Institutional 13F holdings sum to 106.9% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 16,879,909 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | SUVRETTA CAPITAL MANAGEMENT, LLC | 12,327,00012.3M | $290M | 9.94% | ADD 3% |
| 2 | Frazier Life Sciences Management, L.P. | 9,874,5119.9M | $233M | 7.96% | — |
| 3 | BlackRock, Inc. | 9,200,4119.2M | $217M | 7.42% | — |
| 4 | Rubric Capital Management LP | 8,271,5778.3M | $195M | 6.67% | — |
| 5 | STATE STREET CORP | 6,296,1976.3M | $148M | 5.08% | ADD 15% |
| 6 | Polar Capital Holdings Plc | 5,666,9405.7M | $134M | 4.57% | — |
| 7 | JENNISON ASSOCIATES LLC | 4,980,7705.0M | $117M | 4.02% | TRIM -26% |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 4,871,5364.9M | $115M | 3.93% | NEW† |
| 9 | GILDER GAGNON HOWE & CO LLC | 4,304,0104.3M | $101M | 3.47% | TRIM -3% |
| 10 | MORGAN STANLEY | 4,218,9314.2M | $99M | 3.40% | TRIM -3% |
| 11 | UBS Group AG | 3,329,2243.3M | $78M | 2.68% | ADD 3% |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 3,045,3063.0M | $72M | 2.46% | ADD 11% |
| 13 | D. E. Shaw & Co., Inc. | 2,496,2222.5M | $59M | 2.01% | TRIM -7% |
| 14 | MARSHALL WACE, LLP | 2,431,7782.4M | $57M | 1.96% | ADD 435% |
| 15 | FRANKLIN RESOURCES INC | 2,297,9432.3M | $54M | 1.85% | ADD 21% |
| 16 | Driehaus Capital Management LLC | 2,226,0292.2M | $52M | 1.79% | TRIM -13% |
| 17 | BANK OF AMERICA CORP /DE/ | 2,221,2892.2M | $52M | 1.79% | ADD 33% |
| 18 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1,954,6852.0M | $46M | 1.58% | NEW |
| 19 | JANUS HENDERSON GROUP PLC | 1,854,5661.9M | $44M | 1.50% | — |
| 20 | GOLDMAN SACHS GROUP INC | 1,603,0131.6M | $38M | 1.29% | — |
| 21 | AMERICAN CENTURY COMPANIES INC | 1,463,2281.5M | $34M | 1.18% | — |
| 22 | OBERWEIS ASSET MANAGEMENT INC/ | 1,365,9411.4M | $32M | 1.10% | ADD 69% |
| 23 | Pivotal bioVenture Partners Investment Advisor LLC | 1,355,8921.4M | $32M | 1.09% | — |
| 24 | Ensign Peak Advisors, Inc | 1,244,3871.2M | $29M | 1.00% | TRIM -35% |
| 25 | Squarepoint Ops LLC | 1,103,4901.1M | $26M | 0.89% | ADD 142% |
| 26 | Candriam S.C.A. | 1,086,6511.1M | $26M | 0.88% | ADD 35% |
| 27 | FEDERATED HERMES, INC. | 1,077,2671.1M | $25M | 0.87% | ADD 21% |
| 28 | BAMCO INC /NY/ | 1,072,1891.1M | $25M | 0.86% | ADD 112% |
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,012,5551.0M | $24M | 0.82% | — |
| 30 | GW&K Investment Management, LLC | 988,387988,387 | $23M | 0.80% | TRIM -2% |
| 31 | NORTHERN TRUST CORP | 976,512976,512 | $23M | 0.79% | ADD 2% |
| 32 | Perpetual Ltd | 909,546909,546 | $21M | 0.73% | — |
| 33 | Nuveen, LLC | 902,134902,134 | $21M | 0.73% | TRIM -35% |
| 34 | STEMPOINT CAPITAL LP | 827,584827,584 | $19M | 0.67% | ADD 268% |
| 35 | BNP PARIBAS FINANCIAL MARKETS | 812,146812,146 | $19M | 0.65% | ADD 16% |
| 36 | VANGUARD FIDUCIARY TRUST CO | 771,764771,764 | $18M | 0.62% | NEW |
| 37 | MPM BIOIMPACT LLC | 733,966733,966 | $17M | 0.59% | ADD 38% |
