% of shares outstanding not shown: no SEC cover-page share count falls within 120 days of the 2026-Q1 quarter end, so any percentage would rest on a count that cannot speak for this quarter. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Ikarian Capital, LLC | 211,538211,538 | $1M | — | — |
| 2 | Dauntless Investment Group, LLC | 196,592196,592 | $1M | — | NEW |
| 3 | SummitTX Capital, L.P. | 100,300100,300 | $661,980 | — | ADD 55% |
| 4 | Velan Capital Investment Management LP | 84,84984,849 | $560,003 | — | NEW |
| 5 | Woodline Partners LP | 79,58279,582 | $525,241 | — | — |
| 6 | MILLENNIUM MANAGEMENT LLC | 76,24776,247 | $503,230 | — | — |
| 7 | Aberdeen Group plc | 75,00075,000 | $495,000 | — | — |
| 8 | Soleus Capital Management, L.P. | 72,73072,730 | $480,018 | — | ADD 191% |
| 9 | Centiva Capital, LP | 60,00060,000 | $396,000 | — | ADD 398% |
| 10 | BOOTHBAY FUND MANAGEMENT, LLC | 59,83859,838 | $394,931 | — | — |
| 11 | Stonepine Capital Management, LLC | 53,46053,460 | $352,836 | — | TRIM -32% |
| 12 | AIGH Capital Management LLC | 51,00051,000 | $336,600 | — | ADD 3% |
| 13 | CITADEL ADVISORS LLC | 32,51932,519 | $214,625 | — | NEW |
| 14 | Birchview Capital, LP | 20,00020,000 | $132,000 | — | NEW |
| 15 | MORGAN STANLEY | 4,0004,000 | $26,400 | — | ADD 33% |
| 16 | UBS Group AG | 2,5122,512 | $16,579 | — | ADD 14676% |
| 17 | GAMMA Investing LLC | 1,7201,720 | $11,352 | — | TRIM -17% |
| 18 | RHUMBLINE ADVISERS | 1,5211,521 | $10,033 | — | TRIM -9% |
| 19 | BARCLAYS PLC | 1,3001,300 | $8,580 | — | NEW |
| 20 | SBI Securities Co., Ltd. | 22 | $13 | — | TRIM -99% |
| 21 | ROYAL BANK OF CANADA | 1111 | $0 | — | NEW |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 275K | — | — | — | 212K | 212K | $1M |
| Dauntless Investment Group, LLC | — | — | — | — | — | 197K | $1M |
| SummitTX Capital, L.P. | — | — | — | — | 65K | 100K | $661,980 |
| Velan Capital Investment Management LP | — | — | — | — | — | 85K | $560,003 |
| Woodline Partners LP | — | — | — | — | 80K | 80K | $525,241 |
| MILLENNIUM MANAGEMENT LLC | — | — | — | — | 75K | 76K | $503,230 |
| Aberdeen Group plc | — | — | — | — | 75K | 75K | $495,000 |
| Soleus Capital Management, L.P. | — | — | — | — | 25K | 73K | $480,018 |
| Centiva Capital, LP | — | — | — | — | 12K | 60K | $396,000 |
| BOOTHBAY FUND MANAGEMENT, LLC | 81K | — | — | — | 60K | 60K | $394,931 |
| Stonepine Capital Management, LLC | — | — | — | — | 78K | 53K | $352,836 |
| AIGH Capital Management LLC | — | — | — | — | 49K | 51K | $336,600 |
| CITADEL ADVISORS LLC | — | — | — | — | — | 33K | $214,625 |
| Birchview Capital, LP | — | — | — | — | — | 20K | $132,000 |
| MORGAN STANLEY | — | 456 | 206 | — | 3K | 4K | $26,400 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 21 | 1,184,721 | — | $8M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| Dauntless Investment Group, LLC | +196,592 | $1M | OPEN |
| Velan Capital Investment Management LP | +84,849 | $560,003 | OPEN |
| Centiva Capital, LP | +47,947 | $316,450 | ADD |
| Soleus Capital Management, L.P. | +47,730 | $315,018 | ADD |
| SummitTX Capital, L.P. | +35,505 | $234,333 | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| ADAR1 Capital Management, LLC | −58,230 | $384,318 | CLOSE |
| Resolute Capital Asset Partners LLC | −30,000 | $198,000 | CLOSE |
| Stonepine Capital Management, LLC | −24,729 | $163,211 | TRIM |
| Simplify Asset Management Inc. | −17,448 | $115,157 | CLOSE |
| GAMMA Investing LLC | −364 | $2,402 | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| 2025-Q4 | 18 | 842,827 | — | $12M |
| 2025-Q3 | 4 | 1,491 | — | $10,716 |
| 2025-Q2 | 6 | 2,537 | — | $23,400 |
| 2025-Q1 | 10 | 401,630 | — | $90,215 |
| 2024-Q4 | 14 | 1,546,454 | — | $1M |
| 2024-Q3 | 7 | 165,726 | — | $82,557 |
| 2024-Q2 | 10 | 220,718 | — | $128,053 |
| 2024-Q1 | 8 | 194,796 | — | $183,832 |
| 2023-Q4 | 3 | 22,047 | — | $105,643 |
| 2023-Q3 | 3 | 1,735 | — | $7,212 |
| 2023-Q2 | 2 | 48,933 | — | $24,026 |
| 2023-Q1 | 4 | 170,363 | — | $81,072 |
| 2022-Q4 | 4 | 36,644 | — | $52,035 |
| 2022-Q3 | 7 | 121,721 | — | $272,000 |
| 2022-Q2 | 8 | 169,917 | — | $321,000 |
| 2022-Q1 | 6 | 144,587 | 0.0% | $419,000 |
| 2021-Q4 | 7 | 210,731 | 0.0% | $383,000 |
