| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | GordonMD Global Investments LP | 4,244,8184.2M | $37M | 6.98% | TRIM -3% |
| 2 | GILEAD SCIENCES, INC. | 4,126,1194.1M | $36M | 6.79% | — |
| 3 | Bain Capital Life Sciences Investors, LLC | 3,110,0003.1M | $27M | 5.12% | — |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,000,0002.0M | $17M | 3.29% | — |
| 5 | AIGH Capital Management LLC | 2,000,0002.0M | $17M | 3.29% | ADD 33% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1,783,3421.8M | $15M | 2.93% | NEW† |
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,555,2871.6M | $13M | 2.56% | TRIM -12% |
| 8 | Balyasny Asset Management L.P. | 1,125,3211.1M | $10M | 1.85% | ADD 15% |
| 9 | MILLENNIUM MANAGEMENT LLC | 1,005,5081.0M | $9M | 1.65% | ADD 69% |
| 10 | Insight Holdings Group, LLC | 989,054989,054 | $9M | 1.63% | — |
| 11 | MORGAN STANLEY | 977,289977,289 | $8M | 1.61% | TRIM -3% |
| 12 | BlackRock, Inc. | 877,078877,078 | $8M | 1.44% | ADD 61% |
| 13 | Woodline Partners LP | 845,325845,325 | $7M | 1.39% | — |
| 14 | D. E. Shaw & Co., Inc. | 721,581721,581 | $6M | 1.19% | ADD 39% |
| 15 | Propel Bio Management, LLC | 644,421644,421 | $6M | 1.06% | TRIM -3% |
| 16 | MBB PUBLIC MARKETS I LLC | 614,477614,477 | $5M | 1.01% | — |
| 17 | MARSHALL WACE, LLP | 605,512605,512 | $5M | 1.00% | ADD 347% |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 577,600577,600 | $5M | 0.95% | ADD 142% |
| 19 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000500,000 | $4M | 0.82% | TRIM -70% |
| 20 | UBS Group AG | 449,750449,750 | $4M | 0.74% | ADD 122% |
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 423,826423,826 | $4M | 0.70% | ADD 59% |
| 22 | BNP PARIBAS FINANCIAL MARKETS | 412,032412,032 | $4M | 0.68% | ADD 63% |
| 23 | RENAISSANCE TECHNOLOGIES LLC | 367,492367,492 | $3M | 0.60% | ADD 107% |
| 24 | Qube Research & Technologies Ltd | 333,692333,692 | $3M | 0.55% | ADD 425% |
| 25 | VANGUARD FIDUCIARY TRUST CO | 224,584224,584 | $2M | 0.37% | NEW |
| 26 | Point72 Asset Management, L.P. | 222,929222,929 | $2M | 0.37% | ADD 593% |
| 27 | GOLDMAN SACHS GROUP INC | 212,910212,910 | $2M | 0.35% | ADD 59% |
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 211,088211,088 | $2M | 0.35% | ADD 68% |
| 29 | Burkehill Global Management, LP | 200,000200,000 | $2M | 0.33% | — |
| 30 | Invesco Ltd. | 186,674186,674 | $2M | 0.31% | NEW |
| 31 | TWO SIGMA INVESTMENTS, LP | 181,615181,615 | $2M | 0.30% | TRIM -12% |
| 32 | Simplify Asset Management Inc. | 173,106173,106 | $1M | 0.28% | TRIM -10% |
| 33 | TD Asset Management Inc | 169,082169,082 | $1M | 0.28% | TRIM -24% |
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 149,900149,900 | $1M | 0.25% | TRIM -14% |
| 35 | Squarepoint Ops LLC | 146,978146,978 | $1M | 0.24% | ADD 6% |
| 36 | STATE STREET CORP | 138,300138,300 | $1M | 0.23% | ADD 51% |
| 37 | BARCLAYS PLC | 136,375136,375 | $1M | 0.22% | TRIM -17% |
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,530134,530 | $1M | 0.22% | — |
| 39 | STIFEL FINANCIAL CORP | 130,524130,524 | $1M | 0.21% | ADD 4% |
| 40 | Y-Intercept (Hong Kong) Ltd | 114,841114,841 | $991,078 | 0.19% | NEW |
