| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 4,567,2744.6M | $136M | 8.25% | — |
| 2 | TRV GP IV, LLC | 4,473,9584.5M | $134M | 8.08% | — |
| 3 | ARCH Venture Management, LLC | 4,120,0534.1M | $123M | 7.44% | — |
| 4 | Deep Track Capital, LP | 3,477,5623.5M | $104M | 6.28% | TRIM -18% |
| 5 | JANUS HENDERSON GROUP PLC | 2,858,8762.9M | $85M | 5.17% | TRIM -9% |
| 6 | Paradigm Biocapital Advisors LP | 2,744,3992.7M | $82M | 4.96% | NEW† |
| 7 | BlackRock, Inc. | 2,570,4252.6M | $77M | 4.64% | ADD 12% |
| 8 | a16z Capital Management, L.L.C. | 1,702,2251.7M | $51M | 3.08% | — |
| 9 | Venrock Adviser, LLC | 1,602,0341.6M | $48M | 2.89% | ADD 3% |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 1,435,6561.4M | $43M | 2.59% | NEW† |
| 11 | Alphabet Inc. | 1,388,5831.4M | $41M | 2.51% | — |
| 12 | Logos Global Management LP | 1,235,0001.2M | $37M | 2.23% | ADD 30% |
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,178,0001.2M | $35M | 2.13% | NEW† |
| 14 | General Catalyst Group Management, LLC | 1,035,9101.0M | $31M | 1.87% | — |
| 15 | TRV GP V, LLC | 950,800950,800 | $28M | 1.72% | — |
| 16 | FMR LLC | 864,214864,214 | $26M | 1.56% | ADD 19% |
| 17 | CITADEL ADVISORS LLC | 775,714775,714 | $23M | 1.40% | ADD 73% |
| 18 | ArrowMark Colorado Holdings LLC | 767,383767,383 | $23M | 1.39% | — |
| 19 | Casdin Capital, LLC | 758,857758,857 | $23M | 1.37% | — |
| 20 | Cormorant Asset Management, LP | 750,000750,000 | $22M | 1.36% | NEW |
| 21 | Woodline Partners LP | 650,229650,229 | $19M | 1.17% | TRIM -37% |
| 22 | STATE STREET CORP | 636,722636,722 | $19M | 1.15% | ADD 19% |
| 23 | Driehaus Capital Management LLC | 636,162636,162 | $19M | 1.15% | ADD 68% |
| 24 | Caligan Partners LP | 614,962614,962 | $18M | 1.11% | ADD 12% |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 599,967599,967 | $18M | 1.08% | ADD 14% |
| 26 | BESSEMER GROUP INC | 481,790481,790 | $14M | 0.87% | — |
| 27 | Balyasny Asset Management L.P. | 461,151461,151 | $14M | 0.83% | ADD 131% |
| 28 | Ikarian Capital, LLC | 378,999378,999 | $11M | 0.68% | TRIM -41% |
| 29 | FARALLON CAPITAL MANAGEMENT LLC | 373,000373,000 | $11M | 0.67% | NEW |
| 30 | HHLR ADVISORS, LTD.tracked | 366,028366,028 | $11M | 0.66% | TRIM -20% |
| 31 | MARSHALL WACE, LLP | 310,639310,639 | $9M | 0.56% | TRIM -63% |
| 32 | BOOTHBAY FUND MANAGEMENT, LLC | 284,476284,476 | $8M | 0.51% | TRIM -31% |
| 33 | WASHINGTON UNIVERSITY | 280,802280,802 | $8M | 0.51% | — |
| 34 | GOLDMAN SACHS GROUP INC | 279,713279,713 | $8M | 0.51% | ADD 144% |
| 35 | Candriam S.C.A. | 278,167278,167 | $8M | 0.50% | NEW |
| 36 | Squadron Capital Management LLC | 257,500257,500 | $8M | 0.47% | TRIM -47% |
| 37 | Mass General Brigham, Inc | 239,994239,994 | $7M | 0.43% | — |
| 38 | Freestone Grove Partners LP | 234,953234,953 | $7M | 0.42% | ADD 98% |
| 39 | SPHERA FUNDS MANAGEMENT LTD. | 227,343227,343 | $7M | 0.41% | ADD 216% |
| 40 | Aberdeen Group plc | 226,227226,227 | $7M | 0.41% | NEW |
| 41 | NORTHERN TRUST CORP | 211,382211,382 | $6M | 0.38% | ADD 20% |
| 42 | MORGAN STANLEY | 204,831204,831 | $6M | 0.37% | TRIM -21% |
| 43 | Spruce Street Capital LP | 200,000200,000 | $6M | 0.36% | NEW |
| 44 | VANGUARD PORTFOLIO MANAGEMENT LLC | 195,542195,542 | $6M | 0.35% | NEW |
