CYTK US Equity

CYTOKINETICS INC

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Health Care · Pharmaceutical Preparations · CIK 1061983 · FYE 1231

$79.45

-1.17 (-1.45%)

USD · as of 2026-07-28 · marketstack

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Institutional ownership· 13F filers holding CYTK · 2026-Q1 methodology → sources →

437 holders

% of shares outstanding held

—

Shares held (13F)

146,192,836

Reporting holders

437

% of shares outstanding suppressed: the summed institutional 13F holdings (146,192,836) exceed the latest reported shares-outstanding count (124,432,565) by more than securities-lending double counting can explain (FINRA short interest 15,896,196 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.

Top holders

largest 100 of 437 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	T. Rowe Price Investment Management, Inc.	17,523,84017.5M	$1.2B	—	TRIM -35%
2	BlackRock, Inc.	16,548,01116.5M	$1.1B	—	—
3	FMR LLC	10,723,14010.7M	$707M	—	TRIM -16%
4	WELLINGTON MANAGEMENT GROUP LLP	8,009,4898.0M	$528M	—	—
5	VANGUARD PORTFOLIO MANAGEMENT LLC	5,843,7825.8M	$385M	—	NEW†
6	STATE STREET CORP	5,745,1935.7M	$379M	—	—
7	VANGUARD CAPITAL MANAGEMENT LLC	5,488,6345.5M	$362M	—	NEW†
8	Avoro Capital Advisors LLC	3,333,3333.3M	$220M	—	NEW†
9	GEODE CAPITAL MANAGEMENT, LLC	3,215,4153.2M	$212M	—	ADD 5%
10	BANK OF AMERICA CORP /DE/	3,125,4363.1M	$206M	—	ADD 6%
11	RTW INVESTMENTS, LP	2,721,1582.7M	$179M	—	—
12	GOLDMAN SACHS GROUP INC	2,205,7582.2M	$145M	—	TRIM -7%
13	UBS Group AG	2,077,2772.1M	$137M	—	ADD 84%
14	Polar Capital Holdings Plc	1,661,2481.7M	$109M	—	TRIM -31%
15	Integral Health Asset Management, LLC	1,600,0001.6M	$105M	—	ADD 14%
16	PRICE T ROWE ASSOCIATES INC /MD/	1,584,3211.6M	$104M	—	TRIM -18%
17	MORGAN STANLEY	1,505,0751.5M	$99M	—	ADD 19%
18	Paradigm Biocapital Advisors LP	1,480,8571.5M	$98M	—	NEW
19	NORTHERN TRUST CORP	1,441,6341.4M	$95M	—	ADD 4%
20	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1,397,0451.4M	$92M	—	—
21	Deep Track Capital, LP	1,374,3201.4M	$91M	—	TRIM -59%
22	Capital International Investors	1,338,8031.3M	$88M	—	ADD 14%
23	Frazier Life Sciences Management, L.P.	1,159,8791.2M	$76M	—	ADD 24%
24	CITADEL ADVISORS LLC	1,099,8581.1M	$72M	—	TRIM -5%
25	PRINCIPAL FINANCIAL GROUP INC	1,093,4851.1M	$72M	—	ADD 12%
26	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1,087,5911.1M	$72M	—	NEW
27	Bank of New York Mellon Corp	1,006,1851.0M	$66M	—	ADD 18%
28	Woodline Partners LP	1,000,4281.0M	$66M	—	TRIM -39%
29	Balyasny Asset Management L.P.	992,545992,545	$65M	—	NEW
30	Royalty Pharma Sub-Manager, LLC	980,392980,392	$65M	—	—
31	SUSQUEHANNA INTERNATIONAL GROUP, LLP	898,951898,951	$59M	—	ADD 19%
32	Logos Global Management LP	875,000875,000	$58M	—	ADD 192%
33	JPMORGAN CHASE & CO	903,805903,805	$57M	—	TRIM -36%
34	BNP PARIBAS FINANCIAL MARKETS	854,374854,374	$56M	—	ADD 47%
35	Melqart Asset Management (UK) Ltd	843,949843,949	$56M	—	ADD 35%
36	VANGUARD FIDUCIARY TRUST CO	799,622799,622	$53M	—	NEW
37	Qube Research & Technologies Ltd	779,446779,446	$51M	—	ADD 45%
38	Capital Research Global Investors	770,999770,999	$51M	—	NEW
39	Fisher Asset Management, LLC	768,264768,264	$51M	—	TRIM -7%
40	ARMISTICE CAPITAL, LLC	764,538764,538	$50M	—	TRIM -23%
41	Pictet Asset Management Holding SA	750,953750,953	$49M	—	—
42	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	714,344714,344	$47M	—	TRIM -14%
43	D. E. Shaw & Co., Inc.	706,631706,631	$47M	—	ADD 493%