| 41 | WELLS FARGO & COMPANY/MN | 114,399114,399 | $987,263 | 0.19% | ADD 53% |
| 42 | WESBANCO BANK INC | 110,300110,300 | $951,889 | 0.18% | NEW |
| 43 | Kera Capital Partners, Inc. | 108,083108,083 | $932,756 | 0.18% | TRIM -18% |
| 44 | JANE STREET GROUP, LLC | 104,214104,214 | $899,367 | 0.17% | TRIM -43% |
| 45 | 683 Capital Management, LLC | 85,00085,000 | $733,550 | 0.14% | TRIM -26% |
| 46 | DIMENSIONAL FUND ADVISORS LP | 78,41978,419 | $676,756 | 0.13% | — |
| 47 | NORTHERN TRUST CORP | 78,04278,042 | $673,502 | 0.13% | ADD 51% |
| 48 | Hudson Bay Capital Management LP | 71,05971,059 | $613,239 | 0.12% | TRIM -20% |
| 49 | CITADEL ADVISORS LLC | 58,12658,126 | $501,627 | 0.10% | TRIM -79% |
| 50 | BANK OF AMERICA CORP /DE/ | 55,72855,728 | $480,933 | 0.09% | ADD 94% |
| 51 | Man Group plc | 53,54353,543 | $462,076 | 0.09% | NEW |
| 52 | AMERICAN CENTURY COMPANIES INC | 53,23553,235 | $459,418 | 0.09% | ADD 15% |
| 53 | Jump Financial, LLC | 52,76252,762 | $455,336 | 0.09% | TRIM -34% |
| 54 | NANO CAP NEW MILLENNIUM GROWTH FUND L P | 52,00052,000 | $448,760 | 0.09% | TRIM -3% |
| 55 | ExodusPoint Capital Management, LP | 49,01149,011 | $422,965 | 0.08% | NEW |
| 56 | VOYA INVESTMENT MANAGEMENT LLC | 44,04544,045 | $380,108 | 0.07% | TRIM -35% |
| 57 | CITIGROUP INC | 42,26042,260 | $364,704 | 0.07% | ADD 244% |
| 58 | Peapod Lane Capital LLC | 40,40440,404 | $336,470 | 0.07% | TRIM -78% |
| 59 | Quadrature Capital Ltd | 38,41138,411 | $331,487 | 0.06% | TRIM -33% |
| 60 | Walleye Capital LLC | 38,19638,196 | $329,631 | 0.06% | NEW |
| 61 | Banque Cantonale Vaudoise | 30,53230,532 | $263,000 | 0.05% | NEW |
| 62 | ACT CAPITAL MANAGEMENT, LLC | 30,00030,000 | $258,900 | 0.05% | ADD 20% |
| 63 | Susquehanna Portfolio Strategies, LLC | 27,84627,846 | $240,311 | 0.05% | NEW |
| 64 | MANGROVE PARTNERS IM, LLC | 27,01427,014 | $233,131 | 0.04% | NEW |
| 65 | Jefferies Financial Group Inc. | 23,92023,920 | $206,430 | 0.04% | TRIM -25% |
| 66 | ADAR1 Capital Management, LLC | 22,42822,428 | $193,554 | 0.04% | TRIM -61% |
| 67 | FEDERATED HERMES, INC. | 20,70520,705 | $178,684 | 0.03% | — |
| 68 | Schonfeld Strategic Advisors LLC | 20,15420,154 | $173,927 | 0.03% | TRIM -30% |
| 69 | Phoenix Wealth Advisors | 19,80019,800 | $170,874 | 0.03% | ADD 61% |
| 70 | CAXTON CORP | 18,77318,773 | $162,012 | 0.03% | — |
| 71 | Vanguard Personalized Indexing Management, LLC | 18,74718,747 | $161,787 | 0.03% | — |
| 72 | JACOBS LEVY EQUITY MANAGEMENT, INC | 16,59916,599 | $143,249 | 0.03% | TRIM -85% |
| 73 | GSA CAPITAL PARTNERS LLP | 16,16116,161 | $139,000 | 0.03% | NEW |
| 74 | RAYMOND JAMES FINANCIAL INC | 16,08216,082 | $138,788 | 0.03% | TRIM -36% |
| 75 | Diametric Capital, LP | 16,06716,067 | $138,658 | 0.03% | NEW |
| 76 | Vanguard Global Advisers, LLC | 14,98914,989 | $129,355 | 0.02% | NEW |
| 77 | OMERS ADMINISTRATION Corp | 14,80014,800 | $127,724 | 0.02% | TRIM -57% |
| 78 | CANADA PENSION PLAN INVESTMENT BOARD | 13,90013,900 | $119,957 | 0.02% | NEW |
| 79 | Graham Capital Management, L.P. | 11,96511,965 | $103,258 | 0.02% | NEW |
| 80 | Ethic Inc. | 11,92811,928 | $102,939 | 0.02% | TRIM -5% |
