Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-06-11 | Barrett Ronald W | Director | +Grant | 5,500 | — | — |
| 2026-06-11 | CAPPS VICKIE L | Director | +Grant | 5,500 | — | — |
| 2026-06-11 | DOBMEIER ERIC | Director | +Grant | 5,500 | — | — |
| 2026-06-11 | Hernday Natasha | Director | +Grant | 5,500 | — | — |
| 2026-06-11 | Kung Winston | Director | +Grant | 5,500 | — | — |
| 2026-06-11 | Simson Jake | Director | +Grant | 5,500 | — | — |
| 2026-06-11 | RA Capital Nexus Fund II, L.P. | Director | +Grant | 5,500 | — | — |
| 2026-06-02 | Doyle Janeen Noel | Officer | −Sell | 4,059 | $14.03 | $56,948 |
| 2026-05-11 | Dobek Maria | Officer | −Sell | 2,038 | $14.17 | $28,878 |
| 2026-02-02 | Go William | Officer | +Grant | 44,000 | — | — |
| 2026-01-02 | Dobek Maria | Officer | −Sell | 1,462 | $13.73 | $20,073 |
| 2026-01-02 | Dobek Maria | Officer | +Grant | 18,935 | — | — |
| 2026-01-02 | Doyle Janeen Noel | Officer | +Grant | 36,000 | — | — |
| 2026-01-02 | McIver Zachariah | Officer | −Sell | 2,714 | $13.73 | $37,263 |
| 2026-01-02 | McIver Zachariah | Officer | +Grant | 29,000 | — | — |
| 2026-01-02 | Winter Charles M. | Officer | −Sell | 2,401 | $13.73 | $32,966 |
| 2026-01-02 | Winter Charles M. | Officer | +Grant | 28,600 | — | — |
| 2026-01-02 | Campbell David Alan | Director,Officer | −Sell | 8,072 | $13.73 | $110,829 |
| 2026-01-02 | Campbell David Alan | Director,Officer | +Grant | 96,600 | — | — |
| 2026-01-02 | DiRaimondo Thomas | Officer | +Grant | 31,400 | — | — |
| 2026-01-02 | DiRaimondo Thomas | Officer | −Sell | 2,505 | $13.73 | $34,394 |
| 2026-01-02 | Meyer Andrew Hollman | Officer | −Sell | 1,879 | $13.73 | $25,799 |
| 2025-12-01 | Meyer Andrew Hollman | Officer | +Exercise | 3,333 | $10.59 | $35,296 |
| 2025-12-01 | Meyer Andrew Hollman | Officer | −Sell | 2,700 | $32.85 | $88,695 |
| 2025-12-01 | Meyer Andrew Hollman | Officer | −Sell | 633 | $33.52 | $21,218 |
| 2025-11-14 | Meyer Andrew Hollman | Officer | +Exercise | 3,333 | $10.59 | $35,296 |
| 2025-11-14 | Meyer Andrew Hollman | Officer | −Sell | 3,333 | $30.00 | $99,990 |
| 2025-10-28 | Meyer Andrew Hollman | Officer | +Exercise | 6,666 | $10.59 | $70,593 |
| 2025-10-28 | Meyer Andrew Hollman | Officer | +Exercise | 9,999 | $4.21 | $42,096 |
| 2025-10-28 | Meyer Andrew Hollman | Officer | −Sell | 16,665 | $30.06 | $500,950 |
| 2025-06-11 | Kung Winston | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | Simson Jake | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | McNulty Alana B. | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | Hernday Natasha | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | Gujrathi Sheila | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | DOBMEIER ERIC | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | CAPPS VICKIE L | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | Barrett Ronald W | Director | +Grant | 3,750 | — | — |
| 2025-06-11 | RA Capital Healthcare Fund LP | Director,TenPercentOwner | +Grant | 3,750 | — | — |
| 2025-06-02 | Doyle Janeen Noel | Officer | +Grant | 44,000 | — | — |
| 2025-05-01 | Meyer Andrew Hollman | Officer | +Exercise | 3,333 | $4.21 | $14,032 |
| 2025-05-01 | Meyer Andrew Hollman | Officer | −Sell | 2,933 | $31.95 | $93,709 |
| 2025-05-01 | Meyer Andrew Hollman | Officer | −Sell | 400 | $32.60 | $13,040 |