44	Affinity Asset Advisors, LLC	700,483700,483	$46M	—	TRIM -12%
45	FEDERATED HERMES, INC.	699,453699,453	$46M	—	ADD 45%
46	Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	660,310660,310	$44M	—	TRIM -12%
47	MARSHALL WACE, LLP	656,608656,608	$43M	—	ADD 95%
48	ADAR1 Capital Management, LLC	632,556632,556	$42M	—	ADD 17%
49	Point72 Asset Management, L.P.	626,102626,102	$41M	—	NEW
50	BROWN ADVISORY INC	614,655614,655	$41M	—	TRIM -16%
51	Siren, L.L.C.	613,952613,952	$40M	—	NEW
52	Foresite Capital Management IV, LLC	503,295503,295	$33M	—	ADD 10%
53	MPM BIOIMPACT LLC	500,000500,000	$33M	—	NEW
54	GW&K Investment Management, LLC	494,619494,619	$33M	—	ADD 5%
55	Invesco Ltd.	484,980484,980	$32M	—	ADD 137%
56	Aberdeen Group plc	483,274483,274	$32M	—	—
57	EVENTIDE ASSET MANAGEMENT, LLC	479,098479,098	$32M	—	—
58	AMERICAN CENTURY COMPANIES INC	443,957443,957	$29M	—	—
59	ALLIANCEBERNSTEIN L.P.	459,087459,087	$29M	—	ADD 11%
60	TD Asset Management Inc	420,846420,846	$28M	—	TRIM -23%
61	FRANKLIN RESOURCES INC	409,784409,784	$27M	—	—
62	RHUMBLINE ADVISERS	369,575369,575	$24M	—	ADD 4%
63	GROUP ONE TRADING LLC	363,997363,997	$24M	—	TRIM -11%
64	Nuveen, LLC	351,809351,809	$23M	—	TRIM -5%
65	GSK plc	340,434340,434	$22M	—	—
66	Candriam S.C.A.	335,208335,208	$22M	—	ADD 129%
67	GILDER GAGNON HOWE & CO LLC	330,989330,989	$22M	—	TRIM -14%
68	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	311,649311,649	$21M	—	TRIM -5%
69	AMERIPRISE FINANCIAL INC	302,802302,802	$20M	—	TRIM -45%
70	E. Ohman J:or Asset Management AB	300,762300,762	$20M	—	TRIM -17%
71	Vestal Point Capital, LP	300,000300,000	$20M	—	NEW
72	Trails Edge Capital Partners, LP	300,000300,000	$20M	—	NEW
73	TWO SIGMA INVESTMENTS, LP	285,008285,008	$19M	—	ADD 4%
74	First Turn Management, LLC	283,700283,700	$19M	—	TRIM -13%
75	Ikarian Capital, LLC	283,572283,572	$19M	—	ADD 64%
76	JANUS HENDERSON GROUP PLC	282,121282,121	$19M	—	ADD 10%
77	Susquehanna Portfolio Strategies, LLC	278,429278,429	$18M	—	—
78	VOYA INVESTMENT MANAGEMENT LLC	259,459259,459	$17M	—	ADD 296%
79	STEMPOINT CAPITAL LP	259,154259,154	$17M	—	ADD 76%
80	CITIGROUP INC	249,243249,243	$16M	—	ADD 144%
81	Handelsbanken Fonder AB	247,300247,300	$16M	—	ADD 20%
82	Caption Management, LLC	245,000245,000	$16M	—	ADD 775%
83	Capital World Investors	242,041242,041	$16M	—	NEW
84	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	240,632240,632	$16M	—	ADD 2%
85	Swiss National Bank	229,800229,800	$15M	—	ADD 2%
86	Sarissa Capital Management LP	228,623228,623	$15M	—	TRIM -42%
87	HSBC HOLDINGS PLC	221,999221,999	$15M	—	ADD 2903%
88	DAFNA Capital Management LLC	217,497217,497	$14M	—	TRIM -41%
89	Freestone Grove Partners LP	216,769216,769	$14M	—	NEW
90	Catalio Capital Management, LP	215,501215,501	$14M	—	TRIM -17%
91	Mirador Capital Partners LP	202,673202,673	$13M	—	ADD 2%
92	EMERALD ADVISERS, LLC	198,811198,811	$13M	—	NEW
93	California Public Employees Retirement System	198,530198,530	$13M	—	ADD 5%
94	DEUTSCHE BANK AG\	187,138187,138	$12M	—	ADD 6%
95	SEGALL BRYANT & HAMILL, LLC	180,200180,200	$12M	—	TRIM -5%
96	Checkpoint Capital L.P.	180,000180,000	$12M	—	ADD 8%
97	PINNACLE ASSOCIATES LTD	177,062177,062	$12M	—	TRIM -7%
98	Russell Investments Group, Ltd.	174,029174,029	$11M	—	ADD 26%
99	MANUFACTURERS LIFE INSURANCE COMPANY, THE	167,124167,124	$11M	—	TRIM -12%
100	AQR CAPITAL MANAGEMENT LLC	156,544156,544	$10M	—	TRIM -34%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

