ALEC US Equity

Alector, Inc.

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Health Care · Biological Products, (No Diagnostic Substances) · CIK 1653087 · FYE 1231

$1.52

+0.00 (+0.00%)

USD · as of 2026-07-29 · marketstack

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Institutional ownership· 13F filers holding ALEC · 2026-Q1 methodology → sources →

137 holders

% of shares outstanding held

79.6%

Shares held (13F)

88,395,619

Reporting holders

137

Top holders

largest 100 of 137 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	TCG Crossover Management, LLC	10,000,00010.0M	$22M	9.01%	—
2	BlackRock, Inc.	7,741,2457.7M	$17M	6.97%	ADD 8%
3	ACADIAN ASSET MANAGEMENT LLC	4,038,7854.0M	$9M	3.64%	ADD 17%
4	Foresite Capital Management IV, LLC	3,887,2003.9M	$8M	3.50%	—
5	VANGUARD CAPITAL MANAGEMENT LLC	3,678,7223.7M	$8M	3.31%	NEW†
6	Merck & Co., Inc.	3,545,7193.5M	$8M	3.19%	—
7	D. E. Shaw & Co., Inc.	3,332,8353.3M	$7M	3.00%	ADD 41%
8	683 Capital Management, LLC	3,200,0003.2M	$7M	2.88%	TRIM -4%
9	Balyasny Asset Management L.P.	2,935,2532.9M	$6M	2.64%	TRIM -10%
10	Nantahala Capital Management, LLC	2,815,9832.8M	$6M	2.54%	NEW†
11	VANGUARD PORTFOLIO MANAGEMENT LLC	2,583,5422.6M	$6M	2.33%	NEW†
12	GEODE CAPITAL MANAGEMENT, LLC	2,286,2182.3M	$5M	2.06%	ADD 10%
13	JACOBS LEVY EQUITY MANAGEMENT, INC	2,154,3612.2M	$5M	1.94%	—
14	Spruce Street Capital LP	2,101,0682.1M	$5M	1.89%	ADD 88%
15	Ikarian Capital, LLC	2,082,6062.1M	$4M	1.88%	—
16	Kynam Capital Management, LP	2,000,0002.0M	$4M	1.80%	—
17	MILLENNIUM MANAGEMENT LLC	1,979,2262.0M	$4M	1.78%	ADD 48%
18	STATE STREET CORP	1,865,5261.9M	$4M	1.68%	ADD 3%
19	FMR LLC	1,796,1041.8M	$4M	1.62%	TRIM -19%
20	MEDICI CAPITAL LLC	1,652,5201.7M	$4M	1.49%	ADD 10%
21	Eversept Partners, LP	1,351,1061.4M	$3M	1.22%	ADD 34%
22	Euclidean Capital LLC	1,307,8581.3M	$3M	1.18%	—
23	RENAISSANCE TECHNOLOGIES LLC	1,287,6911.3M	$3M	1.16%	TRIM -17%
24	TWO SIGMA INVESTMENTS, LP	1,279,3061.3M	$3M	1.15%	ADD 23%
25	DEUTSCHE BANK AG\	1,092,9031.1M	$2M	0.98%	ADD 6%
26	DEERFIELD MANAGEMENT COMPANY, L.P.	1,055,1921.1M	$2M	0.95%	—
27	ADAR1 Capital Management, LLC	1,050,0001.1M	$2M	0.95%	TRIM -5%
28	DAFNA Capital Management LLC	908,351908,351	$2M	0.82%	—
29	Elmind Capital, LP	900,000900,000	$2M	0.81%	—
30	MACKENZIE FINANCIAL CORP	857,354857,354	$2M	0.77%	ADD 30%
31	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	787,408787,408	$2M	0.71%	ADD 18%
32	AQR CAPITAL MANAGEMENT LLC	711,334711,334	$2M	0.64%	ADD 19%
33	NORTHERN TRUST CORP	692,256692,256	$1M	0.62%	ADD 18%
34	MARSHALL WACE, LLP	620,424620,424	$1M	0.56%	TRIM -47%
35	GOLDMAN SACHS GROUP INC	604,562604,562	$1M	0.54%	ADD 38%
36	PANAGORA ASSET MANAGEMENT INC	590,388590,388	$1M	0.53%	TRIM -31%
37	VANGUARD FIDUCIARY TRUST CO	577,939577,939	$1M	0.52%	NEW
38	XTX Topco Ltd	559,896559,896	$1M	0.50%	TRIM -6%
39	BOOTHBAY FUND MANAGEMENT, LLC	559,726559,726	$1M	0.50%	—
40	Affinity Asset Advisors, LLC	500,000500,000	$1M	0.45%	NEW
41	JANE STREET GROUP, LLC	399,464399,464	$858,848	0.36%	TRIM -60%
42	BANK OF AMERICA CORP /DE/	380,908380,908	$818,951	0.34%	ADD 183%
43	MORGAN STANLEY	364,567364,567	$783,821	0.33%	ADD 14%
44	DIMENSIONAL FUND ADVISORS LP	283,817283,817	$609,754	0.26%	ADD 43%
45	AMERIPRISE FINANCIAL INC	271,272271,272	$583,234	0.24%	TRIM -23%
46	Invesco Ltd.	265,067265,067	$569,893	0.24%	TRIM -5%
47	Bank of New York Mellon Corp	252,297252,297	$542,440	0.23%	ADD 16%
48	NANO CAP NEW MILLENNIUM GROWTH FUND L P	200,000200,000	$430,000	0.18%	—
