Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-26 | Third Rock Ventures V, L.P. | TenPercentOwner | −Sell | 18,572 | $40.05 | $743,809 |
| 2026-05-11 | Third Rock Ventures V, L.P. | TenPercentOwner | −Sell | 133,618 | $40.24 | $5M |
| 2026-05-08 | Third Rock Ventures VI, L.P. | TenPercentOwner | −Sell | 5,018 | $40.31 | $202,276 |
| 2026-05-07 | Third Rock Ventures VI, L.P. | TenPercentOwner | −Sell | 271,495 | $40.12 | $11M |
| 2026-04-17 | Yeleswaram Krishnaswamy | Officer | −Sell | 20,225 | $39.99 | $808,798 |
| 2026-04-17 | Third Rock Ventures VI, L.P. | TenPercentOwner | −Sell | 426,005 | $40.32 | $17M |
| 2026-04-14 | Yeleswaram Krishnaswamy | Officer | −Sell | 10,200 | $35.08 | $357,816 |
| 2026-04-13 | Yeleswaram Krishnaswamy | Officer | −Sell | 9,165 | $34.97 | $320,500 |
| 2026-04-10 | Yeleswaram Krishnaswamy | Officer | −Sell | 500 | $34.98 | $17,490 |
| 2026-04-08 | Yeleswaram Krishnaswamy | Officer | −Sell | 360 | $34.90 | $12,564 |
| 2026-03-30 | Gault Cheryl | Officer | −Sell | 2,839 | $28.55 | $81,053 |
| 2026-03-30 | Gault Cheryl | Officer | −Sell | 7,161 | $28.04 | $200,794 |
| 2026-03-25 | Yeleswaram Krishnaswamy | Officer | −Sell | 10,115 | $29.99 | $303,349 |
| 2026-03-05 | Gault Cheryl | Officer | −Sell | 2,014 | $28.93 | $58,265 |
| 2026-02-19 | Bredt David | Officer | +Exercise | 6,000 | $1.80 | $10,800 |
| 2026-02-18 | Ceesay Abraham | Director,Officer | −Sell | 2,281 | $29.80 | $67,974 |
| 2026-02-18 | Ceesay Abraham | Director,Officer | −Sell | 2,983 | $29.04 | $86,626 |
| 2026-02-18 | Ceesay Abraham | Director,Officer | −Sell | 2,100 | $29.80 | $62,580 |
| 2026-02-18 | Ceesay Abraham | Director,Officer | −Sell | 3,552 | $29.05 | $103,186 |
| 2026-02-17 | Bredt David | Officer | −Sell | 900 | $28.02 | $25,218 |
| 2026-02-17 | Bredt David | Officer | −Sell | 5,400 | $28.95 | $156,330 |
| 2026-02-17 | Bredt David | Officer | −Sell | 2,200 | $29.59 | $65,098 |
| 2026-01-20 | Ceesay Abraham | Director,Officer | −Sell | 5,833 | $26.12 | $152,358 |
| 2026-01-20 | Ceesay Abraham | Director,Officer | −Sell | 5,083 | $26.11 | $132,717 |
| 2026-01-15 | Bredt David | Officer | −Sell | 200 | $27.40 | $5,480 |
| 2026-01-15 | Bredt David | Officer | −Sell | 8,300 | $26.83 | $222,689 |
| 2025-12-31 | Yeleswaram Krishnaswamy | Officer | −Sell | 2,840 | $30.05 | $85,342 |
| 2025-12-31 | Yeleswaram Krishnaswamy | Officer | +Grant | 9,000 | — | — |
| 2025-12-31 | Bredt David | Officer | −Grant | 18,000 | — | — |
| 2025-12-31 | Bredt David | Officer | −Sell | 6,567 | $30.05 | $197,338 |
| 2025-12-17 | Ceesay Abraham | Director,Officer | −Sell | 2,147 | $28.84 | $61,919 |
| 2025-12-17 | Ceesay Abraham | Director,Officer | −Sell | 600 | $31.04 | $18,624 |
| 2025-12-17 | Ceesay Abraham | Director,Officer | −Sell | 2,441 | $28.84 | $70,398 |
| 2025-12-17 | Ceesay Abraham | Director,Officer | −Sell | 2,421 | $30.04 | $72,727 |
| 2025-12-17 | Ceesay Abraham | Director,Officer | −Sell | 515 | $31.04 | $15,986 |
| 2025-12-17 | Ceesay Abraham | Director,Officer | −Sell | 2,792 | $30.04 | $83,872 |
| 2025-12-15 | Bredt David | Officer | −Sell | 796 | $30.68 | $24,421 |
| 2025-12-15 | Bredt David | Officer | −Sell | 7,704 | $29.95 | $230,735 |
| 2025-11-26 | Gault Cheryl | Officer | −Sell | 5,000 | $30.10 | $150,500 |
| 2025-11-26 | Gault Cheryl | Officer | +Exercise | 5,000 | $1.80 | $9,000 |
| 2025-11-17 | Bredt David | Officer | −Sell | 3,156 | $24.84 | $78,395 |
| 2025-11-17 | Bredt David | Officer | −Sell | 5,344 | $25.39 | $135,684 |
| 2025-11-17 | Ceesay Abraham | Director,Officer | −Sell | 2,841 | $25.44 | $72,275 |
| 2025-11-17 | Ceesay Abraham | Director,Officer | −Sell | 2,777 | $24.92 | $69,203 |
| 2025-11-17 | Ceesay Abraham | Director,Officer | −Sell | 3,056 | $25.43 | $77,714 |
| 2025-11-17 | Ceesay Abraham | Director,Officer | −Sell | 2,242 | $24.91 | $55,848 |
| 2025-10-15 | Ceesay Abraham | Director,Officer | −Sell | 755 | $26.17 | $19,758 |