T. Rowe Price Investment Management, Inc.

10.8M

10.0M

17.6M

19.1M

27.1M

17.5M

$1.2B

BlackRock, Inc.

15.5M

15.6M

15.7M

15.5M

16.4M

16.5M

$1.1B

FMR LLC

10.8M

10.3M

11.3M

13.1M

12.8M

10.7M

$707M

WELLINGTON MANAGEMENT GROUP LLP

7.9M

8.0M

7.8M

7.4M

7.9M

8.0M

$528M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

5.8M

$385M

STATE STREET CORP

6.2M

6.1M

6.4M

5.6M

5.8M

5.7M

$379M

VANGUARD CAPITAL MANAGEMENT LLC

—

5.5M

$362M

Avoro Capital Advisors LLC

—

3.3M

$220M

GEODE CAPITAL MANAGEMENT, LLC

2.8M

2.9M

3.0M

3.1M

3.2M

$212M

BANK OF AMERICA CORP /DE/

219K

2.7M

2.6M

3.1M

2.9M

3.1M

$206M

RTW INVESTMENTS, LP

2.7M

$179M

GOLDMAN SACHS GROUP INC

1.2M

1.4M

1.3M

1.6M

2.4M

2.2M

$145M

UBS Group AG

1.2M

2.1M

3.1M

1.8M

1.1M

2.1M

$137M

Polar Capital Holdings Plc

2.2M

2.5M

2.8M

2.4M

1.7M

$109M

Integral Health Asset Management, LLC

1.0M

1.1M

1.0M

1.4M

1.6M

$105M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	437	146,192,836	—	$9.6B
2025-Q4

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · CYTK

Large holders — 13G, passive (top 5 by % of class)

Holder

% of class

Type

As of

T. Rowe Price Investment Management, Inc.

14.5%

QII

2025-12-31

SEC →

VANGUARD CAPITAL MANAGEMENT LLC

5.21%

QII

2026-03-31

SEC →

STATE STREET CORP

4.7%

QII

2025-09-30

SEC →

FMR LLC

3.9%

QII

2026-06-30

SEC →

VANGUARD GROUP INC

QII

Institutional ownership· 13F filers holding CYTK · 2026-Q1 methodology → sources →