49	CANADA PENSION PLAN INVESTMENT BOARD	183,200183,200	$393,880	0.17%	ADD 6%
50	Nuveen, LLC	154,930154,930	$333,100	0.14%	ADD 16%
51	Utah Retirement Systems	154,290154,290	$331,724	0.14%	ADD 15%
52	UBS Group AG	145,344145,344	$312,490	0.13%	ADD 22%
53	BRIDGEWAY CAPITAL MANAGEMENT, LLC	142,500142,500	$306,375	0.13%	ADD 24%
54	PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	136,000136,000	$292,400	0.12%	—
55	SUSQUEHANNA INTERNATIONAL GROUP, LLP	107,597107,597	$231,334	0.10%	TRIM -63%
56	RHUMBLINE ADVISERS	101,327101,327	$217,845	0.09%	—
57	Odyssean, LLC	89,78389,783	$193,033	0.08%	NEW
58	STRS OHIO	86,50086,500	$185,975	0.08%	TRIM -22%
59	Point72 Asset Management, L.P.	80,09180,091	$172,196	0.07%	ADD 247%
60	GSA CAPITAL PARTNERS LLP	78,20778,207	$168,000	0.07%	TRIM -65%
61	CITADEL ADVISORS LLC	77,54577,545	$166,722	0.07%	TRIM -17%
62	Blackstone Inc.	77,14577,145	$165,862	0.07%	ADD 15%
63	Jasper Ridge Partners, L.P.	73,53173,531	$158,092	0.07%	TRIM -23%
64	DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main	69,66669,666	$149,781	0.06%	NEW
65	SIMPLEX TRADING, LLC	68,47768,477	$147,225	0.06%	TRIM -17%
66	ALLIANCEBERNSTEIN L.P.	92,94092,940	$144,986	0.08%	—
67	Russell Investments Group, Ltd.	66,13166,131	$142,181	0.06%	TRIM -8%
68	PRICE T ROWE ASSOCIATES INC /MD/	56,10056,100	$121,000	0.05%	—
69	Cannell & Spears LLC	54,64254,642	$117,480	0.05%	—
70	SEI INVESTMENTS CO	53,84653,846	$115,769	0.05%	ADD 219%
71	Vanguard Personalized Indexing Management, LLC	50,62950,629	$108,852	0.05%	TRIM -5%
72	HSBC HOLDINGS PLC	48,52348,523	$104,810	0.04%	TRIM -50%
73	IEQ CAPITAL, LLC	47,08047,080	$101,222	0.04%	NEW
74	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	42,66142,661	$91,721	0.04%	ADD 14%
75	BARCLAYS PLC	42,59142,591	$91,570	0.04%	TRIM -89%
76	MetLife Investment Management, LLC	36,20836,208	$77,847	0.03%	NEW
77	JPMORGAN CHASE & CO	37,37937,379	$75,505	0.03%	ADD 15%
78	WELLS FARGO & COMPANY/MN	34,52634,526	$74,231	0.03%	TRIM -62%
79	Vanguard Global Advisers, LLC	31,30231,302	$67,299	0.03%	NEW
80	Vontobel Holding Ltd.	30,00030,000	$64,500	0.03%	—
81	CWM, LLC	28,98528,985	$62,318	0.03%	ADD 138%
82	Cerity Partners LLC	26,97626,976	$57,999	0.02%	ADD 97%
83	MANUFACTURERS LIFE INSURANCE COMPANY, THE	26,14826,148	$56,218	0.02%	TRIM -9%
84	Diversified Trust Co	25,89525,895	$55,674	0.02%	ADD 84%
85	INTECH INVESTMENT MANAGEMENT LLC	23,95423,954	$51,501	0.02%	TRIM -31%
86	PRUDENTIAL FINANCIAL INC	23,79523,795	$51,159	0.02%	TRIM -26%
87	Verdad Advisers, LP	23,55423,554	$50,641	0.02%	NEW
88	Police & Firemen's Retirement System of New Jersey	23,42623,426	$50,366	0.02%	—
89	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	18,19718,197	$43,855	0.02%	NEW
90	BNP PARIBAS FINANCIAL MARKETS	20,02720,027	$43,058	0.02%	TRIM -11%
91	Quadrature Capital Ltd	19,48619,486	$41,895	0.02%	TRIM -69%
92	Bronte Capital Management Pty Ltd.	19,28219,282	$41,456	0.02%	—
93	Mariner, LLC	18,79918,799	$40,367	0.02%	NEW
94	VOYA INVESTMENT MANAGEMENT LLC	15,47815,478	$33,278	0.01%	ADD 11%
95	NEUBERGER BERMAN GROUP LLC	14,52814,528	$31,235	0.01%	ADD 3%
96	HAMILTON LANE ADVISORS LLC	14,40014,400	$30,960	0.01%	NEW
97	ProShare Advisors LLC	13,18813,188	$28,354	0.01%	TRIM -10%
98	Merit Financial Group, LLC	10,92810,928	$23,495	0.01%	NEW
99	HighTower Advisors, LLC	10,76010,760	$23,134	0.01%	ADD 7%
100	CAPTRUST FINANCIAL ADVISORS	10,64810,648	$22,886	0.01%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

