| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | SUVRETTA CAPITAL MANAGEMENT, LLC | 4,168,9704.2M | $263M | 11.16% | NEW† |
| 2 | SR One Capital Management, LP | 2,401,8682.4M | $152M | 6.43% | NEW† |
| 3 | CITADEL ADVISORS LLC | 1,825,6721.8M | $115M | 4.89% | NEW† |
| 4 | FMR LLC | 1,792,9091.8M | $113M | 4.80% | NEW† |
| 5 | VIKING GLOBAL INVESTORS LPtracked | 1,690,5551.7M | $107M | 4.53% | NEW† |
| 6 | Siren, L.L.C. | 1,505,3741.5M | $95M | 4.03% | NEW† |
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,100,0001.1M | $69M | 2.95% | NEW† |
| 8 | Aberdeen Group plc | 1,054,6601.1M | $67M | 2.82% | NEW† |
| 9 | JPMORGAN CHASE & CO | 976,166976,166 | $59M | 2.61% | NEW† |
| 10 | INFINITUM ASSET MANAGEMENT, LLC | 731,149731,149 | $46M | 1.96% | NEW |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 699,645699,645 | $44M | 1.87% | NEW |
| 12 | MARSHALL WACE, LLP | 654,601654,601 | $41M | 1.75% | NEW |
| 13 | Balyasny Asset Management L.P. | 532,906532,906 | $34M | 1.43% | NEW |
| 14 | Paradigm Biocapital Advisors LP | 525,000525,000 | $33M | 1.41% | NEW |
| 15 | AMERIPRISE FINANCIAL INC | 514,035514,035 | $32M | 1.38% | NEW |
| 16 | Woodline Partners LP | 500,646500,646 | $32M | 1.34% | NEW |
| 17 | Deep Track Capital, LP | 500,000500,000 | $32M | 1.34% | NEW |
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 477,833477,833 | $30M | 1.28% | NEW |
| 19 | UBS Group AG | 347,075347,075 | $22M | 0.93% | NEW |
| 20 | Vivo Capital, LLC | 300,000300,000 | $19M | 0.80% | NEW |
| 21 | STIFEL FINANCIAL CORP | 294,117294,117 | $19M | 0.79% | NEW |
| 22 | BlackRock, Inc. | 282,611282,611 | $18M | 0.76% | NEW |
| 23 | Kalehua Capital Management LLC | 248,574248,574 | $16M | 0.67% | NEW |
| 24 | FRANKLIN RESOURCES INC | 200,000200,000 | $13M | 0.54% | NEW |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 178,206178,206 | $11M | 0.48% | NEW |
| 26 | Catalio Capital Management, LP | 173,582173,582 | $11M | 0.46% | NEW |
| 27 | GOLDMAN SACHS GROUP INC | 168,975168,975 | $11M | 0.45% | NEW |
| 28 | Ensign Peak Advisors, Inc | 150,000150,000 | $9M | 0.40% | NEW |
| 29 | JENNISON ASSOCIATES LLC | 141,781141,781 | $9M | 0.38% | NEW |
| 30 | D. E. Shaw & Co., Inc. | 134,219134,219 | $8M | 0.36% | NEW |
| 31 | EMERALD ADVISERS, LLC | 132,536132,536 | $8M | 0.35% | NEW |
| 32 | MILLENNIUM MANAGEMENT LLC | 123,220123,220 | $8M | 0.33% | NEW |
| 33 | MYDA Advisors LLC | 120,000120,000 | $8M | 0.32% | NEW |
| 34 | EMERALD MUTUAL FUND ADVISERS TRUST | 109,283109,283 | $7M | 0.29% | NEW |
| 35 | Jones Hill Capital LP | 100,843100,843 | $6M | 0.27% | NEW |
| 36 | MASTERS CAPITAL MANAGEMENT LLC | 100,000100,000 | $6M | 0.27% | NEW |
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 98,00998,009 | $6M | 0.26% | NEW |
| 38 | VANGUARD FIDUCIARY TRUST CO | 97,98597,985 | $6M | 0.26% | NEW |
| 39 | SEVEN GRAND MANAGERS, LLC | 74,75074,750 | $5M | 0.20% | NEW |
| 40 | STATE STREET CORP | 74,40074,400 | $5M | 0.20% | NEW |
| 41 | Sofinnova Investments, Inc. | 73,31573,315 | $5M | 0.20% | NEW |
| 42 | Affinity Asset Advisors, LLC | 70,00070,000 | $4M | 0.19% | NEW |
| 43 | BANK OF AMERICA CORP /DE/ | 65,67565,675 | $4M | 0.18% | NEW |
| 44 | BAMCO INC /NY/ | 59,66859,668 | $4M | 0.16% | NEW |
| 45 | MORGAN STANLEY | 51,69051,690 | $3M | 0.14% | NEW |
| 46 | Monashee Investment Management LLC | 50,00050,000 | $3M | 0.13% | NEW |
| 47 | Polymer Capital Management (HK) LTD | 41,29641,296 | $3M | 0.11% | NEW |
| 48 | BARCLAYS PLC | 36,91136,911 | $2M | 0.10% | NEW |
| 49 | NORTHERN TRUST CORP | 34,53734,537 | $2M | 0.09% | NEW |
| 50 | Brevan Howard Capital Management LP | 30,08230,082 | $2M | 0.08% | NEW |
