| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Velan Capital Investment Management LP | 2,668,3952.7M | $2M | 9.53% | — |
| 2 | MILLENNIUM MANAGEMENT LLC | 1,617,5311.6M | $1M | 5.78% | ADD 51% |
| 3 | ACORN CAPITAL ADVISORS, LLC | 1,411,4921.4M | $1M | 5.04% | TRIM -21% |
| 4 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,352,1061.4M | $1M | 4.83% | NEW† |
| 5 | MORGAN STANLEY | 1,333,4201.3M | $1M | 4.76% | TRIM -32% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1,172,5971.2M | $1M | 4.19% | NEW† |
| 7 | Rock Springs Capital Management LP | 1,100,7261.1M | $964,456 | 3.93% | — |
| 8 | Carlyle Group Inc. | 1,066,1891.1M | $934,195 | 3.81% | — |
| 9 | BOOTHBAY FUND MANAGEMENT, LLC | 582,751582,751 | $510,606 | 2.08% | TRIM -27% |
| 10 | Lion Point Capital, LP | 465,000465,000 | $407,433 | 1.66% | — |
| 11 | JACOBS LEVY EQUITY MANAGEMENT, INC | 322,273322,273 | $282,376 | 1.15% | ADD 488% |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 317,677317,677 | $278,394 | 1.13% | ADD 50% |
| 13 | BANK OF AMERICA CORP /DE/ | 293,259293,259 | $256,895 | 1.05% | — |
| 14 | Soleus Capital Management, L.P. | 276,312276,312 | $242,105 | 0.99% | ADD 38% |
| 15 | BlackRock, Inc. | 242,061242,061 | $212,093 | 0.86% | ADD 2% |
| 16 | RENAISSANCE TECHNOLOGIES LLC | 177,500177,500 | $155,526 | 0.63% | TRIM -22% |
| 17 | Knott David M Jr | 160,789160,789 | $140,883 | 0.57% | TRIM -11% |
| 18 | VANGUARD FIDUCIARY TRUST CO | 149,943149,943 | $131,350 | 0.54% | NEW |
| 19 | ADAR1 Capital Management, LLC | 140,000140,000 | $122,668 | 0.50% | — |
| 20 | Quarry LP | 131,529131,529 | $115,246 | 0.47% | ADD 32% |
| 21 | UBS Group AG | 81,11781,117 | $71,058 | 0.29% | TRIM -36% |
| 22 | Verdad Advisers, LP | 73,96773,967 | $64,810 | 0.26% | NEW |
| 23 | Squarepoint Ops LLC | 64,91564,915 | $56,879 | 0.23% | TRIM -77% |
| 24 | IEQ CAPITAL, LLC | 51,42851,428 | $45,061 | 0.18% | — |
| 25 | MARSHALL WACE, LLP | 45,65645,656 | $40,177 | 0.16% | NEW |
| 26 | STATE STREET CORP | 44,69944,699 | $39,165 | 0.16% | — |
| 27 | NINE MASTS CAPITAL Ltd | 44,16544,165 | $38,697 | 0.16% | NEW |
| 28 | OSAIC HOLDINGS, INC. | 40,85040,850 | $35,793 | 0.15% | — |
| 29 | XTX Topco Ltd | 39,43139,431 | $34,549 | 0.14% | NEW |
| 30 | DIKER MANAGEMENT LLC | 35,00035,000 | $30,667 | 0.13% | NEW |
| 31 | NORTHERN TRUST CORP | 34,57634,576 | $30,295 | 0.12% | — |
| 32 | SIMPLEX TRADING, LLC | 29,27329,273 | $25,643 | 0.10% | NEW |
| 33 | READYSTATE ASSET MANAGEMENT LP | 27,49927,499 | $24,095 | 0.10% | TRIM -72% |
| 34 | Engineers Gate Manager LP | 26,13126,131 | $22,896 | 0.09% | ADD 83% |
| 35 | Ikarian Capital, LLC | 24,09324,093 | $21,110 | 0.09% | — |
| 36 | PANAGORA ASSET MANAGEMENT INC | 21,54321,543 | $18,876 | 0.08% | ADD 11% |
| 37 | JANE STREET GROUP, LLC | 21,41521,415 | $18,764 | 0.08% | ADD 107% |
| 38 | GSA CAPITAL PARTNERS LLP | 19,08419,084 | $17,000 | 0.07% | TRIM -75% |
| 39 | DIMENSIONAL FUND ADVISORS LP | 18,66418,664 | $16,354 | 0.07% | — |
| 40 | Jain Global LLC | 18,02218,022 | $15,791 | 0.06% | TRIM -58% |
| 41 | Rehmann Capital Advisory Group | 15,30015,300 | $13,405 | 0.05% | NEW |
| 42 | Sequent Planning LLC | 14,90014,900 | $13,055 | 0.05% | ADD 19% |
| 43 | LPL Financial LLC | 12,25012,250 | $10,733 | 0.04% | NEW |
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,14911,149 | $9,769 | 0.04% | TRIM -89% |
