked	51,95151,951	$3M	0.04%	ADD 139%
98	Squarepoint Ops LLC	49,95549,955	$2M	0.04%	NEW
99	Legal & General Group Plc	49,91449,914	$2M	0.04%	TRIM -21%
100	SUSQUEHANNA INTERNATIONAL GROUP, LLP	48,23648,236	$2M	0.04%	ADD 272%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

FMR LLC

13.6M

13.8M

14.0M

15.4M

17.2M

$848M

Siren, L.L.C.

9.3M

10.8M

$532M

Redmile Group, LLC

4.5M

4.4M

3.9M

5.2M

9.1M

$446M

BlackRock, Inc.

7.2M

7.3M

6.7M

6.8M

7.2M

7.5M

$367M

SAMSARA BIOCAPITAL, LLC

5.6M

6.9M

$339M

WELLINGTON MANAGEMENT GROUP LLP

1.7M

1.8M

2.0M

4.5M

5.8M

6.7M

$330M

PRICE T ROWE ASSOCIATES INC /MD/

9.3M

8.9M

8.8M

6.9M

6.4M

6.2M

$305M

Orbis Allan Gray Ltd

—

302K

3.4M

4.2M

$205M

STATE STREET CORP

2.6M

3.1M

3.8M

4.0M

$198M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.9M

$191M

Bellevue Group AG

2.5M

2.9M

3.2M

4.1M

3.6M

$176M

JENNISON ASSOCIATES LLC

—

366K

1.6M

2.8M

3.3M

$164M

JANUS HENDERSON GROUP PLC

849K

1.7M

2.5M

3.0M

1.8M

2.2M

$110M

EVENTIDE ASSET MANAGEMENT, LLC

2.7M

2.9M

2.8M

2.4M

2.2M

$108M

GEODE CAPITAL MANAGEMENT, LLC

1.8M

1.9M

2.0M

2.1M

$106M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	274	133,837,895	111.7%	$6.6B
2025-Q4	274	123,523,003	103.1%	$5.4B
2025-Q3	241	116,719,770	97.4%	$4.3B
2025-Q2	236	110,185,079	92.0%	$3.9B
2025-Q1	231	106,604,635	89.0%	$3.4B
2024-Q4	224	104,371,757	87.1%	$4.5B
2024-Q3	161	88,775,907	74.1%	$712M

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · SRRK

Activists — 13D, active intent

Samsara BioCapital, L.P.7.2%NEWSCHEDULE 13D/A · Amd 3 · event 2025-10-03SEC →

6,991,553 shares · 5 reporting persons

Large holders — 13G, passive (top 5 of 6 by % of class)

Holder	% of class	Type	As of
FMR LLC	15%	QII	2024-12-31	SEC →
Invus Global Management, LLC	11.4%	Passive	2024-12-31	SEC →
Redmile Group, LLC	7.6%	Passive	2026-03-31	SEC →

Institutional ownership· 13F filers holding SRRK · 2026-Q1 methodology → sources →

274 holders

% of shares outstanding held

111.7%

Shares held (13F)

