| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Bain Capital Life Sciences Investors, LLC | 8,434,5608.4M | $19M | 18.88% | — |
| 2 | ABG-WTT Global Life Science Capital Partners GP Ltd | 1,848,2961.8M | $4M | 4.14% | — |
| 3 | VANGUARD CAPITAL MANAGEMENT LLC | 982,494982,494 | $2M | 2.20% | NEW† |
| 4 | ESSEX INVESTMENT MANAGEMENT CO LLC | 883,931883,931 | $2M | 1.98% | ADD 1318% |
| 5 | Advent International, L.P. | 552,377552,377 | $1M | 1.24% | TRIM -4% |
| 6 | Evernest Financial Advisors, LLC | 432,510432,510 | $1M | 0.97% | ADD 246% |
| 7 | SEI INVESTMENTS CO | 284,816284,816 | $646,532 | 0.64% | ADD 204% |
| 8 | MILLENNIUM MANAGEMENT LLC | 283,280283,280 | $643,046 | 0.63% | ADD 143% |
| 9 | Legato Capital Management LLC | 274,924274,924 | $624,077 | 0.62% | ADD 1772% |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 247,177247,177 | $561,331 | 0.55% | ADD 14% |
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212,114212,114 | $481,499 | 0.47% | ADD 23% |
| 12 | BlackRock, Inc. | 157,232157,232 | $356,916 | 0.35% | — |
| 13 | JANE STREET GROUP, LLC | 132,925132,925 | $301,739 | 0.30% | ADD 26% |
| 14 | RENAISSANCE TECHNOLOGIES LLC | 126,617126,617 | $287,421 | 0.28% | ADD 10% |
| 15 | 683 Capital Management, LLC | 120,773120,773 | $274,155 | 0.27% | — |
| 16 | VANGUARD FIDUCIARY TRUST CO | 109,712109,712 | $249,046 | 0.25% | NEW |
| 17 | STATE STREET CORP | 93,87493,874 | $213,094 | 0.21% | ADD 3% |
| 18 | DIMENSIONAL FUND ADVISORS LP | 87,58987,589 | $198,679 | 0.20% | ADD 56% |
| 19 | GOLDMAN SACHS GROUP INC | 71,91271,912 | $163,240 | 0.16% | ADD 30% |
| 20 | FIFTH LANE CAPITAL, LP | 71,00071,000 | $161,170 | 0.16% | ADD 301% |
| 21 | XTX Topco Ltd | 61,07061,070 | $138,629 | 0.14% | NEW |
| 22 | NORTHERN TRUST CORP | 48,27948,279 | $109,593 | 0.11% | ADD 19% |
| 23 | BANK OF AMERICA CORP /DE/ | 31,01431,014 | $70,402 | 0.07% | ADD 140% |
| 24 | MORGAN STANLEY | 29,20729,207 | $66,300 | 0.07% | TRIM -7% |
| 25 | ALGERT GLOBAL LLC | 23,18123,181 | $53,000 | 0.05% | NEW |
| 26 | Temasek Holdings (Private) Ltd | 21,81821,818 | $49,527 | 0.05% | NEW |
| 27 | BARCLAYS PLC | 21,59521,595 | $49,020 | 0.05% | TRIM -13% |
| 28 | Catalyst Funds Management Pty Ltd | 21,20021,200 | $48,124 | 0.05% | NEW |
| 29 | Graham Capital Management, L.P. | 20,00020,000 | $45,400 | 0.04% | NEW |
| 30 | AMERICAN CENTURY COMPANIES INC | 16,92216,922 | $38,413 | 0.04% | — |
| 31 | OMERS ADMINISTRATION Corp | 15,90015,900 | $36,093 | 0.04% | TRIM -35% |
| 32 | Qube Research & Technologies Ltd | 15,41015,410 | $34,981 | 0.03% | TRIM -53% |
| 33 | MARSHALL WACE, LLP | 15,22415,224 | $34,558 | 0.03% | TRIM -76% |
| 34 | OSAIC HOLDINGS, INC. | 14,00014,000 | $31,780 | 0.03% | TRIM -2% |
| 35 | BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 12,69112,691 | $29,047 | 0.03% | NEW |
| 36 | Hudson Bay Capital Management LP | 12,52412,524 | $28,429 | 0.03% | NEW |
| 37 | NANO CAP NEW MILLENNIUM GROWTH FUND L P | 12,50012,500 | $28,375 | 0.03% | TRIM -50% |
| 38 | Vanguard Global Advisers, LLC | 11,63011,630 | $26,400 | 0.03% | NEW |
| 39 | UBS Group AG | 11,25211,252 | $25,542 | 0.03% | ADD 27344% |
