Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-05 | Donovan Joanne M. | Officer | +Exercise | 50,000 | $7.08 | $354,000 |
| 2026-05-05 | Donovan Joanne M. | Officer | −Sell | 50,000 | $38.57 | $2M |
| 2026-05-04 | Donovan Joanne M. | Officer | −Sell | 5,230 | $31.29 | $163,647 |
| 2026-04-01 | Donovan Joanne M. | Officer | −Sell | 28,662 | $32.31 | $926,069 |
| 2026-04-01 | Donovan Joanne M. | Officer | +Exercise | 28,662 | $7.08 | $202,927 |
| 2026-04-01 | Fox Jonathan C | Director | +Grant | 339 | — | — |
| 2026-03-31 | Donovan Joanne M. | Officer | +Exercise | 21,338 | $7.08 | $151,073 |
| 2026-03-31 | Donovan Joanne M. | Officer | −Sell | 21,338 | $32.12 | $685,377 |
| 2026-03-27 | Donovan Joanne M. | Officer | −Sell | 6,735 | $30.98 | $208,650 |
| 2026-03-27 | Donovan Joanne M. | Officer | −Sell | 9,623 | $30.98 | $298,121 |
| 2026-01-21 | Edris Badreddin | Director | −Sell | 7,605 | $29.44 | $223,891 |
| 2026-01-21 | Edris Badreddin | Director | −Sell | 17,236 | $29.44 | $507,428 |
| 2026-01-21 | Edris Badreddin | Director | −Sell | 10,463 | $29.44 | $308,031 |
| 2026-01-21 | Edris Badreddin | Director | −Sell | 66,477 | $29.44 | $2M |
| 2026-01-21 | Edris Badreddin | Director | +Exercise | 66,477 | $1.93 | $128,301 |
| 2026-01-21 | Edris Badreddin | Director | +Exercise | 13,690 | $0.39 | $5,339 |
| 2026-01-21 | Edris Badreddin | Director | +Exercise | 17,236 | $0.64 | $11,031 |
| 2026-01-21 | Edris Badreddin | Director | +Exercise | 10,463 | $1.93 | $20,194 |
| 2026-01-21 | Edris Badreddin | Director | +Exercise | 7,605 | $0.71 | $5,400 |
| 2026-01-21 | Edris Badreddin | Director | −Sell | 13,690 | $29.44 | $403,034 |
| 2026-01-02 | Fox Jonathan C | Director | +Grant | 473 | — | — |
| 2025-11-12 | Russell Alan J | Director,Officer | +Exercise | 100,000 | $0.18 | $18,000 |
| 2025-11-12 | Russell Alan J | Director,Officer | −Sell | 100,000 | $21.12 | $2M |
| 2025-11-11 | Fox Jonathan C | Director | +Buy | 10,700 | $18.64 | $199,448 |
| 2025-10-01 | Fox Jonathan C | Director | +Grant | 728 | — | — |
| 2025-08-26 | Russell Alan J | Director,Officer | +Exercise | 100,000 | $0.18 | $18,000 |
| 2025-08-26 | Russell Alan J | Director,Officer | −Sell | 100,000 | $14.60 | $1M |
| 2025-08-12 | Donovan Joanne M. | Officer | +Exercise | 5,781 | — | — |
| 2025-08-12 | Donovan Joanne M. | Officer | −Sell | 2,862 | $13.39 | $38,322 |
| 2025-08-12 | KOCH KEVIN | Director,Officer | +Exercise | 17,968 | — | — |
| 2025-08-12 | KOCH KEVIN | Director,Officer | −Sell | 7,972 | $13.39 | $106,745 |
| 2025-08-12 | Russell Alan J | Director,Officer | +Exercise | 5,781 | — | — |
| 2025-08-12 | Russell Alan J | Director,Officer | −Sell | 1,907 | $13.39 | $25,535 |
| 2025-08-12 | Carruthers R Michael | Officer | −Sell | 1,428 | $13.39 | $19,121 |
| 2025-08-12 | Carruthers R Michael | Officer | +Exercise | 5,781 | — | — |
| 2025-08-12 | Derakhshan Behrad | Officer | +Exercise | 5,781 | — | — |
| 2025-08-12 | Derakhshan Behrad | Officer | −Sell | 2,491 | $13.39 | $33,354 |
| 2025-08-12 | MOORE JOHN R | Officer | +Exercise | 5,781 | — | — |
| 2025-08-12 | MOORE JOHN R | Officer | −Sell | 2,098 | $13.39 | $28,092 |
| 2025-07-01 | Fox Jonathan C | Director | +Grant | 858 | — | — |
