Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-03-04 | Mitchell Shawnte | Officer | −Sell | 24,767 | $24.25 | $600,600 |
| 2026-03-04 | Mitchell Shawnte | Officer | +Exercise | 25,000 | $4.37 | $109,250 |
| 2026-03-04 | Mitchell Shawnte | Officer | −Sell | 233 | $24.69 | $5,753 |
| 2026-03-03 | Mitchell Shawnte | Officer | +Exercise | 15,000 | $4.37 | $65,550 |
| 2026-03-03 | Mitchell Shawnte | Officer | −Sell | 15,000 | $23.01 | $345,150 |
| 2026-02-02 | Austin Sasha Lu | Officer | +Grant | 11,700 | — | — |
| 2026-01-20 | Harmon Cyrus | Director | −Sell | 10,000 | $26.88 | $268,800 |
| 2026-01-15 | Kovacs Shane William Charles | Officer | −Sell | 100,000 | $28.73 | $3M |
| 2026-01-14 | Myles David C. | Officer | −Sell | 35,003 | $28.99 | $1M |
| 2026-01-14 | Myles David C. | Officer | −Sell | 14,997 | $28.60 | $428,914 |
| 2026-01-14 | Myles David C. | Officer | +Exercise | 50,000 | $4.87 | $243,500 |
| 2026-01-14 | Harmon Cyrus | Director | −Sell | 3,489 | $29.12 | $101,600 |
| 2026-01-13 | Myles David C. | Officer | −Sell | 200 | $28.49 | $5,698 |
| 2026-01-13 | Myles David C. | Officer | −Sell | 49,800 | $27.60 | $1M |
| 2026-01-13 | Myles David C. | Officer | +Exercise | 50,000 | $4.87 | $243,500 |
| 2026-01-13 | Kovacs Shane William Charles | Officer | −Sell | 3,822 | $28.01 | $107,054 |
| 2026-01-12 | Myles David C. | Officer | −Sell | 10,000 | $28.34 | $283,400 |
| 2025-12-26 | Bohen Sean | Director,Officer | −Gift | 8,500 | — | — |
| 2025-12-23 | Zojwalla Naseem | Officer | +Exercise | 50,000 | $7.02 | $351,000 |
| 2025-12-23 | Zojwalla Naseem | Officer | −Sell | 99,509 | $27.66 | $3M |
| 2025-12-22 | Zojwalla Naseem | Officer | +Exercise | 7,182 | $7.02 | $50,418 |
| 2025-12-22 | Zojwalla Naseem | Officer | +Exercise | 42,818 | $15.25 | $652,975 |
| 2025-12-22 | Zojwalla Naseem | Officer | −Sell | 100,000 | $28.04 | $3M |
| 2025-12-22 | Harmon Cyrus | Director | −Sell | 2,881 | $28.53 | $82,195 |
| 2025-12-19 | Zojwalla Naseem | Officer | −Sell | 12,921 | $28.93 | $373,805 |
| 2025-12-19 | Zojwalla Naseem | Officer | −Sell | 57,079 | $28.03 | $2M |
| 2025-12-19 | Zojwalla Naseem | Officer | +Exercise | 40,000 | $15.25 | $610,000 |
| 2025-12-19 | Myles David C. | Officer | −Sell | 1,225 | $28.08 | $34,398 |
| 2025-12-19 | Myles David C. | Officer | −Sell | 43,729 | $30.40 | $1M |
| 2025-12-19 | Myles David C. | Officer | −Sell | 6,046 | $31.39 | $189,784 |
| 2025-12-19 | Myles David C. | Officer | −Gift | 9,000 | — | — |
| 2025-12-19 | CLARK IAN T | Director | −Sell | 41,840 | $30.48 | $1M |
| 2025-12-19 | CLARK IAN T | Director | −Sell | 193,056 | $29.71 | $6M |
| 2025-12-19 | CLARK IAN T | Director | −Sell | 29,904 | $28.83 | $862,132 |
| 2025-12-19 | CLARK IAN T | Director | +Exercise | 12,070 | $4.08 | $49,246 |
| 2025-12-19 | CLARK IAN T | Director | +Exercise | 21,520 | $7.84 | $168,717 |
| 2025-12-19 | CLARK IAN T | Director | +Exercise | 21,520 | $3.61 | $77,687 |
| 2025-12-19 | CLARK IAN T | Director | +Exercise | 209,690 | $4.41 | $924,733 |
| 2025-12-08 | Kovacs Shane William Charles | Officer | −Gift | 75,000 | — | — |
| 2025-11-26 | Kovacs Shane William Charles | Officer | −Gift | 225,000 | — | — |
| 2025-11-25 | RAPPAPORT ANDREW | Director | −Gift | 35,868 | — | — |
