MIST US Equity

Milestone Pharmaceuticals Inc.

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Health Care · Pharmaceutical Preparations · CIK 1408443 · FYE 1231

$1.04

-0.03 (-2.80%)

USD · as of 2026-07-29 · marketstack

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Institutional ownership· 13F filers holding MIST · 2026-Q1 methodology → sources →

85 holders

% of shares outstanding held

23.9%

Shares held (13F)

29,798,338

Reporting holders

Top holders

largest 85 of 85 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RTW INVESTMENTS, LP	6,331,0016.3M	$8M	5.09%	ADD 153%
2	Propel Bio Management, LLC	4,118,3214.1M	$5M	3.31%	—
3	TWO SIGMA INVESTMENTS, LP	2,317,1762.3M	$3M	1.86%	ADD 53%
4	GOLDMAN SACHS GROUP INC	2,000,0252.0M	$2M	1.61%	NEW
5	MARSHALL WACE, LLP	1,944,5301.9M	$2M	1.56%	ADD 17%
6	MILLENNIUM MANAGEMENT LLC	1,544,3251.5M	$2M	1.24%	ADD 284%
7	Simplify Asset Management Inc.	1,506,4051.5M	$2M	1.21%	—
8	Point72 Asset Management, L.P.	1,085,6831.1M	$1M	0.87%	ADD 125%
9	Balyasny Asset Management L.P.	851,325851,325	$1M	0.68%	NEW
10	Lion Point Capital, LP	820,000820,000	$975,800	0.66%	ADD 9%
11	TORONTO DOMINION BANK	750,000750,000	$892,500	0.60%	—
12	MORGAN STANLEY	724,141724,141	$861,727	0.58%	TRIM -7%
13	Boxer Capital Management, LLC	666,666666,666	$793,333	0.54%	—
14	SUSQUEHANNA INTERNATIONAL GROUP, LLP	519,046519,046	$617,665	0.42%	TRIM -19%
15	UBS Group AG	494,908494,908	$588,940	0.40%	—
16	Squarepoint Ops LLC	336,825336,825	$400,822	0.27%	ADD 35%
17	Seven Fleet Capital Management LP	333,333333,333	$396,666	0.27%	NEW
18	Aptus Capital Advisors, LLC	280,250280,250	$333,498	0.23%	ADD 6%
19	GUARDIAN WEALTH ADVISORS, LLC / NC	280,250280,250	$333,498	0.23%	ADD 6%
20	CITADEL ADVISORS LLC	196,696196,696	$234,068	0.16%	TRIM -44%
21	LPL Financial LLC	193,373193,373	$230,114	0.16%	ADD 36%
22	BNP PARIBAS FINANCIAL MARKETS	176,504176,504	$210,040	0.14%	TRIM -20%
23	BOOTHBAY FUND MANAGEMENT, LLC	168,675168,675	$200,723	0.14%	NEW
24	JANE STREET GROUP, LLC	159,669159,669	$190,006	0.13%	TRIM -85%
25	SIMPLEX TRADING, LLC	149,291149,291	$177,656	0.12%	NEW
26	Quadrature Capital Ltd	149,105149,105	$177,435	0.12%	NEW
27	Valeo Financial Advisors, LLC	130,699130,699	$155,532	0.10%	—
28	GROUP ONE TRADING LLC	129,764129,764	$154,419	0.10%	TRIM -33%
29	RENAISSANCE TECHNOLOGIES LLC	129,705129,705	$154,349	0.10%	NEW
30	XTX Topco Ltd	120,602120,602	$143,516	0.10%	TRIM -30%
31	TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC	100,000100,000	$119,000	0.08%	—
32	ADAR1 Capital Management, LLC	100,000100,000	$119,000	0.08%	—
33	HRT FINANCIAL LP	62,25662,256	$74,000	0.05%	NEW
34	Cambridge Investment Research Advisors, Inc.	59,62059,620	$71,000	0.05%	ADD 26%
35	October Effect Ltd	51,95051,950	$61,821	0.04%	—
36	SG Americas Securities, LLC	42,51242,512	$51,000	0.03%	TRIM -56%
37	Invesco Ltd.	41,35641,356	$49,214	0.03%	ADD 89%