| 40 | BNP PARIBAS FINANCIAL MARKETS | 9,3279,327 | $21,172 | 0.02% | TRIM -16% |
| 41 | Larson Financial Group LLC | 5,4915,491 | $12,465 | 0.01% | NEW |
| 42 | ROYAL BANK OF CANADA | 719719 | $2,000 | 0.00% | NEW |
| 43 | RESOURCES MANAGEMENT CORP /CT/ /ADV | 500500 | $1,000 | 0.00% | — |
| 44 | CWM, LLC | 188188 | $427 | 0.00% | NEW |
| 45 | JPMORGAN CHASE & CO | 109109 | $242 | 0.00% | — |
| 46 | SBI Securities Co., Ltd. | 1515 | $34 | 0.00% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 8.4M | 8.4M | 8.4M | 8.4M | 8.4M | 8.4M | $19M |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 1.0M | 1.8M | 1.8M | 1.8M | 1.8M | 1.8M | $4M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 982K | $2M |
| ESSEX INVESTMENT MANAGEMENT CO LLC | — | 63K | 62K | 62K | 62K | 884K | $2M |
| Advent International, L.P. | 578K | 578K | 578K | 578K | 578K | 552K | $1M |
| Evernest Financial Advisors, LLC | — | 131K | 44K | 200K | 125K | 433K | $1M |
| SEI INVESTMENTS CO | — | — | — | — | 94K | 285K | $646,532 |
| MILLENNIUM MANAGEMENT LLC | 61K | — | — | — | 117K | 283K | $643,046 |
| Legato Capital Management LLC | — | 15K | 15K | 15K | 15K | 275K | $624,077 |
| GEODE CAPITAL MANAGEMENT, LLC | 153K | 201K | 204K | 205K | 218K | 247K | $561,331 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | — | 159K | 52K | 58K | 172K | 212K | $481,499 |
| BlackRock, Inc. | 573K | 642K | 477K | 484K | 157K | 157K | $356,916 |
| JANE STREET GROUP, LLC | — | — | — | 38K | 105K | 133K | $301,739 |
| RENAISSANCE TECHNOLOGIES LLC | 183K | 111K | 111K | 110K | 116K | 127K | $287,421 |
| 683 Capital Management, LLC | — | — | — | — | 121K | 121K | $274,155 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out |
|---|
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +982,494 | $2M | OPEN |
| ESSEX INVESTMENT MANAGEMENT CO LLC | +821,605 | $2M | ADD |
| Evernest Financial Advisors, LLC | +307,510 | $698,048 | ADD |
| Legato Capital Management LLC | +260,240 | $590,745 | ADD |
| SEI INVESTMENTS CO | +191,200 | $434,024 | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −978,781 | $2M | CLOSE |
| Parkman Healthcare Partners LLC | −354,465 | $804,636 | CLOSE |
| Schonfeld Strategic Advisors LLC | −352,433 | $800,023 | CLOSE |
| CITADEL ADVISORS LLC | −126,539 | $287,244 | CLOSE |
| Informed Momentum Co LLC | −77,182 | $175,203 | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Value held |
|---|
| 2026-Q1 | 46 | 15,839,879 | 35.5% | $36M |
| 2025-Q4 | 42 | 14,620,290 | 32.7% | $43M |
| 2025-Q3 | 29 | 14,829,096 | 33.2% | $50M |
| 2025-Q2 | 29 | 15,145,610 | — | $52M |
| 2025-Q1 | 28 | 15,315,094 | — | $40M |
| 2024-Q4 | 19 | 11,949,584 | — | $11M |
| 2024-Q3 | 19 | 17,880,704 | — | $16M |
| 2024-Q2 | 21 | 19,083,969 | — | $13M |
| 2024-Q1 | 23 | 19,695,617 | — | $19M |
| 2023-Q4 | 26 | 20,854,423 | — | $15M |
| 2023-Q3 | 23 | 21,457,255 | — | $23M |
| 2023-Q2 | 24 | 21,873,676 | — | $22M |
| 2023-Q1 | 31 | 22,855,869 | — | $35M |
| 2022-Q4 | 42 | 24,501,573 | — | $28M |
| 2022-Q3 | 53 | 25,635,123 | — | $83M |
| 2022-Q2 | 52 | 26,108,838 | — | $112M |
| 2022-Q1 | 59 | 26,648,650 | — | $181M |
| 2021-Q4 | 55 | 21,821,895 | — | $232M |
| 2021-Q3 | 49 | 21,751,580 | — | $401M |