| 38 | Qube Research & Technologies Ltd | 724,067724,067 | $17M | 0.58% | ADD 9% |
| 39 | Aberdeen Group plc | 645,066645,066 | $15M | 0.52% | ADD 10% |
| 40 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 636,200636,200 | $15M | 0.51% | TRIM -29% |
| 41 | Nearwater Capital Markets, Ltd | 607,300607,300 | $14M | 0.49% | — |
| 42 | Point72 Asset Management, L.P. | 590,877590,877 | $14M | 0.48% | ADD 39% |
| 43 | Eversept Partners, LP | 576,580576,580 | $14M | 0.46% | ADD 33% |
| 44 | FISHMAN JAY A LTD/MI | 566,730566,730 | $13M | 0.46% | — |
| 45 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 540,511540,511 | $13M | 0.44% | TRIM -41% |
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 503,856503,856 | $12M | 0.41% | ADD 300% |
| 47 | CAPITOLIS LIQUID GLOBAL MARKETS LLC | 500,000500,000 | $12M | 0.40% | NEW |
| 48 | M&G PLC | 469,082469,082 | $11M | 0.38% | NEW |
| 49 | AQR CAPITAL MANAGEMENT LLC | 468,253468,253 | $11M | 0.38% | TRIM -6% |
| 50 | Cormorant Asset Management, LP | 450,000450,000 | $11M | 0.36% | TRIM -10% |
| 51 | PRICE T ROWE ASSOCIATES INC /MD/ | 448,207448,207 | $11M | 0.36% | TRIM -62% |
| 52 | RENAISSANCE TECHNOLOGIES LLC | 440,999440,999 | $10M | 0.36% | ADD 61% |
| 53 | Patient Square Capital LP | 400,645400,645 | $9M | 0.32% | ADD 91% |
| 54 | DEUTSCHE BANK AG\ | 389,847389,847 | $9M | 0.31% | TRIM -58% |
| 55 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 366,000366,000 | $9M | 0.30% | NEW |
| 56 | ZEVENBERGEN CAPITAL INVESTMENTS LLC | 357,490357,490 | $8M | 0.29% | TRIM -14% |
| 57 | FIRST TRUST ADVISORS LP | 351,217351,217 | $8M | 0.28% | TRIM -13% |
| 58 | Penn Capital Management Company, LLC | 333,130333,130 | $8M | 0.27% | NEW |
| 59 | Privium Fund Management B.V. | 320,972320,972 | $8M | 0.26% | ADD 5% |
| 60 | PEREGRINE CAPITAL MANAGEMENT LLC | 306,272306,272 | $7M | 0.25% | NEW |
| 61 | Bank of New York Mellon Corp | 305,532305,532 | $7M | 0.25% | — |
| 62 | CASTLEARK MANAGEMENT LLC | 293,460293,460 | $7M | 0.24% | TRIM -5% |
| 63 | JANE STREET GROUP, LLC | 283,623283,623 | $7M | 0.23% | ADD 28% |
| 64 | FMR LLC | 278,736278,736 | $7M | 0.22% | ADD 36% |
| 65 | NEW YORK STATE COMMON RETIREMENT FUND | 256,628256,628 | $6M | 0.21% | ADD 498% |
| 66 | PRUDENTIAL FINANCIAL INC | 256,545256,545 | $6M | 0.21% | ADD 9% |
| 67 | MYDA Advisors LLC | 240,000240,000 | $6M | 0.19% | TRIM -9% |
| 68 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 237,171237,171 | $6M | 0.19% | ADD 2% |
| 69 | TWO SIGMA INVESTMENTS, LP | 234,307234,307 | $6M | 0.19% | TRIM -42% |
| 70 | Swiss National Bank | 218,200218,200 | $5M | 0.18% | ADD 3% |
| 71 | JUPITER ASSET MANAGEMENT LTD | 217,255217,255 | $5M | 0.18% | TRIM -33% |
| 72 | SEI INVESTMENTS CO | 206,141206,141 | $5M | 0.17% | ADD 98% |
| 73 | WELLS FARGO & COMPANY/MN | 197,810197,810 | $5M | 0.16% | TRIM -30% |
| 74 | Woodline Partners LP | 195,033195,033 | $5M | 0.16% | — |