437 holders

% of shares outstanding held

—

Shares held (13F)

146,192,836

Reporting holders

437

Top holders

largest 100 of 437 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	T. Rowe Price Investment Management, Inc.	17,523,84017.5M	$1.2B	—	TRIM -35%
2	BlackRock, Inc.	16,548,01116.5M	$1.1B	—	—
3	FMR LLC	10,723,14010.7M	$707M	—	TRIM -16%
4	WELLINGTON MANAGEMENT GROUP LLP	8,009,4898.0M	$528M	—	—
5	VANGUARD PORTFOLIO MANAGEMENT LLC	5,843,7825.8M	$385M	—	NEW†
6	STATE STREET CORP	5,745,1935.7M	$379M	—	—
7	VANGUARD CAPITAL MANAGEMENT LLC	5,488,6345.5M	$362M	—	NEW†
8	Avoro Capital Advisors LLC	3,333,3333.3M	$220M	—	NEW†
9	GEODE CAPITAL MANAGEMENT, LLC	3,215,4153.2M	$212M	—	ADD 5%
10	BANK OF AMERICA CORP /DE/	3,125,4363.1M	$206M	—	ADD 6%
11	RTW INVESTMENTS, LP	2,721,1582.7M	$179M	—	—
12	GOLDMAN SACHS GROUP INC	2,205,7582.2M	$145M	—	TRIM -7%
13	UBS Group AG	2,077,2772.1M	$137M	—	ADD 84%
14	Polar Capital Holdings Plc	1,661,2481.7M	$109M	—	TRIM -31%
15	Integral Health Asset Management, LLC	1,600,0001.6M	$105M	—	ADD 14%
16	PRICE T ROWE ASSOCIATES INC /MD/	1,584,3211.6M	$104M	—	TRIM -18%
17	MORGAN STANLEY	1,505,0751.5M	$99M	—	ADD 19%
18	Paradigm Biocapital Advisors LP	1,480,8571.5M	$98M	—	NEW
19	NORTHERN TRUST CORP	1,441,6341.4M	$95M	—	ADD 4%
20	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1,397,0451.4M	$92M	—	—
21	Deep Track Capital, LP	1,374,3201.4M	$91M	—	TRIM -59%
22	Capital International Investors	1,338,8031.3M	$88M	—	ADD 14%
23	Frazier Life Sciences Management, L.P.	1,159,8791.2M	$76M	—	ADD 24%
24	CITADEL ADVISORS LLC	1,099,8581.1M	$72M	—	TRIM -5%
25	PRINCIPAL FINANCIAL GROUP INC	1,093,4851.1M	$72M	—	ADD 12%
26	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1,087,5911.1M	$72M	—	NEW
27	Bank of New York Mellon Corp	1,006,1851.0M	$66M	—	ADD 18%
28	Woodline Partners LP	1,000,4281.0M	$66M	—	TRIM -39%
29	Balyasny Asset Management L.P.	992,545992,545	$65M	—	NEW
30	Royalty Pharma Sub-Manager, LLC	980,392980,392	$65M	—	—
31	SUSQUEHANNA INTERNATIONAL GROUP, LLP	898,951898,951	$59M	—	ADD 19%
32	Logos Global Management LP	875,000875,000	$58M	—	ADD 192%
33	JPMORGAN CHASE & CO	903,805903,805	$57M	—	TRIM -36%
34	BNP PARIBAS FINANCIAL MARKETS	854,374854,374	$56M	—	ADD 47%
35	Melqart Asset Management (UK) Ltd	843,949843,949	$56M	—	ADD 35%
36	VANGUARD FIDUCIARY TRUST CO	799,622799,622	$53M	—	NEW
37	Qube Research & Technologies Ltd	779,446779,446	$51M	—	ADD 45%
38	Capital Research Global Investors	770,999770,999	$51M	—	NEW
39	Fisher Asset Management, LLC	768,264768,264	$51M	—	TRIM -7%
40	ARMISTICE CAPITAL, LLC	764,538764,538	$50M	—	TRIM -23%
41	Pictet Asset Management Holding SA	750,953750,953	$49M	—	—
42	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	714,344714,344	$47M	—	TRIM -14%
43	D. E. Shaw & Co., Inc.	706,631706,631	$47M	—	ADD 493%
44	Affinity Asset Advisors, LLC	700,483700,483	$46M	—	TRIM -12%
45	FEDERATED HERMES, INC.	699,453699,453	$46M	—	ADD 45%
46	Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	660,310660,310	$44M	—	TRIM -12%
47	MARSHALL WACE, LLP	656,608656,608	$43M	—	ADD 95%
48	ADAR1 Capital Management, LLC	632,556632,556	$42M	—	ADD 17%