| 2025-04-21 | Meyer Andrew Hollman | Officer | +Exercise | 3,334 | $4.21 | $14,036 |
| 2025-04-21 | Meyer Andrew Hollman | Officer | −Sell | 3,334 | $30.00 | $100,020 |
| 2025-03-07 | RA Capital Healthcare Fund LP | Director,TenPercentOwner | +Buy | 110,206 | $31.02 | $3M |
| 2025-03-06 | RA Capital Healthcare Fund LP | Director,TenPercentOwner | +Buy | 372,093 | $30.78 | $11M |
| 2025-03-05 | RA Capital Healthcare Fund LP | Director,TenPercentOwner | +Buy | 37,455 | $31.30 | $1M |
| 2025-03-05 | RA Capital Healthcare Fund LP | Director,TenPercentOwner | +Buy | 304,287 | $30.56 | $9M |
| 2025-03-03 | Meyer Andrew Hollman | Officer | −Sell | 2,433 | $31.88 | $77,564 |
| 2025-03-03 | Meyer Andrew Hollman | Officer | −Sell | 901 | $32.85 | $29,598 |
| 2025-03-03 | Meyer Andrew Hollman | Officer | +Exercise | 3,334 | $4.21 | $14,036 |
| 2025-02-03 | Meyer Andrew Hollman | Officer | +Exercise | 3,334 | $4.21 | $14,036 |
| 2025-02-03 | Meyer Andrew Hollman | Officer | −Sell | 2,418 | $42.08 | $101,749 |
| 2025-02-03 | Meyer Andrew Hollman | Officer | −Sell | 816 | $42.77 | $34,900 |
| 2025-02-03 | Meyer Andrew Hollman | Officer | −Sell | 100 | $43.60 | $4,360 |
| 2025-01-07 | Campbell David Alan | Director,Officer | −Sell | 5,000 | $60.00 | $300,000 |
| 2025-01-02 | Meyer Andrew Hollman | Officer | −Sell | 200 | $57.37 | $11,474 |
| 2025-01-02 | Meyer Andrew Hollman | Officer | −Sell | 3,444 | $55.76 | $192,037 |
| 2025-01-02 | Meyer Andrew Hollman | Officer | −Sell | 1,000 | $56.78 | $56,780 |
| 2025-01-02 | Meyer Andrew Hollman | Officer | +Grant | 18,000 | — | — |
| 2025-01-02 | Meyer Andrew Hollman | Officer | −Sell | 2,922 | $53.76 | $157,087 |
| 2025-01-02 | Meyer Andrew Hollman | Officer | −Sell | 5,768 | $54.51 | $314,414 |
| 2025-01-02 | Dobek Maria | Officer | +Grant | 14,000 | — | — |
| 2025-01-02 | DiRaimondo Thomas | Officer | +Grant | 24,000 | — | — |
| 2025-01-02 | Robinson Byron | Officer | +Grant | 28,000 | — | — |
| 2025-01-02 | Campbell David Alan | Director,Officer | +Grant | 81,000 | — | — |
| 2025-01-02 | Winter Charles M. | Officer | +Grant | 23,000 | — | — |
| 2025-01-02 | McIver Zachariah | Officer | +Grant | 26,000 | — | — |
| 2024-12-24 | Campbell David Alan | Director,Officer | −Sell | 25,000 | $56.19 | $1M |
| 2024-12-19 | Meyer Andrew Hollman | Officer | +Exercise | 9,880 | $20.24 | $199,971 |
| 2024-12-19 | Meyer Andrew Hollman | Officer | +Exercise | 1 | $14.02 | $14 |
| 2024-12-03 | Campbell David Alan | Director,Officer | −Sell | 15,000 | $67.00 | $1M |
| 2024-11-25 | Campbell David Alan | Director,Officer | −Sell | 18,281 | $51.43 | $940,192 |
| 2024-11-25 | Campbell David Alan | Director,Officer | −Sell | 6,719 | $52.04 | $349,657 |
| 2024-11-05 | CAPPS VICKIE L | Director | +Other | 2,305 | — | — |
| 2024-11-05 | Gujrathi Sheila | Director | +Other | 4,611 | — | — |
| 2024-10-28 | Campbell David Alan | Director,Officer | −Sell | 11,103 | $53.94 | $598,896 |
| 2024-10-28 | Campbell David Alan | Director,Officer | −Sell | 13,897 | $53.22 | $739,598 |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 102,732 | $50.30 | $5M |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 19,900 | $50.30 | $1M |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 104,892 | $50.30 | $5M |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 15,462 | $51.18 | $791,345 |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 2,995 | $51.18 | $153,284 |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 15,788 | $51.18 | $808,030 |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 104,957 | $44.75 | $5M |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 553,219 | $44.75 | $25M |