133,837,895

Reporting holders

274

Top holders

largest 100 of 274 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	FMR LLC	17,243,15217.2M	$848M	14.39%	ADD 12%
2	Siren, L.L.C.	10,825,01310.8M	$532M	9.03%	—
3	Redmile Group, LLC	9,066,6219.1M	$446M	7.57%	ADD 74%
4	BlackRock, Inc.	7,469,2937.5M	$367M	6.23%	ADD 3%
5	SAMSARA BIOCAPITAL, LLC	6,897,6526.9M	$339M	5.76%	—
6	WELLINGTON MANAGEMENT GROUP LLP	6,717,6556.7M	$330M	5.61%	ADD 17%
7	PRICE T ROWE ASSOCIATES INC /MD/	6,206,6186.2M	$305M	5.18%	TRIM -3%
8	Orbis Allan Gray Ltd	4,179,9834.2M	$205M	3.49%	ADD 22%
9	STATE STREET CORP	4,031,3174.0M	$198M	3.36%	—
10	VANGUARD CAPITAL MANAGEMENT LLC	3,891,3473.9M	$191M	3.25%	NEW†
11	Bellevue Group AG	3,584,5733.6M	$176M	2.99%	TRIM -12%
12	JENNISON ASSOCIATES LLC	3,340,4923.3M	$164M	2.79%	ADD 20%
13	JANUS HENDERSON GROUP PLC	2,236,8372.2M	$110M	1.87%	ADD 26%
14	EVENTIDE ASSET MANAGEMENT, LLC	2,197,3852.2M	$108M	1.83%	TRIM -10%
15	GEODE CAPITAL MANAGEMENT, LLC	2,149,0362.1M	$106M	1.79%	ADD 6%
16	STEMPOINT CAPITAL LP	2,070,9922.1M	$102M	1.73%	ADD 134%
17	Hood River Capital Management LLC	2,049,6792.0M	$101M	1.71%	—
18	Polar Capital Holdings Plc	1,983,6282.0M	$98M	1.66%	ADD 50%
19	Driehaus Capital Management LLC	1,920,2331.9M	$94M	1.60%	—
20	Holocene Advisors, LP	1,890,9271.9M	$93M	1.58%	ADD 36%
21	Woodline Partners LP	1,500,4701.5M	$74M	1.25%	ADD 24%
22	GOLDMAN SACHS GROUP INC	1,398,9831.4M	$69M	1.17%	ADD 6%
23	BANK OF AMERICA CORP /DE/	1,336,6321.3M	$66M	1.12%	ADD 27%
24	Vestal Point Capital, LP	1,324,4221.3M	$65M	1.11%	ADD 89%
25	Paradigm Biocapital Advisors LP	1,226,0801.2M	$60M	1.02%	TRIM -60%
26	Capital World Investors	1,128,7521.1M	$55M	0.94%	—
27	MARSHALL WACE, LLP	1,060,2751.1M	$52M	0.88%	ADD 188%
28	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	981,915981,915	$48M	0.82%	ADD 18%
29	CITADEL ADVISORS LLC	900,799900,799	$44M	0.75%	ADD 82%
30	Pictet Asset Management Holding SA	875,084875,084	$43M	0.73%	TRIM -27%
31	FEDERATED HERMES, INC.	797,913797,913	$39M	0.67%	—
32	NORTHERN TRUST CORP	763,803763,803	$38M	0.64%	ADD 6%
33	Rock Springs Capital Management LP	739,816739,816	$36M	0.62%	—
34	VOYA INVESTMENT MANAGEMENT LLC	725,409725,409	$36M	0.61%	ADD 41%
35	BNP PARIBAS FINANCIAL MARKETS	723,875723,875	$36M	0.60%	ADD 31%
36	VANGUARD PORTFOLIO MANAGEMENT LLC	721,744721,744	$35M	0.60%	NEW
37	Ensign Peak Advisors, Inc	717,253717,253	$35M	0.60%	TRIM -14%
38	AMERICAN CENTURY COMPANIES INC	707,101707,101	$35M	0.59%	—
39	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	701,011701,011	$34M	0.59%	—
40	ADAGE CAPITAL PARTNERS GP, L.L.C.	700,000700,000	$34M	0.58%	NEW
41	Clearbridge Investments, LLC	691,418691,418	$34M	0.58%	ADD 134%
42	UBS Group AG	679,784679,784	$33M	0.57%	TRIM -25%
43	LOOMIS SAYLES & CO L P	638,629638,629	$31M	0.53%	TRIM -8%
44	VANGUARD FIDUCIARY TRUST CO	589,048589,048	$29M	0.49%	NEW
45	Nuveen, LLC	581,654581,654	$29M	0.49%	TRIM -4%
46	JANE STREET GROUP, LLC	560,084560,084	$28M	0.47%	ADD 533%
47	Integral Health Asset Management, LLC	500,000500,000	$25M	0.42%	ADD 67%
48	Eagle Health Investments LP	494,019494,019	$24M	0.41%	ADD 36%
49	Fisher Asset Management, LLC	458,017458,017	$23M	0.38%	TRIM -14%
50	First Turn Management, LLC	446,390446,390	$22M	0.37%	TRIM -3%
