| 1 | 1FMR LLC | 12,452,19912.5M | $297M | 12.10% | ADD 5% |
| 2 | 2ARK Investment Management LLC | 12,133,43312.1M | $289M | 11.79% | TRIM -3% |
| 3 | 3FARALLON CAPITAL MANAGEMENT LLC | 10,134,69610.1M | $242M | 9.85% | — |
| 4 | 4BlackRock, Inc. | 8,487,5698.5M | $202M | 8.25% | — |
| 5 | 5STATE STREET CORP | 5,699,2655.7M | $136M | 5.54% | ADD 9% |
| 6 | 6VANGUARD PORTFOLIO MANAGEMENT LLC | 4,570,7974.6M | $109M | 4.44% | NEW† |
| 7 | 7ARCH Venture Management, LLC | 4,540,1324.5M | $108M | 4.41% | — |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 4,377,3744.4M | $104M | 4.25% | NEW† |
| 9 | 9Sumitomo Mitsui Trust Group, Inc. | 3,825,5853.8M | $91M | 3.72% | TRIM -13% |
| 10 | 10Amova Asset Management Americas, Inc. | 3,825,5853.8M | $91M | 3.72% | TRIM -13% |
| 11 | 11Kynam Capital Management, LP | 3,682,1853.7M | $88M | 3.58% | ADD 51% |
| 12 | 12PRICE T ROWE ASSOCIATES INC /MD/ | 2,713,2302.7M | $65M | 2.64% | — |
| 13 | 13GEODE CAPITAL MANAGEMENT, LLC | 2,418,5922.4M | $58M | 2.35% | ADD 3% |
| 14 | 14DIMENSIONAL FUND ADVISORS LP | 2,154,5752.2M | $51M | 2.09% | ADD 11% |
| 15 | 15UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,653,7141.7M | $39M | 1.61% | TRIM -3% |
| 16 | 16ADAR1 Capital Management, LLC | 1,446,3751.4M | $34M | 1.41% | NEW |
| 17 | 17Casdin Capital, LLC | 1,350,0001.4M | $32M | 1.31% | TRIM -16% |
| 18 | 18Redmile Group, LLC | 1,237,6591.2M | $29M | 1.20% | TRIM -4% |
| 19 | 19TWO SIGMA INVESTMENTS, LP | 1,210,8531.2M | $29M | 1.18% | ADD 8% |
| 20 | 20Qube Research & Technologies Ltd | 1,084,7681.1M | $26M | 1.05% | ADD 171% |
| 21 | 21GOLDMAN SACHS GROUP INC | 1,005,7431.0M | $24M | 0.98% | ADD 92% |
| 22 | 22UBS Group AG | 826,061826,061 | $20M | 0.80% | TRIM -15% |
| 23 | 23NORTHERN TRUST CORP | 825,580825,580 | $20M | 0.80% | ADD 2% |
| 24 | 24Deep Track Capital, LP | 820,765820,765 | $20M | 0.80% | NEW |
| 25 | 25CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 808,436808,436 | $19M | 0.79% | TRIM -3% |
| 26 | 26BNP PARIBAS FINANCIAL MARKETS | 700,647700,647 | $17M | 0.68% | ADD 49% |
| 27 | 27VANGUARD FIDUCIARY TRUST CO | 684,870684,870 | $16M | 0.67% | NEW |
| 28 | 28MORGAN STANLEY | 648,264648,264 | $15M | 0.63% | TRIM -11% |
| 29 | 29RTW INVESTMENTS, LP | 570,394570,394 | $14M | 0.55% | — |
| 30 | 30BANK OF AMERICA CORP /DE/ | 538,290538,290 | $13M | 0.52% | ADD 26% |
| 31 | 31Contrarius Group Holdings Ltd | 533,443533,443 | $13M | 0.52% | NEW |
| 32 | 32CITADEL ADVISORS LLC | 528,970528,970 | $13M | 0.51% | ADD 107% |
| 33 | 33RENAISSANCE TECHNOLOGIES LLC | 513,578513,578 | $12M | 0.50% | ADD 228% |
| 34 | 34JPMORGAN CHASE & CO | 551,355551,355 | $12M | 0.54% | TRIM -11% |