38	GEODE CAPITAL MANAGEMENT, LLC	40,78940,789	$48,538	0.03%	TRIM -45%
39	NORTHERN TRUST CORP	38,77938,779	$46,147	0.03%	—
40	Focus Partners Wealth	36,00036,000	$42,840	0.03%	—
41	Mariner, LLC	30,83030,830	$36,688	0.02%	ADD 23%
42	Bay Rivers Group	29,91129,911	$35,594	0.02%	ADD 4%
43	Federation des caisses Desjardins du Quebec	29,78129,781	$35,439	0.02%	—
44	GSA CAPITAL PARTNERS LLP	26,89326,893	$32,000	0.02%	TRIM -89%
45	RAYMOND JAMES FINANCIAL INC	26,60026,600	$31,654	0.02%	—
46	Safeguard Investment Advisory Group, LLC	25,04425,044	$29,802	0.02%	—
47	Welch & Forbes LLC	25,00025,000	$29,750	0.02%	NEW
48	NATIONAL BANK OF CANADA /FI/	23,50023,500	$27,965	0.02%	ADD 26%
49	STATE STREET CORP	22,33122,331	$26,574	0.02%	ADD 2%
50	ACADIAN ASSET MANAGEMENT LLC	20,46820,468	$24,000	0.02%	TRIM -88%
51	JOURNEY STRATEGIC WEALTH LLC	20,00020,000	$23,800	0.02%	—
52	Stephenson & Company, Inc.	20,00020,000	$23,800	0.02%	—
53	Pathstone Holdings, LLC	17,04017,040	$20,278	0.01%	TRIM -98%
54	AE Wealth Management LLC	15,00015,000	$17,850	0.01%	NEW
55	SJS Investment Consulting Inc.	15,00015,000	$17,850	0.01%	—
56	Taylor Financial Group, Inc.	15,00015,000	$17,850	0.01%	ADD 50%
57	Vision Retirement, LLC	15,00015,000	$17,850	0.01%	NEW
58	Exit Wealth Advisors, LLC.	15,00015,000	$17,850	0.01%	NEW
59	EARNED WEALTH ADVISORS, LLC	14,75614,756	$17,560	0.01%	NEW
60	Cetera Investment Advisers	14,70414,704	$17,498	0.01%	TRIM -29%
61	Beta Wealth Group, Inc.	14,12714,127	$16,811	0.01%	—
62	JONES FINANCIAL COMPANIES LLLP	16,00016,000	$16,640	0.01%	—
63	Strategic Family Wealth Counselors, L.L.C.	13,87513,875	$16,512	0.01%	ADD 9%
64	Creative Planning	13,41013,410	$15,958	0.01%	TRIM -43%
65	Rockefeller Capital Management L.P.	12,50012,500	$14,875	0.01%	ADD 635%
66	IMC-Chicago, LLC	10,94310,943	$13,022	0.01%	NEW
67	Wealthspire Advisors, LLC	10,62910,629	$12,649	0.01%	NEW
68	Bronte Capital Management Pty Ltd.	10,41410,414	$12,393	0.01%	—
69	Eaton Financial Holdings Company, LLC	10,25010,250	$12,198	0.01%	TRIM -20%
70	Bayesian Capital Management, LP	10,01510,015	$11,918	0.01%	TRIM -42%
71	Ancora Advisors LLC	10,00010,000	$11,900	0.01%	—
72	HighTower Advisors, LLC	10,00010,000	$11,900	0.01%	NEW
73	CWM, LLC	10,00010,000	$11,900	0.01%	NEW
74	Secure Asset Management, LLC	10,00010,000	$11,900	0.01%	—
75	INTEGRAL INVESTMENT ADVISORS, INC.	10,00010,000	$11,900	0.01%	—
76	Tower Research Capital LLC (TRC)	9,1479,147	$10,885	0.01%	—
77	ROYAL BANK OF CANADA	6,6986,698	$8,000	0.01%	—
78	US BANCORP \DE\	3,2003,200	$3,808	0.00%	—
79	Caitong International Asset Management Co., Ltd	1,7291,729	$2,058	0.00%	NEW
80	PNC FINANCIAL SERVICES GROUP, INC.	1,0001,000	$1,190	0.00%	NEW
81	Medallion Wealth Advisors, LLC	340340	$405	0.00%	—
82	Rialto Wealth Management, LLC	300300	$357	0.00%	—
83	Key Capital Management, INC	212212	$252	0.00%	—
84	Russell Investments Group, Ltd.	125125	$149	0.00%	NEW
85	SBI Securities Co., Ltd.	1111	$13	0.00%	ADD 83%

