$25.08
-0.27 (-1.07%)
USD · as of 2026-08-21 · marketstack
Institutional 13F holdings sum to 106.9% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 17,547,517 shares (settlement 2026-05-15) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | SUVRETTA CAPITAL MANAGEMENT, LLC | 12,327,00012.3M | $290M | 9.94% | ADD 3% |
| 2 | Frazier Life Sciences Management, L.P. | 9,874,5119.9M | $233M | 7.96% | — |
| 3 | BlackRock, Inc. | 9,200,4119.2M | $217M | 7.42% | — |
| 4 | Rubric Capital Management LP | 8,271,5778.3M | $195M | 6.67% | — |
| 5 | STATE STREET CORP | 6,296,1976.3M | $148M | 5.08% | ADD 15% |
| 6 | Polar Capital Holdings Plc | 5,666,9405.7M | $134M | 4.57% | — |
| 7 | JENNISON ASSOCIATES LLC | 4,980,7705.0M | $117M | 4.02% | TRIM -26% |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 4,871,5364.9M | $115M | 3.93% | NEW† |
| 9 | GILDER GAGNON HOWE & CO LLC | 4,304,0104.3M | $101M | 3.47% | TRIM -3% |
| 10 | MORGAN STANLEY | 4,218,9314.2M | $99M | 3.40% | TRIM -3% |
| 11 | UBS Group AG | 3,329,2243.3M | $78M | 2.68% | ADD 3% |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 3,045,3063.0M | $72M | 2.46% | ADD 11% |
| 13 | D. E. Shaw & Co., Inc. | 2,496,2222.5M | $59M | 2.01% | TRIM -7% |
| 14 | MARSHALL WACE, LLP | 2,431,7782.4M | $57M | 1.96% | ADD 435% |
| 15 | FRANKLIN RESOURCES INC | 2,297,9432.3M | $54M | 1.85% | ADD 21% |
| 16 | Driehaus Capital Management LLC | 2,226,0292.2M | $52M | 1.79% | TRIM -13% |
| 17 | BANK OF AMERICA CORP /DE/ | 2,221,2892.2M | $52M | 1.79% | ADD 33% |
| 18 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1,954,6852.0M | $46M | 1.58% | NEW |
| 19 | JANUS HENDERSON GROUP PLC | 1,854,5661.9M | $44M | 1.50% | — |
| 20 | GOLDMAN SACHS GROUP INC | 1,603,0131.6M | $38M | 1.29% | — |
| 21 | AMERICAN CENTURY COMPANIES INC | 1,463,2281.5M | $34M | 1.18% | — |
| 22 | OBERWEIS ASSET MANAGEMENT INC/ | 1,365,9411.4M | $32M | 1.10% | ADD 69% |
| 23 | Pivotal bioVenture Partners Investment Advisor LLC | 1,355,8921.4M | $32M | 1.09% | — |
| 24 | Ensign Peak Advisors, Inc | 1,244,3871.2M | $29M | 1.00% | TRIM -35% |
| 25 | Squarepoint Ops LLC | 1,103,4901.1M | $26M | 0.89% | ADD 142% |
| 26 | Candriam S.C.A. | 1,086,6511.1M | $26M | 0.88% | ADD 35% |
| 27 | FEDERATED HERMES, INC. | 1,077,2671.1M | $25M | 0.87% | ADD 21% |
| 28 | BAMCO INC /NY/ | 1,072,1891.1M | $25M | 0.86% | ADD 112% |
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,012,5551.0M | $24M | 0.82% | — |
| 30 | GW&K Investment Management, LLC | 988,387988,387 | $23M | 0.80% | TRIM -2% |
| 31 | NORTHERN TRUST CORP | 976,512976,512 | $23M | 0.79% | ADD 2% |
| 32 | Perpetual Ltd | 909,546909,546 | $21M | 0.73% | — |
