| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | TCG Crossover Management, LLC | 3,033,5603.0M | $16M | 2.14% | — |
| 2 | Siren, L.L.C. | 2,911,4382.9M | $15M | 2.05% | — |
| 3 | Redmile Group, LLC | 2,164,7772.2M | $11M | 1.53% | — |
| 4 | Nantahala Capital Management, LLC | 2,146,7312.1M | $11M | 1.51% | ADD 39% |
| 5 | CITADEL ADVISORS LLC | 1,234,8071.2M | $7M | 0.87% | ADD 406% |
| 6 | MILLENNIUM MANAGEMENT LLC | 1,074,1911.1M | $6M | 0.76% | ADD 63% |
| 7 | GREAT POINT PARTNERS LLC | 1,020,4891.0M | $5M | 0.72% | ADD 26% |
| 8 | Nextech Invest, Ltd. | 952,400952,400 | $5M | 0.67% | — |
| 9 | Tetragon Partners GP Ltd | 630,161630,161 | $3M | 0.44% | ADD 72% |
| 10 | 5AM Venture Management, LLC | 476,200476,200 | $3M | 0.34% | — |
| 11 | Ikarian Capital, LLC | 865,784865,784 | $2M | 0.61% | — |
| 12 | Jones Hill Capital LP | 301,604301,604 | $2M | 0.21% | NEW |
| 13 | SG Americas Securities, LLC | 286,698286,698 | $2M | 0.20% | ADD 12% |
| 14 | UBS Group AG | 246,937246,937 | $1M | 0.17% | ADD 19% |
| 15 | BOOTHBAY FUND MANAGEMENT, LLC | 209,088209,088 | $1M | 0.15% | — |
| 16 | BlackRock, Inc. | 204,777204,777 | $1M | 0.14% | ADD 180% |
| 17 | BANK OF MONTREAL /CAN/ | 202,901202,901 | $1M | 0.14% | ADD 26% |
| 18 | ADAR1 Capital Management, LLC | 172,157172,157 | $907,267 | 0.12% | ADD 628% |
| 19 | MARSHALL WACE, LLP | 169,616169,616 | $893,877 | 0.12% | ADD 9% |
| 20 | Seven Fleet Capital Management LP | 156,759156,759 | $826,120 | 0.11% | ADD 6% |
| 21 | BNP PARIBAS FINANCIAL MARKETS | 147,668147,668 | $778,210 | 0.10% | ADD 1128% |
| 22 | Ishara Investments LP | 140,500140,500 | $740,435 | 0.10% | TRIM -41% |
| 23 | HSBC HOLDINGS PLC | 122,834122,834 | $639,965 | 0.09% | TRIM -64% |
| 24 | Point72 Asset Management, L.P. | 119,711119,711 | $630,877 | 0.08% | ADD 5% |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,281115,281 | $607,531 | 0.08% | ADD 584% |
| 26 | XTX Topco Ltd | 106,002106,002 | $558,631 | 0.07% | ADD 805% |
| 27 | Qube Research & Technologies Ltd | 104,555104,555 | $551,005 | 0.07% | ADD 199% |
| 28 | M28 Capital Management LP | 101,203101,203 | $533,340 | 0.07% | TRIM -45% |
| 29 | JANE STREET GROUP, LLC | 100,927100,927 | $531,885 | 0.07% | ADD 246% |
| 30 | Squarepoint Ops LLC | 89,46989,469 | $471,502 | 0.06% | NEW |
| 31 | MORGAN STANLEY | 65,48665,486 | $345,112 | 0.05% | TRIM -80% |
| 32 | GOLDMAN SACHS GROUP INC | 52,51152,511 | $276,733 | 0.04% | ADD 190% |
| 33 | BANK OF AMERICA CORP /DE/ | 29,77329,773 | $156,904 | 0.02% | ADD 904% |
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 29,53829,538 | $155,665 | 0.02% | — |
| 35 | RAYMOND JAMES FINANCIAL INC | 25,00025,000 | $131,750 | 0.02% | — |
| 36 | TWO SIGMA INVESTMENTS, LP | 16,20316,203 | $85,390 | 0.01% | TRIM -59% |
| 37 | RHUMBLINE ADVISERS | 13,93513,935 | $73,431 | 0.01% | ADD 7% |
| 38 | HRT FINANCIAL LP | 11,99411,994 | $63,000 | 0.01% | NEW |
| 39 | Dynamic Technology Lab Private Ltd | 10,49010,490 | $55,282 | 0.01% | NEW |
| 40 | GAMMA Investing LLC | 9,3659,365 | $49,354 | 0.01% | TRIM -7% |
| 41 | China Universal Asset Management Co., Ltd. | 8,3358,335 | $43,925 | 0.01% | TRIM -39% |
| 42 | JPMORGAN CHASE & CO | 7,6367,636 | $38,027 | 0.01% | TRIM -4% |
