$76.84
-0.34 (-0.44%)
USD · as of 2026-08-21 · marketstack
% of shares outstanding suppressed: the summed institutional 13F holdings (146,215,212) exceed the cover-page shares-outstanding count for this quarter (123,162,807, as of 2026-02-23) by more than securities-lending double counting can explain (FINRA short interest 16,461,785 shares at 2026-05-15), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 17,523,84017.5M | $1.2B | — | TRIM -35% |
| 2 | BlackRock, Inc. | 16,548,01116.5M | $1.1B | — | — |
| 3 | FMR LLC | 10,723,14010.7M | $707M | — | TRIM -16% |
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 8,009,4898.0M | $528M | — | — |
| 5 | VANGUARD PORTFOLIO MANAGEMENT LLC | 5,843,7825.8M | $385M | — | NEW |
| 6 | STATE STREET CORP | 5,745,1935.7M | $379M | — | — |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 5,488,6345.5M | $362M | — | NEW |
| 8 | Avoro Capital Advisors LLC | 3,333,3333.3M | $220M | — | NEW |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | 3,215,4153.2M | $212M | — | ADD 5% |
| 10 | BANK OF AMERICA CORP /DE/ | 3,125,4363.1M | $206M | — | ADD 6% |
| 11 | RTW INVESTMENTS, LP | 2,721,1582.7M | $179M | — | — |
| 12 | GOLDMAN SACHS GROUP INC | 2,205,7582.2M | $145M | — | TRIM -7% |
| 13 | UBS Group AG | 2,077,2772.1M | $137M | — | ADD 84% |
| 14 | Polar Capital Holdings Plc | 1,661,2481.7M | $109M | — | TRIM -31% |
| 15 | Integral Health Asset Management, LLC | 1,600,0001.6M | $105M | — | ADD 14% |
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,584,3211.6M | $104M | — | TRIM -18% |
| 17 | MORGAN STANLEY | 1,505,0751.5M | $99M | — | ADD 19% |
| 18 | Paradigm Biocapital Advisors LP | 1,480,8571.5M | $98M | — | NEW |
| 19 | NORTHERN TRUST CORP | 1,441,6341.4M | $95M | — | ADD 4% |
| 20 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,397,0451.4M | $92M | — | — |
| 21 | Deep Track Capital, LP | 1,374,3201.4M | $91M | — | TRIM -59% |
| 22 | Capital International Investors | 1,338,8031.3M | $88M | — | ADD 14% |
| 23 | Frazier Life Sciences Management, L.P. | 1,159,8791.2M | $76M | — | ADD 24% |
| 24 | CITADEL ADVISORS LLC | 1,099,8581.1M | $72M | — | TRIM -5% |
| 25 | PRINCIPAL FINANCIAL GROUP INC | 1,093,4851.1M | $72M | — | ADD 12% |
| 26 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,087,5911.1M | $72M | — | NEW |
| 27 | Bank of New York Mellon Corp | 1,006,1851.0M | $66M | — | ADD 18% |
| 28 | Woodline Partners LP | 1,000,4281.0M | $66M | — | TRIM -39% |
| 29 | Balyasny Asset Management L.P. | 992,545992,545 | $65M | — | NEW |
| 30 | Royalty Pharma Sub-Manager, LLC | 980,392980,392 | $65M | — | — |
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 898,951898,951 | $59M | — | ADD 19% |
| 32 | Logos Global Management LP | 875,000875,000 | $58M | — | ADD 192% |
| 33 | JPMORGAN CHASE & CO | 903,805903,805 | $57M | — | TRIM -36% |
| 34 | BNP PARIBAS FINANCIAL MARKETS | 854,374854,374 | $56M | — | ADD 47% |
| 35 | Melqart Asset Management (UK) Ltd | 843,949843,949 | $56M | — | ADD 35% |
| 36 | VANGUARD FIDUCIARY TRUST CO | 799,622799,622 | $53M | — | NEW |
| 37 | Qube Research & Technologies Ltd | 779,446779,446 | $51M | — | ADD 45% |
| 38 | Capital Research Global Investors | 770,999770,999 | $51M | — | NEW |
| 39 | Fisher Asset Management, LLC | 768,264768,264 | $51M | — | TRIM -7% |
| 40 | ARMISTICE CAPITAL, LLC | 764,538764,538 | $50M | — | TRIM -23% |