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RTW INVESTMENTS, LP

2.5M

6.3M

$8M

Propel Bio Management, LLC

—

1.5M

1.8M

5.1M

4.1M

$5M

TWO SIGMA INVESTMENTS, LP

—

667K

1.5M

2.3M

$3M

GOLDMAN SACHS GROUP INC

942K

—

119K

357K

—

2.0M

$2M

MARSHALL WACE, LLP

—

425K

1.7M

1.9M

$2M

MILLENNIUM MANAGEMENT LLC

2.7M

322K

—

402K

403K

1.5M

$2M

Simplify Asset Management Inc.

—

850K

990K

2.8M

1.5M

$2M

Point72 Asset Management, L.P.

—

482K

1.1M

$1M

Balyasny Asset Management L.P.

—

851K

$1M

Lion Point Capital, LP

1.0M

549K

659K

755K

820K

$975,800

TORONTO DOMINION BANK

750K

$892,500

MORGAN STANLEY

1.3M

969K

820K

3.0M

782K

724K

$861,727

Boxer Capital Management, LLC

309K

—

667K

$793,333

SUSQUEHANNA INTERNATIONAL GROUP, LLP

33K

62K

63K

257K

643K

519K

$617,665

UBS Group AG

90K

112K

323K

398K

492K

495K

$588,940

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	85	29,798,338	23.9%	$36M
2025-Q4	79	26,494,541	21.3%	$54M
2025-Q3	61	34,138,461	27.4%	$68M
2025-Q2	43	11,853,406	9.5%	$23M
2025-Q1	43	11,824,370	9.5%	$9M
2024-Q4	47	24,552,680	19.7%	$58M
2024-Q3	43	28,677,699	23.0%	$44M
2024-Q2	40	31,928,731	25.6%	$42M
2024-Q1	43

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Institutional ownership· 13F filers holding MIST · 2026-Q1 methodology → sources →

85 holders

% of shares outstanding held

23.9%

Shares held (13F)