TCG Crossover Management, LLC

—

10.0M

$22M

BlackRock, Inc.

9.1M

8.3M

8.0M

7.2M

7.1M

7.7M

$17M

ACADIAN ASSET MANAGEMENT LLC

1.0M

1.4M

2.2M

2.4M

3.4M

4.0M

$9M

Foresite Capital Management IV, LLC

—

3.9M

$8M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.7M

$8M

Merck & Co., Inc.

3.5M

$8M

D. E. Shaw & Co., Inc.

369K

469K

534K

978K

2.4M

3.3M

$7M

683 Capital Management, LLC

—

1.0M

3.4M

3.2M

$7M

Balyasny Asset Management L.P.

—

3.3M

2.9M

$6M

Nantahala Capital Management, LLC

—

2.8M

$6M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

2.6M

$6M

GEODE CAPITAL MANAGEMENT, LLC

1.9M

2.0M

1.9M

2.1M

2.3M

$5M

JACOBS LEVY EQUITY MANAGEMENT, INC

1.1M

1.3M

1.2M

2.2M

$5M

Spruce Street Capital LP

—

1.1M

2.1M

$5M

Ikarian Capital, LLC

950K

900K

760K

2.1M

$4M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	137	88,395,619	79.6%	$190M
2025-Q4	130	84,505,149	76.1%	$132M
2025-Q3	149	74,879,530	67.4%	$222M
2025-Q2	136	70,872,649	63.8%	$99M
2025-Q1	141	72,635,517	65.4%	$90M
2024-Q4	150	73,449,395	66.2%	$139M
2024-Q3	159	75,276,413	67.8%	$351M
2024-Q2	159	74,344,012	67.0%	$337M

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · ALEC

Large holders — 13G, passive (top 5 of 8 by % of class)

Holder

% of class

Type

As of

TCG Crossover GP II, LLC

9.2%

Passive

2025-10-22

SEC →

Rosenthal Arnon

7.4%

Exempt

2025-12-31

SEC →

BlackRock, Inc.

5.2%

QII

2026-03-31

SEC →

Polaris Venture Partners VI, L.P.