| 41 | Pictet Asset Management Holding SA | 750,953750,953 | $49M | — | — |
| 42 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 714,344714,344 | $47M | — | TRIM -14% |
| 43 | D. E. Shaw & Co., Inc. | 706,631706,631 | $47M | — | ADD 493% |
| 44 | Affinity Asset Advisors, LLC | 700,483700,483 | $46M | — | TRIM -12% |
| 45 | FEDERATED HERMES, INC. | 699,453699,453 | $46M | — | ADD 45% |
| 46 | Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 660,310660,310 | $44M | — | TRIM -12% |
| 47 | MARSHALL WACE, LLP | 656,608656,608 | $43M | — | ADD 95% |
| 48 | ADAR1 Capital Management, LLC | 632,556632,556 | $42M | — | ADD 17% |
| 49 | Point72 Asset Management, L.P. | 626,102626,102 | $41M | — | NEW |
| 50 | BROWN ADVISORY INC | 614,655614,655 | $41M | — | TRIM -16% |
| 51 | Siren, L.L.C. | 613,952613,952 | $40M | — | NEW |
| 52 | Foresite Capital Management IV, LLC | 503,295503,295 | $33M | — | ADD 10% |
| 53 | MPM BIOIMPACT LLC | 500,000500,000 | $33M | — | NEW |
| 54 | GW&K Investment Management, LLC | 494,619494,619 | $33M | — | ADD 5% |
| 55 | Invesco Ltd. | 484,980484,980 | $32M | — | ADD 137% |
| 56 | Aberdeen Group plc | 483,274483,274 | $32M | — | — |
| 57 | EVENTIDE ASSET MANAGEMENT, LLC | 479,098479,098 | $32M | — | — |
| 58 | AMERICAN CENTURY COMPANIES INC | 443,957443,957 | $29M | — | — |
| 59 | ALLIANCEBERNSTEIN L.P. | 459,087459,087 | $29M | — | ADD 11% |
| 60 | TD Asset Management Inc | 420,846420,846 | $28M | — | TRIM -23% |
| 61 | FRANKLIN RESOURCES INC | 409,784409,784 | $27M | — | — |
| 62 | RHUMBLINE ADVISERS | 369,575369,575 | $24M | — | ADD 4% |
| 63 | GROUP ONE TRADING LLC | 363,997363,997 | $24M | — | TRIM -11% |
| 64 | Nuveen, LLC | 351,809351,809 | $23M | — | TRIM -5% |
| 65 | GSK plc | 340,434340,434 | $22M | — | — |
| 66 | Candriam S.C.A. | 335,208335,208 | $22M | — | ADD 129% |
| 67 | GILDER GAGNON HOWE & CO LLC | 330,989330,989 | $22M | — | TRIM -14% |
| 68 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 311,649311,649 | $21M | — | TRIM -5% |
| 69 | AMERIPRISE FINANCIAL INC | 302,802302,802 | $20M | — | TRIM -45% |
| 70 | E. Ohman J:or Asset Management AB | 300,762300,762 | $20M | — | TRIM -17% |
| 71 | Vestal Point Capital, LP | 300,000300,000 | $20M | — | NEW |
| 72 | Trails Edge Capital Partners, LP | 300,000300,000 | $20M | — | NEW |
| 73 | TWO SIGMA INVESTMENTS, LP | 285,008285,008 | $19M | — | ADD 4% |
| 74 | First Turn Management, LLC | 283,700283,700 | $19M | — | TRIM -13% |
| 75 | Ikarian Capital, LLC | 283,572283,572 | $19M | — | ADD 64% |
| 76 | JANUS HENDERSON GROUP PLC | 282,121282,121 | $19M | — | ADD 10% |
| 77 | Susquehanna Portfolio Strategies, LLC | 278,429278,429 | $18M | — | — |
| 78 | VOYA INVESTMENT MANAGEMENT LLC | 259,459259,459 | $17M | — | ADD 296% |
| 79 | STEMPOINT CAPITAL LP | 259,154259,154 | $17M | — | ADD 76% |
| 80 | CITIGROUP INC | 249,243249,243 | $16M | — | ADD 144% |
| 81 | Handelsbanken Fonder AB | 247,300247,300 | $16M | — | ADD 20% |
| 82 | Caption Management, LLC | 245,000245,000 | $16M | — | ADD 775% |
| 83 | Capital World Investors | 242,041242,041 | $16M | — | NEW |
| 84 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 240,632240,632 | $16M | — | ADD 2% |
| 85 | Swiss National Bank | 229,800229,800 | $15M | — | ADD 2% |
| 86 | Sarissa Capital Management LP | 228,623228,623 | $15M | — | TRIM -42% |