| 43 | ACADIAN ASSET MANAGEMENT LLC | 4,8184,818 | $25,000 | 0.00% | NEW |
| 44 | BARCLAYS PLC | 2,9372,937 | $15,478 | 0.00% | TRIM -42% |
| 45 | Mirae Asset Global Investments Co., Ltd. | 2,4502,450 | $12,912 | 0.00% | ADD 7% |
| 46 | JONES FINANCIAL COMPANIES LLLP | 2,5002,500 | $12,325 | 0.00% | — |
| 47 | Tower Research Capital LLC (TRC) | 2,3132,313 | $12,190 | 0.00% | TRIM -6% |
| 48 | CITIGROUP INC | 1,8351,835 | $9,670 | 0.00% | ADD 13% |
| 49 | Parallel Advisors, LLC | 1,3001,300 | $6,851 | 0.00% | — |
| 50 | GF FUND MANAGEMENT CO. LTD. | 1,0471,047 | $5,518 | 0.00% | ADD 14% |
| 51 | SIMPLEX TRADING, LLC | 612612 | $3,225 | 0.00% | TRIM -85% |
| 52 | Steward Partners Investment Advisory, LLC | 100100 | $527 | 0.00% | — |
| 53 | Rockefeller Capital Management L.P. | 4545 | $237 | 0.00% | — |
| 54 | SBI Securities Co., Ltd. | 2828 | $148 | 0.00% | — |
| 55 | Caitong International Asset Management Co., Ltd | 33 | $16 | 0.00% | NEW |
| 56 | ROYAL BANK OF CANADA | 1616 | $0 | 0.00% | — |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 3.0M | 3.0M | 3.0M | 3.0M | 3.0M | 3.0M | $16M |
| Siren, L.L.C. | 2.8M | 2.8M | 2.9M | 2.9M | 2.9M | 2.9M | $15M |
| Redmile Group, LLC | 2.4M | 2.2M | 2.2M | 2.2M | 2.2M | 2.2M | $11M |
| Nantahala Capital Management, LLC | 1.0M | 1.0M | 1.0M | 1.0M | 1.5M | 2.1M | $11M |
| CITADEL ADVISORS LLC | 283K | 62K | — | 22K | 244K | 1.2M | $7M |
| MILLENNIUM MANAGEMENT LLC | 474K | 397K | 199K | 299K | 660K | 1.1M | $6M |
| GREAT POINT PARTNERS LLC | — | — | — | — | 808K | 1.0M | $5M |
| Nextech Invest, Ltd. | — | 952K | 952K | 952K | 952K | 952K | $5M |
| Tetragon Partners GP Ltd | — | — | — | — | 365K | 630K | $3M |
| 5AM Venture Management, LLC | 476K | 476K | 476K | 476K | 476K | 476K | $3M |
| Ikarian Capital, LLC | — | — | 874K | 901K | 866K | 866K | $2M |
| Jones Hill Capital LP | — | — | — | — | — | 302K | $2M |
| SG Americas Securities, LLC | 318K | 308K | 308K | 308K | 256K | 287K | $2M |
| UBS Group AG | 356K | 320K | 229K | 307K | 208K | 247K | $1M |
| BOOTHBAY FUND MANAGEMENT, LLC | 352K | 250K | 252K | 280K | 209K | 209K | $1M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 56 | 19,909,495 | 14.1% | $102M |
| 2025-Q4 | 58 | 18,262,901 | 12.9% | $107M |
| 2025-Q3 | 54 | 19,712,219 | 13.9% | $96M |
| 2025-Q2 | 55 | 19,762,113 | 13.9% | $108M |
| 2025-Q1 | 59 | 21,916,481 | 15.5% | $61M |
| 2024-Q4 | 65 | 24,817,392 | 17.5% | $168M |
| 2024-Q3 | 69 | 28,197,480 | 19.9% | $493M |
| 2024-Q2 | 71 | 28,909,701 | 20.4% | $534M |
| 2024-Q1 | 64 | 28,218,857 | 19.9% | $599M |
| 2023-Q4 | 34 | 20,602,878 |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| 14.5% |
| $345M |
| 2023-Q3 | 28 | 19,721,335 | 13.9% | $188M |
| 2023-Q2 | 29 | 19,229,837 | 13.6% | $102M |
| 2023-Q1 | 29 | 18,398,088 | 13.0% | $110M |
| 2022-Q4 | 27 | 18,637,187 | 13.2% | $276M |
| 2022-Q3 | 29 | 19,298,505 | 13.6% | $190M |
| 2022-Q2 | 25 | 11,008,805 | 7.8% | $124M |
| 2022-Q1 | 26 | 12,844,987 | 9.1% | $231M |
| 2021-Q4 | 22 | 10,341,295 | 7.3% | $247M |
| 2021-Q3 | 7 | 1,955,799 | 1.4% | $39M |
| 2021-Q2 | 6 | 2,261,433 | 1.6% | $56M |
| 2021-Q1 | 6 | 2,547,036 | 1.8% | $56M |
| 2020-Q4 | 3 | 542,093 | 0.4% | $10M |
| 2020-Q3 | 2 | 542,000 | 0.4% | $8M |