| 51 | Logos Global Management LP | 25,00025,000 | $2M | 0.07% | NEW |
| 52 | Centiva Capital, LP | 20,00020,000 | $1M | 0.05% | NEW |
| 53 | FIRST TRUST ADVISORS LP | 19,77519,775 | $1M | 0.05% | NEW |
| 54 | Shay Capital LLC | 18,00018,000 | $1M | 0.05% | NEW |
| 55 | Squarepoint Ops LLC | 16,61016,610 | $1M | 0.04% | NEW |
| 56 | Penserra Capital Management LLC | 14,70014,700 | $928,000 | 0.04% | NEW |
| 57 | FORMULA GROWTH LTD | 14,00014,000 | $884,100 | 0.04% | NEW |
| 58 | TORONTO DOMINION BANK | 13,42813,428 | $847,978 | 0.04% | NEW |
| 59 | CIBC Bancorp USA Inc. | 13,10013,100 | $827,265 | 0.04% | NEW |
| 60 | XTX Topco Ltd | 11,51011,510 | $726,857 | 0.03% | NEW |
| 61 | Hudson Bay Capital Management LP | 11,07911,079 | $699,639 | 0.03% | NEW |
| 62 | CITIGROUP INC | 10,69110,691 | $675,137 | 0.03% | NEW |
| 63 | Persistent Asset Partners Ltd | 9,1919,191 | $580,412 | 0.02% | NEW |
| 64 | Legal & General Group Plc | 7,1057,105 | $448,681 | 0.02% | NEW |
| 65 | Vanguard Global Advisers, LLC | 6,7486,748 | $426,136 | 0.02% | NEW |
| 66 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 6,7116,711 | $423,800 | 0.02% | NEW |
| 67 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,0005,000 | $315,750 | 0.01% | NEW |
| 68 | Private Advisor Group, LLC | 5,0005,000 | $315,750 | 0.01% | NEW |
| 69 | Ghisallo Capital Management LLC | 5,0005,000 | $315,750 | 0.01% | NEW |
| 70 | Burkehill Global Management, LP | 5,0005,000 | $315,750 | 0.01% | NEW |
| 71 | VANGUARD PORTFOLIO MANAGEMENT LLC | 4,5374,537 | $286,512 | 0.01% | NEW |
| 72 | Schonfeld Strategic Advisors LLC | 3,9003,900 | $246,285 | 0.01% | NEW |
| 73 | Bank of New York Mellon Corp | 3,6683,668 | $231,634 | 0.01% | NEW |
| 74 | ExodusPoint Capital Management, LP | 3,3583,358 | $212,058 | 0.01% | NEW |
| 75 | US BANCORP \DE\ | 470470 | $29,681 | 0.00% | NEW |
| 76 | Allworth Financial LP | 5050 | $3,158 | 0.00% | NEW |
| 77 | NVWM, LLC | 3535 | $2,210 | 0.00% | NEW |
| 78 | SBI Securities Co., Ltd. | 2020 | $1,263 | 0.00% | NEW |
| 79 | ROYAL BANK OF CANADA | 88 | $1,000 | 0.00% | NEW |
| 80 | JONES FINANCIAL COMPANIES LLLP | 1010 | $655 | 0.00% | NEW |
| 81 | Tower Research Capital LLC (TRC) | 1010 | $632 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | — | — | — | — | — | 4.2M | $263M |
| SR One Capital Management, LP | — | — | — | — | — | 2.4M | $152M |
| CITADEL ADVISORS LLC | — | — | — | — | — | 1.8M | $115M |
| FMR LLC | — | — | — | — | — | 1.8M | $113M |
| VIKING GLOBAL INVESTORS LPtracked | — | — | — | — | — | 1.7M | $107M |
| Siren, L.L.C. | — | — | — | — | — | 1.5M | $95M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | — | — | — | — | — | 1.1M | $69M |
| Aberdeen Group plc | — | — | — | — | — | 1.1M | $67M |
| JPMORGAN CHASE & CO | — | — | — | — | — | 976K | $59M |
| INFINITUM ASSET MANAGEMENT, LLC | — | — | — | — | — | 731K | $46M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 700K | $44M |
| MARSHALL WACE, LLP | — | — | — | — | — | 655K | $41M |
| Balyasny Asset Management L.P. | — | — | — | — | — | 533K | $34M |
| Paradigm Biocapital Advisors LP | — | — | — | — | — | 525K | $33M |
| AMERIPRISE FINANCIAL INC | — | — | — | — | — | 514K | $32M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | +4,168,970 | $263M | OPEN |
| SR One Capital Management, LP | +2,401,868 | $152M | OPEN |
| CITADEL ADVISORS LLC | +1,825,672 | $115M | OPEN |
| FMR LLC | +1,792,909 | $113M | OPEN |
| VIKING GLOBAL INVESTORS LP | +1,690,555 | $107M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| No filer reduced its position this quarter. | |||
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