4.7%

Exempt

2026-03-31

SEC →

FMR LLC

3.6%

QII

Institutional ownership· 13F filers holding ALEC · 2026-Q1 methodology → sources →

137 holders

% of shares outstanding held

79.6%

Shares held (13F)

88,395,619

Reporting holders

137

Top holders

largest 100 of 137 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	TCG Crossover Management, LLC	10,000,00010.0M	$22M	9.01%	—
2	BlackRock, Inc.	7,741,2457.7M	$17M	6.97%	ADD 8%
3	ACADIAN ASSET MANAGEMENT LLC	4,038,7854.0M	$9M	3.64%	ADD 17%
4	Foresite Capital Management IV, LLC	3,887,2003.9M	$8M	3.50%	—
5	VANGUARD CAPITAL MANAGEMENT LLC	3,678,7223.7M	$8M	3.31%	NEW†
6	Merck & Co., Inc.	3,545,7193.5M	$8M	3.19%	—
7	D. E. Shaw & Co., Inc.	3,332,8353.3M	$7M	3.00%	ADD 41%
8	683 Capital Management, LLC	3,200,0003.2M	$7M	2.88%	TRIM -4%
9	Balyasny Asset Management L.P.	2,935,2532.9M	$6M	2.64%	TRIM -10%
10	Nantahala Capital Management, LLC	2,815,9832.8M	$6M	2.54%	NEW†
11	VANGUARD PORTFOLIO MANAGEMENT LLC	2,583,5422.6M	$6M	2.33%	NEW†
12	GEODE CAPITAL MANAGEMENT, LLC	2,286,2182.3M	$5M	2.06%	ADD 10%
13	JACOBS LEVY EQUITY MANAGEMENT, INC	2,154,3612.2M	$5M	1.94%	—
14	Spruce Street Capital LP	2,101,0682.1M	$5M	1.89%	ADD 88%
15	Ikarian Capital, LLC	2,082,6062.1M	$4M	1.88%	—
16	Kynam Capital Management, LP	2,000,0002.0M	$4M	1.80%	—
17	MILLENNIUM MANAGEMENT LLC	1,979,2262.0M	$4M	1.78%	ADD 48%
18	STATE STREET CORP	1,865,5261.9M	$4M	1.68%	ADD 3%
19	FMR LLC	1,796,1041.8M	$4M	1.62%	TRIM -19%
20	MEDICI CAPITAL LLC	1,652,5201.7M	$4M	1.49%	ADD 10%
21	Eversept Partners, LP	1,351,1061.4M	$3M	1.22%	ADD 34%
22	Euclidean Capital LLC	1,307,8581.3M	$3M	1.18%	—
23	RENAISSANCE TECHNOLOGIES LLC	1,287,6911.3M	$3M	1.16%	TRIM -17%
24	TWO SIGMA INVESTMENTS, LP	1,279,3061.3M	$3M	1.15%	ADD 23%
25	DEUTSCHE BANK AG\	1,092,9031.1M	$2M	0.98%	ADD 6%
26	DEERFIELD MANAGEMENT COMPANY, L.P.	1,055,1921.1M	$2M	0.95%	—
27	ADAR1 Capital Management, LLC	1,050,0001.1M	$2M	0.95%	TRIM -5%
28	DAFNA Capital Management LLC	908,351908,351	$2M	0.82%	—
29	Elmind Capital, LP	900,000900,000	$2M	0.81%	—
30	MACKENZIE FINANCIAL CORP	857,354857,354	$2M	0.77%	ADD 30%
31	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	787,408787,408	$2M	0.71%	ADD 18%
32	AQR CAPITAL MANAGEMENT LLC	711,334711,334	$2M	0.64%	ADD 19%
33	NORTHERN TRUST CORP	692,256692,256	$1M	0.62%	ADD 18%
34	MARSHALL WACE, LLP	620,424620,424	$1M	0.56%	TRIM -47%
35	GOLDMAN SACHS GROUP INC	604,562604,562	$1M	0.54%	ADD 38%
36	PANAGORA ASSET MANAGEMENT INC	590,388590,388	$1M	0.53%	TRIM -31%
37	VANGUARD FIDUCIARY TRUST CO	577,939577,939	$1M	0.52%	NEW
38	XTX Topco Ltd	559,896559,896	$1M	0.50%	TRIM -6%
39	BOOTHBAY FUND MANAGEMENT, LLC	559,726559,726	$1M	0.50%	—
40	Affinity Asset Advisors, LLC	500,000500,000	$1M	0.45%	NEW
41	JANE STREET GROUP, LLC	399,464399,464	$858,848	0.36%	TRIM -60%
42	BANK OF AMERICA CORP /DE/	380,908380,908	$818,951	0.34%	ADD 183%
43	MORGAN STANLEY	364,567364,567	$783,821	0.33%	ADD 14%
44	DIMENSIONAL FUND ADVISORS LP	283,817283,817	$609,754	0.26%	ADD 43%
45	AMERIPRISE FINANCIAL INC	271,272271,272	$583,234	0.24%	TRIM -23%
46	Invesco Ltd.	265,067265,067	$569,893	0.24%	TRIM -5%
47	Bank of New York Mellon Corp	252,297252,297	$542,440	0.23%	ADD 16%
48	NANO CAP NEW MILLENNIUM GROWTH FUND L P	200,000200,000	$430,000	0.18%	—
49	CANADA PENSION PLAN INVESTMENT BOARD	183,200183,200	$393,880	0.17%	ADD 6%
