| 1 | 1Opaleye Management Inc. | 2,860,0002.9M | $71M | 10.44% | — |
| 2 | 2EcoR1 Capital, LLC | 2,171,9382.2M | $54M | 7.93% | ADD 7% |
| 3 | 3BlackRock, Inc. | 1,717,2861.7M | $42M | 6.27% | — |
| 4 | 4Nantahala Capital Management, LLC | 1,175,9511.2M | $29M | 4.29% | — |
| 5 | 5VANGUARD CAPITAL MANAGEMENT LLC | 994,089994,089 | $25M | 3.63% | NEW† |
| 6 | 6GEODE CAPITAL MANAGEMENT, LLC | 577,666577,666 | $14M | 2.11% | ADD 2% |
| 7 | 7STATE STREET CORP | 530,215530,215 | $13M | 1.94% | ADD 6% |
| 8 | 8National Philanthropic Trust | 492,112492,112 | $12M | 1.80% | — |
| 9 | 9MORGAN STANLEY | 477,957477,957 | $12M | 1.74% | TRIM -3% |
| 10 | 10Westside Investment Management, Inc. | 467,915467,915 | $12M | 1.71% | — |
| 11 | 11OBERWEIS ASSET MANAGEMENT INC/ | 439,300439,300 | $11M | 1.60% | — |
| 12 | 12THOMPSON SIEGEL & WALMSLEY LLC | 406,089406,089 | $10M | 1.48% | — |
| 13 | 13Pillsbury Lake Capital LLC | 364,954364,954 | $9M | 1.33% | NEW |
| 14 | 14CANNELL CAPITAL LLC | 341,985341,985 | $8M | 1.25% | ADD 58% |
| 15 | 15BNP PARIBAS FINANCIAL MARKETS | 302,108302,108 | $7M | 1.10% | ADD 9% |
| 16 | 16NORTHERN TRUST CORP | 237,832237,832 | $6M | 0.87% | ADD 3% |
| 17 | 17GOLDMAN SACHS GROUP INC | 217,446217,446 | $5M | 0.79% | ADD 11% |
| 18 | 18PRELUDE CAPITAL MANAGEMENT, LLC | 188,802188,802 | $5M | 0.69% | ADD 317% |
| 19 | 19Aristides Capital LLC | 186,041186,041 | $5M | 0.68% | ADD 15% |
| 20 | 20Panoramic Capital, LLC | 185,000185,000 | $5M | 0.68% | NEW |
| 21 | 21Lumbard & Kellner, LLC | 175,911175,911 | $4M | 0.64% | — |
| 22 | 22Woodline Partners LP | 170,699170,699 | $4M | 0.62% | ADD 79% |
| 23 | 23UBS Group AG | 168,958168,958 | $4M | 0.62% | ADD 33% |
| 24 | 24Soleus Capital Management, L.P. | 166,381166,381 | $4M | 0.61% | NEW |
| 25 | 25VANGUARD FIDUCIARY TRUST CO | 164,715164,715 | $4M | 0.60% | NEW |
| 26 | 26RENAISSANCE TECHNOLOGIES LLC | 163,321163,321 | $4M | 0.60% | TRIM -21% |
| 27 | 27Diametric Capital, LP | 156,926156,926 | $4M | 0.57% | TRIM -19% |
| 28 | 28JPMORGAN CHASE & CO | 169,876169,876 | $4M | 0.62% | TRIM -8% |
| 29 | 29VANGUARD PORTFOLIO MANAGEMENT LLC | 151,748151,748 | $4M | 0.55% | NEW |
| 30 | 30BANK OF AMERICA CORP /DE/ | 144,367144,367 | $4M | 0.53% | ADD 38% |
| 31 | 31Bank of New York Mellon Corp | 111,255111,255 | $3M | 0.41% | TRIM -13% |
| 32 | 32CITADEL ADVISORS LLC | 107,815107,815 | $3M | 0.39% | ADD 45% |
| 33 | 33TWO SIGMA INVESTMENTS, LP | 106,393106,393 | $3M | 0.39% | ADD 39% |
| 34 | 34JANE STREET GROUP, LLC | 95,42095,420 | $2M | 0.35% | ADD 64% |
| 35 | 35MARSHALL WACE, LLP | 82,72182,721 | $2M | 0.30% | NEW |
