% of shares outstanding not shown: no SEC cover-page share count falls within 120 days of the 2026-Q1 quarter end, so any percentage would rest on a count that cannot speak for this quarter. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Beutel, Goodman & Co Ltd. | 3,666,4653.7M | $26M | — | — |
| 2 | Affinity Asset Advisors, LLC | 1,589,0051.6M | $12M | — | ADD 430% |
| 3 | Balyasny Asset Management L.P. | 1,350,0001.4M | $10M | — | — |
| 4 | Vivo Capital, LLC | 1,350,0001.4M | $10M | — | — |
| 5 | Ikarian Capital, LLC | 1,214,7411.2M | $9M | — | ADD 99% |
| 6 | GREAT POINT PARTNERS LLC | 1,200,0001.2M | $9M | — | — |
| 7 | SCOTIA CAPITAL INC. | 1,342,1781.3M | $7M | — | ADD 4% |
| 8 | Point72 Asset Management, L.P. | 967,575967,575 | $7M | — | ADD 36% |
| 9 | UBS Group AG | 762,635762,635 | $6M | — | ADD 247% |
| 10 | Seven Fleet Capital Management LP | 709,515709,515 | $5M | — | NEW |
| 11 | Redmile Group, LLC | 700,000700,000 | $5M | — | NEW |
| 12 | Rubric Capital Management LP | 691,170691,170 | $5M | — | NEW |
| 13 | Squadron Capital Management LLC | 680,000680,000 | $5M | — | ADD 36% |
| 14 | Ally Bridge Group (NY) LLC | 660,375660,375 | $5M | — | ADD 66% |
| 15 | PFM Health Sciences, LP | 540,871540,871 | $4M | — | NEW |
| 16 | AMERIPRISE FINANCIAL INC | 524,257524,257 | $4M | — | NEW |
| 17 | Woodline Partners LP | 440,551440,551 | $3M | — | NEW |
| 18 | Alyeska Investment Group, L.P. | 375,000375,000 | $3M | — | NEW |
| 19 | Velan Capital Investment Management LP | 352,000352,000 | $3M | — | — |
| 20 | SummitTX Capital, L.P. | 327,997327,997 | $2M | — | ADD 86% |
| 21 | Aisling Capital Management LP | 325,000325,000 | $2M | — | NEW |
| 22 | BOOTHBAY FUND MANAGEMENT, LLC | 323,843323,843 | $2M | — | ADD 107% |
| 23 | DV Trading LLC | 276,000276,000 | $2M | — | NEW |
| 24 | BANK OF AMERICA CORP /DE/ | 268,221268,221 | $2M | — | ADD 6% |
| 25 | ROYAL BANK OF CANADA | 261,376261,376 | $2M | — | ADD 33% |
| 26 | CITADEL ADVISORS LLC | 230,176230,176 | $2M | — | NEW |
| 27 | MARSHALL WACE, LLP | 158,133158,133 | $1M | — | — |
| 28 | CIBC WORLD MARKET INC. | 150,950150,950 | $1M | — | ADD 160% |
| 29 | ACADIAN ASSET MANAGEMENT LLC | 93,60093,600 | $671,000 | — | TRIM -40% |
| 30 | Hudson Bay Capital Management LP | 92,34792,347 | $668,592 | — | NEW |
| 31 | TD Waterhouse Canada Inc. | 81,72581,725 | $589,804 | — | ADD 751% |
| 32 | INGALLS & SNYDER LLC | 75,65075,650 | $548,000 | — | TRIM -2% |
| 33 | 1832 Asset Management L.P. | 60,00060,000 | $434,400 | — | ADD 87% |
| 34 | GOLDMAN SACHS GROUP INC | 53,08053,080 | $384,299 | — | TRIM -9% |
| 35 | RAYMOND JAMES FINANCIAL INC | 50,56050,560 | $366,055 | — | TRIM -5% |
| 36 | DIADEMA PARTNERS LP | 40,00040,000 | $289,600 | — | NEW |
| 37 | BANK OF MONTREAL /CAN/ | 38,25038,250 | $276,115 | — | ADD 3% |
| 38 | Persistent Asset Partners Ltd | 37,92637,926 | $274,584 | — | NEW |
| 39 | JANE STREET GROUP, LLC | 35,21035,210 | $254,030 | — | ADD 19% |
| 40 | TORONTO DOMINION BANK | 32,89832,898 | $237,481 | — | NEW |