50	Nuveen, LLC	154,930154,930	$333,100	0.14%	ADD 16%
51	Utah Retirement Systems	154,290154,290	$331,724	0.14%	ADD 15%
52	UBS Group AG	145,344145,344	$312,490	0.13%	ADD 22%
53	BRIDGEWAY CAPITAL MANAGEMENT, LLC	142,500142,500	$306,375	0.13%	ADD 24%
54	PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	136,000136,000	$292,400	0.12%	—
55	SUSQUEHANNA INTERNATIONAL GROUP, LLP	107,597107,597	$231,334	0.10%	TRIM -63%
56	RHUMBLINE ADVISERS	101,327101,327	$217,845	0.09%	—
57	Odyssean, LLC	89,78389,783	$193,033	0.08%	NEW
58	STRS OHIO	86,50086,500	$185,975	0.08%	TRIM -22%
59	Point72 Asset Management, L.P.	80,09180,091	$172,196	0.07%	ADD 247%
60	GSA CAPITAL PARTNERS LLP	78,20778,207	$168,000	0.07%	TRIM -65%
61	CITADEL ADVISORS LLC	77,54577,545	$166,722	0.07%	TRIM -17%
62	Blackstone Inc.	77,14577,145	$165,862	0.07%	ADD 15%
63	Jasper Ridge Partners, L.P.	73,53173,531	$158,092	0.07%	TRIM -23%
64	DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main	69,66669,666	$149,781	0.06%	NEW
65	SIMPLEX TRADING, LLC	68,47768,477	$147,225	0.06%	TRIM -17%
66	ALLIANCEBERNSTEIN L.P.	92,94092,940	$144,986	0.08%	—
67	Russell Investments Group, Ltd.	66,13166,131	$142,181	0.06%	TRIM -8%
68	PRICE T ROWE ASSOCIATES INC /MD/	56,10056,100	$121,000	0.05%	—
69	Cannell & Spears LLC	54,64254,642	$117,480	0.05%	—
70	SEI INVESTMENTS CO	53,84653,846	$115,769	0.05%	ADD 219%
71	Vanguard Personalized Indexing Management, LLC	50,62950,629	$108,852	0.05%	TRIM -5%
72	HSBC HOLDINGS PLC	48,52348,523	$104,810	0.04%	TRIM -50%
73	IEQ CAPITAL, LLC	47,08047,080	$101,222	0.04%	NEW
74	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	42,66142,661	$91,721	0.04%	ADD 14%
75	BARCLAYS PLC	42,59142,591	$91,570	0.04%	TRIM -89%
76	MetLife Investment Management, LLC	36,20836,208	$77,847	0.03%	NEW
77	JPMORGAN CHASE & CO	37,37937,379	$75,505	0.03%	ADD 15%
78	WELLS FARGO & COMPANY/MN	34,52634,526	$74,231	0.03%	TRIM -62%
79	Vanguard Global Advisers, LLC	31,30231,302	$67,299	0.03%	NEW
80	Vontobel Holding Ltd.	30,00030,000	$64,500	0.03%	—
81	CWM, LLC	28,98528,985	$62,318	0.03%	ADD 138%
82	Cerity Partners LLC	26,97626,976	$57,999	0.02%	ADD 97%
83	MANUFACTURERS LIFE INSURANCE COMPANY, THE	26,14826,148	$56,218	0.02%	TRIM -9%
84	Diversified Trust Co	25,89525,895	$55,674	0.02%	ADD 84%
85	INTECH INVESTMENT MANAGEMENT LLC	23,95423,954	$51,501	0.02%	TRIM -31%
86	PRUDENTIAL FINANCIAL INC	23,79523,795	$51,159	0.02%	TRIM -26%
87	Verdad Advisers, LP	23,55423,554	$50,641	0.02%	NEW
88	Police & Firemen's Retirement System of New Jersey	23,42623,426	$50,366	0.02%	—
89	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	18,19718,197	$43,855	0.02%	NEW
90	BNP PARIBAS FINANCIAL MARKETS	20,02720,027	$43,058	0.02%	TRIM -11%
91	Quadrature Capital Ltd	19,48619,486	$41,895	0.02%	TRIM -69%
92	Bronte Capital Management Pty Ltd.	19,28219,282	$41,456	0.02%	—
93	Mariner, LLC	18,79918,799	$40,367	0.02%	NEW
94	VOYA INVESTMENT MANAGEMENT LLC	15,47815,478	$33,278	0.01%	ADD 11%
95	NEUBERGER BERMAN GROUP LLC	14,52814,528	$31,235	0.01%	ADD 3%
96	HAMILTON LANE ADVISORS LLC	14,40014,400	$30,960	0.01%	NEW
97	ProShare Advisors LLC	13,18813,188	$28,354	0.01%	TRIM -10%
98	Merit Financial Group, LLC	10,92810,928	$23,495	0.01%	NEW
99	HighTower Advisors, LLC	10,76010,760	$23,134	0.01%	ADD 7%
100	CAPTRUST FINANCIAL ADVISORS	10,64810,648	$22,886	0.01%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