| 81 | China Universal Asset Management Co., Ltd. | 10,13810,138 | $87,491 | 0.02% | ADD 42% |
| 82 | CAPITAL ADVISORS INC/OK | 10,00010,000 | $86,300 | 0.02% | — |
| 83 | Grey Ledge Advisors, LLC | 10,00010,000 | $86,300 | 0.02% | NEW |
| 84 | FOX RUN MANAGEMENT, L.L.C. | 11,08911,089 | $84,055 | 0.02% | NEW |
| 85 | FMR LLC | 6,8116,811 | $58,782 | 0.01% | TRIM -2% |
| 86 | JPMORGAN CHASE & CO | 4,6754,675 | $35,437 | 0.01% | ADD 9% |
| 87 | SIMPLEX TRADING, LLC | 3,9983,998 | $34,502 | 0.01% | NEW |
| 88 | DEUTSCHE BANK AG\ | 3,9173,917 | $33,804 | 0.01% | — |
| 89 | Tower Research Capital LLC (TRC) | 3,1283,128 | $26,994 | 0.01% | TRIM -38% |
| 90 | Mirae Asset Global Investments Co., Ltd. | 2,9802,980 | $25,717 | 0.00% | ADD 40% |
| 91 | ROYAL BANK OF CANADA | 2,5482,548 | $23,000 | 0.00% | TRIM -22% |
| 92 | Caitong International Asset Management Co., Ltd | 2,1242,124 | $18,330 | 0.00% | NEW |
| 93 | Zurcher Kantonalbank (Zurich Cantonalbank) | 1,6291,629 | $14,058 | 0.00% | NEW |
| 94 | PNC FINANCIAL SERVICES GROUP, INC. | 1,5301,530 | $13,205 | 0.00% | TRIM -8% |
| 95 | Russell Investments Group, Ltd. | 1,3131,313 | $11,331 | 0.00% | — |
| 96 | GF FUND MANAGEMENT CO. LTD. | 977977 | $8,432 | 0.00% | ADD 14% |
| 97 | Quantbot Technologies LP | 822822 | $7,094 | 0.00% | NEW |
| 98 | OSAIC HOLDINGS, INC. | 725725 | $6,256 | 0.00% | TRIM -78% |
| 99 | Accent Capital Management, LLC | 545545 | $4,703 | 0.00% | NEW |
| 100 | NATIONAL BANK OF CANADA /FI/ | 400400 | $3,452 | 0.00% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| GordonMD Global Investments LP | — | — | — | — | 4.4M | 4.2M | $37M |
| GILEAD SCIENCES, INC. | 4.1M | 4.1M | 4.1M | 4.1M | 4.1M | 4.1M | $36M |
| Bain Capital Life Sciences Investors, LLC | 3.4M | 3.4M | 3.4M | 3.4M | 3.1M | 3.1M | $27M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | — | — | — | — | 2.0M | 2.0M | $17M |
| AIGH Capital Management LLC | — | — | — | — | 1.5M | 2.0M | $17M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.8M | $15M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 594K | 580K | 1.8M | 1.5M | 1.8M | 1.6M | $13M |
| Balyasny Asset Management L.P. | — | — | — | — | 981K | 1.1M | $10M |
| MILLENNIUM MANAGEMENT LLC | 747K | 238K | 453K | 552K | 593K | 1.0M | $9M |
| Insight Holdings Group, LLC | 913K | 989K | 989K | 989K | 989K | 989K | $9M |
| MORGAN STANLEY | 201K | 135K | 202K | 174K | 1.0M | 977K | $8M |
| BlackRock, Inc. | 1.7M | 1.7M | 533K | 482K | 545K | 877K | $8M |
| Woodline Partners LP | — | — | — | 252K | 845K | 845K | $7M |
| D. E. Shaw & Co., Inc. | — | — | — | — | 519K | 722K | $6M |
| Propel Bio Management, LLC | — | — | — | — | 667K | 644K | $6M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 111 | 34,823,533 | 57.3% | $301M |
| 2025-Q4 | 99 | 34,131,802 | 56.1% | $321M |
| 2025-Q3 | 75 | 22,703,109 | 37.3% | $136M |
| 2025-Q2 | 79 | 23,208,767 | 38.2% | $71M |
| 2025-Q1 | 87 | 25,808,424 | 42.5% | $50M |
| 2024-Q4 | 88 | 28,870,900 | 47.5% | $108M |
| 2024-Q3 | 94 | 30,531,779 | 50.2% | $150M |
| 2024-Q2 | 88 | 34,004,168 | 55.9% | $255M |
| 2024-Q1 | 90 | 31,780,760 | 52.3% | $789M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