| 33 | Nuveen, LLC | 902,134902,134 | $21M | 0.73% | TRIM -35% |
| 34 | STEMPOINT CAPITAL LP | 827,584827,584 | $19M | 0.67% | ADD 268% |
| 35 | BNP PARIBAS FINANCIAL MARKETS | 812,146812,146 | $19M | 0.65% | ADD 16% |
| 36 | VANGUARD FIDUCIARY TRUST CO | 771,764771,764 | $18M | 0.62% | NEW |
| 37 | MPM BIOIMPACT LLC | 733,966733,966 | $17M | 0.59% | ADD 38% |
| 38 | Qube Research & Technologies Ltd | 724,067724,067 | $17M | 0.58% | ADD 9% |
| 39 | Aberdeen Group plc | 645,066645,066 | $15M | 0.52% | ADD 10% |
| 40 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 636,200636,200 | $15M | 0.51% | TRIM -29% |
| 41 | Nearwater Capital Markets, Ltd | 607,300607,300 | $14M | 0.49% | — |
| 42 | Point72 Asset Management, L.P. | 590,877590,877 | $14M | 0.48% | ADD 39% |
| 43 | Eversept Partners, LP | 576,580576,580 | $14M | 0.46% | ADD 33% |
| 44 | FISHMAN JAY A LTD/MI | 566,730566,730 | $13M | 0.46% | — |
| 45 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 540,511540,511 | $13M | 0.44% | TRIM -41% |
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 503,856503,856 | $12M | 0.41% | ADD 300% |
| 47 | CAPITOLIS LIQUID GLOBAL MARKETS LLC | 500,000500,000 | $12M | 0.40% | NEW |
| 48 | M&G PLC | 469,082469,082 | $11M | 0.38% | NEW |
| 49 | AQR CAPITAL MANAGEMENT LLC | 468,253468,253 | $11M | 0.38% | TRIM -6% |
| 50 | Cormorant Asset Management, LP | 450,000450,000 | $11M | 0.36% | TRIM -10% |
| 51 | PRICE T ROWE ASSOCIATES INC /MD/ | 448,207448,207 | $11M | 0.36% | TRIM -62% |
| 52 | RENAISSANCE TECHNOLOGIES LLC | 440,999440,999 | $10M | 0.36% | ADD 61% |
| 53 | Patient Square Capital LP | 400,645400,645 | $9M | 0.32% | ADD 91% |
| 54 | DEUTSCHE BANK AG\ | 389,847389,847 | $9M | 0.31% | TRIM -58% |
| 55 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 366,000366,000 | $9M | 0.30% | NEW |
| 56 | ZEVENBERGEN CAPITAL INVESTMENTS LLC | 357,490357,490 | $8M | 0.29% | TRIM -14% |
| 57 | FIRST TRUST ADVISORS LP | 351,217351,217 | $8M | 0.28% | TRIM -13% |
| 58 | Penn Capital Management Company, LLC | 333,130333,130 | $8M | 0.27% | NEW |
| 59 | Privium Fund Management B.V. | 320,972320,972 | $8M | 0.26% | ADD 5% |
| 60 | PEREGRINE CAPITAL MANAGEMENT LLC | 306,272306,272 | $7M | 0.25% | NEW |
| 61 | Bank of New York Mellon Corp | 305,532305,532 | $7M | 0.25% | — |
| 62 | CASTLEARK MANAGEMENT LLC | 293,460293,460 | $7M | 0.24% | TRIM -5% |
| 63 | JANE STREET GROUP, LLC | 283,623283,623 | $7M | 0.23% | ADD 28% |
| 64 | FMR LLC | 278,736278,736 | $7M | 0.22% | ADD 36% |
| 65 | NEW YORK STATE COMMON RETIREMENT FUND | 256,628256,628 | $6M | 0.21% | ADD 498% |
| 66 | PRUDENTIAL FINANCIAL INC | 256,545256,545 | $6M | 0.21% | ADD 9% |