| 45 | BANK OF AMERICA CORP /DE/ | 195,084195,084 | $6M | 0.35% | ADD 961% |
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 186,433186,433 | $6M | 0.34% | ADD 6% |
| 47 | Ensign Peak Advisors, Inc | 185,794185,794 | $6M | 0.34% | — |
| 48 | Foresite Capital Management IV, LLC | 156,901156,901 | $5M | 0.28% | TRIM -70% |
| 49 | VANGUARD FIDUCIARY TRUST CO | 151,000151,000 | $5M | 0.27% | NEW |
| 50 | Holocene Advisors, LP | 136,168136,168 | $4M | 0.25% | NEW |
| 51 | Qube Research & Technologies Ltd | 134,950134,950 | $4M | 0.24% | NEW |
| 52 | PRICE T ROWE ASSOCIATES INC /MD/ | 122,695122,695 | $4M | 0.22% | ADD 6% |
| 53 | Atika Capital Management LLC | 111,500111,500 | $3M | 0.20% | NEW |
| 54 | AMERIPRISE FINANCIAL INC | 107,486107,486 | $3M | 0.19% | ADD 11% |
| 55 | Alyeska Investment Group, L.P. | 100,000100,000 | $3M | 0.18% | TRIM -49% |
| 56 | Integral Health Asset Management, LLC | 100,000100,000 | $3M | 0.18% | — |
| 57 | HighVista Strategies LLC | 99,85099,850 | $3M | 0.18% | TRIM -41% |
| 58 | UBS Group AG | 93,89893,898 | $3M | 0.17% | ADD 227% |
| 59 | ALLIANCEBERNSTEIN L.P. | 64,76264,762 | $3M | 0.12% | ADD 95% |
| 60 | Exome Asset Management LLC | 88,51088,510 | $3M | 0.16% | NEW |
| 61 | Invesco Ltd. | 86,41986,419 | $3M | 0.16% | TRIM -36% |
| 62 | SummitTX Capital, L.P. | 83,75083,750 | $2M | 0.15% | ADD 20% |
| 63 | Bank of New York Mellon Corp | 74,26874,268 | $2M | 0.13% | ADD 23% |
| 64 | RAYMOND JAMES FINANCIAL INC | 69,37569,375 | $2M | 0.13% | ADD 2% |
| 65 | Nuveen, LLC | 63,36063,360 | $2M | 0.11% | ADD 11% |
| 66 | WELLINGTON MANAGEMENT GROUP LLP | 60,58760,587 | $2M | 0.11% | — |
| 67 | OSAIC HOLDINGS, INC. | 59,94359,943 | $2M | 0.11% | — |
| 68 | FRANKLIN RESOURCES INC | 59,63759,637 | $2M | 0.11% | ADD 8% |
| 69 | JPMORGAN CHASE & CO | 58,44658,446 | $2M | 0.11% | ADD 192% |
| 70 | ADAR1 Capital Management, LLC | 50,09550,095 | $1M | 0.09% | TRIM -72% |
| 71 | D. E. Shaw & Co., Inc. | 45,63645,636 | $1M | 0.08% | ADD 35% |
| 72 | Propel Bio Management, LLC | 43,79843,798 | $1M | 0.08% | NEW |
| 73 | ALPS ADVISORS INC | 39,17139,171 | $1M | 0.07% | NEW |
| 74 | SCHRODER INVESTMENT MANAGEMENT GROUP | 37,18137,181 | $1M | 0.07% | NEW |
| 75 | DAFNA Capital Management LLC | 35,00035,000 | $1M | 0.06% | NEW |
| 76 | Aquatic Capital Management LLC | 34,97734,977 | $1M | 0.06% | NEW |
| 77 | Russell Investments Group, Ltd. | 32,52632,526 | $970,919 | 0.06% | ADD 44% |
| 78 | Parkman Healthcare Partners LLC | 31,84431,844 | $950,543 | 0.06% | TRIM -85% |
| 79 | RHUMBLINE ADVISERS | 31,51331,513 | $940,652 | 0.06% | ADD 33% |
| 80 | TWINBEECH CAPITAL LP | 30,98930,989 | $925,022 | 0.06% | NEW |
| 81 | Seven Fleet Capital Management LP | 30,70730,707 | $916,604 | 0.06% | NEW |
| 82 | MILLENNIUM MANAGEMENT LLC | 29,89229,892 | $892,276 | 0.05% | TRIM -81% |
| 83 | AQR CAPITAL MANAGEMENT LLC | 27,94527,945 | $834,158 | 0.05% | — |
| 84 | Walleye Capital LLC | 27,94527,945 | $834,158 | 0.05% | NEW |
| 85 | XTX Topco Ltd | 26,85426,854 | $801,592 | 0.05% | TRIM -19% |
| 86 | Foresite Capital Management V, LLC | 25,90525,905 | $773,264 | 0.05% | TRIM -70% |
| 87 | FIRST TRUST ADVISORS LP | 25,48525,485 | $760,727 | 0.05% | NEW |