| 2025-05-02 | Carruthers R Michael | Officer | −Sell | 1,314 | $16.45 | $21,615 |
| 2025-05-02 | Derakhshan Behrad | Officer | −Sell | 1,691 | $16.45 | $27,817 |
| 2025-05-02 | Donovan Joanne M. | Officer | −Sell | 5,187 | $16.45 | $85,326 |
| 2025-05-02 | KOCH KEVIN | Director,Officer | −Sell | 4,276 | $16.45 | $70,340 |
| 2025-05-02 | MOORE JOHN R | Officer | −Sell | 1,930 | $16.45 | $31,749 |
| 2025-05-02 | Russell Alan J | Director,Officer | −Sell | 1,551 | $16.45 | $25,514 |
| 2025-05-01 | Carruthers R Michael | Officer | +Exercise | 5,209 | — | — |
| 2025-05-01 | Derakhshan Behrad | Officer | +Exercise | 5,209 | — | — |
| 2025-05-01 | Donovan Joanne M. | Officer | +Exercise | 10,417 | — | — |
| 2025-05-01 | KOCH KEVIN | Director,Officer | +Exercise | 10,417 | — | — |
| 2025-05-01 | MOORE JOHN R | Officer | +Exercise | 5,209 | — | — |
| 2025-05-01 | Russell Alan J | Director,Officer | +Exercise | 5,209 | — | — |
| 2025-04-03 | OrbiMed Genesis GP LLC | Director,TenPercentOwner | +Buy | 372,578 | $20.13 | $7M |
| 2025-04-03 | OrbiMed Genesis GP LLC | Director,TenPercentOwner | +Buy | 124,193 | $20.13 | $3M |
| 2025-04-03 | Thompson Peter A. | Director,TenPercentOwner | +Buy | 124,193 | $20.13 | $3M |
| 2025-04-03 | Thompson Peter A. | Director,TenPercentOwner | +Buy | 372,578 | $20.13 | $7M |
| 2025-04-01 | Fox Jonathan C | Director | +Grant | 559 | — | — |
| 2025-03-07 | KOCH KEVIN | Director,Officer | +Exercise | 100 | $0.18 | $18 |
| 2025-03-07 | KOCH KEVIN | Director,Officer | −Sell | 100 | $30.00 | $3,000 |
| 2025-03-07 | Russell Alan J | Director,Officer | −Sell | 200 | $30.02 | $6,004 |
| 2025-03-07 | Russell Alan J | Director,Officer | +Exercise | 200 | $0.18 | $36 |
| 2025-02-06 | KOCH KEVIN | Director,Officer | +Exercise | 900 | $13.11 | $11,799 |
| 2025-02-06 | KOCH KEVIN | Director,Officer | −Sell | 900 | $31.13 | $28,017 |
| 2025-02-06 | Russell Alan J | Director,Officer | +Exercise | 1,200 | $0.18 | $216 |
| 2025-02-06 | Russell Alan J | Director,Officer | −Sell | 1,200 | $30.13 | $36,156 |
| 2025-02-05 | Derakhshan Behrad | Officer | −Sell | 10,000 | $30.03 | $300,300 |
| 2025-02-05 | Derakhshan Behrad | Officer | +Exercise | 10,000 | $1.93 | $19,300 |
| 2025-02-05 | KOCH KEVIN | Director,Officer | −Sell | 8,636 | $30.03 | $259,339 |
| 2025-02-05 | KOCH KEVIN | Director,Officer | +Exercise | 8,636 | $0.18 | $1,554 |
| 2025-02-05 | Russell Alan J | Director,Officer | −Sell | 8,015 | $30.02 | $240,610 |
| 2025-02-05 | Russell Alan J | Director,Officer | +Exercise | 8,015 | $0.18 | $1,443 |
| 2025-01-28 | Donovan Joanne M. | Officer | −Sell | 25,000 | $27.63 | $690,750 |
| 2025-01-28 | Donovan Joanne M. | Officer | +Exercise | 25,000 | $7.08 | $177,000 |
| 2024-12-30 | Russell Alan J | Director,Officer | −Sell | 100,000 | $27.37 | $3M |
| 2024-12-30 | Russell Alan J | Director,Officer | +Exercise | 100,000 | $0.18 | $18,000 |
| 2024-12-24 | Semigran Marc | Officer | −Sell | 1,729 | $30.08 | $52,008 |
| 2024-12-24 | Semigran Marc | Officer | +Exercise | 29,709 | $8.94 | $265,598 |
| 2024-12-24 | Semigran Marc | Officer | −Sell | 27,980 | $29.66 | $829,887 |
| 2024-10-11 | Carruthers R Michael | Officer | +Exercise | 70,000 | $0.71 | $49,700 |
| 2024-09-23 | MOORE JOHN R | Officer | −Sell | 20,922 | $27.63 | $578,075 |