| 87 | HSBC HOLDINGS PLC | 221,999221,999 | $15M | — | ADD 2903% |
| 88 | DAFNA Capital Management LLC | 217,497217,497 | $14M | — | TRIM -41% |
| 89 | Freestone Grove Partners LP | 216,769216,769 | $14M | — | NEW |
| 90 | Catalio Capital Management, LP | 215,501215,501 | $14M | — | TRIM -17% |
| 91 | Mirador Capital Partners LP | 202,673202,673 | $13M | — | ADD 2% |
| 92 | EMERALD ADVISERS, LLC | 198,811198,811 | $13M | — | NEW |
| 93 | California Public Employees Retirement System | 198,530198,530 | $13M | — | ADD 5% |
| 94 | DEUTSCHE BANK AG\ | 187,138187,138 | $12M | — | ADD 6% |
| 95 | SEGALL BRYANT & HAMILL, LLC | 180,200180,200 | $12M | — | TRIM -5% |
| 96 | Checkpoint Capital L.P. | 180,000180,000 | $12M | — | ADD 8% |
| 97 | PINNACLE ASSOCIATES LTD | 177,062177,062 | $12M | — | TRIM -7% |
| 98 | Russell Investments Group, Ltd. | 174,029174,029 | $11M | — | ADD 26% |
| 99 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 167,124167,124 | $11M | — | TRIM -12% |
| 100 | AQR CAPITAL MANAGEMENT LLC | 156,544156,544 | $10M | — | TRIM -34% |
Ranked by each filer’s own reported value, not shares.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD PORTFOLIO MANAGEMENT LLC | +5,843,782 | $385M | OPEN |
| VANGUARD CAPITAL MANAGEMENT LLC | +5,488,634 | $362M | OPEN |
| Avoro Capital Advisors LLC | +3,333,333 | $220M | OPEN |
| Paradigm Biocapital Advisors LP | +1,480,857 | $98M | OPEN |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | +1,087,591 | $72M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −12,048,131 | $794M | CLOSE |
| T. Rowe Price Investment Management, Inc. | −9,582,936 | $632M | TRIM |
| FMR LLC | −2,084,612 | $137M | TRIM |
| Deep Track Capital, LP | −1,962,678 | $129M | TRIM |
| NORGES BANK | −807,070 | $53M | CLOSE |
Prior quarter split-rebased · 13Fs are long, US-listed only.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 10.8M | 10.0M | 17.6M | 19.1M | 27.1M | 17.5M | $1.2B |
| BlackRock, Inc. | 15.5M | 15.6M | 15.7M | 15.5M | 16.4M | 16.5M | $1.1B |
| FMR LLC | 10.8M | 10.3M | 11.3M | 13.1M | 12.8M | 10.7M | $707M |
| WELLINGTON MANAGEMENT GROUP LLP | 7.9M | 8.0M | 7.8M | 7.4M | 7.9M | 8.0M | $528M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 5.8M | $385M |
| STATE STREET CORP | 6.2M | 6.1M | 6.4M | 5.6M | 5.8M | 5.7M | $379M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 5.5M | $362M |
| Avoro Capital Advisors LLC | — | — | — | — | — | 3.3M | $220M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.8M | 2.9M | 3.0M | 3.0M | 3.1M | 3.2M | $212M |
| BANK OF AMERICA CORP /DE/ | 219K | 2.7M | 2.6M | 3.1M | 2.9M | 3.1M | $206M |
| RTW INVESTMENTS, LP | 2.7M | 2.7M | 2.7M | 2.7M | 2.7M | 2.7M | $179M |
| GOLDMAN SACHS GROUP INC | 1.2M | 1.4M | 1.3M | 1.6M | 2.4M | 2.2M | $145M |
| UBS Group AG | 1.2M | 2.1M | 3.1M | 1.8M | 1.1M | 2.1M | $137M |
| Polar Capital Holdings Plc | 2.2M | 2.5M | 2.8M | 2.8M | 2.4M | 1.7M | $109M |
| Integral Health Asset Management, LLC | 1.0M | 1.1M | 1.0M | 1.4M | 1.4M | 1.6M | $105M |
Green = added, red = trimmed, grey = held; a dash is a quarter with no 13F on file — a gap, not an exit.
Breaks = no 13F that quarter.
Short interest has its own tab now — open SI →
SEC Form 13F · ~10,250 filers, 10y · long-only, US-listed, filed ≤45d after quarter-end.
SEC Schedule 13D/G XML · group aggregate.