| 88 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,30125,301 | $755,235 | 0.05% | NEW |
| 89 | Blackstone Inc. | 24,99024,990 | $745,952 | 0.05% | NEW |
| 90 | Y-Intercept (Hong Kong) Ltd | 21,72821,728 | $648,581 | 0.04% | NEW |
| 91 | DEUTSCHE BANK AG\ | 20,26320,263 | $604,851 | 0.04% | ADD 31% |
| 92 | ACUTA CAPITAL PARTNERS, LLC | 19,33519,335 | $577,150 | 0.03% | TRIM -3% |
| 93 | Verition Fund Management LLC | 19,13419,134 | $571,150 | 0.03% | TRIM -15% |
| 94 | PRELUDE CAPITAL MANAGEMENT, LLC | 18,12718,127 | $541,091 | 0.03% | NEW |
| 95 | Caitong International Asset Management Co., Ltd | 17,78317,783 | $530,823 | 0.03% | ADD 408% |
| 96 | GILDER GAGNON HOWE & CO LLC | 17,48717,487 | $521,987 | 0.03% | TRIM -25% |
| 97 | TWO SIGMA INVESTMENTS, LP | 15,84515,845 | $472,973 | 0.03% | ADD 119% |
| 98 | RENAISSANCE TECHNOLOGIES LLC | 15,80015,800 | $471,630 | 0.03% | TRIM -42% |
| 99 | Vanguard Global Advisers, LLC | 15,20215,202 | $453,780 | 0.03% | NEW |
| 100 | Engineers Gate Manager LP | 15,11015,110 | $451,034 | 0.03% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | — | 4.1M | 4.6M | 4.6M | 4.6M | 4.6M | $136M |
| TRV GP IV, LLC | — | 6.1M | 6.1M | 6.1M | 4.5M | 4.5M | $134M |
| ARCH Venture Management, LLC | — | 4.1M | 4.1M | 4.1M | 4.1M | 4.1M | $123M |
| Deep Track Capital, LP | — | 3.3M | 3.9M | 3.9M | 4.2M | 3.5M | $104M |
| JANUS HENDERSON GROUP PLC | — | 1.2M | 1.4M | 752K | 3.1M | 2.9M | $85M |
| Paradigm Biocapital Advisors LP | — | — | — | — | — | 2.7M | $82M |
| BlackRock, Inc. | — | 583K | 615K | 1.3M | 2.3M | 2.6M | $77M |
| a16z Capital Management, L.L.C. | — | 1.7M | 1.7M | 1.7M | 1.7M | 1.7M | $51M |
| Venrock Adviser, LLC | — | — | — | 1.2M | 1.5M | 1.6M | $48M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.4M | $43M |
| Alphabet Inc. | — | 2.4M | 2.4M | 2.4M | 1.4M | 1.4M | $41M |
| Logos Global Management LP | — | 937K | 612K | 1.2M | 950K | 1.2M | $37M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | — | — | — | — | — | 1.2M | $35M |
| General Catalyst Group Management, LLC | — | 1.0M | 1.0M | 1.0M | 1.0M | 1.0M | $31M |
| TRV GP V, LLC | — | 951K | 951K | 951K | 951K | 951K | $28M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 165 | 51,677,474 | 93.4% | $1.5B |
| 2025-Q4 | 143 | 48,366,868 | 100.5% | $2.0B |
| 2025-Q3 | 94 | 42,978,530 | 98.0% | $1.1B |
| 2025-Q2 | 75 | 38,837,530 | 88.7% | $477M |
| 2025-Q1 | 68 | 40,038,713 | 91.4% | $441M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| Paradigm Biocapital Advisors LP | +2,744,399 | $82M | OPEN |
| VANGUARD CAPITAL MANAGEMENT LLC | +1,435,656 | $43M | OPEN |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | +1,178,000 | $35M | OPEN |
| Cormorant Asset Management, LP | +750,000 | $22M | OPEN |
| FARALLON CAPITAL MANAGEMENT LLC | +373,000 | $11M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,697,015 | $51M | CLOSE |
| Bellevue Group AG | −887,708 | $26M | CLOSE |
| Deep Track Capital, LP | −768,878 | $23M | TRIM |
| MARSHALL WACE, LLP | −536,833 | $16M | TRIM |
| Matrix Capital Management Company, LP | −480,000 | $14M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| 6.1% |
| Passive |
| 2026-03-25 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
