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OPRX US Equity

OptimizeRx CorpIndustrials · Services-Business Services, NEC · CIK 1448431 · FY ends Dec 31
$7.71
-0.25 (-3.14%)
USD · as of 2026-08-21 · marketstack

OPRX · 10-K · period ended 2022-12-31

← all OPRX documents
filed 2023-03-10 · EDGAR original ↗

Our rendering of the filing — original pagination and typography are not reproduced, and tables are reduced to their short label cells (the figures live on FA). Nothing is summarized: every line below is the filing's own text.

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Item 1A. Risk Factors

Risks Relating to Our Business

Because we have historically experienced

losses, if we are unable to achieve profitability, our financial condition and company could suffer.

With the exception of 2021, we have historically

incurred losses as a result of investing in future growth. We incurred losses in 2022 as a result of our increased spending to build the

organization to support expected future growth – both through additional new hires, as well as through acquisitions. While we have

increased revenues, we have not yet consistently achieved profitability due to these investments and non-cash expenses. Our ability to

achieve consistent profitability depends on our ability to generate sales through our technology platform and advertising model, while

maintaining reasonable expense levels. If we do not achieve sustainable profitability, it may impact our ability to continue our operations.

Seasonal trends in the pharmaceutical brand marketing industry

could affect our operating results.

In general, the pharmaceutical brand marketing

industry experiences seasonal trends that affect the vast majority of participants in the pharmaceutical digital marketing industry. Many

pharmaceutical companies allocate the largest portion of their brand marketing to the fourth quarter of the calendar year. As a result,

the first quarter tends to reflect lower activity levels and lower revenue, with gradual increases in the following quarters. We generally

expect these seasonality trends to continue and our ability to effectively manage our resources in anticipation of these trends may affect

our operating results.

5

Developing and implementing new and updated

applications, features and services for our portals may be more difficult than expected, may take longer and cost more than expected and

may not result in sufficient increases in revenue to justify the costs.

Attracting and retaining users of our portals

requires us to continue to improve the technology underlying those portals and to continue to develop new and updated applications, features

and services for those portals. If we are unable to do so on a timely basis or if we are unable to implement new applications, features

and services without disruption to our existing ones, we may lose potential users and clients. The costs of development of these enhancements

may negatively impact our ability to achieve profitability.

We rely on a combination of internal development,

strategic relationships, licensing and acquisitions to develop our portals and related applications, features and services. Our development

and/or implementation of new technologies, applications, features and services may cost more than expected, may take longer than originally

expected, may require more testing than originally anticipated and may require the acquisition of additional personnel and other resources.

There can be no assurance that the revenue opportunities from any new or updated technologies, applications, features or services will

justify the amounts spent.

Any failure to offer high-quality customer

support for our portals may adversely affect our relationships with our customers and harm our financial results.

Once our solutions are implemented, our customers

use our support organization to resolve technical issues relating to our solutions. In addition, we also believe that our success in selling

our solutions is highly dependent on our business reputation and on favorable recommendations from our existing customers. Any failure

to maintain high-quality customer support, or a market perception that we do not maintain high-quality support, could harm our reputation,

adversely affect our ability to maintain existing customers or sell our solutions to existing and prospective customers, and harm our

business, operating results and financial condition.

We may be unable to respond quickly enough to

accommodate short-term increases in customer demand for support services. Increased customer demand for these services, without corresponding

revenues, could also increase costs and adversely affect our operating results.

We are dependent on a concentrated group

of customers.

Because the pharmaceutical industry is dominated

by large companies with multiple brands, our revenue is concentrated in a relatively small number of companies. We have approximately

100 pharmaceutical manufacturers as customers, and our revenues are concentrated in these customers. Loss of one or more of our larger

customers could have a negative impact on our operating results. Our top five customers represented 39% of revenue for the year ended

December 31, 2022. In each of 2022 and 2021, we had one customer that each represented slightly over 10% of our revenues.

We expect that we will continue to depend upon

a relatively small number of customers for a significant portion of our total revenues for the foreseeable future. The loss of any of

these customers or groups of customers for any reason, or a change of relationship with any of our key customers could cause a material

decrease in our total revenues.

Additionally, mergers or consolidations among

our customers in the healthcare industry could reduce the number of our customers and could adversely affect our revenues and sales. In

particular, if our customers are acquired by entities that are not also our customers, that do not use our solutions or that have more

favorable contract terms with competitors and choose to discontinue, reduce or change the terms of their use of our solutions, our business

and operating results could be materially and adversely affected.

6

If we are unable to maintain our contracts

with electronic prescription platforms, our business will suffer.

We are reliant upon our contracts with leading

electronic prescribing (“ERx”) platforms and electronic health record (“EHR”) systems to generate our revenues received

from customers. Such arrangements subject us to a number of risks, including the following:

We will need to maintain these relationships as

well as diversify them. The inability to do so could adversely impact our business. We generated 31.8% and 53.9% of our revenue through

our largest partner in 2022 and 2021, respectively.

Our agreements with ERx and EHR channel

partners are subject to audit.

Our agreements with our ERx and EHR channel partners

provide for revenue sharing payments to them based on the revenue we generate through their platforms and systems. These payments are

subject to audit by our channel partners, at their cost, and if there is a dispute as to the calculation, we may be liable for additional

payments. If an underpayment is determined to be in excess of a certain amount, for example 10%, some agreements would require us to pay

for the cost of the audit, as well.

If we fail to attract new customers or retain

and expand existing customers, our business and future prospects may be materially and adversely impacted.

