| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 35,606,97435.6M | $160M | 34.28% | ADD 16% |
| 2 | Blue Owl Capital Holdings LP | 7,120,0077.1M | $32M | 6.85% | ADD 4% |
| 3 | BlackRock, Inc. | 3,752,2003.8M | $17M | 3.61% | — |
| 4 | MILLENNIUM MANAGEMENT LLC | 3,625,2783.6M | $16M | 3.49% | TRIM -30% |
| 5 | AIGH Capital Management LLC | 3,000,0003.0M | $14M | 2.89% | ADD 50% |
| 6 | Driehaus Capital Management LLC | 2,934,3992.9M | $13M | 2.82% | ADD 448% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 2,866,3492.9M | $13M | 2.76% | NEW† |
| 8 | DAFNA Capital Management LLC | 2,029,1642.0M | $9M | 1.95% | ADD 116% |
| 9 | GOLDMAN SACHS GROUP INC | 1,561,5851.6M | $7M | 1.50% | ADD 16% |
| 10 | RTW INVESTMENTS, LP | 1,500,0001.5M | $7M | 1.44% | TRIM -52% |
| 11 | Deep Track Capital, LP | 1,500,0001.5M | $7M | 1.44% | NEW |
| 12 | Woodline Partners LP | 1,400,8501.4M | $6M | 1.35% | ADD 75% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 1,108,7611.1M | $5M | 1.07% | — |
| 14 | Soleus Capital Management, L.P. | 1,066,9601.1M | $5M | 1.03% | NEW |
| 15 | Point72 Asset Management, L.P. | 1,047,3851.0M | $5M | 1.01% | TRIM -28% |
| 16 | MARSHALL WACE, LLP | 933,464933,464 | $4M | 0.90% | NEW |
| 17 | STATE STREET CORP | 911,326911,326 | $4M | 0.88% | — |
| 18 | Gem Investment Advisors, LLC | 854,230854,230 | $4M | 0.82% | ADD 204% |
| 19 | Qube Research & Technologies Ltd | 847,644847,644 | $4M | 0.82% | NEW |
| 20 | AQR CAPITAL MANAGEMENT LLC | 817,517817,517 | $4M | 0.79% | ADD 63% |
| 21 | DIMENSIONAL FUND ADVISORS LP | 798,462798,462 | $4M | 0.77% | ADD 144% |
| 22 | RENAISSANCE TECHNOLOGIES LLC | 739,942739,942 | $3M | 0.71% | ADD 149% |
| 23 | Nuveen, LLC | 674,915674,915 | $3M | 0.65% | ADD 542% |
| 24 | Caption Management, LLC | 635,024635,024 | $3M | 0.61% | ADD 53% |
| 25 | Alyeska Investment Group, L.P. | 617,211617,211 | $3M | 0.59% | TRIM -33% |
| 26 | D. E. Shaw & Co., Inc. | 575,624575,624 | $3M | 0.55% | ADD 32% |
| 27 | JANE STREET GROUP, LLC | 554,007554,007 | $2M | 0.53% | TRIM -18% |
| 28 | CITADEL ADVISORS LLC | 519,132519,132 | $2M | 0.50% | TRIM -62% |
| 29 | TWO SIGMA INVESTMENTS, LP | 475,612475,612 | $2M | 0.46% | ADD 61% |
| 30 | MORGAN STANLEY | 420,813420,813 | $2M | 0.41% | ADD 209% |
| 31 | VANGUARD PORTFOLIO MANAGEMENT LLC | 406,558406,558 | $2M | 0.39% | NEW |
| 32 | SummitTX Capital, L.P. | 379,765379,765 | $2M | 0.37% | NEW |
| 33 | NORTHERN TRUST CORP | 376,503376,503 | $2M | 0.36% | ADD 6% |
| 34 | JPMORGAN CHASE & CO | 331,818331,818 | $1M | 0.32% | ADD 1235% |
| 35 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000300,000 | $1M | 0.29% | NEW |
| 36 | Burkehill Global Management, LP | 300,000300,000 | $1M | 0.29% | NEW |
| 37 | Jump Financial, LLC | 299,700299,700 | $1M | 0.29% | ADD 212% |