| 35 | 35IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 488,417488,417 | $12M | 0.47% | TRIM -8% |
| 36 | 36Elmind Capital, LP | 476,338476,338 | $11M | 0.46% | — |
| 37 | 37BAILLIE GIFFORD & CO | 385,891385,891 | $9M | 0.38% | TRIM -7% |
| 38 | 38Bank of New York Mellon Corp | 344,486344,486 | $8M | 0.33% | TRIM -4% |
| 39 | 39Alphabet Inc. | 321,604321,604 | $8M | 0.31% | — |
| 40 | 40Integral Health Asset Management, LLC | 300,000300,000 | $7M | 0.29% | TRIM -45% |
| 41 | 41Pictet Asset Management Holding SA | 297,504297,504 | $7M | 0.29% | TRIM -9% |
| 42 | 42PEREGRINE INVESTMENT MANAGEMENT INC | 260,050260,050 | $6M | 0.25% | — |
| 43 | 43Nuveen, LLC | 232,596232,596 | $6M | 0.23% | — |
| 44 | 44Man Group plc | 231,994231,994 | $6M | 0.23% | NEW |
| 45 | 45Invesco Ltd. | 219,961219,961 | $5M | 0.21% | ADD 3% |
| 46 | 46HRT FINANCIAL LP | 219,426219,426 | $5M | 0.21% | ADD 45% |
| 47 | 47Swiss National Bank | 180,600180,600 | $4M | 0.18% | — |
| 48 | 48SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,391178,391 | $4M | 0.17% | ADD 81% |
| 49 | 49Vestmark Advisory Solutions, Inc. | 176,865176,865 | $4M | 0.17% | TRIM -10% |
| 50 | 50TD Asset Management Inc | 176,024176,024 | $4M | 0.17% | TRIM -8% |
| 51 | 51Rafferty Asset Management, LLC | 172,948172,948 | $4M | 0.17% | TRIM -2% |
| 52 | 52AMERICAN CENTURY COMPANIES INC | 168,673168,673 | $4M | 0.16% | ADD 14% |
| 53 | 53ALGERT GLOBAL LLC | 164,292164,292 | $4M | 0.16% | ADD 379% |
| 54 | 54MANUFACTURERS LIFE INSURANCE COMPANY, THE | 151,403151,403 | $4M | 0.15% | TRIM -4% |
| 55 | 55Russell Investments Group, Ltd. | 144,722144,722 | $3M | 0.14% | ADD 554% |
| 56 | 56MARSHALL WACE, LLP | 139,241139,241 | $3M | 0.14% | TRIM -85% |
| 57 | 57Susquehanna Portfolio Strategies, LLC | 138,132138,132 | $3M | 0.13% | — |
| 58 | 58FIRST TRUST ADVISORS LP | 135,166135,166 | $3M | 0.13% | ADD 111% |
| 59 | 59WELLS FARGO & COMPANY/MN | 132,249132,249 | $3M | 0.13% | TRIM -17% |
| 60 | 60ALLIANCEBERNSTEIN L.P. | 105,120105,120 | $3M | 0.10% | ADD 4% |
| 61 | 61Clearstead Advisors, LLC | 121,230121,230 | $3M | 0.12% | ADD 7982% |
| 62 | 62MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 118,018118,018 | $3M | 0.11% | ADD 5% |
| 63 | 63RHUMBLINE ADVISERS | 112,239112,239 | $3M | 0.11% | TRIM -14% |
| 64 | 64CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,741107,741 | $3M | 0.10% | ADD 23% |
| 65 | 65Zurcher Kantonalbank (Zurich Cantonalbank) | 102,129102,129 | $2M | 0.10% | ADD 133% |
| 66 | 66D.A. DAVIDSON & CO. | 98,99298,992 | $2M | 0.10% | — |
| 67 | 67JANUS HENDERSON GROUP PLC | 93,25393,253 | $2M | 0.09% | ADD 136% |