29,798,338

Reporting holders

Top holders

largest 85 of 85 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RTW INVESTMENTS, LP	6,331,0016.3M	$8M	5.09%	ADD 153%
2	Propel Bio Management, LLC	4,118,3214.1M	$5M	3.31%	—
3	TWO SIGMA INVESTMENTS, LP	2,317,1762.3M	$3M	1.86%	ADD 53%
4	GOLDMAN SACHS GROUP INC	2,000,0252.0M	$2M	1.61%	NEW
5	MARSHALL WACE, LLP	1,944,5301.9M	$2M	1.56%	ADD 17%
6	MILLENNIUM MANAGEMENT LLC	1,544,3251.5M	$2M	1.24%	ADD 284%
7	Simplify Asset Management Inc.	1,506,4051.5M	$2M	1.21%	—
8	Point72 Asset Management, L.P.	1,085,6831.1M	$1M	0.87%	ADD 125%
9	Balyasny Asset Management L.P.	851,325851,325	$1M	0.68%	NEW
10	Lion Point Capital, LP	820,000820,000	$975,800	0.66%	ADD 9%
11	TORONTO DOMINION BANK	750,000750,000	$892,500	0.60%	—
12	MORGAN STANLEY	724,141724,141	$861,727	0.58%	TRIM -7%
13	Boxer Capital Management, LLC	666,666666,666	$793,333	0.54%	—
14	SUSQUEHANNA INTERNATIONAL GROUP, LLP	519,046519,046	$617,665	0.42%	TRIM -19%
15	UBS Group AG	494,908494,908	$588,940	0.40%	—
16	Squarepoint Ops LLC	336,825336,825	$400,822	0.27%	ADD 35%
17	Seven Fleet Capital Management LP	333,333333,333	$396,666	0.27%	NEW
18	Aptus Capital Advisors, LLC	280,250280,250	$333,498	0.23%	ADD 6%
19	GUARDIAN WEALTH ADVISORS, LLC / NC	280,250280,250	$333,498	0.23%	ADD 6%
20	CITADEL ADVISORS LLC	196,696196,696	$234,068	0.16%	TRIM -44%
21	LPL Financial LLC	193,373193,373	$230,114	0.16%	ADD 36%
22	BNP PARIBAS FINANCIAL MARKETS	176,504176,504	$210,040	0.14%	TRIM -20%
23	BOOTHBAY FUND MANAGEMENT, LLC	168,675168,675	$200,723	0.14%	NEW
24	JANE STREET GROUP, LLC	159,669159,669	$190,006	0.13%	TRIM -85%
25	SIMPLEX TRADING, LLC	149,291149,291	$177,656	0.12%	NEW
26	Quadrature Capital Ltd	149,105149,105	$177,435	0.12%	NEW
27	Valeo Financial Advisors, LLC	130,699130,699	$155,532	0.10%	—
28	GROUP ONE TRADING LLC	129,764129,764	$154,419	0.10%	TRIM -33%
29	RENAISSANCE TECHNOLOGIES LLC	129,705129,705	$154,349	0.10%	NEW
30	XTX Topco Ltd	120,602120,602	$143,516	0.10%	TRIM -30%
31	TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC	100,000100,000	$119,000	0.08%	—
32	ADAR1 Capital Management, LLC	100,000100,000	$119,000	0.08%	—
33	HRT FINANCIAL LP	62,25662,256	$74,000	0.05%	NEW
34	Cambridge Investment Research Advisors, Inc.	59,62059,620	$71,000	0.05%	ADD 26%
35	October Effect Ltd	51,95051,950	$61,821	0.04%	—
36	SG Americas Securities, LLC	42,51242,512	$51,000	0.03%	TRIM -56%
37	Invesco Ltd.	41,35641,356	$49,214	0.03%	ADD 89%
38	GEODE CAPITAL MANAGEMENT, LLC	40,78940,789	$48,538	0.03%	TRIM -45%
39	NORTHERN TRUST CORP	38,77938,779	$46,147	0.03%	—
40	Focus Partners Wealth	36,00036,000	$42,840	0.03%	—
41	Mariner, LLC	30,83030,830	$36,688	0.02%	ADD 23%
42	Bay Rivers Group	29,91129,911	$35,594	0.02%	ADD 4%
43	Federation des caisses Desjardins du Quebec	29,78129,781	$35,439	0.02%	—
44	GSA CAPITAL PARTNERS LLP	26,89326,893	$32,000	0.02%	TRIM -89%
45	RAYMOND JAMES FINANCIAL INC	26,60026,600	$31,654	0.02%	—
46	Safeguard Investment Advisory Group, LLC	25,04425,044	$29,802	0.02%	—
47	Welch & Forbes LLC	25,00025,000	$29,750	0.02%	NEW
48	NATIONAL BANK OF CANADA /FI/	23,50023,500	$27,965	0.02%	ADD 26%
49	STATE STREET CORP	22,33122,331	$26,574	0.02%	ADD 2%
50	ACADIAN ASSET MANAGEMENT LLC	20,46820,468	$24,000	0.02%	TRIM -88%
51	JOURNEY STRATEGIC WEALTH LLC	20,00020,000	$23,800	0.02%	—
52	Stephenson & Company, Inc.	20,00020,000	$23,800	0.02%	—
53	Pathstone Holdings, LLC	17,04017,040	$20,278	0.01%	TRIM -98%
54	AE Wealth Management LLC	15,00015,000	$17,850	0.01%	NEW
55	SJS Investment Consulting Inc.	15,00015,000	$17,850	0.01%	—
56	Taylor Financial Group, Inc.	15,00015,000	$17,850	0.01%	ADD 50%
57	Vision Retirement, LLC	15,00015,000	$17,850	0.01%	NEW
58	Exit Wealth Advisors, LLC.	15,00015,000	$17,850	0.01%	NEW
59	EARNED WEALTH ADVISORS, LLC	14,75614,756	$17,560	0.01%	NEW
60	Cetera Investment Advisers	14,70414,704	$17,498	0.01%	TRIM -29%
61	Beta Wealth Group, Inc.	14,12714,127	$16,811	0.01%	—
62	JONES FINANCIAL COMPANIES LLLP	16,00016,000	$16,640	0.01%	—
63	Strategic Family Wealth Counselors, L.L.C.	13,87513,875	$16,512	0.01%	ADD 9%
64	Creative Planning	13,41013,410	$15,958	0.01%	TRIM -43%
65	Rockefeller Capital Management L.P.	12,50012,500	$14,875	0.01%	ADD 635%
66	IMC-Chicago, LLC	10,94310,943	$13,022	0.01%	NEW
67	Wealthspire Advisors, LLC	10,62910,629	$12,649	0.01%	NEW
68	Bronte Capital Management Pty Ltd.	10,41410,414	$12,393	0.01%	—
69	Eaton Financial Holdings Company, LLC	10,25010,250	$12,198	0.01%	TRIM -20%
70	Bayesian Capital Management, LP	10,01510,015	$11,918	0.01%	TRIM -42%
71	Ancora Advisors LLC	10,00010,000	$11,900	0.01%	—
72	HighTower Advisors, LLC	10,00010,000	$11,900	0.01%	NEW
73	CWM, LLC	10,00010,000	$11,900	0.01%	NEW
74	Secure Asset Management, LLC	10,00010,000	$11,900	0.01%	—
75	INTEGRAL INVESTMENT ADVISORS, INC.	10,00010,000	$11,900	0.01%	—
76	Tower Research Capital LLC (TRC)	9,1479,147	$10,885	0.01%	—
77	ROYAL BANK OF CANADA	6,6986,698	$8,000	0.01%	—
78	US BANCORP \DE\	3,2003,200	$3,808	0.00%	—
79	Caitong International Asset Management Co., Ltd	1,7291,729	$2,058	0.00%	NEW
80	PNC FINANCIAL SERVICES GROUP, INC.	1,0001,000	$1,190	0.00%	NEW
81	Medallion Wealth Advisors, LLC	340340	$405	0.00%	—
82	Rialto Wealth Management, LLC	300300	$357	0.00%	—
83	Key Capital Management, INC	212212	$252	0.00%	—
84	Russell Investments Group, Ltd.	125125	$149	0.00%	NEW
85	SBI Securities Co., Ltd.	1111	$13	0.00%	ADD 83%