| 36 | 36Walleye Capital LLC | 81,96381,963 | $2M | 0.30% | NEW |
| 37 | 37WELLINGTON MANAGEMENT GROUP LLP | 70,12470,124 | $2M | 0.26% | TRIM -14% |
| 38 | 38CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 68,79568,795 | $2M | 0.25% | TRIM -11% |
| 39 | 39SEI INVESTMENTS CO | 58,03458,034 | $1M | 0.21% | NEW |
| 40 | 40Nuveen, LLC | 57,95057,950 | $1M | 0.21% | — |
| 41 | 41BOOTHBAY FUND MANAGEMENT, LLC | 55,60555,605 | $1M | 0.20% | NEW |
| 42 | 42XTX Topco Ltd | 51,77251,772 | $1M | 0.19% | ADD 59% |
| 43 | 43BARCLAYS PLC | 49,37449,374 | $1M | 0.18% | TRIM -4% |
| 44 | 44Informed Momentum Co LLC | 48,62348,623 | $1M | 0.18% | NEW |
| 45 | 45Connor, Clark & Lunn Investment Management Ltd. | 42,69342,693 | $1M | 0.16% | TRIM -44% |
| 46 | 46ANCHOR CAPITAL ADVISORS LLC | 40,85840,858 | $1M | 0.15% | — |
| 47 | 47Manatuck Hill Partners, LLC | 40,00040,000 | $987,200 | 0.15% | NEW |
| 48 | 48Numerai GP LLC | 37,35637,356 | $921,946 | 0.14% | NEW |
| 49 | 49SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,08434,084 | $841,193 | 0.12% | NEW |
| 50 | 50BLAIR WILLIAM & CO/IL | 32,40032,400 | $799,632 | 0.12% | — |
| 51 | 51RHUMBLINE ADVISERS | 30,72630,726 | $758,310 | 0.11% | — |
| 52 | 52POLEN CAPITAL MANAGEMENT LLCtracked | 30,13830,138 | $743,806 | 0.11% | NEW |
| 53 | 53Guilbault Capital LLC | 23,22523,225 | $573,193 | 0.08% | — |
| 54 | 54Invesco Ltd. | 22,87422,874 | $564,531 | 0.08% | ADD 16% |
| 55 | 55Brevan Howard Capital Management LP | 22,50622,506 | $555,448 | 0.08% | NEW |
| 56 | 56Bridge City Capital, LLC | 21,15021,150 | $521,982 | 0.08% | ADD 14% |
| 57 | 57DEUTSCHE BANK AG\ | 21,13621,136 | $521,636 | 0.08% | ADD 16% |
| 58 | 58ESSEX INVESTMENT MANAGEMENT CO LLC | 20,18220,182 | $498,092 | 0.07% | — |
| 59 | 59JUNCTURE WEALTH STRATEGIES, LLC | 19,18119,181 | $473,387 | 0.07% | — |
| 60 | 60STATE OF WISCONSIN INVESTMENT BOARD | 18,64418,644 | $460,134 | 0.07% | TRIM -24% |
| 61 | 61HighTower Advisors, LLC | 18,42318,423 | $454,680 | 0.07% | NEW |
| 62 | 62PRICE T ROWE ASSOCIATES INC /MD/ | 17,65217,652 | $436,000 | 0.06% | ADD 15% |
| 63 | 63CHICAGO TRUST Co NA | 16,70016,700 | $412,156 | 0.06% | — |
| 64 | 64MetLife Investment Management, LLC | 15,53715,537 | $383,453 | 0.06% | — |
| 65 | 65MILLENNIUM MANAGEMENT LLC | 14,93914,939 | $368,695 | 0.05% | TRIM -81% |
| 66 | 66PDT Partners, LLC | 14,89114,891 | $367,510 | 0.05% | — |
| 67 | 67BANK OF NOVA SCOTIA | 15,00015,000 | $365,289 | 0.05% | NEW |
| 68 | 68Voleon Capital Management LP | 13,29013,290 | $327,997 | 0.05% | TRIM -15% |
| 69 | 69RAYMOND JAMES FINANCIAL INC | 12,25012,250 | $302,330 | 0.04% | — |