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 25,61325,613 | $185,438 | — | ADD 84% |
| 42 | AXQ CAPITAL, LP | 15,76015,760 | $114,102 | — | NEW |
| 43 | Integrated Wealth Concepts LLC | 12,00012,000 | $86,880 | — | NEW |
| 44 | TCI Wealth Advisors, Inc. | 11,00011,000 | $79,640 | — | — |
| 45 | TWO SIGMA INVESTMENTS, LP | 10,80010,800 | $78,192 | — | NEW |
| 46 | Aptus Capital Advisors, LLC | 10,50010,500 | $76,020 | — | ADD 5% |
| 47 | GUARDIAN WEALTH ADVISORS, LLC / NC | 10,50010,500 | $76,020 | — | ADD 5% |
| 48 | China Universal Asset Management Co., Ltd. | 10,00010,000 | $72,400 | — | NEW |
| 49 | MORGAN STANLEY | 8,8208,820 | $63,856 | — | NEW |
| 50 | Federation des caisses Desjardins du Quebec | 9,0919,091 | $49,029 | — | — |
| 51 | BNP PARIBAS FINANCIAL MARKETS | 6,4296,429 | $46,546 | — | NEW |
| 52 | JPMORGAN CHASE & CO | 573573 | $3,788 | — | NEW |
| 53 | NATIONAL BANK OF CANADA /FI/ | 359359 | $812 | — | TRIM -39% |
| 54 | Caitong International Asset Management Co., Ltd | 11 | $7 | — | NEW |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Beutel, Goodman & Co Ltd. | — | — | — | 4.1M | 3.7M | 3.7M | $26M |
| Affinity Asset Advisors, LLC | — | — | — | 300K | 300K | 1.6M | $12M |
| Vivo Capital, LLC | — | — | — | 1.4M | 1.4M | 1.4M | $10M |
| Balyasny Asset Management L.P. | — | — | — | 1.4M | 1.4M | 1.4M | $10M |
| Ikarian Capital, LLC | — | — | — | — | 610K | 1.2M | $9M |
| GREAT POINT PARTNERS LLC | — | — | — | 1.2M | 1.2M | 1.2M | $9M |
| SCOTIA CAPITAL INC. | 1.4M | 1.6M | 1.3M | 1.3M | 1.3M | 1.3M | $7M |
| Point72 Asset Management, L.P. | — | — | — | — | 712K | 968K | $7M |
| UBS Group AG | 28K | 51K | 37K | 96K | 220K | 763K | $6M |
| Seven Fleet Capital Management LP | — | — | — | — | — | 710K | $5M |
| Redmile Group, LLC | — | — | — | — | — | 700K | $5M |
| Rubric Capital Management LP | — | — | — | — | — | 691K | $5M |
| Squadron Capital Management LLC | — | — | — | — | 500K | 680K | $5M |
| Ally Bridge Group (NY) LLC | — | — | — | 915K | 398K | 660K | $5M |
| PFM Health Sciences, LP | — | — | — | — | — | 541K | $4M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 54 | 22,260,726 | — | $158M |
| 2025-Q4 | 35 | 13,830,451 | — | $104M |
| 2025-Q3 | 27 | 12,829,790 | — | $75M |
| 2025-Q2 | 14 | 2,398,660 | — | $13M |
| 2025-Q1 | 11 | 2,167,593 | 6.1% | $7M |
| 2024-Q4 | 9 | 1,826,270 | 5.1% | $6M |
| 2024-Q3 | 8 | 1,798,968 | 5.0% | $5M |
| 2024-Q2 | 8 | 1,729,082 | — | $4M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| Affinity Asset Advisors, LLC | +1,289,005 | $9M | ADD |
| Seven Fleet Capital Management LP | +709,515 | $5M | OPEN |
| Redmile Group, LLC | +700,000 | $5M | OPEN |
| Rubric Capital Management LP | +691,170 | $5M | OPEN |
| Ikarian Capital, LLC | +604,741 | $4M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | −278,064 | $2M | CLOSE |
| ACADIAN ASSET MANAGEMENT LLC | −62,166 | $450,082 | TRIM |
| Quadrature Capital Ltd | −43,186 | $312,667 | CLOSE |
| Beutel, Goodman & Co Ltd. | −42,908 | $310,654 | — |
| XTX Topco Ltd | −16,180 | $117,143 | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
