| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | JANUS HENDERSON GROUP PLC | 6,307,6366.3M | $28M | 12.15% | — |
| 2 | 5AM Venture Management, LLC | 5,869,0915.9M | $26M | 11.30% | — |
| 3 | FMR LLC | 4,933,4324.9M | $22M | 9.50% | — |
| 4 | Vivo Capital, LLC | 4,246,5684.2M | $19M | 8.18% | — |
| 5 | Balyasny Asset Management L.P. | 2,632,4372.6M | $12M | 5.07% | ADD 8% |
| 6 | ENAVATE SCIENCES GP, LLC | 2,190,9202.2M | $10M | 4.22% | TRIM -28% |
| 7 | a16z Capital Management, L.L.C. | 2,125,3392.1M | $9M | 4.09% | — |
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,960,7842.0M | $9M | 3.78% | TRIM -10% |
| 9 | Trails Edge Capital Partners, LP | 1,939,5631.9M | $9M | 3.74% | TRIM -2% |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 1,534,7681.5M | $7M | 2.96% | NEW† |
| 11 | Stonepine Capital Management, LLC | 1,389,6221.4M | $6M | 2.68% | ADD 507% |
| 12 | HarbourVest Partners LLC | 1,271,9481.3M | $6M | 2.45% | — |
| 13 | SILVERARC CAPITAL MANAGEMENT, LLC | 653,594653,594 | $3M | 1.26% | NEW |
| 14 | BlackRock, Inc. | 456,371456,371 | $2M | 0.88% | ADD 17% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 382,821382,821 | $2M | 0.74% | ADD 14% |
| 16 | SummitTX Capital, L.P. | 339,521339,521 | $1M | 0.65% | NEW |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 336,047336,047 | $1M | 0.65% | NEW |
| 18 | VANGUARD FIDUCIARY TRUST CO | 195,013195,013 | $860,007 | 0.38% | NEW |
| 19 | STATE STREET CORP | 146,900146,900 | $647,829 | 0.28% | ADD 270% |
| 20 | TWO SIGMA INVESTMENTS, LP | 108,875108,875 | $480,139 | 0.21% | ADD 15% |
| 21 | 683 Capital Management, LLC | 108,000108,000 | $476,280 | 0.21% | TRIM -15% |
| 22 | MILLENNIUM MANAGEMENT LLC | 85,91885,918 | $378,898 | 0.17% | ADD 751% |
| 23 | VICTORY CAPITAL MANAGEMENT INC | 82,45082,450 | $363,605 | 0.16% | — |
| 24 | GOLDMAN SACHS GROUP INC | 78,34578,345 | $345,501 | 0.15% | ADD 316% |
| 25 | NORTHERN TRUST CORP | 70,66670,666 | $311,637 | 0.14% | TRIM -5% |
| 26 | Hudson Bay Capital Management LP | 48,51148,511 | $213,934 | 0.09% | NEW |
| 27 | BARCLAYS PLC | 34,69334,693 | $152,997 | 0.07% | TRIM -53% |
| 28 | BANK OF AMERICA CORP /DE/ | 31,19631,196 | $137,574 | 0.06% | ADD 141700% |
| 29 | HRT FINANCIAL LP | 30,74730,747 | $135,000 | 0.06% | NEW |
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,00025,000 | $110,250 | 0.05% | — |
| 31 | Qube Research & Technologies Ltd | 24,80324,803 | $109,381 | 0.05% | NEW |
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,00020,000 | $88,200 | 0.04% | NEW |
| 33 | Bank of New York Mellon Corp | 18,71818,718 | $82,546 | 0.04% | — |
| 34 | Point72 Asset Management, L.P. | 17,32617,326 | $76,408 | 0.03% | NEW |
| 35 | China Universal Asset Management Co., Ltd. | 16,00016,000 | $70,560 | 0.03% | ADD 60% |
| 36 | Diametric Capital, LP | 14,44614,446 | $63,706 | 0.03% | NEW |
| 37 | Scientech Research LLC | 12,73512,735 | $56,161 | 0.02% | NEW |
| 38 | Vanguard Global Advisers, LLC | 11,61511,615 | $51,222 | 0.02% | NEW |
| 39 | CITIGROUP INC | 9,8879,887 | $43,602 | 0.02% | TRIM -54% |
| 40 | MORGAN STANLEY | 9,5059,505 | $41,917 | 0.02% | TRIM -4% |
| 41 | UBS Group AG | 9,0819,081 | $40,047 | 0.02% | ADD 77% |
| 42 | Tower Research Capital LLC (TRC) | 1,4051,405 | $6,196 | 0.00% | ADD 246% |
| 43 | ROYAL BANK OF CANADA | 236236 | $1,000 | 0.00% | ADD 1211% |
| 44 | Caitong International Asset Management Co., Ltd | 7474 | $326 | 0.00% | NEW |
| 45 | BNP PARIBAS FINANCIAL MARKETS | 3636 | $159 | 0.00% | ADD 9% |
| 46 | SBI Securities Co., Ltd. | 1010 | $44 | 0.00% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | — | — | — | 4.6M | 6.3M | 6.3M | $28M |
| 5AM Venture Management, LLC | 2.9M | 2.9M | 2.9M | 5.9M | 5.9M | 5.9M | $26M |
| FMR LLC | 755K | 767K | 608K | 3.0M | 4.9M | 4.9M | $22M |
| Vivo Capital, LLC | — | — | — | 3.9M | 4.2M | 4.2M | $19M |
| Balyasny Asset Management L.P. | — | — | — | — | 2.4M | 2.6M | $12M |
| ENAVATE SCIENCES GP, LLC | 3.8M | 3.8M | 3.8M | 3.8M | 3.0M | 2.2M | $10M |
| a16z Capital Management, L.L.C. | 2.1M | 2.1M | 2.1M | 2.1M | 2.1M | 2.1M | $9M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | — | — | — | 2.0M | 2.2M | 2.0M | $9M |
| Trails Edge Capital Partners, LP | — | — | — | — | 2.0M | 1.9M | $9M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.5M | $7M |
| Stonepine Capital Management, LLC | — | — | — | — | 229K | 1.4M | $6M |
| HarbourVest Partners LLC | 1.3M | 1.3M | 1.3M | 1.3M | 1.3M | 1.3M | $6M |
| SILVERARC CAPITAL MANAGEMENT, LLC | — | — | — | 654K | — | 654K | $3M |
| BlackRock, Inc. | 265K | 296K | 84K | 11K | 390K | 456K | $2M |
| GEODE CAPITAL MANAGEMENT, LLC | 145K | 160K | 75K | 60K | 336K | 383K | $2M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 46 | 39,782,653 | 76.6% | $176M |
| 2025-Q4 | 40 | 38,247,396 | 73.7% | $235M |
| 2025-Q3 | 29 | 28,210,088 | 54.3% | $85M |
| 2025-Q2 | 29 | 11,745,573 | 22.6% | $17M |
| 2025-Q1 | 39 | 12,677,518 | 24.4% | $51M |
| 2024-Q4 | 36 | 12,854,103 | 24.8% | $67M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
