Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-06-26 | Kihara James | Officer | −Sell | 11,421 | $26.08 | $297,860 |
| 2026-05-29 | Daly James M | Director | +Exercise | 8,107 | — | — |
| 2026-05-29 | GAROFALO ELIZABETH A. | Director | +Exercise | 8,107 | — | — |
| 2026-05-29 | Poole Jonathan | Director | +Exercise | 2,010 | — | — |
| 2026-05-29 | Brege Laura | Director | +Exercise | 8,107 | — | — |
| 2026-05-29 | Ndu Adora | Director | +Exercise | 8,107 | — | — |
| 2026-05-29 | HARRIGAN EDMUND | Director | +Exercise | 8,107 | — | — |
| 2026-05-29 | Baker Brothers Life Sciences LP | Director,TenPercentOwner | +Grant | 18,622 | — | — |
| 2026-05-29 | Baker Brothers Life Sciences LP | Director,TenPercentOwner | +Grant | 18,622 | — | — |
| 2026-05-26 | Kihara James | Officer | −Sell | 5,401 | $21.18 | $114,393 |
| 2026-05-04 | Schneyer Mark C. | Officer | −Sell | 3,506 | $21.79 | $76,396 |
| 2026-05-04 | Kihara James | Officer | −Sell | 1,332 | $21.79 | $29,024 |
| 2026-05-01 | Schneyer Mark C. | Officer | +Exercise | 6,815 | — | — |
| 2026-05-01 | Kihara James | Officer | +Exercise | 2,596 | — | — |
| 2026-04-07 | Kihara James | Officer | −Sell | 1,030 | $22.20 | $22,866 |
| 2026-04-07 | Schneyer Mark C. | Officer | −Sell | 2,709 | $22.20 | $60,140 |
| 2026-04-05 | Kihara James | Officer | +Exercise | 2,010 | — | — |
| 2026-04-05 | Schneyer Mark C. | Officer | +Exercise | 5,276 | — | — |
| 2026-03-26 | Schneyer Mark C. | Officer | −Sell | 37 | $21.72 | $804 |
| 2026-03-26 | Schneyer Mark C. | Officer | −Sell | 3,171 | $21.65 | $68,652 |
| 2026-03-26 | Kihara James | Officer | −Sell | 12 | $21.73 | $261 |
| 2026-03-26 | Kihara James | Officer | −Sell | 1,097 | $21.65 | $23,750 |
| 2026-03-25 | Schneyer Mark C. | Officer | −Sell | 4,177 | $21.47 | $89,680 |
| 2026-03-25 | Schneyer Mark C. | Officer | +Exercise | 6,178 | — | — |
| 2026-03-25 | Kihara James | Officer | +Exercise | 2,142 | — | — |
| 2026-03-25 | Kihara James | Officer | −Sell | 833 | $21.47 | $17,885 |
| 2026-03-25 | Thompson Elizabeth H.Z. | Officer | −Sell | 3,435 | $21.47 | $73,749 |
| 2026-03-25 | Rhodes Jennifer J | Officer | −Sell | 3,844 | $21.47 | $82,531 |
| 2026-03-25 | Owen Adams Catherine | Director,Officer | −Sell | 11,641 | $21.47 | $249,932 |
| 2026-03-24 | Schneyer Mark C. | Officer | +Exercise | 8,138 | — | — |
| 2026-03-24 | Kihara James | Officer | +Exercise | 1,627 | — | — |
| 2026-03-24 | Thompson Elizabeth H.Z. | Officer | +Exercise | 6,715 | — | — |
| 2026-03-24 | Rhodes Jennifer J | Officer | +Exercise | 7,515 | — | — |
| 2026-03-24 | Owen Adams Catherine | Director,Officer | +Exercise | 23,509 | — | — |
| 2026-02-09 | Rhodes Jennifer J | Officer | −Sell | 6,950 | $23.38 | $162,491 |
| 2026-02-06 | Rhodes Jennifer J | Officer | +Exercise | 12,944 | — | — |
| 2025-11-18 | Kihara James | Officer | −Sell | 4,084 | $23.69 | $96,750 |
| 2025-11-18 | Schneyer Mark C. | Officer | −Sell | 10,262 | $23.69 | $243,107 |
| 2025-11-17 | Kihara James | Officer | +Exercise | 3,966 | — | — |
| 2025-11-17 | Kihara James | Officer | +Exercise | 3,966 | — | — |
