| 1 | 1Redmile Group, LLC | 12,872,94612.9M | $15M | 11.04% | — |
| 2 | 2BlackRock, Inc. | 10,068,61410.1M | $12M | 8.64% | — |
| 3 | 3VANGUARD CAPITAL MANAGEMENT LLC | 4,192,0634.2M | $5M | 3.60% | NEW† |
| 4 | 4VANGUARD PORTFOLIO MANAGEMENT LLC | 4,134,5854.1M | $5M | 3.55% | NEW† |
| 5 | 5ACADIAN ASSET MANAGEMENT LLC | 4,120,2004.1M | $5M | 3.53% | ADD 41% |
| 6 | 6TWO SIGMA INVESTMENTS, LP | 3,466,7863.5M | $4M | 2.97% | ADD 100% |
| 7 | 7JOHNSON & JOHNSON | 3,379,0643.4M | $4M | 2.90% | — |
| 8 | 8AQR CAPITAL MANAGEMENT LLC | 3,001,5213.0M | $4M | 2.58% | ADD 158% |
| 9 | 9RENAISSANCE TECHNOLOGIES LLC | 2,974,6833.0M | $4M | 2.55% | ADD 26% |
| 10 | 10GEODE CAPITAL MANAGEMENT, LLC | 2,590,4292.6M | $3M | 2.22% | ADD 5% |
| 11 | 11STATE STREET CORP | 2,263,1732.3M | $3M | 1.94% | — |
| 12 | 12UBS Group AG | 1,821,7151.8M | $2M | 1.56% | ADD 351% |
| 13 | 13GOLDMAN SACHS GROUP INC | 1,327,7571.3M | $2M | 1.14% | TRIM -7% |
| 14 | 14TANG CAPITAL MANAGEMENT LLC | 1,167,7731.2M | $1M | 1.00% | — |
| 15 | 15CITADEL ADVISORS LLC | 942,926942,926 | $1M | 0.81% | ADD 26% |
| 16 | 16DIMENSIONAL FUND ADVISORS LP | 883,790883,790 | $1M | 0.76% | TRIM -44% |
| 17 | 17Irenic Capital Management LP | 878,055878,055 | $1M | 0.75% | NEW |
| 18 | 18NORTHERN TRUST CORP | 811,920811,920 | $974,305 | 0.70% | ADD 11% |
| 19 | 19Monaco Asset Management SAM | 810,000810,000 | $972,000 | 0.69% | TRIM -2% |
| 20 | 20Bruce & Co., Inc. | 789,188789,188 | $947,026 | 0.68% | ADD 8% |
| 21 | 21MORGAN STANLEY | 767,748767,748 | $921,298 | 0.66% | TRIM -16% |
| 22 | 22CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 756,273756,273 | $907,528 | 0.65% | TRIM -4% |
| 23 | 23VANGUARD FIDUCIARY TRUST CO | 653,761653,761 | $784,513 | 0.56% | NEW |
| 24 | 24JANE STREET GROUP, LLC | 646,979646,979 | $776,375 | 0.56% | TRIM -23% |
| 25 | 25DAFNA Capital Management LLC | 550,000550,000 | $660,000 | 0.47% | — |
| 26 | 26Connor, Clark & Lunn Investment Management Ltd. | 469,785469,785 | $563,742 | 0.40% | ADD 322% |
| 27 | 27Man Group plc | 430,073430,073 | $516,088 | 0.37% | ADD 65% |
| 28 | 28Privium Fund Management B.V. | 414,311414,311 | $497,173 | 0.36% | ADD 12% |
| 29 | 29XTX Topco Ltd | 389,169389,169 | $467,003 | 0.33% | ADD 7% |
| 30 | 30Invesco Ltd. | 375,886375,886 | $451,063 | 0.32% | — |
| 31 | 31Nuveen, LLC | 339,073339,073 | $406,888 | 0.29% | — |
| 32 | 32IEQ CAPITAL, LLC | 324,788324,788 | $389,746 | 0.28% | ADD 167% |
| 33 | 33Bank of New York Mellon Corp | 306,987306,987 | $368,384 | 0.26% | — |
| 34 | 34GSA CAPITAL PARTNERS LLP | 298,881298,881 | $359,000 | 0.26% | ADD 40% |
| 35 | 35SUSQUEHANNA INTERNATIONAL GROUP, LLP | 298,496298,496 | $358,195 | 0.26% | TRIM -4% |