We currently work with many leading pharmaceutical

companies, medical device manufacturers, associations, and other companies. While we have experienced customer growth, this growth may

not continue at the same pace in the future or at all. Achieving growth in our customer base may require us to engage in increasingly

sophisticated and costly sales and marketing efforts that may not result in additional customers. We may also need to modify our pricing

model to attract and retain such customers. If we fail to attract new customers or fail to maintain or expand existing relationships in

a cost-effective manner, our business and future prospects may be materially and adversely impacted.

Actual or perceived failures to comply with

applicable laws and regulations that affect the healthcare industry, including data protection, privacy and security, fraud and abuse

laws, regulations, standards and other requirements could adversely affect our business, results of operations, and financial condition.

The global data protection landscape is rapidly

evolving, and we are or may become subject to numerous state, federal and foreign laws, requirements and regulations governing the collection,

use, disclosure, retention, and security of personal information, including health-related information. This evolution may create uncertainty

in our business, affect our ability to operate in certain jurisdictions or to collect, store, transfer, use and share personal information,

necessitate the acceptance of more onerous obligations in our contracts, result in liability or impose additional costs on us. The cost

of compliance with these laws, regulations and standards is high and is likely to increase in the future. Any failure or perceived failure

by us to comply with federal, state or foreign laws or regulation, our internal policies and procedures or our contracts governing our

processing of personal information could result in negative publicity, government investigations and enforcement actions, claims by third

parties, and damage to our reputation, any of which could have a material adverse effect on our operations, financial performance and

business.

7

We also may be bound by contractual obligations

and other obligations relating to privacy, data protection, and information security that are more stringent than applicable laws and

regulations. The costs of compliance with, and other burdens imposed by, laws, regulations, standards, and other obligations relating

to privacy, data protection, and information security are significant. Although we work to comply with applicable laws, regulations, and

standards, our contractual obligations and other legal obligations, these requirements are evolving and may be modified, interpreted and

applied in an inconsistent manner from one jurisdiction to another, and may conflict with another or other legal obligations with which

we must comply. Accordingly, our failure, or perceived inability, to comply with these laws, regulations, standards, and other obligations

may limit the use and adoption of our solution, reduce overall demand for our solution, lead to regulatory investigations, breach of contract

claims, litigation, and significant fines, penalties, or liabilities for actual or alleged noncompliance or slow the pace at which we

close sales transactions, any of which could harm our business.

The Health Insurance Portability and Accountability

Act of 1996, or HIPAA, and the rules promulgated thereunder require certain entities, referred to as Covered Entities, to comply with

established standards, including standards regarding the privacy and security of protected health information, or PHI. HIPAA further requires

that Covered Entities enter into agreements meeting certain regulatory requirements with their business associates, as such term is defined

by HIPAA, which, among other things, obligate the business associates to safeguard the covered entity’s PHI against improper use

and disclosure. While we are not a Covered Entity, we have contracted as a business associate of our Covered Entity customers and, as

such, may be regulated by HIPAA and have contractual obligations unders such agreements, including to enter into business associate agreements

with our third-party vendors. We, and our Covered Entity customers might face significant contractual liability pursuant to such business

associate agreements if the business associate breaches the agreement or causes the Covered Entity to fail to comply with HIPAA. It is

possible that HIPAA compliance could become a substantial regulatory burden and expense to our operations as we expand our point of care

technology solutions to help patients start and stay on therapies.

Certain other laws and regulations such as federal

and state anti-kickback and false claims laws may apply to us indirectly through our relationships with our customers and partners. Violations

can result in considerable penalties and sanctions. If we are found to have violated, or to have facilitated the violation of such laws,

we could be subject to significant penalties.

The markets in which we operate are competitive,

continually evolving and, in some cases, subject to rapid change.

Our platforms face competition from numerous other

companies, both in attracting users and in generating revenue from advertisers and sponsors. We compete for users with online services

and websites that provide savings on medications and healthcare products, including both commercial sites and not-for-profit sites. We

compete for advertisers and sponsors with health-related web sites, general purpose consumer web sites that offer specialized health sub-channels,

other high-traffic web sites that include both healthcare-related and non-healthcare-related content and services, search engines that

provide specialized health searches, and advertising networks that aggregate traffic from multiple sites.

Many of our competitors have greater financial,

technical, product development, marketing and other resources than we do. These organizations may be better known than we are and have

more customers or users than we do. We cannot provide assurance that we will be able to compete successfully against these organizations

or any alliances they have formed or may form. Since there are no substantial barriers to entry into the markets in which our public portals

participate, we expect that competitors will continue to enter these markets.

Developments in the healthcare industry

could adversely affect our business.

Most of our revenue is derived from pharmaceutical

manufacturers and could be affected by changes affecting the broader healthcare industry, including decreased spending in the industry

overall.

General reductions in expenditures by healthcare

industry participants could result from, among other things:

● Consolidation of healthcare industry participants;

● Reductions in governmental funding for healthcare; and

8

Even if general expenditures by industry participants

remain the same or increase, developments in the healthcare industry may result in reduced spending in some or all of the specific market

segments that we serve now or may serve in the future. For example, use of our solutions and services could be affected by:

● A decrease in the number of new drugs or medical devices coming to market; and

The healthcare industry has changed significantly

in recent years and we expect that significant changes will continue to occur. However, the timing and impact of developments in the healthcare

industry are difficult to predict. We cannot assure you that the demands for our solutions and services will continue to exist at current

levels or that we will have adequate technical, financial and marketing resources to react to changes in the healthcare industry.