| 68 | 68Jump Financial, LLC | 89,38689,386 | $2M | 0.09% | NEW |
| 69 | 69DEUTSCHE BANK AG\ | 87,14187,141 | $2M | 0.08% | ADD 12% |
| 70 | 70Legal & General Group Plc | 81,91281,912 | $2M | 0.08% | TRIM -11% |
| 71 | 71Liontrust Investment Partners LLP | 80,76480,764 | $2M | 0.08% | TRIM -53% |
| 72 | 72VANGUARD ASSET MANAGEMENT, Ltd | 80,69780,697 | $2M | 0.08% | NEW |
| 73 | 73PROFUND ADVISORS LLC | 77,09577,095 | $2M | 0.07% | ADD 17% |
| 74 | 74Universal- Beteiligungs- und Servicegesellschaft mbH | 69,01369,013 | $2M | 0.07% | — |
| 75 | 75LPL Financial LLC | 66,93366,933 | $2M | 0.07% | ADD 20% |
| 76 | 76CITIGROUP INC | 66,85866,858 | $2M | 0.06% | ADD 150% |
| 77 | 77Privium Fund Management B.V. | 63,98263,982 | $2M | 0.06% | TRIM -11% |
| 78 | 78Alessandra Capital Management, LLC | 62,60662,606 | $1M | 0.06% | ADD 23% |
| 79 | 79HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 62,08962,089 | $1M | 0.06% | NEW |
| 80 | 80SG Americas Securities, LLC | 60,18060,180 | $1M | 0.06% | TRIM -42% |
| 81 | 81Ishara Investments LP | 57,40057,400 | $1M | 0.06% | ADD 15% |
| 82 | 82STATE OF WISCONSIN INVESTMENT BOARD | 57,21757,217 | $1M | 0.06% | TRIM -2% |
| 83 | 83Aquatic Capital Management LLC | 54,95354,953 | $1M | 0.05% | NEW |
| 84 | 84Y-Intercept (Hong Kong) Ltd | 53,16453,164 | $1M | 0.05% | NEW |
| 85 | 85MetLife Investment Management, LLC | 52,99452,994 | $1M | 0.05% | TRIM -3% |
| 86 | 86Engineers Gate Manager LP | 52,82552,825 | $1M | 0.05% | NEW |
| 87 | 87XTX Topco Ltd | 52,06152,061 | $1M | 0.05% | ADD 239% |
| 88 | 88WCG Wealth Advisors LLC | 50,11950,119 | $1M | 0.05% | ADD 26% |
| 89 | 89BARCLAYS PLC | 47,63847,638 | $1M | 0.05% | TRIM -85% |
| 90 | 90TUDOR INVESTMENT CORP ET AL | 47,31047,310 | $1M | 0.05% | ADD 192% |
| 91 | 91ENVESTNET ASSET MANAGEMENT INC | 42,19442,194 | $1M | 0.04% | ADD 34% |
| 92 | 92VOYA INVESTMENT MANAGEMENT LLC | 41,49341,493 | $988,778 | 0.04% | TRIM -26% |
| 93 | 93Raiffeisen Bank International AG | 45,00045,000 | $985,500 | 0.04% | ADD 5% |
| 94 | 94Canal Insurance CO | 40,00040,000 | $953,000 | 0.04% | NEW |
| 95 | 95Vanguard Global Advisers, LLC | 39,41239,412 | $939,188 | 0.04% | NEW |
| 96 | 96WELLINGTON MANAGEMENT GROUP LLP | 38,82438,824 | $925,177 | 0.04% | ADD 5% |
| 97 | 97Generali Investments Towarzystwo Funduszy Inwestycyjnych | 38,00038,000 | $905,540 | 0.04% | TRIM -16% |
| 98 | 98GUGGENHEIM CAPITAL LLC | 35,88435,884 | $855,116 | 0.03% | ADD 22% |
| 99 | 99Bridgefront Capital, LLC | 34,01834,018 | $810,649 | 0.03% | NEW |
| 100 | 100Handelsbanken Fonder AB | 33,62333,623 | $801,000 | 0.03% | — |