| 2025-10-15 | Ceesay Abraham | Director,Officer | −Sell | 4,328 | $25.75 | $111,446 |
| 2025-10-15 | Ceesay Abraham | Director,Officer | −Sell | 4,647 | $25.72 | $119,521 |
| 2025-10-15 | Ceesay Abraham | Director,Officer | −Sell | 1,186 | $26.14 | $31,002 |
| 2025-10-15 | Bredt David | Officer | −Sell | 7,418 | $25.73 | $190,865 |
| 2025-10-15 | Bredt David | Officer | −Sell | 1,082 | $26.16 | $28,305 |
| 2025-09-17 | Ceesay Abraham | Director,Officer | −Sell | 700 | $27.04 | $18,928 |
| 2025-09-17 | Ceesay Abraham | Director,Officer | −Sell | 34,885 | $26.30 | $917,476 |
| 2025-09-17 | Ceesay Abraham | Director,Officer | −Sell | 1,400 | $26.87 | $37,618 |
| 2025-09-17 | Ceesay Abraham | Director,Officer | −Sell | 39,435 | $26.30 | $1M |
| 2025-09-15 | Bredt David | Officer | −Sell | 3,402 | $24.66 | $83,893 |
| 2025-09-15 | Bredt David | Officer | −Sell | 5,098 | $23.88 | $121,740 |
| 2025-09-12 | PAUL STEVEN M | Director | +Buy | 13,382 | $24.97 | $334,149 |
| 2025-09-12 | PAUL STEVEN M | Director | +Buy | 28,284 | $24.50 | $692,958 |
| 2025-09-12 | Huber Reid M | Director | +Buy | 20,400 | $24.48 | $499,392 |
| 2025-09-11 | Young Wendy B. | Director | +Buy | 3,500 | $22.60 | $79,100 |
| 2025-09-08 | Gault Cheryl | Officer | −Sell | 5,000 | $38.33 | $191,650 |
| 2025-09-08 | Gault Cheryl | Officer | +Exercise | 5,000 | $1.80 | $9,000 |
| 2025-08-15 | Bredt David | Officer | −Sell | 200 | $15.79 | $3,158 |
| 2025-08-15 | Bredt David | Officer | −Sell | 8,300 | $14.98 | $124,334 |
| 2025-07-15 | Bredt David | Officer | −Sell | 8,500 | $14.00 | $119,000 |
| 2025-06-16 | Bredt David | Officer | −Sell | 8,500 | $11.00 | $93,500 |
| 2025-05-15 | Bredt David | Officer | −Sell | 8,500 | $9.56 | $81,260 |
| 2025-04-15 | Bredt David | Officer | −Sell | 8,500 | $9.57 | $81,345 |
| 2025-03-14 | Bredt David | Officer | −Sell | 8,500 | $10.85 | $92,225 |
| 2025-03-13 | Ignelzi Troy A. | Officer | +Buy | 100 | $9.98 | $998 |
| 2025-03-12 | Young Wendy B. | Director | +Buy | 6,000 | $10.21 | $61,260 |
| 2025-03-12 | Ignelzi Troy A. | Officer | +Buy | 9,900 | $10.10 | $99,990 |
| 2025-03-03 | Gault Cheryl | Officer | +Grant | 13,987 | — | — |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 3,657 | $24.21 | $88,536 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 3,630 | $23.08 | $83,780 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 2,748 | $26.06 | $71,613 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 4,878 | $25.02 | $122,048 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 3,828 | $24.21 | $92,676 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 3,799 | $23.08 | $87,681 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 2,559 | $26.06 | $66,688 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 4,544 | $25.02 | $113,691 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 3,565 | $24.21 | $86,309 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 3,538 | $23.08 | $81,657 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 2,625 | $26.06 | $68,408 |
| 2024-07-01 | HEALY JAMES | Director | +Buy | 4,661 | $25.02 | $116,618 |
| 2024-06-10 | HEALY JAMES | Director | +Conversion | 1,392,738 | — | — |
| 2024-06-10 | HEALY JAMES | Director | +Buy | 17,861 | $17.00 | $303,637 |
| 2024-06-10 | HEALY JAMES | Director | +Buy | 26,278 | $17.00 | $446,726 |
| 2024-06-10 | HEALY JAMES | Director | +Buy | 25,455 | $17.00 | $432,735 |
| 2024-06-10 | HEALY JAMES | Director | +Buy | 18,641 | $17.00 | $316,897 |
| 2024-06-10 | HEALY JAMES | Director | +Buy | 470,589 | $17.00 | $8M |
| 2024-06-10 | Third Rock Ventures V, L.P. | TenPercentOwner | +Conversion | 969,218 | — | — |
| 2024-06-10 | Third Rock Ventures V, L.P. | TenPercentOwner | +Conversion | 6,551,449 | — | — |
| 2024-06-10 | NELSEN ROBERT | TenPercentOwner | +Conversion | 3,728,738 | — | — |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