If we are unable to manage growth, our operations

could be adversely affected.

Our ability to manage growth effectively will

depend on our ability to improve and expand operations, including our financial and management information systems, and to recruit, train

and manage personnel. There can be no assurance that management will be able to manage growth effectively. To manage growth effectively,

we will be required to continue to implement and improve our operating and financial systems and controls to expand, train and manage

our employee base. Our ability to manage our operations and growth effectively will require us to continue to expend funds to enhance

our operational, financial and management controls, reporting systems and procedures, and to attract and retain sufficient talented personnel.

If we do not properly manage the growth of our

business, we may experience significant strains on our management and operations and disruptions in our business. Various risks arise

when companies grow too quickly. If our business grows too quickly, our ability to meet customer demand in a timely and efficient manner

could be challenged. We may also experience development delays as we seek to meet increased demand for our solutions. Our failure to properly

manage the growth that we or our industry might experience could negatively impact our ability to execute on our operating plan and, accordingly,

could have an adverse impact on our business, our cash flow and results of operations, and our reputation with our current or potential

customers.

Our growth may be impacted by acquisitions.

We may not be able to identify suitable acquisition candidates, complete acquisitions or integrate acquisitions successfully.

Our future growth is likely to depend to some

degree on our ability to acquire and successfully integrate new businesses. We may not be able to identify suitable acquisition candidates,

complete acquisitions, or integrate acquisitions successfully. We may seek additional acquisition opportunities, both to further diversify

our business and to penetrate or expand important product offerings or markets. There are no assurances, however, that we will be able

to successfully identify suitable candidates, negotiate appropriate terms, obtain financing on acceptable terms, complete proposed acquisitions,

successfully integrate acquired businesses, or expand into new markets. Once acquired, operations may not achieve anticipated levels of

revenues or profitability. Acquisitions involve risks, including difficulties in the integration of the operations, technologies, services

and products of the acquired companies and the diversion of management’s attention from other business concerns. Although our management

will endeavor to evaluate the risks inherent in any particular transaction, there are no assurances that we will properly ascertain all

such risks. Difficulties encountered with acquisitions could have a material adverse impact on our business.

9

Our business and growth may suffer if we

are unable to attract and retain members of our senior management team and other key employees.

Our success has been largely dependent on the

skills, experience and efforts of our senior management team and key employees and the loss of the services of any of our senior management

team or other key employees, without a properly executed transition plan, could have an adverse effect on us. The loss of any member of

our senior management team or any of our other key employees could damage critical customer relationships, result in the loss of vital

knowledge, experience and expertise, could lead to an increase in recruitment and training costs and make it more difficult to successfully

operate our business and execute our business strategy. We may not be able to find qualified potential replacements for these individuals

and the integration of potential replacements may be disruptive to our business.

Furthermore, our ability to expand operations

to accommodate our anticipated growth will also depend on our ability to attract and retain qualified management, sales and technical

personnel. However, competition for these types of employees is intense due to the limited number of qualified professionals. Our ability

to meet our business development objectives will depend in part on our ability to recruit, train and retain top quality people with advanced

skills who understand our industry, technology and business. If we are unable to engage and retain the necessary personnel, our business

may be materially and adversely affected.

We could be subject to economic, political,

regulatory and other risks arising from our international operations.

Operating in international markets requires significant

resources and management attention and will subject us to regulatory, economic and political risks that may be different from and incremental

to those in the United States. In addition to the risks that we face in the United States, our international operations in Israel and

Croatia, may involve risks that could adversely affect our business, including:

● unexpected changes in regulatory requirements;

● less favorable foreign intellectual property laws;

● profit repatriation and other restrictions on the transfer of funds;

● new and different sources of competition; and

Our failure to manage any of these risks successfully

could harm our international operations and our overall business, as well as results of our operations.

10

A global pandemic may disrupt our business

or the business of our customers.

In December 2019, a novel strain of corona virus,

which causes the infectious disease known as COVID-19 was reported. The World Health Organization declared COVID-19 a Public Health Emergency

and Global Pandemic. Although many economies around the world have started to rebound from the severe impact of COVID-19, the healthcare

industry in which we operate remains impacted. The emergence and spread of new variants and resurgences, or other epidemics or pandemics,

actions taken by governmental authorities and others in response to the pandemic, the acceptance, and the ability of pharmaceutical manufacturers

and other life sciences companies to develop effective and safe treatment, and global economic conditions could affect the desire and/or

need for our solutions. We are prepared to take steps to modify our business practices and mitigate the impact of the emergence and spread

of new variants and resurgences, or another pandemic or epidemic; however, there can be no assurance that such steps will be successful,

or that our business operations, or the operations of our customers or partners will not be materially and adversely affected by the consequences

of such pandemic or epidemic, which could materially impact our results of operations, cash flows, and financial condition.

Risks Related to Inflation and Other Adverse

Economic Conditions

Inflation and other adverse economic conditions

may adversely affect our business, results of operations and financial condition.

Recently, inflation has increased throughout the

U.S. economy. In an inflationary environment, we may experience increases in the prices of labor and other costs of doing business. Additionally,

cost increases may outpace our expectations, causing us to use our cash and other liquid assets faster than forecasted. If we are unable

to successfully manage the effects of inflation, our business, operating results, cash flows and financial condition may be adversely

affected.