| 2025-11-21 | RAPPAPORT ANDREW | Director | +Exercise | 35,868 | $0.39 | $13,989 |
| 2025-09-18 | Harmon Cyrus | Director | −Sell | 3,086 | $8.32 | $25,676 |
| 2025-09-18 | Harmon Cyrus | Director | −Sell | 10,000 | $8.33 | $83,300 |
| 2025-09-16 | Harmon Cyrus | Director | −Sell | 1,914 | $8.08 | $15,465 |
| 2025-09-16 | Harmon Cyrus | Director | −Sell | 10,000 | $8.04 | $80,400 |
| 2025-01-10 | Bain Capital Life Sciences Investors, LLC | TenPercentOwner | −Other | 3,500,000 | — | — |
| 2025-01-10 | BVF Partners OS Ltd. | Director,Other | −Disp→issuer | 22,740 | — | — |
| 2025-01-10 | BVF Partners OS Ltd. | Director,Other | −Disp→issuer | 235,450 | — | — |
| 2025-01-10 | BVF Partners OS Ltd. | Director,Other | −Disp→issuer | 161,810 | — | — |
| 2025-01-08 | Bain Capital Life Sciences Investors, LLC | TenPercentOwner | +Buy | 300,000 | $5.76 | $2M |
| 2024-12-17 | Graham G. Walmsley | Director | −Sell | 700,761 | $6.75 | $5M |
| 2024-12-17 | Graham G. Walmsley | Director | −Buy | 700,761 | $6.75 | $5M |
| 2024-12-16 | Zojwalla Naseem | Officer | +Exercise | 14,000 | $4.87 | $68,180 |
| 2024-12-13 | Graham G. Walmsley | Director | +Buy | 700,761 | $6.75 | $5M |
| 2024-12-13 | Graham G. Walmsley | Director | −Sell | 700,761 | $6.75 | $5M |
| 2024-12-11 | Bohen Sean | Director,Officer | −Sell | 55,907 | $8.66 | $484,155 |
| 2024-12-11 | Bohen Sean | Director,Officer | −Sell | 1,267 | $9.39 | $11,897 |
| 2024-12-11 | Kovacs Shane William Charles | Officer | −Sell | 406 | $9.39 | $3,812 |
| 2024-12-11 | Kovacs Shane William Charles | Officer | −Sell | 17,950 | $8.66 | $155,447 |
| 2024-12-11 | Zojwalla Naseem | Officer | −Sell | 14,202 | $8.66 | $122,989 |
| 2024-12-11 | Zojwalla Naseem | Officer | −Sell | 320 | $9.39 | $3,005 |
| 2024-12-11 | Myles David C. | Officer | −Sell | 13,314 | $8.66 | $115,299 |
| 2024-12-11 | Myles David C. | Officer | −Sell | 300 | $9.39 | $2,817 |
| 2024-12-11 | Harmon Cyrus | Director | −Sell | 179 | $9.39 | $1,681 |
| 2024-12-11 | Harmon Cyrus | Director | −Sell | 7,958 | $8.66 | $68,916 |
| 2024-12-10 | Bohen Sean | Director,Officer | −Sell | 52,328 | $9.37 | $490,313 |
| 2024-12-10 | Kovacs Shane William Charles | Officer | −Sell | 16,803 | $9.37 | $157,444 |
| 2024-12-10 | Zojwalla Naseem | Officer | −Sell | 13,283 | $9.37 | $124,462 |
| 2024-12-10 | Myles David C. | Officer | −Sell | 12,452 | $9.38 | $116,800 |
| 2024-12-10 | Harmon Cyrus | Director | −Sell | 8,256 | $9.37 | $77,359 |
| 2024-12-09 | Bohen Sean | Director,Officer | +Grant | 204,750 | — | — |
| 2024-12-09 | Kovacs Shane William Charles | Officer | +Grant | 68,250 | — | — |
| 2024-12-09 | Zojwalla Naseem | Officer | +Grant | 52,000 | — | — |
| 2024-12-09 | Myles David C. | Officer | +Grant | 48,750 | — | — |
| 2024-12-09 | Harmon Cyrus | Director | +Grant | 29,250 | — | — |
| 2024-12-04 | BVF INC/IL | Director,Other | −Disp→issuer | 153,441 | — | — |
| 2024-12-04 | BVF INC/IL | Director,Other | −Disp→issuer | 1,797,527 | — | — |
| 2024-12-04 | BVF INC/IL | Director,Other | −Disp→issuer | 1,418,736 | — | — |
| 2024-11-15 | Kovacs Shane William Charles | Officer | +Exercise | 25,000 | $7.02 | $175,500 |
| 2024-08-01 | Paradigm Biocapital Advisors LP | TenPercentOwner | −Sell | 1,870,499 | $14.92 | $28M |
