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Clinical trials
catalyst calendar across sponsors →Studies where NSIS-B.CO is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
13 interventional
government filings 180d: none disclosed
| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Updated |
|---|---|---|---|---|---|---|---|
| Effect of Limosilactobacillus Reuteri DSM 17648 in Healthy Adults Reporting Upper Gastrointestinal DiscomfortNCT07163637Change from Baseline in the total score of Frequency Scale for the Symptoms of GERD (FSSG) at 8 weeksRandomized · Triple-masked · Treatment | Not applicable | Completed | Dietary supplement: Limosilactobacillus reuteri DSM 17648, Placebo | Healthy Participants, Upper Gastrointestinal Discomfort | 324 | 2026-05-27actual | 2026-06-16 |
| Bacillus Velezensis DSM 33864 for Reduction of the Risk of Recurrent Clostridioides Difficile InfectionsNCT05606159C. difficile colonizationRandomized · Quadruple-masked · Supportive care | Not applicable | Withdrawnsponsor's stated reason: Research Project closed | Dietary supplement: Bacillus velezensis DSM 33864, Placebo | Clostridium Difficile Infection Recurrence | 0 | Nov 2024 | 2024-11-22 |
| Effect of a Combination of Lactase and L. Salivarius DSM 34078 in Individuals With Lactose IntoleranceNCT06107088Difference in change in concentration of breath hydrogen between Test product1 and Comparator at the second lactose challenge of Visit 2, compared to baseline (Visit 0)Randomized · Triple-masked · Treatment | Not applicable | Completed | Dietary supplement: Active 1, Active 2, Active 3, Placebo | Lactose Intolerance | 76 | 2024-07-10actual | 2024-07-16 |
| Effect of Enzyme-containing Lozenge on Dental Biofilm Formation, Composition and FunctionalityNCT06142409Change in in-vivo dental biofilm accumulationRandomized · Quadruple-masked · Supportive care | Not applicable | Completed | Dietary supplement: Enzyme containing lozenge | Dental Biofilm Accumulation | 34 | 2024-02-25actual | 2025-01-03 |
| RCT: Enzyme Blend Toothpaste on Dental Biofilm Plaque AccumulationNCT07079683Whole mouth dental plaque accumulation at Day 28.Randomized · Quadruple-masked · Prevention | Not applicable | Completed | Other: Toothpaste Product, Toothpaste Product | Dental Biofilm Accumulation | 132 | 2023-12-07actual | 2025-08-08 |
| Effect of Lactobacillus Plantarum DSM 33464 on Blood Lead Levels in Young Women of Child-bearing AgeNCT05507021Blood Lead levelsRandomized · Quadruple-masked · Supportive care | Not applicable | Completed | Dietary supplement: Lactobacillus plantarum DSM 33464, MegaMetalliQ, Placebo | Elevated Blood Lead Levels | 47 | 2023-04-12actual | 2024-09-23 |
| A Trial to Evaluate the Efficacy and Safety of Lactobacillus Plantarum DSM 33464 on Blood Lead Levels in ChildrenNCT04891666Reduction of blood lead levelsRandomized · Quadruple-masked · Supportive care | Not applicable | Completed | Dietary supplement: Lactobacillus plantarum DSM 33464, Placebo | Elevated Blood Lead Levels | 66 | 2023-03-17actual | 2023-07-14 |
| Clinical Trial to Evaluate the Efficacy and Safety of the Probiotic Strains Limosilactocillus Reuteri DSM 32910 and Lacticaseibacillus Paracasei DSM 32851 on Glucose Homeostatis in Prediabetic AdultsNCT04767789Glycated Hemoglobin A1c (HbA1c)Randomized · Quadruple-masked · Prevention | Not applicable | Completed | Dietary supplement: NZ-GHMH-01, Placebo | Prediabetic State, Dysglycemia | 100 | 2022-11-29actual | 2023-06-15 |
| Effect of Enzymes on Dental Biofilm AccumulationNCT055799384-day biofilm accumulation in the absence of oral mechanical hygieneRandomized · Quadruple-masked · Treatment | Not applicable | Completed | Dietary supplement: Enzyme-containing lozenge, Placebo lozenge | Dental Plaque | 28 | 2022-10-19actual | 2023-04-12 |
| Effect of Enzymes on Dental Biofilm Accumulation in Healthy IndividualsNCT05082103Plaque amountRandomized · Quadruple-masked · Prevention | Not applicable | Terminatedsponsor's stated reason: The study was terminated after interim data analysis | Other: Enzyme lozenge 1, Enzyme lozenge 2, Placebo lozenge | Dental Plaque | 80 | 2022-03-31actual | 2022-06-09 |
| Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)NCT05413382Immediate Total Volatile Sulphur Compounds (T-VSC)Randomized · Quadruple-masked · Other | Not applicable | Completed | Dietary supplement: Biofresh® 4plus, Placebo | Halitosis | 53 | 2021-11-04actual | 2022-06-10 |
| Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals.NCT05070507Accumulation of dental plaque after 24 hoursRandomized · Triple-masked · Prevention | Not applicable | Completed | Dietary supplement: Enzyme containing lozenge, Placebo lozenge | Dental Plaque, Gingivitis, Microbial Colonization | 24 | 2021-02-26actual | 2021-10-07 |
| Clinical Study of the Effect of Two Experimental Lozenges on Oral Malodor After Single UseNCT05950529Total VSC (OralChroma) readingsRandomized · Single-masked · Supportive care | Not applicable | Completed | Other: Experimental lozenge with the enzyme Polyphenol oxidase and green coffee extract, Experimental lozenge with the enzyme Polyphenol oxidase, green coffee extract and flavor, Placebo lozenge control (sorbitol only), No product | Oral Malodor | 156 | 2020-03-11actual | 2023-07-18 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19