The occurrence or perception of an economic slowdown

or recession, or of a further increase in inflation, may have a negative impact on the global economy and may reduce customer demand for

our products and services. In addition, macroeconomic effects such as increases in interest rates and other measures taken by central

banks and other policy makers could have a negative effect on overall economic activity that could reduce our customers’ demand

for our products and serves. Adverse changes in demand could impact our business, collection of accounts receivable and our expected cash

flow generation, which may adversely impact our financial condition and results of operations.

Risks Related to Our Intellectual Property

and Technology

We are dependent, in part, on our intellectual

property. If we are not able to protect our proprietary rights or if those rights are invalidated or circumvented, our business may be

adversely affected.

Our business is dependent, in part, on our ability

to innovate, and, as a result, we are reliant on our intellectual property. We generally protect our intellectual property through patents,

trademarks, trade secrets, confidentiality and nondisclosure agreements and other measures to the extent our budget permits. There can

be no assurance that patents will be issued from pending applications that we have filed or that our patents will be sufficient to protect

our key technology from misappropriation or falling into the public domain, nor can assurances be made that any of our patents, patent

applications, trademarks or our other intellectual property or proprietary rights will not be challenged, invalidated or circumvented.

In the event a competitor or other party successfully challenges our solutions, processes, patents or licenses or claims that we have

infringed upon their intellectual property, we could incur substantial litigation costs defending against such claims, be required to

pay royalties, license fees or other damages or be barred from using the intellectual property at issue, any of which could have a material

adverse effect on our business, operating results and financial condition. We cannot assure you that steps taken by us to protect our

intellectual property and other contractual agreements for our business will be adequate, that our competitors will not independently

develop or patent substantially equivalent or superior technologies or be able to design around patents that we may receive, or that our

intellectual property will not be misappropriated.

If we are unable to protect our proprietary rights,

we may be at a disadvantage to others who do not incur the substantial time and expense we incur. Preventing unauthorized use or infringement

of our intellectual property rights is inherently difficult. Moreover, it may be difficult or practically impossible to detect theft or

unauthorized use of our intellectual property. Any of the foregoing could have a material adverse effect upon our business, financial

condition and results of operations.

11

Cybersecurity incidents could disrupt business

operations, result in the loss of critical and confidential information, and adversely impact our reputation and results of operations.

Global cybersecurity threats can range from uncoordinated

individual attempts to gain unauthorized access to our information technology (IT) systems to sophisticated and targeted measures known

as advanced persistent threats. While we employ comprehensive measures to prevent, detect, address and mitigate these threats (including

access controls, insurance, vulnerability assessments, continuous monitoring of our IT networks and systems, maintenance of backup and

protective systems and user training and education), cybersecurity incidents, depending on their nature and scope, could potentially result

in the misappropriation, destruction, corruption or unavailability of critical data and confidential or proprietary information (our own

or that of third parties) and the disruption of business operations. The potential consequences of a material cybersecurity incident include

reputational damage, loss of customers, litigation with customers and other parties, loss of trade secrets and other proprietary business

data and increased cybersecurity protection and remediation costs, which in turn could adversely affect our competitiveness and results

of operations.

We may be unable to support our technology

to further scale our operations successfully.

Our plan is to grow through further integration

of our technology in electronic platforms. Our growth will place significant demands on our management and technology development, as

well as our financial, administrative and other resources. We cannot guarantee that any of the systems, procedures and controls we put

in place will be adequate to support the commercialization of our operations. Our operating results will depend substantially on the ability

of our officers and key employees to manage changing business conditions and to implement and improve our financial, administrative and

other resources. If we are unable to respond to and manage changing business conditions, or the scale of our solutions, services and operations,

then the quality of our services, our ability to retain key personnel and our business could be harmed.

Our business will suffer if our network

systems fail or become unavailable.

A reduction in the performance, reliability and

availability of our network infrastructure would harm our ability to distribute our solutions to our users, as well as our reputation

and ability to attract and retain customers. Our systems and operations could be damaged or interrupted by fire, flood, power loss, telecommunications

failure, Internet breakdown, earthquake and similar events. Our systems could also be subject to viruses, break-ins, sabotage, acts of

terrorism, acts of vandalism, hacking, cyber-terrorism and similar misconduct. We might not carry adequate business interruption insurance

to compensate us for losses that may occur from a system outage. Any system error or failure that causes interruption in availability

of our solutions or an increase in response time could result in a loss of potential customers, which could have a material adverse effect

on our business, financial condition and results of operations. If we suffer sustained or repeated interruptions, then our solutions and

services could be less attractive to our users and our business would be materially harmed.

Risks Relating to Our Common Stock

If a market for our common stock is not

maintained, shareholders may be unable to sell their shares.

Our common stock is traded under the symbol “OPRX”

on the Nasdaq Capital Market. We do not currently have a consistent active trading market. There can be no assurance that a consistent

active and liquid trading market will develop or, if developed, that it will be sustained.

Historically, our securities have been thinly

traded. Accordingly, it may be difficult to sell shares of our common stock without significantly depressing the value of the stock. Unless

we are successful in developing continued investor interest in our stock, sales of our stock could continue to result in major fluctuations

in the price of the stock.

12

The market price of our common stock may

be highly volatile and could fluctuate widely in price in response to various factors, many of which are beyond our control.

Our stock price is subject to a number of factors,

including:

● Government regulation of our solutions and services;

● The establishment of partnerships with other healthcare companies;

● Intellectual property disputes;

● Additions or departures of key personnel;

● Sales of our common stock;

● Our ability to execute our business plan;

● Operating results below or exceeding expectations;

● Our operating and financial performance and prospects;

● Loss or addition of any strategic relationship;

● Period-to-period fluctuations in our financial results.

