| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Opaleye Management Inc. | 2,561,9502.6M | $14M | 11.77% | ADD 24% |
| 2 | Solas Capital Management, LLC | 1,924,6171.9M | $11M | 8.84% | TRIM -2% |
| 3 | AWM Investment Company, Inc. | 1,672,1681.7M | $9M | 7.68% | — |
| 4 | Cable Car Capital, LP | 1,382,3391.4M | $8M | 6.35% | ADD 30% |
| 5 | Ikarian Capital, LLC | 1,056,2591.1M | $6M | 4.85% | — |
| 6 | SPHERA FUNDS MANAGEMENT LTD. | 567,616567,616 | $3M | 2.61% | — |
| 7 | Alyeska Investment Group, L.P. | 365,000365,000 | $2M | 1.68% | — |
| 8 | BOOTHBAY FUND MANAGEMENT, LLC | 256,393256,393 | $1M | 1.18% | — |
| 9 | Aristides Capital LLC | 218,510218,510 | $1M | 1.00% | — |
| 10 | CANTOR FITZGERALD, L. P. | 188,631188,631 | $1M | 0.87% | ADD 15% |
| 11 | CITADEL ADVISORS LLC | 89,58989,589 | $491,844 | 0.41% | TRIM -24% |
| 12 | VILLERE ST DENIS J & CO LLC | 71,15871,158 | $390,657 | 0.33% | TRIM -4% |
| 13 | TUDOR INVESTMENT CORP ET AL | 61,59661,596 | $338,162 | 0.28% | — |
| 14 | ACT CAPITAL MANAGEMENT, LLC | 51,50051,500 | $282,735 | 0.24% | — |
| 15 | BERKSHIRE ASSET MANAGEMENT LLC/PA | 19,82419,824 | $108,834 | 0.09% | — |
| 16 | TWO SIGMA INVESTMENTS, LP | 15,88615,886 | $87,214 | 0.07% | TRIM -72% |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 11,99211,992 | $65,836 | 0.06% | — |
| 18 | RAYMOND JAMES FINANCIAL INC | 10,00010,000 | $54,900 | 0.05% | NEW |
| 19 | NATIONAL BANK OF CANADA /FI/ | 5,2925,292 | $28,298 | 0.02% | — |
| 20 | Allworth Financial LP | 750750 | $4,118 | 0.00% | — |
| 21 | ROYAL BANK OF CANADA | 679679 | $4,000 | 0.00% | ADD 457% |
| 22 | UBS Group AG | 438438 | $2,405 | 0.00% | TRIM -53% |
| 23 | Steward Partners Investment Advisory, LLC | 200200 | $1,098 | 0.00% | — |
| 24 | JONES FINANCIAL COMPANIES LLLP | 100100 | $508 | 0.00% | NEW |
| 25 | HARBOUR INVESTMENTS, INC. | 44 | $25 | 0.00% | NEW |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | — | — | — | 115K | 2.1M | 2.6M | $14M |
| Solas Capital Management, LLC | 1.4M | 1.4M | 1.3M | 1.3M | 2.0M | 1.9M | $11M |
| AWM Investment Company, Inc. | — | 1.1M | 1.1M | 1.1M | 1.7M | 1.7M | $9M |
| Cable Car Capital, LP | 515K | 515K | 869K | 869K | 1.1M | 1.4M | $8M |
| Ikarian Capital, LLC | 756K | 968K | 918K | 946K | 1.1M | 1.1M | $6M |
| SPHERA FUNDS MANAGEMENT LTD. | 620K | 597K | 377K | 339K | 568K | 568K | $3M |
| Alyeska Investment Group, L.P. | 400K | 337K | — | — | 365K | 365K | $2M |
| BOOTHBAY FUND MANAGEMENT, LLC | 218K | 281K | 263K | 292K | 256K | 256K | $1M |
| Aristides Capital LLC | 200K | 200K | 165K | 165K | 215K | 219K | $1M |
| CANTOR FITZGERALD, L. P. | — | — | — | — | 163K | 189K | $1M |
| CITADEL ADVISORS LLC | — | — | — | — | 118K | 90K | $491,844 |
| VILLERE ST DENIS J & CO LLC | 24K | 72K | 64K | 65K | 74K | 71K | $390,657 |
| TUDOR INVESTMENT CORP ET AL | 70K | 70K | 70K | 62K | 62K | 62K | $338,162 |
| ACT CAPITAL MANAGEMENT, LLC | — | — | — | — | 52K | 52K | $282,735 |
| BERKSHIRE ASSET MANAGEMENT LLC/PA | — | — | 12K | 18K | 20K | 20K | $108,834 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 25 | 10,532,491 | 48.4% | $58M |
| 2025-Q4 | 27 | 9,909,100 | 45.5% | $64M |
| 2025-Q3 | 28 | 5,643,121 | 25.9% | $37M |
| 2025-Q2 | 26 | 5,719,161 | 26.3% | $53M |
| 2025-Q1 | 22 | 6,338,463 | 29.1% | $32M |
| 2024-Q4 | 23 | 5,943,397 | 27.3% | $35M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| Opaleye Management Inc. | 14.22% | Passive | 2026-07-23 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