| 2024-10-18 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 541,824 | $44.75 | $24M |
| 2024-10-18 | Kolchinsky Peter | Director,TenPercentOwner | +Buy | 1,200,000 | $44.75 | $54M |
| 2024-10-17 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 1,843 | $50.02 | $92,187 |
| 2024-10-17 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 237 | $39.80 | $9,433 |
| 2024-10-17 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 836 | $17.00 | $14,212 |
| 2024-10-17 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 348 | $10.73 | $3,734 |
| 2024-10-17 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 348 | $13.22 | $4,601 |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 60,179 | $49.69 | $3M |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 11,657 | $49.69 | $579,236 |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 61,445 | $49.69 | $3M |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 29,474 | $50.61 | $1M |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 5,710 | $50.61 | $288,983 |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 30,094 | $50.61 | $2M |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 4,968 | $17.00 | $84,456 |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 2,070 | $10.73 | $22,211 |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 2,070 | $13.22 | $27,365 |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | +Exercise | 1,407 | $39.80 | $55,999 |
| 2024-10-16 | Avalon BioVentures SPV I, L.P. | TenPercentOwner | −Sell | 10,957 | $50.80 | $556,616 |
| 2024-09-30 | Avalon BioVentures I, LP | TenPercentOwner | +Exercise | 434 | $17.00 | $7,378 |
| 2024-09-30 | Avalon BioVentures I, LP | TenPercentOwner | +Exercise | 181 | $10.73 | $1,942 |
| 2024-09-30 | Avalon BioVentures I, LP | TenPercentOwner | +Exercise | 181 | $13.22 | $2,393 |
| 2024-09-30 | Avalon BioVentures I, LP | TenPercentOwner | +Exercise | 123 | $39.80 | $4,895 |
| 2024-09-30 | Avalon BioVentures I, LP | TenPercentOwner | −Sell | 958 | $46.24 | $44,298 |
| 2024-09-27 | Campbell David Alan | Director,Officer | −Sell | 795 | $47.84 | $38,033 |
| 2024-09-27 | Campbell David Alan | Director,Officer | −Sell | 5,248 | $46.86 | $245,921 |
| 2024-09-27 | Campbell David Alan | Director,Officer | −Sell | 18,957 | $46.09 | $873,728 |
| 2024-09-27 | DiRaimondo Thomas | Officer | −Sell | 675 | $47.22 | $31,874 |
| 2024-09-27 | DiRaimondo Thomas | Officer | −Sell | 4,325 | $46.21 | $199,858 |
| 2024-09-27 | Meyer Andrew Hollman | Officer | +Exercise | 50,000 | $4.21 | $210,500 |
| 2024-09-27 | Meyer Andrew Hollman | Officer | −Sell | 50,000 | $45.96 | $2M |
| 2024-09-27 | Avalon BioVentures I, LP | TenPercentOwner | −Sell | 1,826 | $46.19 | $84,343 |
| 2024-09-27 | Avalon BioVentures I, LP | TenPercentOwner | +Exercise | 234 | $39.80 | $9,313 |
| 2024-09-27 | Avalon BioVentures I, LP | TenPercentOwner | +Exercise | 345 | $13.22 | $4,561 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
