| 1 | 1Matrix Capital Management Company, LP | 6,922,8706.9M | $46M | 6.70% | — |
| 2 | 2Frazier Life Sciences Management, L.P. | 5,100,0005.1M | $34M | 4.93% | — |
| 3 | 3ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,881,1254.9M | $33M | 4.72% | — |
| 4 | 4Long Focus Capital Management, LLC | 4,619,5824.6M | $31M | 4.47% | — |
| 5 | 5SUVRETTA CAPITAL MANAGEMENT, LLC | 4,372,8844.4M | $29M | 4.23% | — |
| 6 | 6BlackRock, Inc. | 3,586,6403.6M | $24M | 3.47% | — |
| 7 | 7Medicxi Ventures Management (Jersey) Ltd | 3,039,8923.0M | $20M | 2.94% | — |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 2,243,8282.2M | $15M | 2.17% | NEW† |
| 9 | 9Nantahala Capital Management, LLC | 2,117,6972.1M | $14M | 2.05% | — |
| 10 | 10FRANKLIN RESOURCES INC | 2,072,7262.1M | $14M | 2.00% | TRIM -6% |
| 11 | 11GEODE CAPITAL MANAGEMENT, LLC | 1,310,8621.3M | $9M | 1.27% | ADD 4% |
| 12 | 12MILLENNIUM MANAGEMENT LLC | 1,097,6271.1M | $7M | 1.06% | ADD 78% |
| 13 | 13STATE STREET CORP | 964,670964,670 | $6M | 0.93% | ADD 4% |
| 14 | 14LEVIN CAPITAL STRATEGIES, L.P. | 941,400941,400 | $6M | 0.91% | TRIM -9% |
| 15 | 15B Group, Inc. | 597,576597,576 | $4M | 0.58% | ADD 4% |
| 16 | 16ACORN CAPITAL ADVISORS, LLC | 595,744595,744 | $4M | 0.58% | — |
| 17 | 17DIMENSIONAL FUND ADVISORS LP | 558,158558,158 | $4M | 0.54% | ADD 8% |
| 18 | 18Balyasny Asset Management L.P. | 557,654557,654 | $4M | 0.54% | NEW |
| 19 | 19Regency Capital Management Inc.\DE | 532,495532,495 | $4M | 0.52% | — |
| 20 | 20NORTHERN TRUST CORP | 430,522430,522 | $3M | 0.42% | ADD 4% |
| 21 | 21PRICE T ROWE ASSOCIATES INC /MD/ | 415,191415,191 | $3M | 0.40% | TRIM -6% |
| 22 | 22VANGUARD FIDUCIARY TRUST CO | 397,160397,160 | $3M | 0.38% | NEW |
| 23 | 23VANGUARD PORTFOLIO MANAGEMENT LLC | 391,334391,334 | $3M | 0.38% | NEW |
| 24 | 24Caligan Partners LP | 229,864229,864 | $2M | 0.22% | NEW |
| 25 | 25MORGAN STANLEY | 224,041224,041 | $1M | 0.22% | ADD 3% |
| 26 | 26GOLDMAN SACHS GROUP INC | 178,726178,726 | $1M | 0.17% | ADD 28% |
| 27 | 27WELLINGTON MANAGEMENT GROUP LLP | 127,543127,543 | $853,263 | 0.12% | TRIM -10% |
| 28 | 28BANK OF AMERICA CORP /DE/ | 125,356125,356 | $838,632 | 0.12% | TRIM -24% |
| 29 | 29UBS Group AG | 118,904118,904 | $795,467 | 0.12% | TRIM -31% |
| 30 | 30PLATINUM INVESTMENT MANAGEMENT LTD | 111,865111,865 | $748,377 | 0.11% | — |
| 31 | 31RENAISSANCE TECHNOLOGIES LLC | 102,100102,100 | $683,049 | 0.10% | TRIM -30% |
| 32 | 32Bank of New York Mellon Corp | 99,43399,433 | $665,206 | 0.10% | TRIM -8% |
| 33 | 33CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 97,13997,139 | $649,860 | 0.09% | TRIM -28% |
| 34 | 34Quantinno Capital Management LP | 91,07591,075 | $609,292 | 0.09% | ADD 150% |
