Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-27 | ORBIMED ADVISORS LLC | Director | −Sell | 101 | $44.49 | $4,493 |
| 2026-05-27 | Thompson Peter A. | Director | −Sell | 101 | $44.49 | $4,493 |
| 2026-05-11 | ORBIMED ADVISORS LLC | Director | −Sell | 184,639 | $46.22 | $9M |
| 2026-05-11 | Thompson Peter A. | Director | −Sell | 184,639 | $46.22 | $9M |
| 2026-05-08 | ORBIMED ADVISORS LLC | Director | −Sell | 59,767 | $44.58 | $3M |
| 2026-05-08 | Thompson Peter A. | Director | −Sell | 59,767 | $44.58 | $3M |
| 2026-05-07 | ORBIMED ADVISORS LLC | Director | −Sell | 48,546 | $44.61 | $2M |
| 2026-05-07 | Thompson Peter A. | Director | −Sell | 48,546 | $44.61 | $2M |
| 2026-04-18 | ORBIMED ADVISORS LLC | Director | −Sell | 2,948 | $44.52 | $131,245 |
| 2026-04-18 | Thompson Peter A. | Director | −Sell | 2,948 | $44.52 | $131,245 |
| 2026-04-17 | ORBIMED ADVISORS LLC | Director | −Sell | 52,397 | $44.68 | $2M |
| 2026-04-17 | Thompson Peter A. | Director | −Sell | 52,397 | $44.68 | $2M |
| 2026-04-16 | ORBIMED ADVISORS LLC | Director | −Sell | 226,906 | $45.34 | $10M |
| 2026-04-16 | Thompson Peter A. | Director | −Sell | 226,906 | $45.34 | $10M |
| 2026-04-15 | ORBIMED ADVISORS LLC | Director | −Sell | 235,863 | $44.64 | $11M |
| 2026-04-15 | Thompson Peter A. | Director | −Sell | 235,863 | $44.64 | $11M |
| 2026-04-14 | ORBIMED ADVISORS LLC | Director | −Sell | 47,814 | $44.51 | $2M |
| 2026-04-14 | Thompson Peter A. | Director | −Sell | 47,814 | $44.51 | $2M |
| 2026-03-05 | Fitzpatrick Jennifer | Officer | +Exercise | 10,250 | $6.11 | $62,628 |
| 2026-03-05 | Fitzpatrick Jennifer | Officer | −Sell | 10,250 | $33.86 | $347,065 |
| 2026-02-03 | OrbiMed Capital GP VIII LLC | Director | −Sell | 29,063 | $44.58 | $1M |
| 2026-02-03 | Thompson Peter A. | Director | −Sell | 29,063 | $44.58 | $1M |
| 2026-02-02 | OrbiMed Capital GP VIII LLC | Director | −Sell | 1,890 | $44.57 | $84,237 |
| 2026-02-02 | Thompson Peter A. | Director | −Sell | 1,890 | $44.57 | $84,237 |
| 2026-01-22 | WINKELRIED JON | TenPercentOwner | −Sell | 250,000 | $40.00 | $10M |
| 2025-12-24 | Thompson Peter A. | Director | −Sell | 33,356 | $44.55 | $1M |
| 2025-12-24 | OrbiMed Capital GP VIII LLC | Director | −Sell | 33,356 | $44.55 | $1M |
| 2025-12-19 | Thompson Peter A. | Director | −Sell | 875 | $44.49 | $38,929 |
| 2025-12-19 | OrbiMed Capital GP VIII LLC | Director | −Sell | 875 | $44.49 | $38,929 |
| 2025-12-18 | Thompson Peter A. | Director | −Sell | 100 | $44.49 | $4,449 |
| 2025-12-18 | OrbiMed Capital GP VIII LLC | Director | −Sell | 100 | $44.49 | $4,449 |
| 2025-12-17 | Thompson Peter A. | Director | −Sell | 900 | $44.50 | $40,050 |
| 2025-12-17 | OrbiMed Capital GP VIII LLC | Director | −Sell | 900 | $44.50 | $40,050 |
| 2025-12-05 | Fitzpatrick Jennifer | Officer | +Exercise | 10,250 | $6.11 | $62,628 |
| 2025-12-05 | Fitzpatrick Jennifer | Officer | −Sell | 10,250 | $40.52 | $415,330 |
| 2025-11-26 | Thompson Peter A. | Director | −Sell | 1,600 | $44.49 | $71,184 |
| 2025-11-26 | ORBIMED ADVISORS LLC | Director | −Sell | 1,600 | $44.49 | $71,184 |
| 2025-11-25 | Thompson Peter A. | Director | −Sell | 11,890 | $44.60 | $530,294 |
| 2025-11-25 | ORBIMED ADVISORS LLC | Director | −Sell | 11,890 | $44.60 | $530,294 |
| 2025-11-24 | Thompson Peter A. | Director | −Sell | 94,583 | $44.54 | $4M |
| 2025-11-24 | ORBIMED ADVISORS LLC | Director | −Sell | 94,583 | $44.54 | $4M |
| 2025-11-21 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 6,440 | $39.50 | $254,380 |
| 2025-11-21 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 9,924 | $39.50 | $391,998 |
| 2025-11-21 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 1,210 | $39.50 | $47,795 |
| 2025-11-21 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 7,609 | $39.50 | $300,556 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 788 | $40.50 | $31,914 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 604 | $40.50 | $24,462 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 512 | $40.50 | $20,736 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 96 | $40.50 | $3,888 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 947 | $39.89 | $37,776 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 801 | $39.89 | $31,952 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 1,235 | $39.89 | $49,264 |
| 2025-11-20 | Kolchinsky Peter | Director,TenPercentOwner | −Sell | 150 | $39.89 | $5,984 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 2,276 | $40.01 | $91,063 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 18,684 | $40.01 | $747,547 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 12,126 | $40.01 | $485,161 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 14,325 | $40.01 | $573,143 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 2 | $40.61 | $81 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 12 | $40.61 | $487 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 8 | $40.61 | $325 |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 9 | $40.61 | $365 |