| 75 | Universal- Beteiligungs- und Servicegesellschaft mbH | 190,014190,014 | $4M | 0.15% | TRIM -19% |
| 76 | Hillsdale Investment Management Inc. | 188,220188,220 | $4M | 0.15% | ADD 5% |
| 77 | NORDEA INVESTMENT MANAGEMENT AB | 192,920192,920 | $4M | 0.16% | TRIM -4% |
| 78 | Rafferty Asset Management, LLC | 183,024183,024 | $4M | 0.15% | ADD 6% |
| 79 | KORNITZER CAPITAL MANAGEMENT INC /KS | 175,870175,870 | $4M | 0.14% | ADD 55% |
| 80 | PRINCIPAL FINANCIAL GROUP INC | 168,826168,826 | $4M | 0.14% | NEW |
| 81 | Tejara Capital Ltd | 166,191166,191 | $4M | 0.13% | NEW |
| 82 | RHUMBLINE ADVISERS | 161,131161,131 | $4M | 0.13% | — |
| 83 | PDT Partners, LLC | 155,075155,075 | $4M | 0.13% | — |
| 84 | LAZARD ASSET MANAGEMENT LLC | 154,566154,566 | $4M | 0.12% | ADD 66% |
| 85 | LOS ANGELES CAPITAL MANAGEMENT LLC | 154,422154,422 | $4M | 0.12% | ADD 139% |
| 86 | RAYMOND JAMES FINANCIAL INC | 149,867149,867 | $4M | 0.12% | ADD 3% |
| 87 | ALLIANCEBERNSTEIN L.P. | 118,223118,223 | $3M | 0.10% | — |
| 88 | ESSEX INVESTMENT MANAGEMENT CO LLC | 143,934143,934 | $3M | 0.12% | — |
| 89 | Invesco Ltd. | 139,843139,843 | $3M | 0.11% | TRIM -55% |
| 90 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 128,317128,317 | $3M | 0.10% | ADD 25% |
| 91 | Pictet Asset Management Holding SA | 138,112138,112 | $3M | 0.11% | ADD 58% |
| 92 | Voleon Capital Management LP | 123,683123,683 | $3M | 0.10% | TRIM -30% |
| 93 | LPL Financial LLC | 119,381119,381 | $3M | 0.10% | ADD 7% |
| 94 | 1492 Capital Management LLC | 118,156118,156 | $3M | 0.10% | NEW |
| 95 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,179112,179 | $3M | 0.09% | ADD 1165% |
| 96 | JPMORGAN CHASE & CO | 112,954112,954 | $2M | 0.09% | ADD 6% |
| 97 | AMERIPRISE FINANCIAL INC | 101,674101,674 | $2M | 0.08% | ADD 3% |
| 98 | STATE OF WISCONSIN INVESTMENT BOARD | 100,902100,902 | $2M | 0.08% | — |
| 99 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 98,84798,847 | $2M | 0.08% | NEW |
| 100 | SCHRODER INVESTMENT MANAGEMENT GROUP | 104,356104,356 | $2M | 0.08% | ADD 83% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11.4M | 11.4M | 11.5M | 10.5M | 12.0M | 12.3M | $290M |
| Frazier Life Sciences Management, L.P. | 8.8M | 8.8M | 9.9M | 9.9M | 9.9M | 9.9M | $233M |
| BlackRock, Inc. | 9.1M | 8.9M | 8.5M | 8.6M | 9.1M | 9.2M | $217M |
| Rubric Capital Management LP | 11.0M | 11.0M | 10.7M | 10.7M | 8.3M | 8.3M | $195M |
| STATE STREET CORP | 5.0M | 4.5M | 4.5M | 4.6M | 5.5M | 6.3M | $148M |
| Polar Capital Holdings Plc | 7.4M | 6.7M | 5.0M | 5.3M | 5.6M | 5.7M | $134M |
| JENNISON ASSOCIATES LLC | 12.3M | 11.4M | 11.1M | 12.3M | 6.8M | 5.0M | $117M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 4.9M | $115M |
| GILDER GAGNON HOWE & CO LLC | 3.9M | 4.1M | 4.2M | 4.4M | 4.5M | 4.3M | $101M |
| MORGAN STANLEY | 4.2M | 3.8M | 4.3M | 4.3M | 4.3M | 4.2M | $99M |