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RTW INVESTMENTS, LP

2.5M

6.3M

$8M

Propel Bio Management, LLC

—

1.5M

1.8M

5.1M

4.1M

$5M

TWO SIGMA INVESTMENTS, LP

—

667K

1.5M

2.3M

$3M

GOLDMAN SACHS GROUP INC

942K

—

119K

357K

—

2.0M

$2M

MARSHALL WACE, LLP

—

425K

1.7M

1.9M

$2M

MILLENNIUM MANAGEMENT LLC

2.7M

322K

—

402K

403K

1.5M

$2M

Simplify Asset Management Inc.

—

850K

990K

2.8M

1.5M

$2M

Point72 Asset Management, L.P.

—

482K

1.1M

$1M

Balyasny Asset Management L.P.

—

851K

$1M

Lion Point Capital, LP

1.0M

549K

659K

755K

820K

$975,800

TORONTO DOMINION BANK

750K

$892,500

MORGAN STANLEY

1.3M

969K

820K

3.0M

782K

724K

$861,727

Boxer Capital Management, LLC

309K

—

667K

$793,333

SUSQUEHANNA INTERNATIONAL GROUP, LLP

33K

62K

63K

257K

643K

519K

$617,665

UBS Group AG

90K

112K

323K

398K

492K

495K

$588,940

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	85	29,798,338	23.9%	$36M
2025-Q4	79	26,494,541	21.3%	$54M
2025-Q3	61	34,138,461	27.4%	$68M
2025-Q2	43	11,853,406	9.5%	$23M
2025-Q1	43	11,824,370	9.5%	$9M
2024-Q4	47	24,552,680	19.7%	$58M
2024-Q3	43	28,677,699	23.0%	$44M
2024-Q2	40	31,928,731	25.6%	$42M
2024-Q1	43

Short interest has its own tab now — open SI →

MIST US Equity☆

Institutional ownership· 13F filers holding MIST · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Institutional ownership· 13F filers holding MIST · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

MIST US Equity