Clinical trials
catalyst calendar across sponsors →Studies where APYX is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
10 interventional · 10 with posted results
Held by 9 tracked-famous managers (RENAISSANCE TECHNOLOGIES LLC, MILLENNIUM MANAGEMENT LLC, MARSHALL WACE, LLP, SUSQUEHANNA INTERNATIONAL GROUP, LLP, CITADEL ADVISORS LLC, +4 more) · FINRA short interest 4.7 days to cover (settled 2026-07-31) · government filings 180d: none disclosed
| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Updated |
|---|---|---|---|---|---|---|---|
| Histological Evaluation of Human Skin Bx to Assess the Effects of APR Tx as an Adjunct Procedure in Facelift SurgeryNCT06243744results2026-03-24Analysis of Elasticity (Collagen & Elastin)Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Renuvion APR System | Skin Laxity, Tissue Degeneration, Tissue Breakdown, Collagen Degeneration, Collagen Shrinkage | 7 | 2025-07-10actual | 2026-03-24 |
| Measuring Renuvion Soft Tissue Contraction Using UltrasoundNCT05968495results2025-02-03Analysis of Contraction From Baseline to Day 365Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Renuvion APR Handpiece | Skin Laxity | 5 | 2024-09-30actual | 2025-02-03 |
| A Post-Market Study in Greece of a Minimally Invasive Breast Lift Procedure Utilizing the Renuvion APR SystemNCT05665335results2025-05-14Independent Photographic Review of Before and After Images Compared to Baseline Compared to D180.Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Renuvion APR System | Breast Ptosis | 15 | 2024-04-26actual | 2025-05-14 |
| Evaluation of the Use of the Renuvion APR System in the LabiaNCT05323630results2025-12-23Evaluation of Change Between Baseline and Follow-up Images as Determined by a Masked, Qualitative Assessment of Photographs at 90-days and 180-days Post-treatment Compared to Baseline.Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Renuvion APR System | Labia Enlarged, Labium; Hypertrophy | 10 | 2024-04-23actual | 2025-12-23 |
| Post-Market Lower Eyelid Treatment With Renuvion in GreeceNCT05605691results2025-03-26Day 180 Number of Participants With Improvement in Lower Eyelid Area as Determined by a Masked, Qualitative Assessment.Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Renuvion APR System | Skin Laxity | 16 | 2024-03-05actual | 2025-03-26 |
| Renuvion APR System When Used as an Adjunct Procedure In Gynecomastia SurgeryNCT05093049results2024-02-08Analysis of Bilateral Occurrence of Adverse EventsRandomized · Double-masked · TreatmentStudy Protocol ↗ | Not applicable | Completed | Device: Renuvion APR System · Procedure: Gynecomastia Correction Surgery | Gynecomastia | 10 | 2022-08-17actual | 2024-02-08 |
| Renuvion APR Device to Improve the Appearance of Lax Tissue in the Neck and Submental RegionNCT04146467results2022-07-08Day 180 Number of Participants With Improvement Measured By Independent Photographic ReviewNon-randomized · Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Renuvion APR Device | Lax Skin | 82 | 2022-02-28actual | 2022-07-20 |
| Renuvion Dermal System for Dermal ResurfacingNCT04185909results2022-06-03Independent Photo Reviewer Fitzpatrick Wrinkle and Elastosis Scale (FWS)Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Renuvion Dermal System | Wrinkle, Rhytides | 55 | 2021-03-23actual | 2022-06-22 |
| The Use of J-Plasma® for Dermal ResurfacingNCT03286283results2019-08-07Improvement in Fitzpatrick Wrinkle and Elastosis Scale (FWS) ScoreOpen-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: J-Plasma | Facial Wrinkles, Rhytides | 55 | 2018-08-20actual | 2022-07-27 |
| Cold Plasma for the Reduction of Lymphoceles Following PLNDNCT02658851results2020-12-02Number of Participants With Incidence of Lymphocele FormationOpen-label · PreventionStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: J-Plasma | Lymphoceles Following Pelvic Lymph Node Dissection | 100 | 2017-06-27actual | 2020-12-02 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19