| 35 | 35BNP PARIBAS FINANCIAL MARKETS | 90,05590,055 | $602,468 | 0.09% | TRIM -21% |
| 36 | 36XTX Topco Ltd | 89,52189,521 | $598,895 | 0.09% | ADD 47% |
| 37 | 37Fisher Asset Management, LLC | 83,50883,508 | $558,668 | 0.08% | NEW |
| 38 | 38Nuveen, LLC | 72,71272,712 | $486,443 | 0.07% | — |
| 39 | 39Permanent Capital Management, LP | 62,36962,369 | $439,701 | 0.06% | TRIM -18% |
| 40 | 40RHUMBLINE ADVISERS | 64,72064,720 | $432,967 | 0.06% | — |
| 41 | 41TBH Global Asset Management, LLC | 60,32260,322 | $403,556 | 0.06% | — |
| 42 | 42MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,41957,419 | $384,133 | 0.06% | TRIM -3% |
| 43 | 43Maven Securities LTD | 50,00050,000 | $334,500 | 0.05% | NEW |
| 44 | 44AMERICAN CENTURY COMPANIES INC | 48,32348,323 | $323,281 | 0.05% | ADD 19% |
| 45 | 45AQR CAPITAL MANAGEMENT LLC | 46,14346,143 | $308,697 | 0.04% | ADD 233% |
| 46 | 46AMERIPRISE FINANCIAL INC | 42,26942,269 | $282,780 | 0.04% | — |
| 47 | 47TD Asset Management Inc | 40,50240,502 | $270,958 | 0.04% | — |
| 48 | 48Vanguard Global Advisers, LLC | 39,78939,789 | $266,188 | 0.04% | NEW |
| 49 | 49DEUTSCHE BANK AG\ | 37,97137,971 | $254,026 | 0.04% | ADD 23% |
| 50 | 50Invesco Ltd. | 34,26834,268 | $229,252 | 0.03% | ADD 26% |
| 51 | 51ALLIANCEBERNSTEIN L.P. | 41,66041,660 | $227,047 | 0.04% | — |
| 52 | 52COMMONWEALTH EQUITY SERVICES, LLC | 30,28430,284 | $202,600 | 0.03% | — |
| 53 | 53Brevan Howard Capital Management LP | 29,74629,746 | $199,001 | 0.03% | NEW |
| 54 | 54Susquehanna Portfolio Strategies, LLC | 28,72928,729 | $192,197 | 0.03% | TRIM -20% |
| 55 | 55LETKO, BROSSEAU & ASSOCIATES INC | 28,30028,300 | $189,327 | 0.03% | — |
| 56 | 56SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,48327,483 | $183,861 | 0.03% | NEW |
| 57 | 57CANADA PENSION PLAN INVESTMENT BOARD | 27,00027,000 | $180,630 | 0.03% | ADD 44% |
| 58 | 58EntryPoint Capital, LLC | 26,30026,300 | $175,947 | 0.03% | — |
| 59 | 59MetLife Investment Management, LLC | 24,96224,962 | $166,996 | 0.02% | — |
| 60 | 60JPMORGAN CHASE & CO | 23,53523,535 | $145,917 | 0.02% | — |
| 61 | 61Point72 Asset Management, L.P. | 21,70821,708 | $145,227 | 0.02% | TRIM -60% |
| 62 | 6249 WEALTH MANAGEMENT, LLC | 21,70421,704 | $145,200 | 0.02% | ADD 14% |
| 63 | 63Trexquant Investment LP | 20,99820,998 | $140,477 | 0.02% | TRIM -51% |
| 64 | 64MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,86920,869 | $139,614 | 0.02% | ADD 3% |
| 65 | 65BOOTHBAY FUND MANAGEMENT, LLC | 20,40220,402 | $136,489 | 0.02% | NEW |
| 66 | 66ExodusPoint Capital Management, LP | 17,95517,955 | $120,119 | 0.02% | TRIM -65% |
| 67 | 67Inscription Capital, LLC | 17,80617,806 | $119,122 | 0.02% | NEW |