Our stock price may fluctuate widely as a result

of any of the above. In addition, the securities markets have from time to time experienced significant price and volume fluctuations

that are unrelated to the operating performance of particular companies. These market fluctuations may also materially and adversely affect

the market price of our common stock.

We do not expect to pay dividends in the

foreseeable future and any return on investment may be limited to the value of our common stock.

We have never declared or paid any cash dividends

on our common stock. We currently intend to retain all available funds and future earnings, if any, to fund our future growth and do not

expect to declare or pay any dividend on shares of our common stock in the foreseeable future. As a result, the success of an investment

in our common stock may depend entirely upon any future appreciation in its value. There is no guarantee that our common stock will appreciate

in value or even maintain the price at which it is purchased.

Anti-takeover provisions may make it more

difficult for a third party to acquire control of us, even if the change in control would be beneficial to shareholders.

The Company is a Nevada corporation. Anti-takeover

provisions in Nevada law and our charter and bylaws could make it more difficult for a third party to acquire control of us. These provisions

could adversely affect the market price of the common stock and could reduce the amount that shareholders might receive if the Company

is sold. For example, our charter provides that the board of directors may issue preferred stock without shareholder approval. In addition,

our bylaws provide that shareholders cannot act by written consent and that directors may be removed by shareholders only with the approval

of the holders of not less than two-thirds of the voting power of the issued and outstanding stock entitled to vote at an annual or special

meeting of the shareholders.

Risks Related to Being a Public Company

We have identified a material weakness in

our internal control over financial reporting. Failure to remediate the material weakness or any other material weaknesses that we identify

in the future could result in material misstatements in our financial statements.

Pursuant to Section 404 of the Sarbanes-Oxley

Act of 2002, as amended, our management is required to report on the effectiveness of our internal control over financial reporting. The

rules governing the standards that must be met for management to assess our internal control over financial reporting are complex and

require significant documentation, testing and possible remediation. Annually, we perform activities that include reviewing, documenting

and testing our internal control over financial reporting. In addition, if we fail to maintain the adequacy of our internal control over

financial reporting, we will not be able to conclude on an ongoing basis that we have effective internal control over financial reporting

in accordance with Section 404 of the Sarbanes-Oxley Act of 2002. If we fail to achieve and maintain an effective internal control environment,

we could suffer misstatements in our financial statements and fail to meet our reporting obligations, which would likely cause investors

to lose confidence in our reported financial information. This could result in significant expenses to remediate any internal control

deficiencies and lead to a decline in our stock price.

13

The Company has identified a material weakness

in the Company’s internal control over financial reporting. A material weakness is a deficiency, or a combination of deficiencies,

in internal control over financial reporting, such that there is a reasonable possibility that a material misstatement of a company’s

annual or interim financial statements will not be prevented or detected on a timely basis. For further discussion of the material weaknesses,

see Item 9A, Controls and Procedures.

We cannot provide assurance that we have identified

all, or that we will not in the future have additional, material weaknesses in our internal control over financial reporting. As a result,

we may be required to implement further remedial measures and to design enhanced processes and controls to address deficiencies. If we

do not effectively remediate the material weakness identified by management and maintain adequate internal controls over financial reporting

in the future, we may not be able to prepare reliable financial reports and comply with our reporting obligations under the Exchange

Act on a timely basis. Any such delays in the preparation of financial reports and the filing of our periodic reports may result in a

loss of public confidence in the reliability of our financial statements, which, in turn, could materially adversely affect our business,

the market value of our common stock and our access to capital markets.

Item 1B. Unresolved Staff comments

None

Item 2. Properties

Currently, we do not own any real estate. Our

principal executive offices are located at 400 Water Street, Suite 200, Rochester, Michigan 48307.

As of December 31, 2022, we have operating

leases for office space in two multitenant facilities. The leases include our headquarters space in Rochester, Michigan and a technical

facility in Zagreb, Croatia. The lease in Rochester, Michigan expires November 30, 2023, with a two-year renewal option through 2025,

and has a monthly rent of $6,384 to $6,688. The lease in Zagreb, Croatia expires February 2024 and has a monthly rent of approximately

$1,883. We also had a lease on office space in Cranbury, New Jersey which expired in January 2022; we did not renew this lease. We also

lease minor amounts of space in shared space facilities on a month-to-month basis as necessary.

Item 3. Legal Proceedings

We have no current legal proceedings.

Item 4. Mine Safety Disclosures

Not applicable.

Item 4.1 Information About Our Executive Officers

The following information sets forth the names,

ages, and positions of our executive officers as of March 10, 2023.

Name Age Positions and Offices Held

William J. Febbo 54 Chief Executive Officer

Stephen L. Silvestro 45 Chief Commercial Officer

Marion Odence-Ford 58 General Counsel and Chief Compliance Officer

Edward Stelmakh 57 Chief Financial Officer and Chief Operations Officer

Todd Inman 67 Chief Technology Officer

Doug Besch 41 Chief Product Officer

Set forth below is a brief description of the

background and business experience of each of our current executive officers.