| 36 | 36Woodline Partners LP | 238,650238,650 | $286,380 | 0.20% | TRIM -33% |
| 37 | 37Assenagon Asset Management S.A. | 190,252190,252 | $228,302 | 0.16% | ADD 28% |
| 38 | 38BANK OF AMERICA CORP /DE/ | 188,564188,564 | $226,276 | 0.16% | ADD 25% |
| 39 | 39BRIDGEWAY CAPITAL MANAGEMENT, LLC | 185,000185,000 | $222,000 | 0.16% | ADD 37% |
| 40 | 40ALLIANCEBERNSTEIN L.P. | 187,700187,700 | $184,434 | 0.16% | — |
| 41 | 41LPL Financial LLC | 147,746147,746 | $177,295 | 0.13% | ADD 2% |
| 42 | 42CWM, LLC | 139,796139,796 | $167,755 | 0.12% | ADD 170% |
| 43 | 43SEI INVESTMENTS CO | 138,580138,580 | $166,290 | 0.12% | ADD 105% |
| 44 | 44RHUMBLINE ADVISERS | 132,308132,308 | $158,761 | 0.11% | TRIM -10% |
| 45 | 45Headlands Technologies LLC | 125,708125,708 | $150,850 | 0.11% | NEW |
| 46 | 46National Philanthropic Trust | 125,000125,000 | $150,000 | 0.11% | — |
| 47 | 47Quadrature Capital Ltd | 120,343120,343 | $144,412 | 0.10% | TRIM -60% |
| 48 | 48Cerity Partners LLC | 113,544113,544 | $136,253 | 0.10% | ADD 116% |
| 49 | 49WELLS FARGO & COMPANY/MN | 100,975100,975 | $121,169 | 0.09% | TRIM -41% |
| 50 | 50SCHULHOFF & CO INC | 100,000100,000 | $120,000 | 0.09% | NEW |
| 51 | 51Mariner, LLC | 98,29598,295 | $117,911 | 0.08% | ADD 560% |
| 52 | 52HSBC HOLDINGS PLC | 97,68497,684 | $116,244 | 0.08% | TRIM -50% |
| 53 | 53LOS ANGELES CAPITAL MANAGEMENT LLC | 95,18595,185 | $114,222 | 0.08% | — |
| 54 | 54DEUTSCHE BANK AG\ | 91,67991,679 | $110,015 | 0.08% | — |
| 55 | 55State of Tennessee, Department of Treasury | 90,00090,000 | $108,000 | 0.08% | — |
| 56 | 56SG Americas Securities, LLC | 80,13980,139 | $96,000 | 0.07% | ADD 106% |
| 57 | 57PRICE T ROWE ASSOCIATES INC /MD/ | 76,63376,633 | $92,000 | 0.07% | ADD 41% |
| 58 | 58Virtu Financial LLC | 76,56176,561 | $92,000 | 0.07% | ADD 11% |
| 59 | 59BARCLAYS PLC | 72,99672,996 | $87,596 | 0.06% | TRIM -76% |
| 60 | 60WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 71,49171,491 | $87,219 | 0.06% | ADD 105% |
| 61 | 61Leo Wealth, LLC | 70,43970,439 | $84,527 | 0.06% | — |
| 62 | 62Graham Capital Management, L.P. | 64,76664,766 | $77,719 | 0.06% | TRIM -67% |
| 63 | 63MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,61953,619 | $64,343 | 0.05% | ADD 2% |
| 64 | 64Vanguard Personalized Indexing Management, LLC | 50,02450,024 | $60,029 | 0.04% | — |
| 65 | 65MERCER GLOBAL ADVISORS INC /ADV | 49,80449,804 | $59,765 | 0.04% | ADD 258% |
| 66 | 66Creative Planning | 49,42549,425 | $59,310 | 0.04% | ADD 107% |
| 67 | 67FMR LLC | 47,59047,590 | $57,108 | 0.04% | ADD 273% |
| 68 | 68Focus Partners Wealth | 46,16846,168 | $55,402 | 0.04% | ADD 44% |