| 2024-09-23 | MOORE JOHN R | Officer | +Exercise | 20,922 | $0.71 | $14,855 |
| 2024-09-20 | Carruthers R Michael | Officer | −Sell | 50,000 | $28.55 | $1M |
| 2024-09-20 | Carruthers R Michael | Officer | +Exercise | 50,000 | $1.93 | $96,500 |
| 2024-09-20 | Carruthers R Michael | Officer | −Sell | 24,960 | $28.59 | $713,606 |
| 2024-09-20 | Carruthers R Michael | Officer | −Sell | 4,064 | $28.59 | $116,190 |
| 2024-09-20 | Carruthers R Michael | Officer | −Sell | 46,068 | $28.59 | $1M |
| 2024-09-20 | Carruthers R Michael | Officer | +Exercise | 46,068 | $1.93 | $88,911 |
| 2024-09-20 | Derakhshan Behrad | Officer | −Sell | 42,068 | $29.03 | $1M |
| 2024-09-20 | Derakhshan Behrad | Officer | +Exercise | 42,068 | $1.93 | $81,191 |
| 2024-09-20 | Donovan Joanne M. | Officer | −Sell | 7,162 | $28.29 | $202,613 |
| 2024-09-20 | MOORE JOHN R | Officer | +Exercise | 50,000 | $0.71 | $35,500 |
| 2024-09-20 | MOORE JOHN R | Officer | −Sell | 50,000 | $28.37 | $1M |
| 2024-09-20 | Russell Alan J | Director,Officer | −Sell | 815 | $29.51 | $24,051 |
| 2024-09-20 | Russell Alan J | Director,Officer | +Exercise | 75,000 | $0.18 | $13,500 |
| 2024-09-20 | Russell Alan J | Director,Officer | −Sell | 74,185 | $28.25 | $2M |
| 2024-05-02 | KOCH KEVIN | Director,Officer | −Sell | 3,152 | $18.91 | $59,604 |
| 2024-05-02 | Donovan Joanne M. | Officer | −Sell | 3,682 | $18.91 | $69,627 |
| 2024-05-02 | Russell Alan J | Director,Officer | −Sell | 1,576 | $18.91 | $29,802 |
| 2024-05-02 | Derakhshan Behrad | Officer | −Sell | 1,718 | $18.91 | $32,487 |
| 2024-05-02 | Carruthers R Michael | Officer | −Sell | 2,157 | $18.91 | $40,789 |
| 2024-05-02 | MOORE JOHN R | Officer | −Sell | 1,956 | $18.91 | $36,988 |
| 2024-05-01 | KOCH KEVIN | Director,Officer | +Exercise | 10,417 | — | — |
| 2024-05-01 | Donovan Joanne M. | Officer | +Exercise | 10,417 | — | — |
| 2024-05-01 | Russell Alan J | Director,Officer | +Exercise | 5,208 | — | — |
| 2024-05-01 | Derakhshan Behrad | Officer | +Exercise | 5,208 | — | — |
| 2024-05-01 | Carruthers R Michael | Officer | +Exercise | 5,208 | — | — |
| 2024-05-01 | MOORE JOHN R | Officer | +Exercise | 5,208 | — | — |
| 2024-02-09 | Derakhshan Behrad | Officer | −Sell | 4,800 | $20.04 | $96,192 |
| 2024-02-09 | Derakhshan Behrad | Officer | +Exercise | 4,800 | $1.93 | $9,264 |
| 2024-02-09 | MOORE JOHN R | Officer | −Sell | 8,029 | $20.01 | $160,660 |
| 2024-02-09 | MOORE JOHN R | Officer | +Exercise | 8,029 | $1.93 | $15,496 |
| 2024-02-08 | Derakhshan Behrad | Officer | +Exercise | 4,600 | $1.93 | $8,878 |
| 2024-02-08 | Derakhshan Behrad | Officer | −Sell | 4,600 | $20.01 | $92,046 |
| 2024-02-08 | MOORE JOHN R | Officer | +Exercise | 3,813 | $1.93 | $7,359 |
| 2024-02-08 | MOORE JOHN R | Officer | −Sell | 3,813 | $20.01 | $76,298 |
| 2024-02-07 | Derakhshan Behrad | Officer | +Exercise | 600 | $1.93 | $1,158 |
| 2024-02-07 | Derakhshan Behrad | Officer | −Sell | 600 | $20.00 | $12,000 |
| 2024-02-07 | MOORE JOHN R | Officer | −Sell | 17,993 | $20.00 | $359,860 |
| 2024-02-07 | MOORE JOHN R | Officer | +Exercise | 17,993 | $1.93 | $34,726 |
| 2024-01-23 | OrbiMed Capital GP VI LLC | Director,TenPercentOwner | +Buy | 454,545 | $11.00 | $5M |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