| 70 | 70Aquatic Capital Management LLC | 12,06112,061 | $297,665 | 0.04% | TRIM -47% |
| 71 | 71MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,03812,038 | $297,098 | 0.04% | — |
| 72 | 72AMERICAN CENTURY COMPANIES INC | 11,92611,926 | $294,334 | 0.04% | NEW |
| 73 | 73Quantum Private Wealth, LLC | 11,50011,500 | $283,820 | 0.04% | — |
| 74 | 74ENVESTNET ASSET MANAGEMENT INC | 10,73910,739 | $265,039 | 0.04% | — |
| 75 | 75LOS ANGELES CAPITAL MANAGEMENT LLC | 10,26910,269 | $253,439 | 0.04% | TRIM -30% |
| 76 | 76WELLS FARGO & COMPANY/MN | 9,5599,559 | $235,917 | 0.03% | TRIM -66% |
| 77 | 77State of Wyoming | 9,4989,498 | $234,411 | 0.03% | ADD 16% |
| 78 | 78Vanguard Global Advisers, LLC | 8,9918,991 | $221,898 | 0.03% | NEW |
| 79 | 79Granite Investment Partners, LLC | 8,4798,479 | $209,262 | 0.03% | NEW |
| 80 | 80Jain Global LLC | 8,2878,287 | $204,523 | 0.03% | NEW |
| 81 | 81NEW YORK STATE COMMON RETIREMENT FUND | 8,1008,100 | $199,908 | 0.03% | — |
| 82 | 82Quantbot Technologies LP | 7,7877,787 | $192,183 | 0.03% | TRIM -17% |
| 83 | 83NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 7,5007,500 | $185,100 | 0.03% | TRIM -25% |
| 84 | 84Police & Firemen's Retirement System of New Jersey | 7,2097,209 | $177,918 | 0.03% | — |
| 85 | 85State of Alaska, Department of Revenue | 6,9436,943 | $171,000 | 0.03% | — |
| 86 | 86China Universal Asset Management Co., Ltd. | 4,7594,759 | $117,452 | 0.02% | ADD 9% |
| 87 | 87Russell Investments Group, Ltd. | 2,6702,670 | $65,895 | 0.01% | TRIM -95% |
| 88 | 88CITIGROUP INC | 2,5482,548 | $62,884 | 0.01% | ADD 76% |
| 89 | 89Legal & General Group Plc | 2,3302,330 | $57,481 | 0.01% | TRIM -15% |
| 90 | 90Ameritas Investment Partners, Inc. | 2,1672,167 | $53,482 | 0.01% | — |
| 91 | 91FMR LLC | 1,5191,519 | $37,480 | 0.01% | TRIM -51% |
| 92 | 92Mirae Asset Global Investments Co., Ltd. | 1,3991,399 | $34,527 | 0.01% | ADD 7% |
| 93 | 93CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,3881,388 | $34,256 | 0.01% | TRIM -12% |
| 94 | 94Truvestments Capital LLC | 1,1831,183 | $29,196 | 0.00% | — |
| 95 | 95Tower Research Capital LLC (TRC) | 1,1561,156 | $28,530 | 0.00% | TRIM -61% |
| 96 | 96GF FUND MANAGEMENT CO. LTD. | 597597 | $14,734 | 0.00% | ADD 13% |
| 97 | 97UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 368368 | $9,082 | 0.00% | NEW |
| 98 | 98JONES FINANCIAL COMPANIES LLLP | 350350 | $8,134 | 0.00% | ADD 58% |
| 99 | 99Parallel Advisors, LLC | 303303 | $7,478 | 0.00% | NEW |
| 100 | 100SBI Securities Co., Ltd. | 263263 | $6,491 | 0.00% | ADD 2530% |