51	ADAR1 Capital Management, LLC	407,273407,273	$20M	0.34%	ADD 485%
52	Casdin Capital, LLC	350,000350,000	$17M	0.29%	ADD 35%
53	SILVERARC CAPITAL MANAGEMENT, LLC	339,613339,613	$17M	0.28%	NEW
54	ARMISTICE CAPITAL, LLC	336,959336,959	$17M	0.28%	ADD 68%
55	NAN FUNG TRINITY (HK) LTD	285,495285,495	$14M	0.24%	ADD 8%
56	RAYMOND JAMES FINANCIAL INC	253,599253,599	$12M	0.21%	ADD 3%
57	DEUTSCHE BANK AG\	241,794241,794	$12M	0.20%	ADD 7%
58	Bank of New York Mellon Corp	232,672232,672	$11M	0.19%	—
59	Candriam S.C.A.	225,998225,998	$11M	0.19%	ADD 55%
60	TD Asset Management Inc	223,064223,064	$11M	0.19%	TRIM -21%
61	MORGAN STANLEY	219,027219,027	$11M	0.18%	TRIM -41%
62	AQR CAPITAL MANAGEMENT LLC	211,960211,960	$10M	0.18%	TRIM -24%
63	TWO SIGMA INVESTMENTS, LP	178,672178,672	$9M	0.15%	TRIM -56%
64	Universal- Beteiligungs- und Servicegesellschaft mbH	177,377177,377	$9M	0.15%	ADD 5%
65	MANUFACTURERS LIFE INSURANCE COMPANY, THE	173,765173,765	$9M	0.15%	TRIM -7%
66	Cinctive Capital Management LP	172,535172,535	$8M	0.14%	NEW
67	Granahan Investment Management, LLC	156,314156,314	$8M	0.13%	—
68	JPMORGAN CHASE & CO	174,419174,419	$8M	0.15%	ADD 2%
69	Balyasny Asset Management L.P.	149,714149,714	$7M	0.12%	ADD 799%
70	PEREGRINE CAPITAL MANAGEMENT LLC	146,606146,606	$7M	0.12%	TRIM -4%
71	SEI INVESTMENTS CO	143,359143,359	$7M	0.12%	ADD 19%
72	GordonMD Global Investments LP	132,500132,500	$7M	0.11%	NEW
73	iA Global Asset Management Inc.	123,212123,212	$6M	0.10%	—
74	Swiss National Bank	123,200123,200	$6M	0.10%	—
75	Invesco Ltd.	119,597119,597	$6M	0.10%	ADD 45%
76	EFG International AG	112,730112,730	$6M	0.09%	TRIM -5%
77	RHUMBLINE ADVISERS	112,501112,501	$6M	0.09%	ADD 3%
78	Rafferty Asset Management, LLC	104,456104,456	$5M	0.09%	TRIM -19%
79	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	102,912102,912	$5M	0.09%	TRIM -4%
80	XTX Topco Ltd	100,425100,425	$5M	0.08%	ADD 750%
81	FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A.	98,70098,700	$5M	0.08%	TRIM -4%
82	Artia Global Partners LP	96,28596,285	$5M	0.08%	—
83	SPHERA FUNDS MANAGEMENT LTD.	94,26594,265	$5M	0.08%	TRIM -40%
84	ALLIANCEBERNSTEIN L.P.	100,690100,690	$4M	0.08%	ADD 23%
85	Hudson Bay Capital Management LP	83,45083,450	$4M	0.07%	TRIM -17%
86	Nicholas Investment Partners, LP	82,51182,511	$4M	0.07%	NEW
87	Aisling Capital Management LP	77,03177,031	$4M	0.06%	—
88	Trexquant Investment LP	76,74876,748	$4M	0.06%	ADD 57%
89	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	74,91674,916	$4M	0.06%	ADD 23%
90	StoneCrest Wealth Management, Inc.	70,91470,914	$3M	0.06%	ADD 20%
91	ExodusPoint Capital Management, LP	67,06867,068	$3M	0.06%	TRIM -37%
92	VANGUARD ASSET MANAGEMENT, Ltd	64,61764,617	$3M	0.05%	NEW
93	Man Group plc	62,11862,118	$3M	0.05%	TRIM -66%
94	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	61,90661,906	$3M	0.05%	ADD 35%
95	Moody Aldrich Partners LLC	60,20160,201	$3M	0.05%	TRIM -29%
96	Ishara Investments LP	57,40057,400	$3M	0.05%	NEW
97	POLEN CAPITAL MANAGEMENT LLCtracked	51,95151,951	$3M	0.04%	ADD 139%
98	Squarepoint Ops LLC	49,95549,955	$2M	0.04%	NEW
99	Legal & General Group Plc	49,91449,914	$2M	0.04%	TRIM -21%
100	SUSQUEHANNA INTERNATIONAL GROUP, LLP	48,23648,236	$2M	0.04%	ADD 272%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

