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Clinical trials
catalyst calendar across sponsors →Studies where HTFL is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
3 interventional · 7 observational · 6 with posted results
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| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| Using CTA Measures to Define Cardiac Risk In NFL AlumniNCT06831409observationalParticipants with CAD | — | Recruiting | Diagnostic test: Coronary computed tomography angiography | Coronary Artery Disease (CAD), Heart Disease, Coronary Atherosclerosis | 300 | 2026-12-31 | in 134 d | 2025-08-26 |
| The NAVIGATE-PCI Registry: A New Approach to VIew CT-derived Guidance Ahead of Stenting To Plan Efficient PCINCT07479433observationalPrimary Endpoint | — | Recruiting | Diagnostic test: Heartflow PCI Navigator | Coronary Artery Disease (CAD) | 5,000 | 2026-09-30 | in 42 d | 2026-03-23 |
| AI DErived Plaque Quantification: CCTA and AI-QCPA for Determining Effective CAD ManagementNCT06376851observationalPrimary Endpoint | — | Active, not recruiting | Diagnostic test: AI-enabled quantitative coronary plaque analysis (AI-QCPA) | Coronary Artery Disease | 20,000 | 2026-03-27 | — | 2025-10-14 |
| Assessing Diagnostic Value of Non-invasive FFR-CT in Coronary Care in the Emergency DepartmentNCT05325112observationalReclassification rate between the coronary management plan based on the review of the CCTA alone compared to the coronary management plan based on the review of the CCTA and the FFR-CT analysis.Study Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Sponsor decision to terminate the study | Diagnostic test: FFR-CT | Coronary Artery Disease | 18 | 2022-11-14actual | — | 2026-05-22 |
| The REVEALPLAQUE Study: A pRospEctiVe, multicEnter Study to AnaLyze PLAQUE Using CCTANCT05138289results2025-01-29observationalComparison of Total Plaque VolumeStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Other: Total Plaque Volume | Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)) | 258 | 2022-11-08actual | — | 2025-08-22 |
| The PRECISE Protocol: Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and RevascularizationNCT03702244results2023-12-29Primary Composite (Number) of Deaths / MIs / Invasive Coronary Angiography Without Obstructive DiseaseRandomized · Open-label · OtherStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Diagnostic test: cCTA with selective FFRct | Coronary Artery Disease | 2,103 | 2022-05-20actual | — | 2023-12-29 |
| Assessing Diagnostic Value of Non-invasive FFRCT in Coronary CareNCT02499679results2025-07-30observationalPercentage of Participants With Reclassification of CAD Management, Assessed as the Therapeutic Recommendations Made Based on Review of Coronary CTA Alone Versus CTA + FFRCT, When Available, by a Central Integration Core Laboratory.Study Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Coronary Artery Disease | 4,737 | Feb 2019actual | — | 2025-07-30 |
| The PLATFORM Study: Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts)NCT01943903results2025-09-05observationalNumber of Participants With Negative Invasive Coronary Angiography | — | Completed | — | Coronary Artery Disease | 584 | Dec 2015actual | — | 2025-09-05 |
| HeartFlowNXT - HeartFlow Analysis of Coronary Blood Flow Using Coronary CT AngiographyNCT01757678results2017-11-14AUC of FFRct Versus Coronary CTA for Demonstration of Ischemia (≤0.80) on a Per-patient BasisDouble-masked · Diagnostic | Not applicable | Completed | Procedure: ICA (Invasive Coronary Angiography), FFR (Fractional Flow Reserve), cCTA (coronary computed tomography angiography) · Other: FFRct Analysis (Fractional Flow Reserve Computed Tomography) | Coronary Artery Disease | 276 | Sep 2013actual | — | 2017-11-14 |
| Determination of Fractional Flow Reserve by Anatomic Computed Tomographic AngiographyNCT01233518results2021-01-22Percentage of Participants With Diagnostic Accuracy of CCTA Plus FFRCT and CCTA AloneOpen-label · Diagnostic | Not applicable | Completed | Device: FFR | Coronary Artery Disease | 285 | Nov 2011actual | — | 2021-02-09 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19