49	Point72 Asset Management, L.P.	626,102626,102	$41M	—	NEW
50	BROWN ADVISORY INC	614,655614,655	$41M	—	TRIM -16%
51	Siren, L.L.C.	613,952613,952	$40M	—	NEW
52	Foresite Capital Management IV, LLC	503,295503,295	$33M	—	ADD 10%
53	MPM BIOIMPACT LLC	500,000500,000	$33M	—	NEW
54	GW&K Investment Management, LLC	494,619494,619	$33M	—	ADD 5%
55	Invesco Ltd.	484,980484,980	$32M	—	ADD 137%
56	Aberdeen Group plc	483,274483,274	$32M	—	—
57	EVENTIDE ASSET MANAGEMENT, LLC	479,098479,098	$32M	—	—
58	AMERICAN CENTURY COMPANIES INC	443,957443,957	$29M	—	—
59	ALLIANCEBERNSTEIN L.P.	459,087459,087	$29M	—	ADD 11%
60	TD Asset Management Inc	420,846420,846	$28M	—	TRIM -23%
61	FRANKLIN RESOURCES INC	409,784409,784	$27M	—	—
62	RHUMBLINE ADVISERS	369,575369,575	$24M	—	ADD 4%
63	GROUP ONE TRADING LLC	363,997363,997	$24M	—	TRIM -11%
64	Nuveen, LLC	351,809351,809	$23M	—	TRIM -5%
65	GSK plc	340,434340,434	$22M	—	—
66	Candriam S.C.A.	335,208335,208	$22M	—	ADD 129%
67	GILDER GAGNON HOWE & CO LLC	330,989330,989	$22M	—	TRIM -14%
68	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	311,649311,649	$21M	—	TRIM -5%
69	AMERIPRISE FINANCIAL INC	302,802302,802	$20M	—	TRIM -45%
70	E. Ohman J:or Asset Management AB	300,762300,762	$20M	—	TRIM -17%
71	Vestal Point Capital, LP	300,000300,000	$20M	—	NEW
72	Trails Edge Capital Partners, LP	300,000300,000	$20M	—	NEW
73	TWO SIGMA INVESTMENTS, LP	285,008285,008	$19M	—	ADD 4%
74	First Turn Management, LLC	283,700283,700	$19M	—	TRIM -13%
75	Ikarian Capital, LLC	283,572283,572	$19M	—	ADD 64%
76	JANUS HENDERSON GROUP PLC	282,121282,121	$19M	—	ADD 10%
77	Susquehanna Portfolio Strategies, LLC	278,429278,429	$18M	—	—
78	VOYA INVESTMENT MANAGEMENT LLC	259,459259,459	$17M	—	ADD 296%
79	STEMPOINT CAPITAL LP	259,154259,154	$17M	—	ADD 76%
80	CITIGROUP INC	249,243249,243	$16M	—	ADD 144%
81	Handelsbanken Fonder AB	247,300247,300	$16M	—	ADD 20%
82	Caption Management, LLC	245,000245,000	$16M	—	ADD 775%
83	Capital World Investors	242,041242,041	$16M	—	NEW
84	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	240,632240,632	$16M	—	ADD 2%
85	Swiss National Bank	229,800229,800	$15M	—	ADD 2%
86	Sarissa Capital Management LP	228,623228,623	$15M	—	TRIM -42%
87	HSBC HOLDINGS PLC	221,999221,999	$15M	—	ADD 2903%
88	DAFNA Capital Management LLC	217,497217,497	$14M	—	TRIM -41%
89	Freestone Grove Partners LP	216,769216,769	$14M	—	NEW
90	Catalio Capital Management, LP	215,501215,501	$14M	—	TRIM -17%
91	Mirador Capital Partners LP	202,673202,673	$13M	—	ADD 2%
92	EMERALD ADVISERS, LLC	198,811198,811	$13M	—	NEW
93	California Public Employees Retirement System	198,530198,530	$13M	—	ADD 5%
94	DEUTSCHE BANK AG\	187,138187,138	$12M	—	ADD 6%
95	SEGALL BRYANT & HAMILL, LLC	180,200180,200	$12M	—	TRIM -5%
96	Checkpoint Capital L.P.	180,000180,000	$12M	—	ADD 8%
97	PINNACLE ASSOCIATES LTD	177,062177,062	$12M	—	TRIM -7%
98	Russell Investments Group, Ltd.	174,029174,029	$11M	—	ADD 26%
99	MANUFACTURERS LIFE INSURANCE COMPANY, THE	167,124167,124	$11M	—	TRIM -12%
100	AQR CAPITAL MANAGEMENT LLC	156,544156,544	$10M	—	TRIM -34%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