14

William J. Febbo

Mr. Febbo joined the Company as Chief Executive

Officer and as a director in February 2016. Mr. Febbo founded Plexuus, LLC, a payment processing business for medical professionals in

September 2015 and remained its Chairman from September 2015 to December 2020. From April 2007 to September 2015, Mr. Febbo served as

Chief Operating Officer of Merriman Holdings, Inc., an investment banking firm, where he assisted with capital raises in the tech, biotech,

cleantech, consumer and resources industries. Mr. Febbo was a co-founder of, and from September 2013 to September 2015 served as Chief

Executive Officer of, Digital Capital Network, Inc., a transaction platform for institutional and accredited investors. Mr. Febbo was

a co-founder of, and from January 1999 to September 2015 was Chief Executive Officer of, MedPanel, LLC, a provider of market intelligence

and communications for the pharmaceutical, biomedical, and medical device industries. Since 2017, Mr. Febbo has been a faculty member

of the Massachusetts Institute of Technology’s linQ program, which is a collaborative initiative focused on increasing the potential

of innovative research to benefit society and the economy. Mr. Febbo currently serves as a director of Modular Medical (NASDAQ: MODD),

a development stage medical device company focused on the design, development and eventual commercialization of an innovative insulin

pump, and as a director of Augmedix, Inc. (NASDAQ: AUGX), a provider of automated medical

documentation and data services. In addition, Mr. Febbo has been a board member of the United Nations Association of Greater Boston, a

resource for the citizens of Greater Boston on the broad agenda of critical global issues addressed by the UN and its agencies, since

2004.

On January 29, 2018, FINRA accepted a Letter of

Acceptance, Waiver and Consent (the “Consent”) submitted by William Febbo. Without admitting or denying the findings, Mr.

Febbo consented to the sanctions and to the entry of findings that he permitted Merriman Capital, Inc. to conduct a securities business

while below its net capital requirement. From August 2012 to October 2015, Mr. Febbo was the Financial and Operations Principal (FinOp)

for a registered broker-dealer, Merriman Capital, Inc. (“Merriman”). During certain months while Mr. Febbo was FinOp, FINRA

found that certain of Merriman’s net capital filings with FINRA were inaccurate because of the method by which Merriman calculated

net capital and that, when corrected, it was retroactively determined that Merriman had operated below its minimum net capital requirements.

Mr. Febbo, as FinOp, signed certain of these reports and was thus held responsible. Based on the Consent, in settlement, Mr. Febbo, who

was then no longer registered with any broker-dealer, accepted a fine of $5,000, a 10-business day suspension from acting as FinOp for

any FINRA member and required to requalify by examination for the Series 27 license before again acting in a FinOp capacity.

Stephen L. Silvestro

Mr. Silvestro joined the Company as Chief Commercial

Officer on April 29, 2019. Mr. Silvestro was with CCH® Tagetik, a Wolters Kluwer company that provides corporate performance management

software solutions for planning, consolidation and reporting, as its Vice President and General Manager from January 2018 until April

2019. From April 2017 to January 2018, Mr. Silvestro was with Prognos Health, Inc., a healthcare data and analytics company, as its Chief

Commercial Officer and, before that, from September 2007 to April 2017, he was with Decision Resources Group, a multi-national corporation

that provides high value global data solutions, analytics and consulting services to pharmaceutical, biotech, medical device, healthcare

provider and payer, and managed care companies, in various capacities with him last serving as Executive Vice President, Head of Global

Sales.

Marion Odence-Ford

Ms. Odence-Ford joined the Company as General

Counsel & Chief Compliance Officer in February 2021. From April 2013 to June 2020, Ms. Odence-Ford was Vice President & Deputy

General Counsel at Decision Resources Group, a multi-national corporation that provides high value global data solutions, analytics and

consulting services to pharmaceutical, biotech, medical device, healthcare provider and payer, and managed care companies. From November

2004 to November 2012, Ms. Odence-Ford was Vice President & Associate General Counsel at CRA International, Inc. (dba Charles River

Associates) (NASDAQ: CRAI), a global consulting firm that offers economic, financial, and strategic expertise to major law firms, corporations,

accounting firms, and governments around the world. From May 2004 to November 2004, Ms. Odence-Ford was a member of the GTC Law Group,

LLP, a law firm specializing in the business affairs of companies in the high tech and biotech industries. Prior to joining the GTC Law

Group, Ms. Odence-Ford worked on the legal teams of Bank of America Corporation/Fleet Boston Financial Corporation (NYSE: BAC) from November

2002 to May 2004, and Akamai Technologies, Inc. (NASDAQ: AKAM) from October 1999 to November 2002. Ms. Odence-Ford began her legal career

in private practice at Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, PC, where she advised public and private companies on corporate

matters.

15

Edward Stelmakh

Mr. Stelmakh joined the Company as Chief Financial

Officer and Chief Operating Officer on October 11, 2021. Prior to joining the Company, Mr. Stelmakh served as Senior Vice President, Chief

Financial Officer and Chief Operating Officer of Otsuka America Pharmaceuticals Inc. (“Otsuka”), a US division of a Japanese

global healthcare enterprise, since April 2020. Previously, he held various positions at Otsuka including Senior Vice President and Chief

Financial Officer (December 2017 – March 2020) and Vice President and Chief Financial Officer (December 2015 – November 2017).

From March 2010 to December 2015, Mr. Stelmakh worked at Covance, a division of LabCorp, Inc., as Vice President, Finance, Clinical Development

and Commercialization Services. Prior thereto, Mr. Stelmakh held a variety of positions of increasing responsibilities at Johnson &

Johnson, Sanofi-Aventis, Organon/Schering-Plough and Mylan.