| UBS Group AG | 2.8M | 2.9M | 2.9M | 2.9M | 3.2M | 3.3M | $78M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.5M | 2.5M | 2.6M | 2.6M | 2.8M | 3.0M | $72M |
| D. E. Shaw & Co., Inc. | 2.5M | 2.0M | 2.2M | 2.1M | 2.7M | 2.5M | $59M |
| MARSHALL WACE, LLP | — | 58K | — | 18K | 454K | 2.4M | $57M |
| FRANKLIN RESOURCES INC | 3.3M | 2.8M | 2.7M | 2.3M | 1.9M | 2.3M | $54M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“FLS VIII, FHM Life Sciences VIII, L.L.C, FLS X, FLSPF, FLSPOF, FLS XI and FLS XII each acquired the FLS VIII Shares (as defined below), the FHM Life Sciences VIII, L.L.C. Shares (as defined below), the FLS X Shares (as defined below), the FLSPF Shares (as defined below), the FLSPOF Shares (as defined below), the FLS XI Shares (as defined below) and the FLS XII Shares (as defined below), as the case me be, for investment purposes. Depending on market conditions, its continuing evaluation of the b”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +4,871,536 | $115M | OPEN |
| MARSHALL WACE, LLP | +1,977,545 | $47M | ADD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +1,954,685 | $46M | OPEN |
| STATE STREET CORP | +807,896 | $19M | ADD |
| VANGUARD FIDUCIARY TRUST CO | +771,764 | $18M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −7,253,936 | $171M | CLOSE |
| JENNISON ASSOCIATES LLC | −1,777,236 | $42M | TRIM |
| PRICE T ROWE ASSOCIATES INC /MD/ | −718,141 | $17M | TRIM |
| Ensign Peak Advisors, Inc | −658,003 | $16M | TRIM |
| DEUTSCHE BANK AG\ | −540,355 | $13M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 267 | 132,595,231 | 106.9% | $3.1B |
| 2025-Q4 | 282 | 129,102,306 | 105.4% | $3.7B |
| 2025-Q3 | 239 | 125,922,700 | 105.0% | $2.4B |
| 2025-Q2 | 230 | 127,384,480 | 106.9% | $1.8B |
| 2025-Q1 | 241 | 125,728,827 | 106.0% | $2.0B |
| 2024-Q4 | 208 | 128,914,672 | — | $1.8B |
| 2024-Q3 | 188 | 129,938,585 | — | $1.2B |
| 2024-Q2 | 186 | 127,789,202 | — | $1.2B |
| 2024-Q1 | 168 | 134,000,438 | — | $1.3B |
| 2023-Q4 | 133 | 107,428,236 | — | $347M |
| 2023-Q3 | 134 | 67,160,109 | 108.9% | $357M |
| 2023-Q2 | 136 | 71,843,932 | — | $685M |
| 2023-Q1 | 143 | 80,736,766 | — | $897M |
| 2022-Q4 | 141 | 66,084,409 | 108.5% | $974M |
| 2022-Q3 | 139 | 59,691,633 | — | $1.1B |
| 2022-Q2 | 115 | 49,302,718 | 95.9% | $1.1B |
| 2022-Q1 | 106 | 48,662,301 | 96.6% | $937M |
| 2021-Q4 | 93 | 46,394,009 | 92.2% | $962M |
| 2021-Q3 | 103 | 45,697,558 | 91.0% | $1.1B |
| 2021-Q2 | 102 | 45,718,255 | 91.1% | $1.2B |
| 2021-Q1 | 94 | 46,841,404 | 93.5% | $1.4B |
| 2020-Q4 | 78 | 40,984,930 | 93.9% | $1.2B |
| 2020-Q3 | 63 | 34,765,042 | 91.0% | $1.0B |
| 2020-Q2 | 56 | 33,776,856 | 88.5% | $1.0B |
| 2020-Q1 | 50 | 32,687,581 | 85.7% | $974M |
| PRUDENTIAL FINANCIAL INC | 4.3% | QII | 2026-03-31 | SEC → |
| Polar Capital Holdings Plc | 4.2% | QII | 2025-06-30 | SEC → |
| JENNISON ASSOCIATES LLC | 4% | QII | 2026-03-31 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