| 38 | Hudson Bay Capital Management LP | 292,250292,250 | $1M | 0.28% | NEW |
| 39 | VANGUARD FIDUCIARY TRUST CO | 289,632289,632 | $1M | 0.28% | NEW |
| 40 | Seven Fleet Capital Management LP | 256,585256,585 | $1M | 0.25% | NEW |
| 41 | Cerity Partners LLC | 247,912247,912 | $1M | 0.24% | ADD 6% |
| 42 | JACOBS LEVY EQUITY MANAGEMENT, INC | 169,144169,144 | $761,148 | 0.16% | NEW |
| 43 | DIADEMA PARTNERS LP | 166,637166,637 | $749,867 | 0.16% | NEW |
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 145,342145,342 | $654,039 | 0.14% | TRIM -10% |
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 140,060140,060 | $630,270 | 0.13% | TRIM -45% |
| 46 | WELLINGTON MANAGEMENT GROUP LLP | 136,530136,530 | $614,386 | 0.13% | NEW |
| 47 | SEVEN GRAND MANAGERS, LLC | 125,000125,000 | $562,500 | 0.12% | NEW |
| 48 | HRT FINANCIAL LP | 121,885121,885 | $548,000 | 0.12% | NEW |
| 49 | IEQ CAPITAL, LLC | 114,038114,038 | $513,172 | 0.11% | ADD 132% |
| 50 | Bank of New York Mellon Corp | 107,331107,331 | $482,989 | 0.10% | TRIM -7% |
| 51 | DEUTSCHE BANK AG\ | 93,13293,132 | $419,095 | 0.09% | ADD 171% |
| 52 | Marex Group plc | 82,00082,000 | $369,000 | 0.08% | TRIM -74% |
| 53 | AMERICAN CENTURY COMPANIES INC | 77,63677,636 | $349,362 | 0.07% | ADD 3% |
| 54 | Connor, Clark & Lunn Investment Management Ltd. | 69,08769,087 | $310,892 | 0.07% | ADD 228% |
| 55 | Creative Planning | 65,03765,037 | $292,667 | 0.06% | ADD 83% |
| 56 | CWM, LLC | 64,12664,126 | $288,567 | 0.06% | ADD 97% |
| 57 | FMR LLC | 63,57063,570 | $286,065 | 0.06% | ADD 394% |
| 58 | ALLIANCEBERNSTEIN L.P. | 74,53074,530 | $283,959 | 0.07% | — |
| 59 | RHUMBLINE ADVISERS | 62,68562,685 | $282,079 | 0.06% | — |
| 60 | FEDERATED HERMES, INC. | 61,35061,350 | $276,076 | 0.06% | TRIM -83% |
| 61 | CANADA PENSION PLAN INVESTMENT BOARD | 59,70059,700 | $268,650 | 0.06% | TRIM -36% |
| 62 | ACADIAN ASSET MANAGEMENT LLC | 59,48159,481 | $265,000 | 0.06% | TRIM -8% |
| 63 | CIBC WORLD MARKET INC. | 53,00053,000 | $238,500 | 0.05% | NEW |
| 64 | AXQ CAPITAL, LP | 52,97352,973 | $238,379 | 0.05% | ADD 200% |
| 65 | ADAR1 Capital Management, LLC | 52,74552,745 | $237,353 | 0.05% | TRIM -72% |
| 66 | Virtu Financial LLC | 51,79151,791 | $233,000 | 0.05% | NEW |
| 67 | Vanguard Global Advisers, LLC | 51,04551,045 | $229,703 | 0.05% | NEW |
| 68 | BANK OF AMERICA CORP /DE/ | 47,35947,359 | $213,116 | 0.05% | ADD 17% |
| 69 | EntryPoint Capital, LLC | 44,47944,479 | $200,156 | 0.04% | TRIM -17% |
| 70 | INCEPTIONR LLC | 44,00644,006 | $198,027 | 0.04% | NEW |
| 71 | Persistent Asset Partners Ltd | 42,12442,124 | $189,558 | 0.04% | NEW |
| 72 | Next Level Private LLC | 41,70041,700 | $187,650 | 0.04% | — |
| 73 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 41,21641,216 | $185,472 | 0.04% | TRIM -63% |
| 74 | HighTower Advisors, LLC | 38,46538,465 | $173,093 | 0.04% | NEW |