| 69 | 69Point72 Asset Management, L.P. | 43,11943,119 | $51,743 | 0.04% | TRIM -97% |
| 70 | 70JPMORGAN CHASE & CO | 44,88844,888 | $50,723 | 0.04% | ADD 3% |
| 71 | 71CAPTRUST FINANCIAL ADVISORS | 41,88041,880 | $50,246 | 0.04% | ADD 64% |
| 72 | 72Tower Research Capital LLC (TRC) | 38,25638,256 | $45,907 | 0.03% | ADD 247% |
| 73 | 73Abel Hall, LLC | 36,74836,748 | $44,098 | 0.03% | NEW |
| 74 | 74HighTower Advisors, LLC | 35,32235,322 | $42,386 | 0.03% | ADD 10% |
| 75 | 75Thrivent Financial for Lutherans | 34,10534,105 | $41,000 | 0.03% | — |
| 76 | 76MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,11732,117 | $38,540 | 0.03% | TRIM -10% |
| 77 | 77Vanguard Global Advisers, LLC | 30,76730,767 | $36,920 | 0.03% | NEW |
| 78 | 78INTECH INVESTMENT MANAGEMENT LLC | 29,92629,926 | $35,911 | 0.03% | TRIM -42% |
| 79 | 79Corient Private Wealth LLC | 29,86529,865 | $35,838 | 0.03% | TRIM -50% |
| 80 | 80FPC INVESTMENT ADVISORY, INC. | 26,45626,456 | $35,187 | 0.02% | — |
| 81 | 81COMMONWEALTH EQUITY SERVICES, LLC | 29,04829,048 | $34,860 | 0.02% | ADD 9% |
| 82 | 82NEW YORK STATE COMMON RETIREMENT FUND | 28,01528,015 | $33,618 | 0.02% | — |
| 83 | 83PRUDENTIAL FINANCIAL INC | 26,33026,330 | $31,596 | 0.02% | ADD 14% |
| 84 | 84BNP PARIBAS FINANCIAL MARKETS | 25,71525,715 | $30,858 | 0.02% | TRIM -12% |
| 85 | 85CANADA LIFE ASSURANCE Co | 23,60623,606 | $28,000 | 0.02% | TRIM -3% |
| 86 | 86Bronte Capital Management Pty Ltd. | 22,85322,853 | $27,424 | 0.02% | — |
| 87 | 87VOYA INVESTMENT MANAGEMENT LLC | 22,50222,502 | $27,002 | 0.02% | — |
| 88 | 88Pallas Capital Advisors LLC | 22,43022,430 | $26,916 | 0.02% | ADD 53% |
| 89 | 89Police & Firemen's Retirement System of New Jersey | 20,76820,768 | $24,922 | 0.02% | — |
| 90 | 90Quinn Opportunity Partners LLC | 20,00020,000 | $24,000 | 0.02% | — |
| 91 | 91R Squared Ltd | 18,52418,524 | $22,229 | 0.02% | ADD 77% |
| 92 | 92Parametrica Management Ltd | 18,47218,472 | $22,166 | 0.02% | — |
| 93 | 93Merit Financial Group, LLC | 17,75917,759 | $21,311 | 0.02% | NEW |
| 94 | 94TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC | 17,59217,592 | $21,110 | 0.02% | NEW |
| 95 | 95Parcion Private Wealth LLC | 16,46816,468 | $19,762 | 0.01% | ADD 17% |
| 96 | 96SIMPLEX TRADING, LLC | 16,43616,436 | $19,723 | 0.01% | ADD 909% |
| 97 | 97ProShare Advisors LLC | 15,76415,764 | $18,917 | 0.01% | TRIM -21% |
| 98 | 98Krilogy Financial LLC | 13,61113,611 | $18,647 | 0.01% | NEW |
| 99 | 99NEUBERGER BERMAN GROUP LLC | 15,35015,350 | $18,420 | 0.01% | ADD 10% |
| 100 | 100Focus Partners Advisor Solutions, LLC | 15,22115,221 | $18,265 | 0.01% | NEW |