| 2025-11-17 | Schneyer Mark C. | Officer | +Exercise | 9,913 | — | — |
| 2025-11-17 | Schneyer Mark C. | Officer | +Exercise | 9,913 | — | — |
| 2025-11-10 | Daly James M | Director | −Sell | 30,000 | $22.37 | $671,100 |
| 2025-09-15 | Schneyer Mark C. | Officer | −Sell | 3,498 | $23.65 | $82,728 |
| 2025-09-12 | Schneyer Mark C. | Officer | +Grant | 6,815 | — | — |
| 2025-09-02 | GAROFALO ELIZABETH A. | Director | −Sell | 1,600 | $25.98 | $41,568 |
| 2025-08-18 | Schneyer Mark C. | Officer | −Sell | 22,000 | $25.18 | $553,960 |
| 2025-06-04 | Brege Laura | Director | −Sell | 14,446 | $21.78 | $314,634 |
| 2025-05-29 | Baker Bros. Advisors (GP) LLC | Director,TenPercentOwner | +Grant | 16,214 | — | — |
| 2025-05-29 | Baker Bros. Advisors (GP) LLC | Director,TenPercentOwner | +Grant | 16,214 | — | — |
| 2025-05-29 | Brege Laura | Director | +Exercise | 9,387 | — | — |
| 2025-05-29 | Daly James M | Director | +Exercise | 9,387 | — | — |
| 2025-05-29 | GAROFALO ELIZABETH A. | Director | +Exercise | 9,387 | — | — |
| 2025-05-29 | HARRIGAN EDMUND | Director | +Exercise | 9,387 | — | — |
| 2025-05-29 | Ndu Adora | Director | +Exercise | 9,387 | — | — |
| 2025-05-29 | SOLAND DANIEL B | Director | +Exercise | 9,387 | — | — |
| 2025-05-16 | Schneyer Mark C. | Officer | −Sell | 2,000 | $25.00 | $50,000 |
| 2025-05-16 | Kihara James | Officer | −Sell | 2,000 | $25.00 | $50,000 |
| 2025-05-16 | Kihara James | Officer | −Sell | 2,000 | $20.00 | $40,000 |
| 2025-05-02 | Schneyer Mark C. | Officer | −Sell | 3,498 | $14.60 | $51,071 |
| 2025-05-02 | Kihara James | Officer | −Sell | 1,327 | $14.60 | $19,374 |
| 2025-05-01 | Schneyer Mark C. | Officer | +Exercise | 6,815 | — | — |
| 2025-05-01 | Kihara James | Officer | +Exercise | 2,596 | — | — |
| 2025-04-08 | Kihara James | Officer | −Sell | 1,028 | $14.82 | $15,235 |
| 2025-04-08 | Schneyer Mark C. | Officer | −Sell | 2,708 | $14.82 | $40,133 |
| 2025-04-05 | Kihara James | Officer | +Exercise | 2,010 | — | — |
| 2025-04-05 | Schneyer Mark C. | Officer | +Exercise | 5,275 | — | — |
| 2025-03-26 | Schneyer Mark C. | Officer | −Sell | 3,171 | $17.05 | $54,066 |
| 2025-03-26 | Kihara James | Officer | −Sell | 1,095 | $17.05 | $18,670 |
| 2025-03-25 | Schneyer Mark C. | Officer | +Exercise | 6,178 | — | — |
| 2025-03-25 | Kihara James | Officer | +Exercise | 2,142 | — | — |
| 2025-03-05 | GAROFALO ELIZABETH A. | Director | −Sell | 4,919 | $18.23 | $89,673 |
| 2025-02-24 | Schneyer Mark C. | Officer | −Sell | 773 | $19.96 | $15,429 |
| 2025-02-24 | Kihara James | Officer | −Sell | 475 | $19.96 | $9,481 |
| 2025-02-23 | Schneyer Mark C. | Officer | +Exercise | 1,353 | — | — |
| 2025-02-23 | Kihara James | Officer | +Exercise | 840 | — | — |
| 2024-11-19 | Schneyer Mark C. | Officer | −Sell | 10,259 | $16.81 | $172,454 |
| 2024-11-19 | Kihara James | Officer | −Sell | 4,073 | $16.81 | $68,467 |
| 2024-11-19 | Teehan Brendan | Officer | −Sell | 10,329 | $16.81 | $173,630 |
| 2024-11-17 | Schneyer Mark C. | Officer | +Exercise | 9,913 | — | — |