| 67 | MYDA Advisors LLC | 240,000240,000 | $6M | 0.19% | TRIM -9% |
| 68 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 237,171237,171 | $6M | 0.19% | ADD 2% |
| 69 | TWO SIGMA INVESTMENTS, LP | 234,307234,307 | $6M | 0.19% | TRIM -42% |
| 70 | Swiss National Bank | 218,200218,200 | $5M | 0.18% | ADD 3% |
| 71 | JUPITER ASSET MANAGEMENT LTD | 217,255217,255 | $5M | 0.18% | TRIM -33% |
| 72 | SEI INVESTMENTS CO | 206,141206,141 | $5M | 0.17% | ADD 98% |
| 73 | WELLS FARGO & COMPANY/MN | 197,810197,810 | $5M | 0.16% | TRIM -30% |
| 74 | Woodline Partners LP | 195,033195,033 | $5M | 0.16% | — |
| 75 | Universal- Beteiligungs- und Servicegesellschaft mbH | 190,014190,014 | $4M | 0.15% | TRIM -19% |
| 76 | Hillsdale Investment Management Inc. | 188,220188,220 | $4M | 0.15% | ADD 5% |
| 77 | NORDEA INVESTMENT MANAGEMENT AB | 192,920192,920 | $4M | 0.16% | TRIM -4% |
| 78 | Rafferty Asset Management, LLC | 183,024183,024 | $4M | 0.15% | ADD 6% |
| 79 | KORNITZER CAPITAL MANAGEMENT INC /KS | 175,870175,870 | $4M | 0.14% | ADD 55% |
| 80 | PRINCIPAL FINANCIAL GROUP INC | 168,826168,826 | $4M | 0.14% | NEW |
| 81 | Tejara Capital Ltd | 166,191166,191 | $4M | 0.13% | NEW |
| 82 | RHUMBLINE ADVISERS | 161,131161,131 | $4M | 0.13% | — |
| 83 | PDT Partners, LLC | 155,075155,075 | $4M | 0.13% | — |
| 84 | LAZARD ASSET MANAGEMENT LLC | 154,566154,566 | $4M | 0.12% | ADD 66% |
| 85 | LOS ANGELES CAPITAL MANAGEMENT LLC | 154,422154,422 | $4M | 0.12% | ADD 139% |
| 86 | RAYMOND JAMES FINANCIAL INC | 149,867149,867 | $4M | 0.12% | ADD 3% |
| 87 | ALLIANCEBERNSTEIN L.P. | 118,223118,223 | $3M | 0.10% | — |
| 88 | ESSEX INVESTMENT MANAGEMENT CO LLC | 143,934143,934 | $3M | 0.12% | — |
| 89 | Invesco Ltd. | 139,843139,843 | $3M | 0.11% | TRIM -55% |
| 90 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 128,317128,317 | $3M | 0.10% | ADD 25% |
| 91 | Pictet Asset Management Holding SA | 138,112138,112 | $3M | 0.11% | ADD 58% |
| 92 | Voleon Capital Management LP | 123,683123,683 | $3M | 0.10% | TRIM -30% |
| 93 | LPL Financial LLC | 119,381119,381 | $3M | 0.10% | ADD 7% |
| 94 | 1492 Capital Management LLC | 118,156118,156 | $3M | 0.10% | NEW |
| 95 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,179112,179 | $3M | 0.09% | ADD 1165% |
| 96 | JPMORGAN CHASE & CO | 112,954112,954 | $2M | 0.09% | ADD 6% |
| 97 | AMERIPRISE FINANCIAL INC | 101,674101,674 | $2M | 0.08% | ADD 3% |
| 98 | STATE OF WISCONSIN INVESTMENT BOARD | 100,902100,902 | $2M | 0.08% | — |
| 99 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 98,84798,847 | $2M | 0.08% | NEW |
| 100 | SCHRODER INVESTMENT MANAGEMENT GROUP | 104,356104,356 | $2M | 0.08% | ADD 83% |
† NEW this big is usually a rename.