| 75 | Schonfeld Strategic Advisors LLC | 38,09038,090 | $171,404 | 0.04% | TRIM -38% |
| 76 | CITIGROUP INC | 36,10736,107 | $162,482 | 0.03% | ADD 457% |
| 77 | JOURNEY STRATEGIC WEALTH LLC | 35,88335,883 | $161,474 | 0.03% | — |
| 78 | Ethic Inc. | 35,45135,451 | $159,529 | 0.03% | TRIM -48% |
| 79 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 32,79932,799 | $157,107 | 0.03% | ADD 110% |
| 80 | PRICE T ROWE ASSOCIATES INC /MD/ | 34,76834,768 | $157,000 | 0.03% | ADD 20% |
| 81 | Graham Capital Management, L.P. | 34,43834,438 | $154,971 | 0.03% | TRIM -18% |
| 82 | J. Goldman & Co LP | 33,75633,756 | $151,902 | 0.03% | TRIM -17% |
| 83 | Velan Capital Investment Management LP | 33,00033,000 | $148,500 | 0.03% | — |
| 84 | PRUDENTIAL FINANCIAL INC | 32,79332,793 | $147,569 | 0.03% | NEW |
| 85 | Mariner, LLC | 31,64531,645 | $142,351 | 0.03% | NEW |
| 86 | Caitong International Asset Management Co., Ltd | 31,34731,347 | $141,062 | 0.03% | ADD 2539% |
| 87 | XTX Topco Ltd | 30,88430,884 | $138,978 | 0.03% | TRIM -74% |
| 88 | UBS Group AG | 29,69929,699 | $133,646 | 0.03% | TRIM -74% |
| 89 | Fi3 FINANCIAL ADVISORS, LLC | 29,49329,493 | $132,719 | 0.03% | — |
| 90 | STATE OF WISCONSIN INVESTMENT BOARD | 28,79628,796 | $129,582 | 0.03% | NEW |
| 91 | MetLife Investment Management, LLC | 26,66826,668 | $120,006 | 0.03% | ADD 96% |
| 92 | ExodusPoint Capital Management, LP | 26,44526,445 | $119,002 | 0.03% | TRIM -92% |
| 93 | COMMONWEALTH EQUITY SERVICES, LLC | 24,78224,782 | $111,520 | 0.02% | ADD 8% |
| 94 | MIRABELLA FINANCIAL SERVICES LLP | 24,56524,565 | $110,543 | 0.02% | NEW |
| 95 | Dynamic Technology Lab Private Ltd | 24,00924,009 | $108,041 | 0.02% | NEW |
| 96 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,09123,091 | $103,910 | 0.02% | ADD 2% |
| 97 | Headlands Technologies LLC | 22,92522,925 | $103,163 | 0.02% | NEW |
| 98 | STRS OHIO | 21,70021,700 | $97,650 | 0.02% | ADD 175% |
| 99 | FRED ALGER MANAGEMENT, LLC | 21,26721,267 | $95,702 | 0.02% | NEW |
| 100 | WELLS FARGO & COMPANY/MN | 20,22820,228 | $91,026 | 0.02% | TRIM -64% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 21.2M | 21.2M | 21.2M | 30.6M | 30.6M | 35.6M | $160M |
| Blue Owl Capital Holdings LP | 4.7M | 4.8M | 4.9M | 5.9M | 6.8M | 7.1M | $32M |
| BlackRock, Inc. | 3.3M | 3.1M | 3.0M | 3.3M | 3.7M | 3.8M | $17M |
| MILLENNIUM MANAGEMENT LLC | 255K | 673K | 3.7M | 4.9M | 5.2M | 3.6M | $16M |
| AIGH Capital Management LLC | — | — | — | 1.0M | 2.0M | 3.0M | $14M |
| Driehaus Capital Management LLC | 1.3M | 356K | 535K | 535K | 535K | 2.9M | $13M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 2.9M | $13M |
| DAFNA Capital Management LLC | 371K | 371K | 371K | 1.0M | 939K | 2.0M | $9M |
| GOLDMAN SACHS GROUP INC | 4.2M | 2.7M | 132K | 1.6M | 1.3M | 1.6M | $7M |