Todd Inman

Mr. Inman joined the Company on January 1, 2019

as Vice President, Technology and became the Company’s Chief Technology Officer in November 2019. Prior to joining the Company,

from May 2017 to December 2018, Mr. Inman was the Founder and Chief Technology Officer of Meghadata, LLC, a master data management firm,

and from July 2016 to December 2017, Mr. Inman was the Founder and Managing Partner of Data Solutions Partners, a data intelligence solutions

company. From January 2011 through June 2016, Mr. Inman was Director of Data Solutions at Change HealthCare, a healthcare technology and

business solutions company, and from 2005 to 2011, Mr. Inman was the Director of Data Integration of Emdeon Business Services, LLC, an

information technology and services company. Prior to Emdeon, from 2001 to 2005, Mr. Inman was the Director of Clearinghouse Services

at WebMD Health Corp and, from 1996 to 2001, he was the Manager of Clearinghouse Operations at Professional Office Systems, a CareFirst

subsidiary, providing medical office electronic data interchange services.

Doug Besch

Dr. Besch joined the Company on May 24, 2021 as

SVP Product Strategy & Innovation and became the Company’s Chief Product Officer in October 2022. Prior to joining the Company, from

January 2018 to May 2021, Dr. Besch was the Vice President over Payor and Market Access Solutions for Clarivate (previously Decision Resources

Group (DRG)), a multi-national corporation that provides high value global data solutions, analytics and consulting services to pharmaceutical,

biotech, medical device, healthcare provider and payer, and managed care companies. Prior to Clarivate, from January 2012 to June 2017,

Dr. Besch was a co-founder and the Chief Product Officer for Rx Savings Solution, a company which helps members

and payers reduce prescription drug costs through a combination of clinical technology, transparency, member engagement and concierge

support. Dr. Besch holds a PharmD and MBA from Creighton University and practiced as a pharmacist for the Walgreens Boots Alliance

corporation from 2007 through 2013.

16

PART II

Item 5. Market for Registrant’s Common

Equity and Related Stockholder Matters and Issuer Purchases of Equity Securities

Our common stock is traded under the symbol “OPRX”

on the Nasdaq Capital Market. At February 28, 2023, there were approximately 350 shareholders of record of our common stock.

We currently intend to retain future earnings

for the operation of our business. We have never declared or paid cash dividends on our common stock, and we do not anticipate paying

any cash dividends in the foreseeable future. Any payment of future dividends will be at the discretion of our board of directors and

will depend upon, among other things, our earnings, financial condition, capital requirements, level of indebtedness, and other factors

that our board of directors deems relevant.

For the information regarding our equity compensation

plans, see PART III, Item 12, “Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.”

Issuer Purchases of Equity Securities

During the three months ended December 31, 2022, we purchased

shares of our common stock as follows:

Item 6. Reserved

Item 7. Management’s Discussion and Analysis

of Financial Condition and Results of Operations

Overview

We are a digital health technology company enabling

care-focused engagement between life sciences organizations, healthcare providers, and patients at critical junctures throughout the patient

care journey. Connecting over 60% of U.S. healthcare providers and millions of their patients through an intelligent technology platform

embedded within a proprietary point-of-care network, OptimizeRx helps patients start and stay on their medications.

Historically, our revenue was generated primarily

through the facilitation of financial messages to health care providers via their EHR and ePrescribe systems using the OptimizeRx proprietary

network to solve the ever-increasing communication barriers between pharmaceutical representatives and healthcare providers that have

presented in the rapidly changing healthcare industry. Over time, as the demand for communication of an increasing variety of different

health information between life science companies, providers, and patients continued to rise, our platform has expanded to encompass additional

solutions that enable healthcare providers to access information for patients at the point of care. These solutions include brand messaging,

therapeutic support messaging, brand support, and innovative patient engagement services, all of which now make up a significant portion

of our total revenue.

17

We employ a “land and expand” strategy

focused on growing our existing client base and generating greater and more consistent revenues in part through the continued shift in

our business model toward enterprise level engagements, while also broadening our platform with innovative proprietary solutions such

as our TelaRepTM virtual communication solution and our AI-powered real-world evidence solution which uses sophisticated proprietary

algorithms to derive additional revenue from our existing network. In addition, we have continued to expand our team in preparation for

future growth aspirations, which may be supplemented with future acquisitions and other strategic collaborations and investments. Our

strategy for driving revenue growth is also expected to work in tandem with our efforts to increase margin and profitability using the

aforementioned recurring revenue models that have inherently higher margins.

Because the pharmaceutical industry is dominated by large companies

with multiple brands, our revenue is concentrated in a relatively small number of companies. We have approximately 100 pharmaceutical

companies as customers, and our revenues are concentrated in these customers. Loss of one of more of our larger customers could have a

negative impact on our operating results. Our top five customers represented 39% of our revenue for the year ended December 31, 2022.

In each of 2022 and 2021, we had one customer that each represented more than 10% of our revenues.

Seasonality

In general, the pharmaceutical brand marketing

industry experiences seasonal trends that affect the vast majority of participants in the pharmaceutical digital marketing industry. Many

pharmaceutical companies allocate the largest portion of their brand marketing to the fourth quarter of the calendar year. As a result,

the first quarter tends to reflect lower activity levels and lower revenue, with gradual increases in the following quarters. We generally

expect these seasonality trends to continue and our ability to effectively manage our resources in anticipation of these trends may affect

our operating results.