| 45 | Tower Research Capital LLC (TRC) | 6,3056,305 | $5,524 | 0.02% | ADD 453% |
| 46 | Vanguard Global Advisers, LLC | 3,9723,972 | $3,479 | 0.01% | NEW |
| 47 | FEDERATED HERMES, INC. | 3,8683,868 | $3,389 | 0.01% | TRIM -22% |
| 48 | GROUP ONE TRADING LLC | 885885 | $775 | 0.00% | ADD 12% |
| 49 | US BANCORP \DE\ | 500500 | $438 | 0.00% | — |
| 50 | WELLS FARGO & COMPANY/MN | 500500 | $438 | 0.00% | TRIM -62% |
| 51 | NATIONAL BANK OF CANADA /FI/ | 160160 | $139 | 0.00% | — |
| 52 | BNP PARIBAS FINANCIAL MARKETS | 141141 | $124 | 0.00% | — |
| 53 | SBI Securities Co., Ltd. | 6565 | $57 | 0.00% | — |
| 54 | JONES FINANCIAL COMPANIES LLLP | 5050 | $53 | 0.00% | — |
| 55 | JPMORGAN CHASE & CO | 99 | $8 | 0.00% | — |
| 56 | Optiver Holding B.V. | 77 | $6 | 0.00% | — |
| 57 | Caitong International Asset Management Co., Ltd | 11 | $1 | 0.00% | NEW |
| 58 | ROYAL BANK OF CANADA | 120120 | $0 | 0.00% | ADD 60% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Velan Capital Investment Management LP | 1.4M | 1.4M | 1.4M | 2.7M | 2.7M | 2.7M | $2M |
| MILLENNIUM MANAGEMENT LLC | — | 26K | 145K | 365K | 1.1M | 1.6M | $1M |
| ACORN CAPITAL ADVISORS, LLC | — | — | — | 1.4M | 1.8M | 1.4M | $1M |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 447K | 490K | 685K | 1.3M | — | 1.4M | $1M |
| MORGAN STANLEY | 605K | 654K | 770K | 790K | 2.0M | 1.3M | $1M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.2M | $1M |
| Rock Springs Capital Management LP | 463K | 545K | 545K | 1.1M | 1.1M | 1.1M | $964,456 |
| Carlyle Group Inc. | 1.1M | 1.1M | 1.1M | 1.1M | 1.1M | 1.1M | $934,195 |
| BOOTHBAY FUND MANAGEMENT, LLC | 14K | — | — | 443K | 794K | 583K | $510,606 |
| Lion Point Capital, LP | 32K | 147K | 147K | 399K | 465K | 465K | $407,433 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | — | — | — | — | 55K | 322K | $282,376 |
| GEODE CAPITAL MANAGEMENT, LLC | 258K | 264K | 131K | 131K | 212K | 318K | $278,394 |
| BANK OF AMERICA CORP /DE/ | 287K | 361K | 293K | 295K | 293K | 293K | $256,895 |
| Soleus Capital Management, L.P. | 1.5M | 1.5M | 1.5M | 1.5M | 200K | 276K | $242,105 |
| BlackRock, Inc. | 808K | 788K | 226K | 205K | 236K | 242K | $212,093 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 58 | 15,813,260 | 56.5% | $14M |
| 2025-Q4 | 55 | 19,606,545 | 70.1% | $36M |
| 2025-Q3 | 60 | 20,155,837 | — | $48M |
| 2025-Q2 | 65 | 12,532,334 | 83.4% | $70M |
| 2025-Q1 | 69 | 13,047,750 | 86.9% | $56M |
| 2024-Q4 | 88 | 15,654,471 | 104.2% | $335M |
| 2024-Q3 | 81 | 14,701,379 | — | $275M |
| 2024-Q2 | 69 | 14,570,885 | — | $330M |
| 2024-Q1 | 61 |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Item 4 is hereby amended to add the following: On July 16, 2026, the Issuer acquired Kira Pharmaceuticals ("Kira"), a Cayman Islands exempted company, in accordance with the terms of the Agreement and Plan of Merger, dated July 16, 2026 (the "Merger Agreement"), by and among the Issuer, Kira and Kira Holdco Inc., a Delaware corporation and a wholly owned subsidiary of the Issuer ("Merger Sub"). Pursuant to the Merger Agreement, Kira merged with and into Merger Sub, with Merger Sub continuing as ”
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| INTEGRATED CORE STRATEGIES (US) LLC | 1.7% | Passive | 2026-06-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| 13,381,717 |
| — |
| $391M |
| 2023-Q4 | 1 | 494,706 | 0.4% | $390,323 |