| RTW INVESTMENTS, LP | — | — | — | 3.1M | 3.1M | 1.5M | $7M |
| Deep Track Capital, LP | — | — | — | — | — | 1.5M | $7M |
| Woodline Partners LP | 623K | 623K | 623K | 1.6M | 801K | 1.4M | $6M |
| GEODE CAPITAL MANAGEMENT, LLC | 886K | 908K | 904K | 1.0M | 1.1M | 1.1M | $5M |
| Soleus Capital Management, L.P. | — | — | — | — | — | 1.1M | $5M |
| Point72 Asset Management, L.P. | — | — | — | 1.2M | 1.5M | 1.0M | $5M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Item 4 of the Schedule 13D is hereby amended by adding the following: Each Fund acquired its February 2026 Shares for investment purposes in an underwritten offering conducted by the Company (the "February 2026 Offering") pursuant to the Prospectus Supplement, dated as of February 25, 2026, to the Issuer's Prospectus, dated as of May 24, 2024 (the "February 2026 Offering").”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | +5,000,000 | $23M | ADD |
| VANGUARD CAPITAL MANAGEMENT LLC | +2,866,349 | $13M | OPEN |
| Driehaus Capital Management LLC | +2,398,935 | $11M | ADD |
| Deep Track Capital, LP | +1,500,000 | $7M | OPEN |
| DAFNA Capital Management LLC | +1,090,000 | $5M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −3,046,216 | $14M | CLOSE |
| RTW INVESTMENTS, LP | −1,625,000 | $7M | TRIM |
| MILLENNIUM MANAGEMENT LLC | −1,581,086 | $7M | TRIM |
| CITADEL ADVISORS LLC | −847,618 | $4M | TRIM |
| Verition Fund Management LLC | −567,683 | $3M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 162 | 87,757,046 | 84.5% | $395M |
| 2025-Q4 | 136 | 72,706,187 | 84.9% | $277M |
| 2025-Q3 | 136 | 85,523,462 | 99.9% | $275M |
| 2025-Q2 | 116 | 62,410,423 | 97.5% | $180M |
| 2025-Q1 | 103 | 60,839,563 | 95.0% | $132M |
| 2024-Q4 | 116 | 63,434,788 | 99.4% | $245M |
| 2024-Q3 | 123 | 64,350,902 | 100.9% | $421M |
| 2024-Q2 | 106 | 65,334,831 | 102.4% | $474M |
| 2024-Q1 | 104 | 63,827,809 | 100.0% | $484M |
| 2023-Q4 | 69 | 39,573,225 | 90.1% | $180M |
| 2023-Q3 | 65 | 38,745,880 | 89.5% | $153M |
| 2023-Q2 | 65 | 39,027,692 | 90.2% | $120M |
| 2023-Q1 | 68 | 38,431,710 | 88.8% | $174M |
| 2022-Q4 | 48 | 38,767,079 | 89.6% | $160M |
| 2022-Q3 | 59 | 40,907,922 | — | $131M |
| 2022-Q2 | 40 | 14,393,224 | 81.3% | $28M |
| 2022-Q1 | 45 | 15,257,801 | 86.2% | $62M |
| 2021-Q4 | 49 | 14,666,747 | 82.8% | $158M |
| 2021-Q3 | 54 | 14,519,562 | 82.0% | $167M |
| 2021-Q2 | 45 | 14,544,160 | 94.6% | $143M |
| 2021-Q1 | 57 | 14,110,546 | 91.8% | $206M |
| 2020-Q4 | 43 | 14,252,367 | 92.8% | $305M |
| 2020-Q3 | 38 | 13,625,034 | 88.7% | $207M |
| 2020-Q2 | 37 | 12,953,274 | — | $166M |
| BlackRock, Inc. | 4.8% | QII | 2025-03-31 | SEC → |
| GOLDMAN SACHS GROUP INC | 4.1% | QII | 2025-03-31 | SEC → |
| MILLENNIUM MANAGEMENT LLC | 3.5% | Passive | 2026-03-31 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