Impact of Macroeconomic Events

Unfavorable conditions in the economy may

negatively affect the growth of our business and our results of operations. For example, macroeconomic events including the COVID-19

pandemic, rising inflation and the U.S. Federal Reserve raising interest rates have led to economic uncertainty. In addition, high

levels of employee turnover across the pharmaceutical industry as well as fewer number of U.S. drug approvals could create

additional certainty within our target customer markets. Historically, during periods of economic uncertainty and downturns,

businesses may slow spending, which may impact our business and our customers’ businesses. Adverse changes in demand could

impact our business, collection of accounts receivable and our expected cash flow generation, which may adversely impact our

financial condition and results of operations.

Key Performance Indicators

We monitor the following key performance indicators

to help us evaluate our business, measure our performance, identify trends affecting our business and make strategic decisions.

Average revenue per top 20 pharmaceutical manufacturer.

Average revenue per top 20 pharmaceutical manufacturer is calculated by taking the total revenue the company recognized through pharmaceutical

manufacturers listed in Fierce Pharma’s “The top 20 pharma companies by 2020 revenue” over the last twelve months, divided

by the total number of the aforementioned pharmaceutical manufacturers that our solutions helped support over that time period. The Company

uses this metric to monitor its progress in “landing and expanding” with key customers within its largest customer vertical

and believe it also provides investors with a transparent way to chart our progress in penetrating this important customer segment. The

decrease in the average in 2022 as compared to 2021 is primarily the result of the convergence of numerous macroeconomic factors that

resulted in our customers slowing their rate of spend, particularly for large and/or new implementations, which we believe prolonged sales

cycles with the top 20 pharmaceutical manufacturers that were existing customers.

Twelve Months Ended December 31

18

Percent of top 20 pharmaceutical manufacturers

that are customers. Percent of top 20 pharmaceutical manufacturers that are customers is calculated by taking the number of revenue

generating customers that are pharmaceutical manufacturers listed in Fierce Pharma’s “The top 20 pharma companies by 2020

revenue” over the last 12 months, which is then divided by 20—which is the number of pharmaceutical manufacturers included

in the aforementioned list. The Company uses this metric to monitor its progress in penetrating key customers within its largest customer

vertical and believes it also provides investors with a transparent way to chart our progress in penetrating this important customer segment.

The decrease in 2022 was due to the Company not supporting programs for a smaller revenue customer from 2021 in 2022.

Twelve Months Ended December 31

Percent of top 20 pharmaceutical manufacturers that are customers 90 % 95 %

Percent of total revenue attributable to top

20 pharmaceutical manufacturers. Percent of total revenue attributable to top 20 pharmaceutical manufacturers is calculated by taking

the total revenue the company recognized through pharmaceutical manufacturers listed in Fierce Pharma’s “The top 20 pharma

companies by 2020 revenue” over the last twelve months, divided by our consolidated revenue over the same period. The Company uses

this metric to monitor its progress in “landing and expanding” with key customers within its largest customer vertical and

believes it also provides investors with a transparent way to chart our progress in penetrating this important customer segment. Our revenue

from customers that aren’t top 20 pharmaceutical manufacturers increased faster than our overall revenue, decreasing the percentage of

our overall revenues from top 20 pharmaceutical manufacturers.

Twelve Months Ended December 31

Net revenue retention. Net revenue retention

is a comparison of revenue generated from all customers in the previous twelve-month period to total revenue generated from the same customers

in the following twelve-month period (i.e., excludes new customer relationships for the most recent twelve-month period). The Company

uses this metric to monitor its ability to improve its penetration with existing customers and believes it also provides investors with

a metric to chart our ability to increase our year-over-year penetration and revenue with existing customers. The retention rate in 2022

decreased due to the convergence of numerous macroeconomic factors that resulted in our customers slowing their rate of spend, particularly

for large and/or new implementations, which we believe prolonged sales cycles.

Twelve Months Ended December 31

Net revenue retention 90 % 127 %

Revenue per average full-time employee.

We define revenue per average full-time employee as total revenue over the last twelve months divided by the average number of employees

over the last twelve months (i.e., the average between the number of FTEs at the end of the reported period and the number of FTEs at

the end of the same period of the prior year). The Company uses this metric to monitor the productivity of its workforce and its ability

to scale efficiently over time and believes the metric provides investors with a way to chart our productivity and scalability. Our revenue

rate per employee declined year over year due to slower revenue growth and a higher average number of FTEs over the last 12 month period.

Twelve Months Ended December 31

19

Results of Operations for the Years Ended December

31, 2022 and 2021

The following table sets forth, for the periods

indicated, the dollar value and percentage of total return represented by certain items in our consolidated statements of operations:

Years Ended December 31,

(in thousands, except percentage data) 2022 2021

Income (loss) before provision for income taxes (11,438 ) (18.3 )% 378 0.6 %

Income tax benefit — — % — — %

Net Revenue

Our net revenue increased 2% to $62.5 million

for the year ended December 31, 2022 from $61.3 million for the year ended December 31, 2021. This increase resulted from increases

in sales of our access solutions.

Cost of Revenues

Our total cost of revenues, composed

primarily of revenue share expense paid to our network partners, decreased in the year ended December 31, 2022 compared to the

year ended December 31, 2021. Our cost of revenues as a percentage of revenue decreased to approximately 38% in the year ended

December 31, 2022 from approximately 42% in the year ended December 31, 2021. This decrease in our cost of revenues as a

Source: SEC EDGAR (public domain) · 10-K for the period ended 2022-12-31, filed 2023-03-10 · accession 0001213900-23-019233

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