FMR LLC

13.6M

13.8M

14.0M

15.4M

17.2M

$848M

Siren, L.L.C.

9.3M

10.8M

$532M

Redmile Group, LLC

4.5M

4.4M

3.9M

5.2M

9.1M

$446M

BlackRock, Inc.

7.2M

7.3M

6.7M

6.8M

7.2M

7.5M

$367M

SAMSARA BIOCAPITAL, LLC

5.6M

6.9M

$339M

WELLINGTON MANAGEMENT GROUP LLP

1.7M

1.8M

2.0M

4.5M

5.8M

6.7M

$330M

PRICE T ROWE ASSOCIATES INC /MD/

9.3M

8.9M

8.8M

6.9M

6.4M

6.2M

$305M

Orbis Allan Gray Ltd

—

302K

3.4M

4.2M

$205M

STATE STREET CORP

2.6M

3.1M

3.8M

4.0M

$198M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.9M

$191M

Bellevue Group AG

2.5M

2.9M

3.2M

4.1M

3.6M

$176M

JENNISON ASSOCIATES LLC

—

366K

1.6M

2.8M

3.3M

$164M

JANUS HENDERSON GROUP PLC

849K

1.7M

2.5M

3.0M

1.8M

2.2M

$110M

EVENTIDE ASSET MANAGEMENT, LLC

2.7M

2.9M

2.8M

2.4M

2.2M

$108M

GEODE CAPITAL MANAGEMENT, LLC

1.8M

1.9M

2.0M

2.1M

$106M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	274	133,837,895	111.7%	$6.6B
2025-Q4	274	123,523,003	103.1%	$5.4B
2025-Q3	241	116,719,770	97.4%	$4.3B
2025-Q2	236	110,185,079	92.0%	$3.9B
2025-Q1	231	106,604,635	89.0%	$3.4B
2024-Q4	224	104,371,757	87.1%	$4.5B
2024-Q3	161	88,775,907	74.1%	$712M

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · SRRK

Activists — 13D, active intent

Samsara BioCapital, L.P.7.2%NEWSCHEDULE 13D/A · Amd 3 · event 2025-10-03SEC →

6,991,553 shares · 5 reporting persons

Large holders — 13G, passive (top 5 of 6 by % of class)

Holder	% of class	Type	As of
FMR LLC	15%	QII	2024-12-31	SEC →
Invus Global Management, LLC	11.4%	Passive	2024-12-31	SEC →
Redmile Group, LLC	7.6%	Passive	2026-03-31	SEC →

SRRK US Equity☆

Institutional ownership· 13F filers holding SRRK · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · SRRK

Institutional ownership· 13F filers holding SRRK · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · SRRK

SRRK US Equity