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Clinical trials
catalyst calendar across sponsors →Studies where BIOG-B.ST is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
18 interventional · 2 with posted results
government filings 180d: none disclosed
| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| Influence of Probiotics on Early Gut Microbial ColonizationNCT07608341To assess early gut microbial colonization in C-section newborns after probiotic supplementation + vitamin D3 or placebo + vitamin D3 and in vaginal born controls.Randomized · Quadruple-masked · Basic science | Not applicable | Not yet recruiting | Dietary supplement: Probiotic drops, Placebo drops | C-Section | 150 | 2030-08-01 | in 1,443 d | 2026-05-27 |
| Efficacy and Tolerability of a Probiotic OintmentNCT07701447Primary EndpointRandomized · Single-masked · Treatment | Not applicable | Not yet recruiting | Other: Probiotic Ointment, Comparator product | Atopic Dermatitis | 92 | Nov 2028 | ≤ 834 d | 2026-07-15 |
| An Open-label, Single-arm Interventional Study to Evaluate the Safety and Efficacy of a Probiotic-containing Cream in Children With Dry SkinNCT07713303Primary objectiveOpen-label · Treatment | Not applicable | Not yet recruiting | Other: Probiotic Ointment | Dry Skin | 40 | 2027-02-01 | in 166 d | 2026-07-20 |
| Evaluating the Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying and Fussing Time in Infants With ColicNCT07190859Crying and fussing timeRandomized · Quadruple-masked · Treatment | Not applicable | Recruiting | Dietary supplement: L. reuteri, Placebo | Infantile Colic | 50 | 2026-02-17 | — | 2025-09-24 |
| Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying Time in Infants With ColicNCT05512234Crying and fussing timeRandomized · Quadruple-masked · Treatment | Not applicable | Recruiting | Dietary supplement: L. reuteri, Placebo | Colic, Infantile | 102 | 2025-10-30 | — | 2025-09-22 |
| Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying and Fussing Time in Infants With ColicNCT06462651Crying and fussing timeRandomized · Quadruple-masked · Treatment | Not applicable | Completed | Dietary supplement: L. reuteri, Placebo | Infantile Colic | 50 | 2026-03-15actual | — | 2026-03-19 |
| Validation of Active-Insights Device to Measure Crying TimeNCT05165589Device feasibility: Comparison of device-generated versus diary-reported crying and fussing time dataNon-randomized · Open-label · Device feasibility | Not applicable | Unknown status | Device: ActiveInsights accelerometer device | Infant Behavior | 13 | Jan 2022 | — | 2021-12-21 |
| Study Evaluating the Safety and Tolerability of a ProbioitcNCT05044949To evaluate the incidence of treatment emergency adverse events (safety and tolerability).Randomized · Quadruple-masked · Other | Not applicable | Completed | Other: Probiotic, Placebo | Healthy Volunteers, Tolerability, Safety | 35 | 2021-12-31actual | — | 2022-02-11 |
| Effect of Probiotics on Testosterone in MenNCT04577625Concentration of total testosteroneRandomized · Quadruple-masked · Basic science | Not applicable | Completed | Dietary supplement: Lactobacillus reuteri (L. reuteri) | Healthy | 60 | 2021-06-05actual | — | 2021-06-21 |
| Study Evaluating the Safety and TolerabilityNCT04692506To evaluate the incidence of treatment emergent adverse events ( safety and tolerability) of B. longum administered to healthy subjects for 28 days.Randomized · Quadruple-masked · Other | Not applicable | Completed | Other: Probiotic | Healthy Volunteers | 36 | 2021-02-24actual | — | 2021-06-18 |
| Lactobacillus Reuteri DSM 17938 in Gut Microbiota Development in Infant Born by Caesarean SectionNCT03675048Composition of gut microbiota in infants born by Caesarean sectionRandomized · Quadruple-masked · Prevention | Not applicable | Completed | Dietary supplement: BioGaia Protectis drops, Placebo | Dysbiosis, Prophylaxis | 97 | 2020-10-05actual | — | 2021-09-20 |
| Evaluation and Comparison of 2 Cosmetic Investigational Products in Adults With Atopic DermatitisNCT03632174Appraisal of Cutaneous acceptability of the investigational products by dermatologist investigatorRandomized · Double-masked · Other | Not applicable | Completed | Other: Topical Ointment with L. reuteri, Topical Ointment without L. reuteri | Atopic Dermatitis | 36 | 2019-09-02actual | — | 2019-10-22 |
| Evaluating the Effect of the Probiotic on Recurrent Urinary Tract Infection in Adult WomenNCT03366077results2025-09-15To Evaluate the Effect of Oral Supplementation With Lactobacillus Reuteri on the Frequency of Confirmed UTI in Adult Women With Recurrent UTI.Randomized · Double-masked · PreventionStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Dietary supplement: Probiotic | Recurrent Urinary Tract Infection in Adult Women | 140 | 2019-07-12actual | — | 2025-09-15 |
| Effectiveness of Probiotic Supplementation on Crying Time in Infantile ColicNCT03106285Daily average of crying time with L reuteri vs placeboRandomized · Triple-masked · Other | Not applicable | Withdrawnsponsor's stated reason: Cannot perform the study due to practical issues | Dietary supplement: Lactobacillus reuteri DSM17938, Placebo | Colic, Infantile | 0 | 2019-05-01actual | — | 2022-05-05 |
| The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia NervosaNCT02004288results2021-06-22Number of Participants That Drop Out From Rome III Criteria for ConstipationRandomized · Triple-masked · Supportive care | Not applicable | Completed | Dietary supplement: Lactobacillus reuteri Protectis DSM17938 | Anorexia Nervosa, Constipation | 31 | Sep 2016actual | — | 2021-06-23 |
| Effect of Lactobacillus Gasseri DSM 27123 on Functional Constipation in Healthy WomenNCT02592200Change in frequency of complete spontaneous bowel movements (CSBMs)Randomized · Quadruple-masked · Treatment | Not applicable | Completed | Dietary supplement: Lactobacillus gasseri DSM 27123, Placebo | Functional Constipation | 40 | 2016-06-21actual | — | 2021-01-05 |
| Lactobacillus Reuteri Supplementation in the Treatment of Infantile ColicNCT01887444The responder rate (infants for whom daily crying time decreases by 50% compared to baseline, D0) at D7 in the probiotic group compared to placebo. The daily crying time will be sound recorded during 24 hours at D0 and D7.and expressed in minutes.Randomized · Quadruple-masked · Treatment | Not applicable | Withdrawnsponsor's stated reason: Never started | Dietary supplement: Lactobacillus reuteri DSM17938 probiotic · Other: Placebo | Infantile Colic | 0 | May 2014actual | — | 2021-02-04 |
| Efficacy of Lactobacillus Reuteri Protectis on Functional Abdominal Pain (FAP) in Children 8-14 Years OldNCT01498666Primary endpointRandomized · Triple-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: The recruitment rate was too slow according to study protocol and agreement. | Dietary supplement: L. reuteri protectis, Placebo tablet | Abdominal Pain | 9 | Apr 2013actual | — | 2021-06-02 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19