Ranked by each filer’s own reported value, not shares.
1 holder — The filer reported no value for this line, so it carries no dollar figure and is left out of the percentage and value columns.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +4,871,536 | $115M | OPEN |
| MARSHALL WACE, LLP | +1,977,545 | $47M | ADD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +1,954,685 | $46M | OPEN |
| STATE STREET CORP | +807,896 | $19M | ADD |
| VANGUARD FIDUCIARY TRUST CO | +771,764 | $18M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −7,253,936 | $171M | CLOSE |
| JENNISON ASSOCIATES LLC | −1,777,236 | $42M | TRIM |
| PRICE T ROWE ASSOCIATES INC /MD/ | −718,141 | $17M | TRIM |
| Ensign Peak Advisors, Inc | −658,003 | $16M | TRIM |
| DEUTSCHE BANK AG\ | −540,355 | $13M | TRIM |
Prior quarter split-rebased · 13Fs are long, US-listed only.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11.4M | 11.4M | 11.5M | 10.5M | 12.0M | 12.3M | $290M |
| Frazier Life Sciences Management, L.P. | 8.8M | 8.8M | 9.9M | 9.9M | 9.9M | 9.9M | $233M |
| BlackRock, Inc. | 9.1M | 8.9M | 8.5M | 8.6M | 9.1M | 9.2M | $217M |
| Rubric Capital Management LP | 11.0M | 11.0M | 10.7M | 10.7M | 8.3M | 8.3M | $195M |
| STATE STREET CORP | 5.0M | 4.5M | 4.5M | 4.6M | 5.5M | 6.3M | $148M |
| Polar Capital Holdings Plc | 7.4M | 6.7M | 5.0M | 5.3M | 5.6M | 5.7M | $134M |
| JENNISON ASSOCIATES LLC | 12.3M | 11.4M | 11.1M | 12.3M | 6.8M | 5.0M | $117M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 4.9M | $115M |
| GILDER GAGNON HOWE & CO LLC | 3.9M | 4.1M | 4.2M | 4.4M | 4.5M | 4.3M | $101M |
| MORGAN STANLEY | 4.2M | 3.8M | 4.3M | 4.3M | 4.3M | 4.2M | $99M |
| UBS Group AG | 2.8M | 2.9M | 2.9M | 2.9M | 3.2M | 3.3M | $78M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.5M | 2.5M | 2.6M | 2.6M | 2.8M | 3.0M | $72M |
| D. E. Shaw & Co., Inc. | 2.5M | 2.0M | 2.2M | 2.1M | 2.7M | 2.5M | $59M |
| MARSHALL WACE, LLP | — | 58K | — | 18K | 454K | 2.4M | $57M |
| FRANKLIN RESOURCES INC | 3.3M | 2.8M | 2.7M | 2.3M | 1.9M | 2.3M | $54M |
Green = added, red = trimmed, grey = held; a dash is a quarter with no 13F on file — a gap, not an exit.
Breaks = no 13F that quarter.
Short interest has its own tab now — open SI →
SEC Form 13F · ~10,250 filers, 10y · long-only, US-listed, filed ≤45d after quarter-end.
“FLS VIII, FHM Life Sciences VIII, L.L.C, FLS X, FLSPF, FLSPOF, FLS XI and FLS XII each acquired the FLS VIII Shares (as defined below), the FHM Life Sciences VIII, L.L.C. Shares (as defined below), the FLS X Shares (as defined below), the FLSPF Shares (as defined below), the FLSPOF Shares (as defined below), the FLS XI Shares (as defined below) and the FLS XII Shares (as defined below), as the case me be, for investment purposes. Depending on market conditions, its continuing evaluation of the b”
SEC Schedule 13D/G XML · group aggregate.