| 68 | 68WELLS FARGO & COMPANY/MN | 16,99416,994 | $113,690 | 0.02% | TRIM -65% |
| 69 | 69BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,27616,276 | $108,886 | 0.02% | — |
| 70 | 70INTECH INVESTMENT MANAGEMENT LLC | 15,78115,781 | $105,575 | 0.02% | TRIM -25% |
| 71 | 71Vontobel Holding Ltd. | 15,00015,000 | $100,350 | 0.01% | NEW |
| 72 | 72Creative Planning | 14,07314,073 | $94,148 | 0.01% | ADD 25% |
| 73 | 73BROWN ADVISORY INC | 13,40013,400 | $89,646 | 0.01% | — |
| 74 | 74LOS ANGELES CAPITAL MANAGEMENT LLC | 13,27413,274 | $88,803 | 0.01% | NEW |
| 75 | 75NEW YORK STATE COMMON RETIREMENT FUND | 13,10413,104 | $87,666 | 0.01% | — |
| 76 | 76PRELUDE CAPITAL MANAGEMENT, LLC | 13,00013,000 | $86,970 | 0.01% | TRIM -74% |
| 77 | 77WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 12,92012,920 | $84,497 | 0.01% | ADD 10% |
| 78 | 78CITADEL ADVISORS LLC | 12,50312,503 | $83,645 | 0.01% | TRIM -82% |
| 79 | 79CITIGROUP INC | 12,48212,482 | $83,504 | 0.01% | TRIM -64% |
| 80 | 80BARCLAYS PLC | 11,54011,540 | $77,202 | 0.01% | TRIM -83% |
| 81 | 81Police & Firemen's Retirement System of New Jersey | 11,39711,397 | $76,246 | 0.01% | — |
| 82 | 82China Universal Asset Management Co., Ltd. | 11,26911,269 | $75,390 | 0.01% | ADD 9% |
| 83 | 83Quadrature Capital Ltd | 10,66710,667 | $71,362 | 0.01% | NEW |
| 84 | 84SIMPLEX TRADING, LLC | 8,4308,430 | $56,396 | 0.01% | ADD 220% |
| 85 | 85Parallel Advisors, LLC | 5,6655,665 | $37,899 | 0.01% | ADD 130% |
| 86 | 86Ameritas Investment Partners, Inc. | 4,5444,544 | $30,399 | 0.00% | — |
| 87 | 87UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,5174,517 | $30,219 | 0.00% | ADD 184% |
| 88 | 88Legal & General Group Plc | 4,0964,096 | $27,402 | 0.00% | TRIM -6% |
| 89 | 89CWM, LLC | 4,0184,018 | $26,880 | 0.00% | ADD 395% |
| 90 | 90Tower Research Capital LLC (TRC) | 3,9133,913 | $26,178 | 0.00% | ADD 100% |
| 91 | 91Russell Investments Group, Ltd. | 3,6753,675 | $24,585 | 0.00% | — |
| 92 | 92Mirae Asset Global Investments Co., Ltd. | 3,3123,312 | $22,157 | 0.00% | ADD 7% |
| 93 | 93FMR LLC | 2,8942,894 | $19,361 | 0.00% | TRIM -64% |
| 94 | 94Rockefeller Capital Management L.P. | 2,8692,869 | $19,193 | 0.00% | ADD 1649% |
| 95 | 95CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,3772,377 | $15,902 | 0.00% | TRIM -12% |
| 96 | 96Smartleaf Asset Management LLC | 1,7901,790 | $11,098 | 0.00% | ADD 3% |
| 97 | 97Versant Capital Management, Inc | 1,4611,461 | $9,774 | 0.00% | ADD 84% |
| 98 | 98GF FUND MANAGEMENT CO. LTD. | 1,4161,416 | $9,473 | 0.00% | ADD 14% |
| 99 | 99ROYAL BANK OF CANADA | 1,3801,380 | $9,000 | 0.00% | TRIM -55% |
| 100 | 100Sterling Capital Management LLC | 1,1211,121 | $7,499 | 0.00% | TRIM -38% |