| 2024-08-01 | Paradigm Biocapital Advisors LP | TenPercentOwner | −Sell | 529,501 | $14.92 | $8M |
| 2024-07-30 | Harmon Cyrus | Director | −Sell | 934 | $15.55 | $14,524 |
| 2024-07-29 | Harmon Cyrus | Director | −Sell | 4,066 | $15.58 | $63,348 |
| 2024-07-11 | Harmon Cyrus | Director | −Sell | 5,000 | $12.26 | $61,300 |
| 2024-06-28 | Harmon Cyrus | Director | −Sell | 20,000 | $10.77 | $215,400 |
| 2024-06-04 | Harmon Cyrus | Director | −Sell | 5,000 | $12.33 | $61,650 |
| 2024-06-04 | Graham G. Walmsley | Director | −Sell | 700,000 | $14.85 | $10M |
| 2024-06-04 | Graham G. Walmsley | Director | −Sell | 475,000 | $14.85 | $7M |
| 2024-06-04 | Graham G. Walmsley | Director | −Sell | 700,000 | $14.85 | $10M |
| 2024-06-04 | Graham G. Walmsley | Director | −Sell | 475,000 | $14.85 | $7M |
| 2024-06-03 | Harmon Cyrus | Director | −Sell | 5,000 | $10.93 | $54,650 |
| 2024-05-31 | Harmon Cyrus | Director | −Sell | 15,000 | $9.41 | $141,150 |
| 2024-05-24 | Zojwalla Naseem | Officer | +Exercise | 9,460 | $4.87 | $46,070 |
| 2024-05-06 | Harmon Cyrus | Director | −Sell | 5,000 | $10.92 | $54,600 |
| 2024-04-30 | Harmon Cyrus | Director | −Sell | 15,000 | $9.51 | $142,650 |
| 2024-03-28 | Harmon Cyrus | Director | −Sell | 20,000 | $10.97 | $219,400 |
| 2024-03-18 | Zojwalla Naseem | Officer | +Exercise | 13,700 | $4.87 | $66,719 |
| 2024-03-05 | RAPPAPORT ANDREW | Director | −Other | 481,014 | — | — |
| 2024-03-05 | RAPPAPORT ANDREW | Director | +Other | 385,965 | — | — |
| 2024-02-29 | Harmon Cyrus | Director | −Sell | 100 | $13.00 | $1,300 |
| 2024-02-29 | Harmon Cyrus | Director | −Sell | 24,900 | $12.41 | $309,009 |
| 2024-02-01 | Harmon Cyrus | Director | −Sell | 5,000 | $15.56 | $77,800 |
| 2024-01-31 | Harmon Cyrus | Director | −Sell | 25,000 | $12.23 | $305,750 |
| 2024-01-25 | Zojwalla Naseem | Officer | +Exercise | 20,000 | $7.02 | $140,400 |
| 2024-01-12 | Kovacs Shane William Charles | Officer | +Exercise | 50,000 | $7.02 | $351,000 |
| 2023-12-29 | Harmon Cyrus | Director | −Sell | 22,500 | $13.30 | $299,250 |
| 2023-12-29 | Harmon Cyrus | Director | −Sell | 2,500 | $14.10 | $35,250 |
| 2023-12-12 | Kovacs Shane William Charles | Officer | +Exercise | 10,000 | $7.02 | $70,200 |
| 2023-12-11 | Zojwalla Naseem | Officer | +Exercise | 2,900 | $7.02 | $20,358 |
| 2023-12-06 | Zojwalla Naseem | Officer | +Exercise | 13,100 | $7.02 | $91,962 |
| 2023-12-06 | Paradigm BioCapital International Fund Ltd. | TenPercentOwner | +Buy | 100,000 | $11.60 | $1M |
| 2023-12-05 | Graham G. Walmsley | Director | +Buy | 31,870 | $14.73 | $469,445 |
| 2023-12-05 | Graham G. Walmsley | Director | +Buy | 50,000 | $14.95 | $747,500 |
| 2023-12-05 | Graham G. Walmsley | Director | +Buy | 50,000 | $13.09 | $654,500 |
| 2023-11-30 | Harmon Cyrus | Director | −Sell | 25,000 | $12.57 | $314,250 |
| 2023-11-22 | Kovacs Shane William Charles | Officer | −Sell | 9,145 | $13.89 | $127,024 |
| 2023-11-22 | Bohen Sean | Director,Officer | −Sell | 27,932 | $13.90 | $388,255 |
| 2023-11-22 | Harmon Cyrus | Director | −Sell | 3,989 | $13.90 | $55,447 |
| 2023-11-22 | Myles David C. | Officer | −Sell | 6,653 | $13.89 | $92,410 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