| 2024-11-17 | Schneyer Mark C. | Officer | +Exercise | 9,913 | — | — |
| 2024-11-17 | Kihara James | Officer | +Exercise | 3,965 | — | — |
| 2024-11-17 | Kihara James | Officer | +Exercise | 3,965 | — | — |
| 2024-11-17 | Teehan Brendan | Officer | +Exercise | 9,913 | — | — |
| 2024-11-17 | Teehan Brendan | Officer | +Exercise | 9,913 | — | — |
| 2024-10-12 | Ndu Adora | Director | +Exercise | 4,381 | — | — |
| 2024-08-19 | DAVIS STEPHEN | Director,Officer | −Sell | 31,747 | $15.28 | $485,094 |
| 2024-08-19 | Teehan Brendan | Officer | −Sell | 9,534 | $15.28 | $145,680 |
| 2024-08-19 | Schneyer Mark C. | Officer | −Sell | 9,733 | $15.28 | $148,720 |
| 2024-08-16 | DAVIS STEPHEN | Director,Officer | +Grant | 17,333 | — | — |
| 2024-08-16 | DAVIS STEPHEN | Director,Officer | +Grant | 44,782 | — | — |
| 2024-08-16 | Teehan Brendan | Officer | +Grant | 13,629 | — | — |
| 2024-08-16 | Teehan Brendan | Officer | +Grant | 5,024 | — | — |
| 2024-08-16 | Schneyer Mark C. | Officer | +Grant | 5,275 | — | — |
| 2024-08-16 | Schneyer Mark C. | Officer | +Grant | 13,629 | — | — |
| 2024-06-10 | Schneyer Mark C. | Officer | −Sell | 975 | $14.79 | $14,420 |
| 2024-06-08 | Schneyer Mark C. | Officer | +Exercise | 1,893 | — | — |
| 2024-05-29 | BAKER BROS. ADVISORS LP | Director,TenPercentOwner | +Grant | 18,774 | — | — |
| 2024-05-29 | BAKER BROS. ADVISORS LP | Director,TenPercentOwner | +Grant | 18,774 | — | — |
| 2024-05-29 | Brege Laura | Director | +Exercise | 6,652 | — | — |
| 2024-05-29 | SOLAND DANIEL B | Director | +Exercise | 6,652 | — | — |
| 2024-05-29 | HARRIGAN EDMUND | Director | +Exercise | 6,652 | — | — |
| 2024-05-29 | Daly James M | Director | +Exercise | 6,652 | — | — |
| 2024-05-29 | GAROFALO ELIZABETH A. | Director | +Exercise | 6,652 | — | — |
| 2024-05-29 | Ndu Adora | Director | +Exercise | 6,652 | — | — |
| 2024-05-02 | Kihara James | Officer | −Sell | 1,326 | $16.94 | $22,462 |
| 2024-05-02 | Schneyer Mark C. | Officer | −Sell | 3,503 | $16.94 | $59,341 |
| 2024-05-02 | DAVIS STEPHEN | Director,Officer | −Sell | 11,427 | $16.94 | $193,573 |
| 2024-05-02 | Teehan Brendan | Officer | −Sell | 3,477 | $16.94 | $58,900 |
| 2024-05-01 | Kihara James | Officer | +Exercise | 2,596 | — | — |
| 2024-05-01 | Schneyer Mark C. | Officer | +Exercise | 6,814 | — | — |
| 2024-05-01 | DAVIS STEPHEN | Director,Officer | +Exercise | 22,391 | — | — |
| 2024-05-01 | Teehan Brendan | Officer | +Exercise | 6,814 | — | — |
| 2024-04-08 | Schneyer Mark C. | Officer | −Sell | 2,716 | $17.87 | $48,535 |
| 2024-04-08 | Kihara James | Officer | −Sell | 1,028 | $17.87 | $18,370 |
| 2024-04-08 | Kihara James | Officer | −Sell | 762 | $17.87 | $13,617 |
| 2024-04-08 | Teehan Brendan | Officer | −Sell | 2,568 | $17.87 | $45,890 |
| 2024-04-08 | DAVIS STEPHEN | Director,Officer | −Sell | 8,858 | $17.87 | $158,292 |
| 2024-04-08 | DAVIS STEPHEN | Director,Officer | −Sell | 17,716 | $17.87 | $316,585 |
| 2024-04-07 | Kihara James | Officer | +Exercise | 1,489 | — | — |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