T. Rowe Price Investment Management, Inc.

10.8M

10.0M

17.6M

19.1M

27.1M

17.5M

$1.2B

BlackRock, Inc.

15.5M

15.6M

15.7M

15.5M

16.4M

16.5M

$1.1B

FMR LLC

10.8M

10.3M

11.3M

13.1M

12.8M

10.7M

$707M

WELLINGTON MANAGEMENT GROUP LLP

7.9M

8.0M

7.8M

7.4M

7.9M

8.0M

$528M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

5.8M

$385M

STATE STREET CORP

6.2M

6.1M

6.4M

5.6M

5.8M

5.7M

$379M

VANGUARD CAPITAL MANAGEMENT LLC

—

5.5M

$362M

Avoro Capital Advisors LLC

—

3.3M

$220M

GEODE CAPITAL MANAGEMENT, LLC

2.8M

2.9M

3.0M

3.1M

3.2M

$212M

BANK OF AMERICA CORP /DE/

219K

2.7M

2.6M

3.1M

2.9M

3.1M

$206M

RTW INVESTMENTS, LP

2.7M

$179M

GOLDMAN SACHS GROUP INC

1.2M

1.4M

1.3M

1.6M

2.4M

2.2M

$145M

UBS Group AG

1.2M

2.1M

3.1M

1.8M

1.1M

2.1M

$137M

Polar Capital Holdings Plc

2.2M

2.5M

2.8M

2.4M

1.7M

$109M

Integral Health Asset Management, LLC

1.0M

1.1M

1.0M

1.4M

1.6M

$105M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	437	146,192,836	—	$9.6B
2025-Q4

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · CYTK

Large holders — 13G, passive (top 5 by % of class)

Holder

% of class

Type

As of

T. Rowe Price Investment Management, Inc.

14.5%

QII

2025-12-31

SEC →

VANGUARD CAPITAL MANAGEMENT LLC

5.21%

QII

2026-03-31

SEC →

STATE STREET CORP

4.7%

QII

2025-09-30

SEC →

FMR LLC

3.9%

QII

2026-06-30

SEC →

VANGUARD GROUP INC

QII

CYTK US Equity☆

Institutional ownership· 13F filers holding CYTK · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · CYTK

Institutional ownership· 13F filers holding CYTK · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · CYTK

CYTK US Equity