TCG Crossover Management, LLC

—

10.0M

$22M

BlackRock, Inc.

9.1M

8.3M

8.0M

7.2M

7.1M

7.7M

$17M

ACADIAN ASSET MANAGEMENT LLC

1.0M

1.4M

2.2M

2.4M

3.4M

4.0M

$9M

Foresite Capital Management IV, LLC

—

3.9M

$8M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.7M

$8M

Merck & Co., Inc.

3.5M

$8M

D. E. Shaw & Co., Inc.

369K

469K

534K

978K

2.4M

3.3M

$7M

683 Capital Management, LLC

—

1.0M

3.4M

3.2M

$7M

Balyasny Asset Management L.P.

—

3.3M

2.9M

$6M

Nantahala Capital Management, LLC

—

2.8M

$6M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

2.6M

$6M

GEODE CAPITAL MANAGEMENT, LLC

1.9M

2.0M

1.9M

2.1M

2.3M

$5M

JACOBS LEVY EQUITY MANAGEMENT, INC

1.1M

1.3M

1.2M

2.2M

$5M

Spruce Street Capital LP

—

1.1M

2.1M

$5M

Ikarian Capital, LLC

950K

900K

760K

2.1M

$4M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	137	88,395,619	79.6%	$190M
2025-Q4	130	84,505,149	76.1%	$132M
2025-Q3	149	74,879,530	67.4%	$222M
2025-Q2	136	70,872,649	63.8%	$99M
2025-Q1	141	72,635,517	65.4%	$90M
2024-Q4	150	73,449,395	66.2%	$139M
2024-Q3	159	75,276,413	67.8%	$351M
2024-Q2	159	74,344,012	67.0%	$337M

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · ALEC

Large holders — 13G, passive (top 5 of 8 by % of class)

Holder

% of class

Type

As of

TCG Crossover GP II, LLC

9.2%

Passive

2025-10-22

SEC →

Rosenthal Arnon

7.4%

Exempt

2025-12-31

SEC →

BlackRock, Inc.

5.2%

QII

2026-03-31

SEC →

Polaris Venture Partners VI, L.P.

4.7%

Exempt

2026-03-31

SEC →

FMR LLC

3.6%

QII

ALEC US Equity☆

Institutional ownership· 13F filers holding ALEC · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · ALEC

Institutional ownership· 13F filers holding ALEC · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · ALEC

ALEC US Equity