| 2025-11-18 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 2,092 | $39.57 | $82,780 |
| 2025-11-18 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 332 | $39.57 | $13,137 |
| 2025-11-18 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 2,728 | $39.57 | $107,947 |
| 2025-11-18 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 1,770 | $39.57 | $70,039 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 2,182 | $40.20 | $87,716 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 17,913 | $40.20 | $720,103 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 11,626 | $40.20 | $467,365 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 13,734 | $40.20 | $552,107 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 1,701 | $41.05 | $69,826 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 13,964 | $41.05 | $573,222 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 9,063 | $41.05 | $372,036 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 10,707 | $41.05 | $439,522 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 331 | $42.10 | $13,935 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 280 | $42.10 | $11,788 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 433 | $42.10 | $18,229 |
| 2025-11-17 | RA CAPITAL MANAGEMENT, L.P. | Director,TenPercentOwner | −Sell | 53 | $42.10 | $2,231 |
| 2025-10-28 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 31,392 | $39.58 | $1M |
| 2025-10-28 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 17,118 | $39.58 | $677,530 |
| 2025-10-28 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 10,476 | $39.58 | $414,640 |
| 2025-10-28 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 3,624 | $39.58 | $143,438 |
| 2025-10-24 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 14,116 | $39.50 | $557,582 |
| 2025-10-24 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 107,941 | $39.50 | $4M |
| 2025-10-24 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 122,271 | $39.50 | $5M |
| 2025-10-24 | RA Capital Nexus Fund III, L.P. | Director | −Sell | 66,672 | $39.50 | $3M |
| 2025-10-21 | Booth Bruce | Director | −Sell | 22,339 | $32.69 | $730,262 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 4,688 | $32.69 | $153,251 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 19,948 | $33.87 | $675,639 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 4,187 | $33.87 | $141,814 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 5,763 | $34.91 | $201,186 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 1,210 | $34.91 | $42,241 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 25,327 | $35.69 | $903,921 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 5,316 | $35.69 | $189,728 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 17 | $36.42 | $619 |
| 2025-10-21 | Booth Bruce | Director | −Sell | 83 | $36.42 | $3,023 |
| 2025-10-21 | Cloonan Michael | Director,Officer | +Exercise | 30,049 | $6.11 | $183,599 |
| 2025-10-21 | Cloonan Michael | Director,Officer | −Sell | 13,324 | $34.44 | $458,879 |
| 2025-10-21 | Cloonan Michael | Director,Officer | +Exercise | 13,324 | $6.11 | $81,410 |
| 2025-10-21 | Cloonan Michael | Director,Officer | −Sell | 33,532 | $37.31 | $1M |
| 2025-10-21 | Cloonan Michael | Director,Officer | +Exercise | 33,532 | $6.11 | $204,881 |
| 2025-10-21 | Cloonan Michael | Director,Officer | −Sell | 22,895 | $36.60 | $837,957 |
| 2025-10-21 | Cloonan Michael | Director,Officer | +Exercise | 22,895 | $6.11 | $139,888 |
| 2025-10-21 | Cloonan Michael | Director,Officer | −Sell | 30,049 | $35.63 | $1M |
| 2025-10-20 | Booth Bruce | Director | −Sell | 20,485 | $31.79 | $651,218 |
| 2025-10-20 | Booth Bruce | Director | −Sell | 4,300 | $31.79 | $136,697 |
| 2025-10-20 | Booth Bruce | Director | −Sell | 25,788 | $32.33 | $833,726 |
| 2025-10-20 | Booth Bruce | Director | −Sell | 5,412 | $32.33 | $174,970 |
| 2025-10-17 | Booth Bruce | Director | −Sell | 248 | $33.47 | $8,301 |
| 2025-10-17 | Booth Bruce | Director | −Sell | 4,503 | $32.71 | $147,293 |
| 2025-10-17 | Booth Bruce | Director | −Sell | 21,451 | $32.71 | $701,662 |
| 2025-10-17 | Booth Bruce | Director | −Sell | 6,049 | $32.10 | $194,173 |
| 2025-10-17 | Booth Bruce | Director | −Sell | 28,821 | $32.10 | $925,154 |
| 2025-10-17 | Booth Bruce | Director | −Sell | 52 | $33.47 | $1,740 |
| 2025-10-16 | Cloonan Michael | Director,Officer | +Exercise | 200 | $6.11 | $1,222 |
| 2025-10-16 | Cloonan Michael | Director,Officer | −Sell | 200 | $34.00 | $6,800 |
| 2025-10-16 | Cloonan Michael | Director,Officer | −Sell | 10,225 | $31.46 | $321,679 |
| 2025-10-16 | Cloonan Michael | Director,Officer | +Exercise | 10,225 | $6.11 | $62,475 |
| 2025-10-16 | Booth Bruce | Director | −Sell | 12,888 | $33.38 | $430,201 |
| 2025-10-16 | Booth Bruce | Director | −Sell | 8,596 | $30.15 | $259,169 |
| 2025-10-16 | Booth Bruce | Director | −Sell | 1,804 | $30.15 | $54,391 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
